Imibuzo evame ukubuzwa.

I-Blupreme Methylene Blue ingathengwa ngokuqondile ku-blupreme.com nakubathengisi abagunyaziwe abasohlwini lwewebhusayithi yethu.

I-Blupreme ihlolwa ngokuhambisana nakho konke ukucaciswa okusebenzayo kwe-monograph ye-USP–NF Methylene Blue, izimfuneko zezincibilikisi eziyinsalela kanye nezimfuneko ezengeziwe zekhwalithi. Isixazululo esiphelile esingu-1% sikhiqizwa futhi sifakwe emabhodleleni e-Lithuania ngaphansi kwamazinga e-GMP futhi siqukethe i-methylene blue yezinga le-USP namanzi ahlanziwe kuphela.

I-USP–NF iyindinganiso eyaziwayo yekhwalithi yezemithi. Isimangalo sezinga le-USP sidinga ukuhambisana nazo zonke izimfuneko ezisebenzayo ze-monograph nezimfuneko ezivamile, kuhlanganise nobunikazi, ukuhlolwa kokuqukethwe, ukungcola kwezinhlanganisela zekhabhoni nezinye izilawuli ezifanele.

Impushana ingabiza kancane ukuyipakisha nokuyithutha, kodwa idinga ukukalwa okunembile, ukukalwa kwamanzi nokuxutshwa. Isixazululo se-Blupreme esinamanzi esingu-1% sesilungile, ngakho akudingeki ukukala impushana noma ukulungisa isixazululo.

Isixazululo esingu-1% wesisindo ngevolumu siqukethe igremu elingu-1 le-methylene blue ku-100 mL wesixazululo. Lokhu kulingana no-10 mg ngemililitha.

Isixazululo esingu-0.1% wesisindo ngevolumu siqukethe igremu elingu-1 le-methylene blue ilitha ngalinye. Isixazululo se-Blupreme sigxile ku-1%, hhayi ku-0.1%.

Gcina ibhodlela liqondile, livikelekile ekukhanyeni, nangaphansi kwe-25 °C. Yigcine kude nezingane futhi uyisebenzise ngaphambi kwedethi engcono kakhulu yangaphambi kokuphrinta ephaketheni.

Yebo. Ibhodlela ngalinye lihlinzekwa nephiphethi eliconsisayo elinezimpawu zokukala ku-0.25 mL, 0.5 mL naku-1 mL. Asikho isidingo sokuthenga iphiphethi eliconsisayo elihlukile.

Cishe amaconsi amabili aqukethe u-1 mg we-methylene blue, kanti amaconsi ayishumi aqukethe cishe u-5 mg. Ubukhulu bamaconsi bungahluka kuye ngendlela iphiphethi eliconsisayo elibanjwa futhi lisetshenziswe ngayo.

I-methylene blue imunca ukukhanya kakhulu. Lokhu kungenza isixazululo esiluhlaza okwesibhakabhaka okumnyama sibonakale sicishe sibe mnyama ebhodleleni.

Isitifiketi sokuhlaziywa, noma i-COA, siyidokhumenti yelabhorethri eqondene neqoqo. Sihlonza into ehloliwe, inombolo yeqoqo, ukucaciswa kwekhwalithi, imiphumela yokuhlolwa nokuthi iqoqo lihlangabezane yini nezimfuneko ezishiwo.

Vula ikhasi Lokuhlolwa Kwekhwalithi bese ulandela imiyalelo yamarekhodi eqoqo. Qondanisa inombolo yeqoqo ebhodleleni lakho neqoqo lesithako elisohlwini kanye nesitifiketi salo sokuhlaziywa.

Yebo. Ikhasi Lokuhlola Ikhwalithi lichaza izivivinyo ezenziwe, izincazelo ezisebenzayo, nokuthi imiphumela ibonisani.

Yebo. Iqoqo ngalinye lihlolwa ngokuhambisana nokucaciswa kwesithako nomkhiqizo ophelile ngaphambi kokukhishwa.

Ukuhlola kwenziwa uzakwethu waselabhorethri e-Lithuania esebenzisa izindlela ezichaziwe nemikhawulo yokwamukela.

Ukuhlolwa kwezinsimbi ezisindayo kukala ukungcola kwezakhi okukhethiwe kodwa akunikezi ulwazi ngokuhlolwa kokuqukethwe, i-Azure B, okunye ukungcola kwezinhlanganisela zekhabhoni, izincibilikisi eziyinsalela, amazinga amagciwane noma ama-endotoxin ebhaktheriya.

I-Azure B iwukungcola kwenhlanganisela yekhabhoni okuqanjwe ngegama futhi iwumkhiqizo oseceleni ongafuneki wokukhiqizwa kwe-methylene blue. I-monograph ye-USP–NF ibeka umkhawulo wayo omkhulu. Ukuhlolwa kwezinsimbi ezisindayo akukwazi ukuyithola.

Ukungcola kwezinhlanganisela zekhabhoni yizinto ezihlobene namakhemikhali ezingavela ngesikhathi sokukhiqiza noma ukucekelwa phansi kwezithako. Ukuhlola kuhlanganisa ukungcola okucacisiwe okufana ne-Azure B, ukungcola ngakunye okungacacisiwe, kanye nenani eliphelele lokunye ukungcola.

Izincibilikisi eziyinsalela zingamakhemikhali aguquguqukayo angase asale ngemva kokukhiqizwa kwesithako. Ukuhlola kunquma ukuthi izincibilikisi ezishiwo zikhona yini nokuthi amazinga azo angaphakathi kwemikhawulo ebekiwe.

Ukuhlolwa kwensalela ngemva kokushiswa, okubizwa nangokuthi ukuhlolwa komlotha one-sulfate, kukala izinto ezingaphili ezingaguquguquki ezisala ngemva kokushiswa kwesampula ngaphansi kwezimo ezilawulwayo. Kuhlukile ekuhlolweni kwezincibilikisi eziyinsalela.

Ukuhlolwa kokungcola kwezakhi kwe-Blupreme kuhlanganisa umthofu, i-arsenic, i-cadmium ne-mercury. Le miphumela iyingxenye eyodwa yokuhlolwa kwekhwalithi iyonke.

Ukuhlolwa kwe-microbial kukala inani eliphelele lama-microorganisms e-aerobic kanye nama-yeasts kanye nesikhunta. Iphinde ihlole izinto eziphilayo ezithile ezifana ne-E. coli.

Ama-endotoxin amagciwane yizinto ezihlobene nolwelwesi lwangaphandle lwamagciwane athile. Ukuhlolwa kwe-endotoxin kuthola ukungcola okungenzeka kungabonakali ngokuhlolwa kwesibalo se-microbial okuvamile.

Ukuhlolwa kokuqukethwe kukala ukuthi ingakanani i-methylene blue ekhona esithakweni esihloliwe bese kuqhathaniswa umphumela nebanga lokwamukelwa le-USP–NF elisebenzayo.

Igama ngezinye izikhathi lisetshenziswa ngaphandle kobufakazi bokuhlola USP–NF okuphelele. Isimangalo esifanele kufanele sisekelwe yimiphumela ebonisa ukuthobelana nazo zonke izidingo ezisebenzayo ze-monograph nezimfuneko ezivamile, hhayi isigaba esisodwa esikhethiwe sokungcola.

I-Good Production Practice iwuhlelo lokukhiqiza olulawulwayo oluhlanganisa abasebenzi, izinsiza, okokusebenza, izinto zokwakha, amarekhodi, inhlanzeko, ukulawula ikhwalithi, ukuchezuka, nokukhululwa kweqoqo. GMP ukukhiqiza akufaki ukuhlolwa komkhiqizo. Kudingeka kokubili.

Isixazululo se-Blupreme methylene blue siqukethe amanzi ahlanzekile alungiselwe ukwenziwa komkhiqizo olawulwayo futhi ahlolwe ngokumelene nemikhawulo echaziwe yamakhemikhali kanye ne-microbiological. Ukwakhiwa akuqukethe utshwala, ama-flavour, ama-sweeteners, izithasiselo, noma izilondolozi.

Okwamanje asinaso isitifiketi senkampani yangaphandle esingesona se-GMO se-Blupreme.

Cha. Gcina ibhodlela limile, livikelekile ekukhanyeni, nangaphansi kwe-25 °C. Ungawubeki elangeni eliqondile noma eduze nomthombo wokushisa.

Gcina ibhodlela livaliwe ngokuvikelekile futhi ulisebenzise ngaphambi kwedethi engcono kakhulu yangaphambi kokuphrinta ephaketheni. Okwamanje asicacisi sepaisilinganiso sesikhathi sokulinganisa sokusebenzisa isisombululo ngemva kokuvula ibhodlela. Yilahle uma uphawu lwangempela lonakalisiwe noma isixazululo siba noshintsho olungalindelekile ekubukekeni.

Ukushisa isikhathi eside, ukukhanya okuqondile, noma ukubanda kungathinta ibhodlela noma ikhwalithi yomkhiqizo. Gcina i-Blupreme ngezansi 25 °C futhi ungayifrizi.

Ungavumeli iphiphethi eliconsisayo ukuthi ithinte izandla zakho, umlomo, indawo yokusebenza, noma ezinye izinto. Libuyisele ebhodleleni ngokushesha ngemva kokulisebenzisa futhi ulivale ngokuphepha.

Gcoba ukuchitheka ngokushesha ngezinto ezilahlwayo, hlambulula indawo ethintekile ngamanzi abandayo, futhi uyihlanze ngesihlanzi esifanele. Ungawahlanganisi amakhemikhali okuhlanza. Hlola noma iyiphi indlela endaweni engabonakali ngoba methylene blue ingaba namabala unaphakade.

Yebo. I-I-methylene eluhlaza okwesibhakabhaka idayi enamandla futhi ingangcolisa isikhumba, izingubo, indawo yokusebenza, i-grout, nezinye izinto ezimbotshana. Phatha ibhodlela ngokucophelela futhi uvikele izindawo ezizungezile.

Ibhodlela 100 mL lihlangabezana nomkhawulo ojwayelekile we-EU wesiqukathi esingasodwana esiwuketshezi emthwalweni wesandla. Yigcine ivaliwe ekufakweni kwayo kwasekuqaleni futhi uqinisekise izidingo zamanje zesikhumulo sezindiza nezenkampani yendiza ngaphambi kohambo.

I-Methylene blue iyi-monoamine oxidase inhibitor enamandla ehlehliswayo. Ukuyihlanganisa nemithi eyandisa i-serotonin kungabangela i-serotonin syndrome.

Kubantu abanokushoda kwe-glucose-6-phosphate dehydrogenase (G6PD), methylene blue ingabangela ukubhujiswa kwamaseli abomvu egazi, abizwa ngokuthi i-hemolysis. Imithi egunyaziwe methylene blue ayivunyelwe kubantu abanokuntula G6PD.

Ngobuningi beqoqo, xhumana ne-support@blupreme.com ngobuningi obudingekayo, izwe okuyiwa kulo, nezimfuneko zokulethwa.

Ungakwazi ukubonisa futhi ukhokhe nge-EUR, USD, GBP, CAD, AUD, CHF, JPYno>JPY translate=",> translate="no">SEK, NOK, DKK, noma NZD. Imali ekhethiwe kanye nesamba sokugcina siboniswa ngaphambi kokukhokha.

Izindleko zokuthumela zibalwa ekuphumeni ngokusekelwe endaweni kanye nesevisi yokulethwa etholakalayo.

Izindlela zokukhokha ezitholakalayo ziboniswa ekuphumeni. Izinketho zokukhokha kuphela ezitholakalayo ze-oda, izwe, kanye nemali eboniswayo.

Hlola imininingwane yekhadi nekheli lokukhokha, bese ubuza ibhange lakho ukuthi ingabe likuvimbile yini umsebenzi. Uma ibhange liqinisekisa ukuthi awukho umkhawulo, xhumana ne-support@blupreme.com.

Engeza umkhiqizo ekalishini lakho, qhubekela ekuphumeni, faka imininingwane yakho yokulethwa, khetha indlela yokukhokha yekhadi etholakalayo, bese uqedela i-oda ngemva kokubuyekeza isamba nemininingwane yokulethwa.

Yebo. Amazwe esiwathumela kuwo okwamanje akuhlu ekuphumeni. Ukutholakala kuncike kusevisi yenkampani yenethiwekhi yamanje kanye nemikhawulo yendawo oya kuyo.

Ama-oda ahamba phakathi kwamazwe angamalungu e-EU ngokuvamile awakho ngaphansi kwentela yempahla evela kwamanye amazwe. Imithetho ehlukile ingase isebenze ezindaweni ezingaphandle kwendawo yentela yempahla ye-EU.

Ulwazi lokulandelela luthunyelwa nge-imeyili ngemva kokuthunyelwa. Sebenzisa isixhumanisi kuleyo imeyili ukuze ulandele ukuthunyelwa.

Ukulethwa kwe-EU ngokuvamile kuthatha izinsuku ezi-3 kuya kwezi-4. Ukulethwa ngaphandle kwe-EU cishe izinsuku eziyi-10. Lezi yizilinganiso, akuzona iziqinisekiso.

Yebo. Sithengisela kokubili amakhasimende ngamanye kanye namabhizinisi.