Ukubuyekezwa kwe-Methylene Blue Nemibiko ye-Reddit: Indlela Yokuyifunda

Thayipha ukuthi “ukubuyekezwa kwe-methylene blue” ebhokisini lokusesha, bese imibiko ivela ngaphambi kwezivivinyo. Omunye ubhala ukuthi usephinde wakwazi ukwenza izinto ntambama. Omunye ubhala ukuthi akwenzekanga lutho. Owesithathu uchaza ubusuku obubi bese eyeka ukuthumela. Kuyalinga ukuyibala: uma abantu abanele bechaza ushintsho olufanayo, kumelwe kube nokuthile okukhona.

Iqoqo lemibiko yomuntu siqu alisona isivivinyo esincane somtholampilo. Liwuhlobo oluhlukile lwento, oluhlanganiswe abantu abangakaze bavume ukuba yisampula.

Okuqukethwe umbiko owodwa

Cabanga ngokuthunyelwe okunengqondo: “Sekungamaviki amabili ngisebenzisa i-methylene blue, amaconsi ayishumi emanzini njalo ekuseni. Ukufiphala kokucabanga sekuphelile, sengizizwa ngingumina futhi.”

Kuleyo misho emithathu kunezitatimende ezine. Kwakukhona umkhiqizo, kwasetshenziswa inani, kwadlula isikhathi, futhi kukhona okwashintsha. Sifunda isitatimende sokugcina bese sithatha ezintathu zokuqala njengemininingwane nje, kuyilapho ziyizona ezibeka imikhawulo. Umkhiqizo uyilokho okwakusebhodleleni. Inani liwukubalwa kwamaconsi, okungesona isilinganiso. Ushintsho luwumbono womuntu siqu, olulinganiswe yilowo obelindele ukuthi kwenzeke okuthile, kungekho ukuqhathanisa futhi kungekho rekhodi lesimo sokuqala. Lokho kungokubonwa okukodwa, futhi kungokoqobo, ngoba lowo muntu wazizwa ehlukile ngempela. Akukabi yincazelo.

Ezinye izincazelo ezine nazo ziyahambisana kahle nalowo musho: ukulindela, okunye okushintsha ngesikhathi esifanayo, ukuguquguquka kophawu ngokwalo, nokushintsha kwendlela yokulinganisa. Akukho nokukodwa okungakhishwa ngalo mbiko kuphela.

Abantu abangazwanga lutho banesizathu esincane sokubhala

Ubufakazi obucace kakhulu bokuthi imibiko eku-inthanethi iyisampula ehlanekezelwe buvela ekuqhathanisweni kwango-2014 kokubuyekezwa okungu-1,901 kwe-Amazon kwezindlela zokwehlisa isisindo nezokwelapha izinkinga zokuzala nemiphumela yezivivinyo. Ngemva kwezinyanga eziyisithupha ekudleni kwe-Atkins, u-93% wababhala ukubuyekezwa ku-inthanethi (64 kwabangu-69) wabika ukwehla kwesisindo okungenani ngo-10 kg, kuyilapho u-27% wabahlanganyeli besivivinyo (19 kwabangu-71) wafinyelela ushintsho olufanayo. Isiphetho sababhali siwumusho okufanele ukhunjulwe: “Ukubuyekezwa ku-inthanethi kweqisa izinzuzo zokwelashwa, mhlawumbe ngoba abantu abanemiphumela engemihle abathambekele kangako ekutsheleni abanye ngalokho ababhekane nakho.” Umuntu othuthukile unendaba angayixoxa; umuntu ochithe amaviki ayisithupha ezizwa ngendlela efanayo akanalutho angalubika.

Ukuhlanekezela akubheki ohlangothini olufanayo njalo, futhi lokho kuyafundisa. Ukuhlaziywa kwango-2025 kokuthunyelwe okungu-369 ku-Reddit mayelana nezithasiselo zokuzala kwathola isimo esiphambene: kubabhali abangu-279 ababika ukuthi bathatha izithasiselo, u-9.3% wachaza umphumela obonakala umuhle, u-12.9% wachaza omubi, kanti u-21.1% wacela iseluleko. Enkundleni egxile ekuxazululeni izinkinga, leyo yindlela elindelekile. Olunye ucwaningo lwathola ukuthi iziguli ezajoyina umphakathi wezempilo eku-inthanethi zazinamaphuzu aphezulu okucindezeleka nokukhathazeka kunabantu ababengewona amalungu.

Ingxube yemibiko iwuphawu lomphakathi, hhayi ukubalwa okuphelele kwemiphumela.

Ukulindela kuyingxenye yalokho okwenzekayo

Ukuphikisa okuvamile kuphathelene nomuntu uqobo: “Angilona uhlobo lomuntu okhohliswa ukulindela.”

Ngo-2010, ithimba elaliholwa yi-Harvard lanikeza abantu abangu-80 abanesifo samathumbu acasukayo amaphilisi e-placebo achazwa kubo ngokwethembeka njengangenawo umuthi osebenzayo, noma langabanikeza nhlobo ukwelashwa, amaqembu womabili enesikhathi esilinganayo sokuxhumana nodokotela. Emasontweni amathathu, amaphuzu okuthuthuka kukonke ayengu-5.0 ± 1.5 eqenjini elalazi ukuthi lithatha i-placebo, uma kuqhathaniswa no-3.9 ± 1.3 eqenjini elalingelashwa. Kamuva, ukuhlaziywa okuhlanganisiwe kwezivivinyo eziyishumi nanye ezazinabahlanganyeli abangu-654 kwathola umphumela ohlanganisiwe wokuphambuka okujwayelekile okungu-0.72. Umuntu othatha i-methylene blue akekho ngisho nasesimweni se-placebo echazwe ngokwethembeka: ukholelwa ukuthi iyasebenza, uyikhethile, uyikhokhele, futhi nguyena oqopha umphumela.

Izilinganiso zokusebenza komzimba nazo ziyashintsha. Ocwaningweni lwe-placebo olwahlukanisa umphumela we-caffeine nowokwaziswa ngayo kubagijimi, izikhathi zokugijima ibanga le-1000-metre zathuthuka kuphela lapho abahlanganyeli bekholelwa ukuthi bathathe i-caffeine, kungakhathaliseki ukuthi yayikhona yini ekhephsuleni: ubukhulu bomphumela babungu-0.43 esimweni sokukhohliswa, uma kuqhathaniswa no-0.42 lapho bethathe i-caffeine yangempela. Ukutshelwa ukuthi bathathe i-placebo akuzange kulethe ukuthuthuka ngisho nalapho i-caffeine yayisemzimbeni.

Akekho ongafihla umbala

Izithasiselo eziningi zivumela umngane ukuba alungiselele amakhephsula afanayo. I-methylene blue ayikuvumeli lokho: uma ithathwa ngomlomo, yenza umchamo ube luhlaza okwesibhakabhaka noma ube luhlaza, futhi ngezinye izikhathi ishintsha nombala wendle.

Isivivinyo esabelwa ngokungahleliwe sango-2016 ku-Radiology sakusingatha ngokucophelela lokhu. Abahlanganyeli banikezwa i-methylene blue yezinga le-USP engu-280 mg ngomlomo noma isithako sokufaka umbala ekudleni i-FD&C Blue No. 2 kumakhephsula afanayo angabonakali ngaphakathi, futhi bacelwa ukuba bachame ngaphambi kokuthatha umthamo, kodwa bangachami ngemva kwawo kuze kuphele ukuskenwa, ukuze umbala womchamo ungadaluli ukuthi ubani othole ini. Umzamo ubhaliwe, kanjalo nokwehluleka kwawo: bonke abahlanganyeli abathola i-methylene blue babika umchamo oluhlaza okwesibhakabhaka ngemva kwalokho, futhi akekho eqenjini le-placebo owakubika. Ababhali babiza lokho kushintsha kombala ngokuthi “uphawu oluvela kamuva oluqinisekisa ukuthi bathole umuthi.”

Isibonelo esikhulu sibonisa okudingeka kudelwe. Isivivinyo sesigaba 3 se-LMTM sango-2016 sabela iziguli ezingu-891 ezinesifo se-Alzheimer ngokungahleliwe, futhi sasingenalo nhlobo iqembu le-placebo. Iqembu laso lokuqhathanisa lathola u-4 mg kabili ngosuku, owakhethwa, njengoba ababhali besho, “ukuze kugcinwe ukufihlwa kokwabelwa ngokuphathelene nokushintsha kombala womchamo noma wendle.” Iphilisi elingenawo umuthi osebenzayo beliyobonakala ngokwenzeka endlini yangasese. Ucwaningo lokushintshanisa ukwelashwa kwesifo se-bipolar olwamukela iziguli ezingu-37 futhi lwabiza iqembu lalo lika-15 mg ngokuthi “i-placebo” lwenza ukuyekethisa okufanayo lapho luqhathanisa neqembu lomthamo osebenzayo ka-195 mg.

Funda lezo zindlela zokuhlela ucwaningo njengesexwayiso mayelana nokuzilinga komuntu siqu. Uma amakhulu eziguli esivivinyweni esixhaswe ngemali, esinamakhephsula angabonakali ngaphakathi nohlu lokwabela ngokungahleliwe olwenziwe isazi sezibalo, ayesakwazi ukubona ukuthi abelwe ini, umuntu olinganisa amaconsi engilazini yamanzi ekhaya usevele uyazi ukuthi uthathani. Ukufihla lokho akunzima nje lapha. Akutholakali.

Uphawu lunesikhathi salo

Abantu abavamile ukuqala isithasiselo ngeviki elihle. Baqala ngelibi, okuletha ukubuyela esilinganisweni esimaphakathi: amanani akude kakhulu nesilinganiso asondela futhi kumanani avamile, kungakhathaliseki ukuthi kwenziwa okuthile ngawo yini.

Lokho kubuyela kuyalinganiseka. Eqenjini leziguli ezingelashwa ezazinobuhlungu obungapheli engxenyeni engezansi yomhlane, ubuhlungu obumaphakathi esikalini sika-0 kuya ku-100 basuka ku-56 ekuvakasheni kokuqala baya ku-54 ezinyangeni ezimbili kamuva naku-46 ngemva kwezinyanga ezine. Ababhali bathi ingxenye yalolo shintsho ibangelwa ukunakwa okuhambisana nokuba yingxenye yocwaningo, esinye isici esididayo esikhona kunoma yikuphi ukuzilinga.

Ukuthuthuka okuzenzekelayo kuvamile ezimweni abantu abazibalayo lapho bexoxa nge-methylene blue. Ezigulini ezingu-79 ezazinesifo sokukhathala okungapheli esase sithathe isikhathi esingaphansi kweminyaka emibili futhi ezingazange zithole ukungenelela okuhlelekile, u-46% wabika ukuthuthuka ngemva konyaka. Eqenjini labantu abangu-1,266 ababelaliswe esibhedlela nge-COVID-19, cishe u-65% walabo ababika ukufiphala kokucabanga, ukulahlekelwa inkumbulo, noma ukwehla kokugxila esikhathini esimaphakathi sezinyanga ezingu-8.4 awusakubikanga ezinyangeni ezingu-13.2, kuyilapho abanye baba nalolo phawu phakathi nesikhathi esifanayo. Kubantu abanokucindezeleka okukhulu okungelashwa abavela ekunakekelweni okuyisisekelo, kulinganiselwa ukuthi u-23% uyadamba izimpawu phakathi kwezinyanga ezintathu kanti u-53% phakathi nonyaka.

Akukho kulokhu okusho ukuthi i-methylene blue ayenzi lutho. Kuchaza isimo sokuqala umbiko womuntu siqu ongenaso, futhi ushintsho lobukhulu obuvame ukuchazwa kokuthunyelwe enkundleni lungaphakathi kobubanzi boshintsho olwenzeka ngokwalo.

Amaphuzu anesikhathi sawo

Ukuphinda ukulinganisa kushintsha isilinganiso. Abantu abadala abanempilo enhle abaqeda uchungechunge olukhulu lokuhlolwa kokusebenza kwengqondo nobuchopho izikhathi eziyisikhombisa ngonyaka bathuthuka ngokuphindaphinda nje kuphela: imiphumela yokuzijwayeza yokuphambuka okujwayelekile okungu-0.36 kuya ku-1.19 ngesikhathi sokuhlolwa njalo kuze kube yinyanga yesithathu, ngemva kwalokho ukusebenza kwahlala ezingeni elifanayo. Ukwenyuka okukhulu kakhulu kwenzeka ekuhlolweni kwesibili. Amaphuzu akhuphukayo phakathi kwamaviki amathathu okuhlolwa kwansuku zonke kokuqeqesha ubuchopho awumphumela olindelekile wokwenza ukuhlolwa amaviki amathathu elandelana.

Izikali umuntu azilinganisela kuzo nazo azivikelekile. Ukuphindaphindwa kohlu lwemibuzo lwe-Beck Depression Inventory esampuleni yabafundi kwaveza ukwehla kwamaphuzu ngo-40% phakathi kwamaviki ayisishiyagalombili okwabangelwa ukulinganisa okuphindaphindiwe kuphela, okwachaza cishe u-10% wokuhlukahluka. “Bengilokhu ngilinganisela isimo sami sengqondo njalo ekuseni futhi siya siba ngcono” kuwumusho ophathelene nokulinganisa ngendlela ofana ngayo nophathelene nesimo sengqondo.

Ngokuvamile kukhona okunye okwashintsha ngesikhathi esifanayo

Abantu abaningi ababhala umbiko nge-methylene blue base bevele beshintsha ezinye izinto: ukulala, ukuzivocavoca, utshwala, isithasiselo sesibili, ukukhanya kwemini, noma umsebenzi owawubacindezela osuphelile. Umbiko ubiza umkhiqizo ngoba uyinto entsha kakhulu ohlwini, hhayi ngoba uwukuphela kwento.

Umbiko awufiki nenani eliqinisekisiwe

Amaconsi ayiyunithi evamile ekubuyekezweni kwe-methylene blue, kodwa awayona iyunithi yokulinganisa. Ucwaningo lwamabhodlela angu-19 anamaconsisi anemithamo eminingi lwathola umthamo wethonsi elilodwa usukela ku-33.8 kuya ku-63.4 microlitres, umehluko osondele kokuphindwe kabili phakathi kwamabhodlela, kanti ukuwatshekisa kancane kwakukhiqiza amaconsi amancane. “Amaconsi ayishumi” ebhodleleni elilodwa angacishe aphindwe kabili kunalawo ebhodleleni elinye, futhi okuthunyelwe ngokuvamile akusho ukugxila komkhiqizo, ngakho ngisho nomthamo woketshezi olinganiswe kahle awukwazi ukuguqulelwa esisindweni. Umhlahlandlela wamayunithi omthamo uchaza okudingekayo kulokho kuguqula.

Inani libalulekile nangendlela engabonakali kalula, ngoba ubudlelwano phakathi komthamo nomphumela abuwona umugqa oqondile. Ezivivinyweni zamagundane, u-4 mg/kg wathuthukisa ukujwayela kokuziphatha nokubona izinto ezazibonwe ngaphambili, u-50 kuya ku-100 mg/kg wehlisa ukugijima esondweni, kanti ukugxila okuphansi kwandisa ukusetshenziswa komoya-mpilo wobuchopho ngaphandle komzimba nangemva kokunikezwa emzimbeni ophilayo, indlela ababhali abayichaza ngokuthi incike emthamo kuzo zombili izinhlangothi. Ukubuyekezwa kwenkumbulo nokugxila kuhlukanisa ucwaningo lwabantu ngokomthamo ngesizathu esifanayo. Ngakho ukubuyekezwa okuhle akukhombi inani elingakusebenzela, futhi indaba yokungazizwa lutho ayikhiphi ukuthi kungaba nomphumela ngenani elihlukile.

Kukhona elinye igebe phakathi kwenani nokuthi umzimba uthola okungakanani. Ocwaningweni lokushintshanisa olwabandakanya abantu abadala abangu-16 abanempilo enhle, isilinganiso sokutholakala emzimbeni komthamo owawuthathwe ngomlomo uncibilikiswe emanzini sasingu-72.3%, nokuphambuka okujwayelekile okungamaphuzu amaphesenti angu-23.9. Abantu ababili abathatha inani elifanayo elilinganisiwe abadingi ukufinyelela ekugxileni okufanayo egazini, njengoba ukubuyekezwa kokumuncwa nokusakazwa emzimbeni kuchaza.

Umbiko awufiki nomkhiqizo oqinisekisiwe

Konke ukubuyekezwa kuwukubuyekezwa kwebhodlela, futhi okuqukethwe okulinganisiwe kuvame ukuhluka kokuselebula. Ukuhlaziywa kwemikhiqizo engu-30 ye-melatonin kwathola ukuthi ngaphezu kuka-71% kwakungaphandle kobubanzi buka-10% bokuqukethwe okushiwo, kusukela ku-83% ngaphansi kuya ku-478% ngaphezu kwenani elishiwo, umehluko phakathi kwamaqoqo okufinyelela ku-465%, futhi eyisishiyagalombili yayo yayine-serotonin. Eqoqweni lezithasiselo zamakhambi nezokudla ezingu-272 ezazihlotshaniswa nokulimala kwesibindi, u-51% wawunamalebula angalungile, okwakukhuphukela ku-82% emikhiqizweni yama-steroid.

I-methylene blue inemibandela yayo, futhi izinto ezenzelwe ukudaya azidingeki ukuba ziyilandele. Umkhiqizo ohambisana nencazelo esemthethweni encwadini yamazinga emithi uhlolwa ukuze kuqinisekiswe ukuthi uyinto efanele, ubumsulwa, ukungcola kwezinhlanganisela eziphilayo njenge-Azure B, izinsalela zezincibilikisi, ukungcola kwezakhi zamakhemikhali, izinsalela ngemva kokushiswa, imikhawulo yamagciwane namanye amagciwane amancane, kanye nama-endotoxin amagciwane. Isihloko sokungcola nezindlela zokuhlola sibonisa lezo zivivinyo nalokho imiphumela eshicilelwe yamasampula e-methylene blue ekuhlanganisayo nengakuhlanganisi.

Lena yingxenye yesinqumo sokuthenga umfundi angayiqinisekisa. Abathengisi abaningi be-methylene blue abakhangisa ukuthi ihambisana ne-USP bahlola izinsimbi ezisindayo kuphela bese bechaza lokho njengokuhambisana ngokugcwele. I-Blupreme isebenza nomkhiqizi wemithi we-methylene blue futhi ishicilela izitifiketi zokuhlaziywa eziqondene neqoqo ngalinye, ezixhumanisa inombolo yeqoqo esebhodleleni neqoqo lesithako elihloliwe. Ikhasi lesiqu se-USP lichaza lokho imibandela ekuhlanganisayo, kanti umhlahlandlela wokufunda isitifiketi sokuhlaziywa ubonisa indlela yokufanisa umbiko neqoqo olitholile.

Ukwazi ukuthi kwakukhona ini ebhodleleni kususa isici esisodwa esididayo. Akuguquli umbiko womuntu oyedwa obekwazi ukuthi uthathani ube ubufakazi bokuthi umkhiqizo ubangele ushintsho.

Yimiphi imibiko esasifanele ukuyifunda

Izindaba zomuntu siqu ziwubufakazi obubuthaka benzuzo futhi ziwubufakazi obunengqondo bokunye: inkinga engase ibe khona. Uma abantu abaningana, ngokuzimela, bechaza ukusabela okufanayo okuhlukile, lokho kuwumbono udokotela angawuhlola, futhi ukubuka konke kwemiphumela engemihle kuchaza indlela yokuchaza lokho okuthathiwe nokuthi ukusabela okusolwayo kungabikwa kuphi. Umhlahlandlela wokweqisa umthamo nokungenwa ubuthi uchaza uhlangothi oluphuthumayo lwalokho.

Imibiko ikutshela futhi ukuthi yimiphi imibuzo okufanele uyibuze. Ingxoxo yabantu abaphikisanayo ngokuthi i-methylene blue ibasizile yini ekulaleni iwuphawu lokuthi ukulala kufanele kubhekwe ezincwadini zezivivinyo, hhayi uphawu lokuthi i-methylene blue iyasiza ekulaleni. Ukubuyekezwa kobufakazi kubantu kubonisa lokho lezo zincwadi ezikuqukethe, kanti umtapo wocwaningo uqoqa izivivinyo.

Ukufunda ingxoxo ngaphandle kokuzikhohlisa

Indlela imfushane. Kopisha isitatimende njengoba sinjalo. Hlukanisa lokho umuntu akubonile nalokho aphethe ngokuthi kusho ukuthini. Bese ubala izincazelo ezingaba khona ubuze ukuthi yisiphi lo mbiko osikhiphayo. Ezimweni eziningi impendulo eqotho ithi akukho, futhi isimo sombiko siwukuthi awukaxazululwa kunokuthi uyiqiniso noma ungamanga.

Landa ishidi lokuhlola indaba yomuntu siqu ukuze wenze lokho kuhlola engxoxweni ethile. Libala imininingwane evame ukushoda, indawo yokuqopha izincazelo ezincintisanayo, kanye nendlela yokugcina irekhodi kunoma ubani onquma ukuzama okuthile noma kunjalo.

Uma uzihlola okuthile, ukukhetha okune kwenza irekhodi libe usizo kakhulu kunokuthunyelwe okuvamile: nquma umphumela ozowulinganisa nesikali sokuwulinganisa ngaphambi komthamo wokuqala, gcina irekhodi lesimo sokuqala isikhathi esanele ukuze libonise indlela uphawu oluguquka ngayo ngokuvamile, shintsha into eyodwa ngesikhathi, futhi uqophe nezinsuku ezihambe kabi. Umhlahlandlela wokuhlola uhlelo olutholwe ku-inthanethi usebenzisa ukuqaphela okufanayo emiyalweni kunasezintweni abantu ababhekane nazo.

Amaqiniso amabili ahambisanayo aphetha le mpikiswano. Ukuzizwa ungcono akufakazeli ukuthi umkhiqizo ubangele ukuthuthuka, futhi ukungazizwa lutho akufakazeli ukuthi umkhiqizo awenzi lutho nganoma yiliphi inani noma nganoma yiluphi uhlobo. Womabili la maphutha avela ekuthatheni okubonwe kanye kuphela, umuntu azi ukuthi uthathani, njengomphumela. Lokho ukubuyekezwa okungakwengeza kuyisizathu sokubheka kabanzi, kanye nesexwayiso okufanele sithathwe isinyathelo ngaso.