Ongororo dzemethylene blue: izvo zvinotaurwa nevanhu zvinogona nezvisingagoni kukuudza

Nyora kuti “ongororo dzemethylene blue” mubhokisi rekutsvaga, uye zvinotaurwa nevanhu zvinotanga kuoneka miedzo isati yaoneka. Mumwe anonyora kuti ava kunzwa zvakanaka zvakare masikati. Mumwe anonyora kuti hapana chakaitika. Wechitatu anotsanangura usiku hwakaipa obva arega kunyora. Zvinokwezva kuzviverenga: kana vanhu vakawanda vachitsanangura shanduko imwe chete, panofanira kunge paine chimwe chinhu chiripo.

Muunganidzwa wezvinotaurwa nevanhu hauzi muyedzo mudiki wekiriniki. Chinhu cherumwe rudzi, chakaunganidzwa nevanhu vasina kumbobvuma kuva boka rinomiririra vamwe.

Zviri muzvinotaurwa nemunhu mumwe

Funga nezvechinyorwa chinogona kunyatsoonekwa: “Mavhiki maviri ndichitora methylene blue, madonhwe gumi mumvura mangwanani oga oga. Kusajeka kwepfungwa kwapera, ndava kunzwa sendaimboita zvakare.”

Pane zvinhu zvina zvinonzi zvakaitika mumitsara mitatu iyoyo. Paiva nechigadzirwa, uwandu hwakashandiswa, nguva yakapfuura, uye chimwe chinhu chakashanduka. Tinoverenga chirevo chekupedzisira toona zvitatu zvekutanga sezvinongoshongedza nyaya, asi ndizvo zvinoratidza miganhu yayo. Chigadzirwa chacho chero chaiva mubhodhoro. Uwandu hwacho kuverengwa kwemadonhwe, kusiri kuyerwa. Shanduko yacho maonero emunhu pachake, akaiswa chiyero nemunhu aitarisira kuti chimwe chinhu chiitike, pasina chekuenzanisa nacho uye pasina zvakanyorwa pakutanga. Icho chinhu chimwe chakacherechedzwa, uye ndechechokwadi, nokuti munhu wacho akanzwa akasiyana. Hachisati chava tsananguro.

Dzimwe tsananguro ina dzinokodzerawo mutsara iwoyo zvakafanana: zvinotarisirwa nemunhu, chimwe chinhu chichishanduka panguva imwe chete, kushanduka kwechiratidzo pachacho, uye kuchinja kwenzira yekuyera. Hapana inogona kubviswa pachishandiswa chinyorwa ichocho chete.

Vanhu vasina chavakanzwa vane chikonzero chidiki chekunyora

Uchapupu hwakajeka zvikuru hwokuti zvinotaurwa paindaneti iboka rakarerekera hunobva pakuenzanisa kwakaitwa muna 2014 pakati peongororo 1,901 dzepaAmazon dzemishonga yekuderedza uremu neyekubatsira kubereka nemhedzisiro yemiedzo. Mushure memwedzi mitanhatu vachitevera kudya kweAtkins, 93% yevakanyora ongororo paindaneti (64 pa69) vakati vakarasikirwa neuremu hunosvika 10 kg kana kupfuura, asi 27% yevakapinda mumiedzo (19 pa71) chete ndivo vakawana shanduko imwe chete. Mhedziso yevanyori ndiyo mutsara wokurangarira: “Ongororo dzepaindaneti dzinowedzeredza mabhenefiti emishonga, zvichida nokuti vanhu vane mhedzisiro isina kunaka havanyanyi kuda kuudza vamwe zvakaitika kwavari.” Munhu akaita zviri nani ane nyaya yekutaura; munhu akapedza mavhiki matanhatu achinzwa sezvaaimboita haana chaangataura.

Kuti kurerekera uku kunoenda kudivi ripi hakuna kugara kwakafanana, uye izvi zvinodzidzisa. Ongororo ya2025 yezvinyorwa 369 zveReddit pamusoro pezvinowedzerwa mukudya zvekubatsira kubereka yakawana zvakapesana: pavanyori 279 vakati vakatora zvinowedzerwa mukudya, 9.3% vakatsanangura zvakanaka zvavaifunga kuti zvakaitika uye 12.9% vakatsanangura zvakaipa, nepo 21.1% vakakumbira mazano. Kuforamu yakanangana nekugadzirisa matambudziko, ndiwo maitiro anotarisirwa. Imwe ongororo yakawana kuti varwere vakapinda muboka rezveutano repaindaneti vaiva nezvibodzwa zvekuora mwoyo nekufunganya zvakakwirira kupfuura zvevasiri nhengo.

Musanganiswa wezvinotaurwa unoratidza boka racho, kwete kuverengwa kwemhedzisiro yose.

Zvinotarisirwa zvine zvazvinoita

Kuramba kunowanzobva pamaonero emunhu pachake: “Handisi munhu anonyengedzwa nezvaanotarisira.”

Muna 2010, boka raitungamirirwa neHarvard rakapa vanhu 80 vane irritable bowel syndrome mapiritsi eplacebo avakatsanangurirwa chokwadi kuti haana chinhu chinoshanda, kana kusavapa kurapwa zvachose, uye mapoka ose ari maviri aiwana nguva yakaenzana nevashandi vezveutano. Pamasvondo matatu, zvibodzwa zvekuvandudzika kwose zvaiva 5.0 ± 1.5 muboka raiziva kuti raitora placebo, zvichienzaniswa ne3.9 ± 1.3 muboka risina kurapwa. Imwe ongororo yakabatanidza miedzo gumi neimwe yaiva nevanhu 654 yakazotevera yakawana saizi yemhedzisiro yakabatanidzwa ye0.72 yemwero wekutsauka kubva paavhareji. Munhu anotora methylene blue haasi kunyange mumamiriro eplacebo yakatsanangurwa pachena: anotenda kuti ine chinhu chinoshanda, akaisarudza, akaibhadharira, uye ndiye anonyora mhedzisiro yacho.

Zviyero zvemashandiro emuviri zvinoshandukawo. Muongororo yevamhanyi yaipatsanura zvakapiwa nezvavaifunga kuti vapiwa, nguva dzemijaho ye1000-metre dzakavandudzika chete apo vanhu vaitenda kuti vakanga vatora caffeine, zvisinei nokuti caffeine yaiva mukapuleti here kana kuti kwete: saizi yemhedzisiro yaiva 0.43 pavakanyengedzwa, ichienzaniswa ne0.42 pavakatora caffeine chaiyo. Kuudzwa kuti vakanga vatora placebo hakuna kuvandudza nguva, kunyange caffeine yaiva mumuviri.

Hapana anogona kuvanza ruvara

Zvizhinji zvinowedzerwa mukudya zvinobvumira shamwari kugadzira makapuleti anotaridzika zvakafanana. Methylene blue haibvumiri izvi: ikatorwa nemuromo, inoita kuti weti ive yebhuruu kana yegirini, uye dzimwe nguva tsvina zvakare.

Muyedzo wa2016 wakabudiswa muRadiology, waigovera vanhu mumapoka nenzira isina kurerekera, wakabata nyaya iyi nokungwarira. Vanhu vakapiwa 280 mg yemethylene blue yegiredhi reUSP yekutorwa nemuromo kana dhayi yezvokudya yeFD&C Blue No. 2 mumakapuleti akafanana asingaratidzi zviri mukati, uye vakakumbirwa kuita weti vasati vatora zvakapiwa, asi vozorega kusvika kuongororwa nemuchina kwapera, kuitira kuti ruvara rweweti rusavazivisa boka ravaiva mariri. Kuedza uku kwakanyorwa, uye kukundikana kwako kwakanyorwawo: vanhu vose vakapiwa methylene blue vakati weti yavo yakazova yebhuruu, asi hapana wemuboka replacebo akataura kudaro. Vanyori vakadana kushanduka kweruvara kuti “chiratidzo chakazononoka kuoneka, chichisimbisa kuti vakanga vapiwa mushonga.”

Muenzaniso mukuru unoratidza mutengo weizvi. Muyedzo wechikamu 3 weLMTM wa2016 wakagovera varwere 891 vane chirwere cheAlzheimer mumapoka nenzira isina kurerekera uye wakanga usina boka replacebo zvachose. Boka rayo rekuenzanisa rakapiwa 4 mg kaviri pazuva, uwandu hwakasarudzwa, sekutaura kwevanyori, “kuti vanhu vasazive boka ravo vachitarisa kushanduka kweruvara rweweti kana tsvina.” Piritsi risina chinhu chinoshanda raizozivikanwa pachimbuzi. Ong ororo yebipolar disorder yaichinjanisa vanhu pakati pemapoka, yakanyoresa varwere 37 uye yakadana boka re15 mg kuti “placebo”, yakaitawo kubvumirana kwakadaro ichienzanisa neboka re195 mg raiva nemushonga unoshanda.

Verenga magadzirirwo iwayo seyambiro pamusoro pekuzviedzera. Kana mazana evarwere mumuyedzo une mari, nemakapuleti asingaratidzi zviri mukati uye runyoro rwakagadzirwa nenyanzvi yezviverengero rwekugovera mapoka nenzira isina kurerekera, vaigona kuziva boka ravo, munhu anodira madonhwe mugirazi remvura kumba anotoziva zvaari kutora. Kuvanza ruzivo urwu hakusi kungonetsa pano. Hakugone kuitwa.

Chiratidzo chine nguva yacho pachacho

Vanhu havawanzotanga kutora chinowedzerwa mukudya muvhiki rakanaka. Vanotanga muvhiki rakaipa, izvo zvinounza kudzokera paavhareji: zviyero zviri kure neavhareji zvinodzokera pedyo nayo zvisinei nokuti pane chaitwa nezvazvo here kana kuti kwete.

Kudzokera uku kunogona kuyerwa. Muboka risina kurapwa revarwere vaiva nemarwadzo asingaperi kuzasi kwemusana, avhareji yemarwadzo pachiyero che0 kusvika 100 yakabva pa56 pakushanya kwekutanga kuenda pa54 mushure memwedzi miviri uye 46 mushure memwedzi mina. Vanyori vanoti chikamu cheshanduko iyoyo chakakonzerwa nokutariswa kwavaiitwa vari muongororo, chimwe chinhu chinovhiringidza mhedziso chiripowo mukuzviedzera kwose.

Kuvandudzika kunoitika kwega kwakajairika mumamiriro anotaurwa nevanhu pavanokurukura methylene blue. Pavarwere 79 vaiva nechronic fatigue syndrome kwemakore asingasviki maviri, uye vasina chirongwa chakarongeka chekupindira, 46% vakati vakanga vavandudzika papera gore rimwe. Muboka revanhu 1,266 vakaiswa muchipatara vaine COVID-19, vanenge 65% yevaiti vaiva nekusajeka kwepfungwa, kurasikirwa nendangariro, kana kutadza kuisa pfungwa pachinhu paavhareji yemwedzi 8.4 vakanga vasisatauri izvozvo pamwedzi 13.2, asi vamwe vakatanga kuva nechiratidzo ichocho panguva imwe cheteyo. Pavanhu vaiva nekuora mwoyo kwakanyanya vasina kurapwa, vakatorwa kubva mumakiriniki ekutanga, zvinofungidzirwa kuti 23% vanenge vasisaratidzi chirwere mukati memwedzi mitatu uye 53% mukati megore.

Hapana pane izvi chinoreva kuti methylene blue haina zvainoita. Zvinotsanangura mamiriro ekutanga asipo muzvinotaurwa nemunhu, uye shanduko yehukuru hunowanzotsanangurwa muforamu iri mukati memiganhu yezvinogona kuitika zvega.

Chibodzwa chine nguva yacho pachacho

Kudzokorora kuyera kunochinja chiyero chacho. Vanhu vakuru vaiva neutano vakapedza bvunzo dzakawanda dzemashandiro epfungwa kanomwe mugore vakavandudzika nokudzokorora chete: mhedzisiro yekujaira bvunzo yaiva 0.36 kusvika 1.19 yemwero wekutsauka kubva paavhareji panguva yekuongororwa kakawanda kusvika pamwedzi wechitatu, mushure maizvozvo kugona kwavo kwakazomira padanho rimwe. Kukwira kukuru kwakaitika pakuita bvunzo kechipiri. Chibodzwa chinokwira mumavhiki matatu ebvunzo dzezuva nezuva dzekudzidzisa pfungwa ndicho chinotarisirwa pakuita bvunzo kwemavhiki matatu akatevedzana.

Zviyero zvinozadzwa nemunhu achizviongorora hazvipunyuki izvi. Kudzokorora Beck Depression Inventory muboka revadzidzi kwakabudisa kudzikira kwezvibodzwa ne40% mumavhiki masere kwakakonzerwa nekudzokorora kuyera chete, kuchitsanangura inenge 10% yekusiyana kwezvibodzwa. “Ndanga ndichiyera manzwiro angu mangwanani oga oga uye ari kuvandudzika” mutsara unotaura nezvekuyera zvakangofanana nezvaunotaura nezvemanzwiro acho.

Kazhinji chimwe chinhu chakashandukawo panguva imwe chete

Vanhu vazhinji vanonyora nezvemethylene blue vakanga vachitochinja zvimwe zvinhu: kurara, maekisesaizi, doro, chimwe chinowedzerwa mukudya, chiedza chemasikati, kana basa rainetsa rakapera. Chinyorwa chinodoma chigadzirwa nokuti ndicho chitsva zvikuru parunyoro, kwete nokuti ndicho chete.

Zvinotaurwa hazvina uwandu hwakasimbiswa

Madonhwe ndiwo anowanzoshandiswa sechiyero muongororo dzemethylene blue, asi haasi chiyero chakatarwa. Ong ororo yemabhodhoro 19 ane zvinodonhedza uye anoshandiswa kakawanda yakawana kuti vhoriyamu yedonhwe rimwe yaibva pa33.8 kusvika 63.4 microlitres, musiyano waiva pedyo nekaviri pakati pemabhodhoro, uye kukotamisa bhodhoro zvishoma kwaibudisa madonhwe madiki. “Madonhwe gumi” kubva mune rimwe bhodhoro anogona kuda kuenzana nekaviri “madonhwe gumi” kubva mune rimwe, uye chinyorwa chinowanzosiya kuti mushonga wakanyungudutswa wakawanda sei mumvura, saka kunyange vhoriyamu yakayerwa zvakanaka haigoni kushandurwa kuva huremu. Nhungamiro yezviyero zveuwandu hunotorwa inotsanangura zvinodiwa pakushandura ikoko.

Uwandu hunokoshawo nenzira isiri pachena, nokuti ukama pakati peuwandu hunotorwa nemhedzisiro hahusi mutsetse wakatwasuka. Mumiedzo yemakonzo, 4 mg/kg yakavandudza kujaira kwezviito uye kuziva zvinhu, 50 kusvika 100 mg/kg yakaderedza kumhanya pavhiri, uye uwandu hushoma hwakawedzera kushandiswa kweoxygen neuropi muzviyedzo kunze kwemuviri uye mushure mekupiwa mushonga mumhuka mhenyu, maitiro anotsanangurwa nevanyori seanoenderana neuwandu mumativi ose ari maviri. Ongororo yendangariro nekuisa pfungwa pachinhu inopatsanura zvidzidzo zvevanhu maererano neuwandu nokuda kwechikonzero chimwe chetecho. Saka ongororo yakanaka haitauri uwandu hungakushandira, uye nyaya yekusanzwa chinhu haibvisi mukana wekuti paungave nemhedzisiro pauwandu hwakasiyana.

Pane mumwezve musiyano pakati peuwandu hunotorwa nehunonyatsosvika mumuviri. Muongororo yaichinjanisa vanhu vakuru 16 vane utano pakati pemapoka, avhareji yechikamu chemushonga wakanyungudutswa mumvura uye wakatorwa nemuromo chaisvika muropa chaiva 72.3%, nemwero wekutsauka kubva paavhareji wemapoindi eperesenti 23.9. Vanhu vaviri vanotora uwandu hwakayerwa hwakafanana havafaniri havo kuva neuwandu hwakafanana muropa, sezvinotsanangurwa neongororo yekunyudzwa nekuparadzirwa mumuviri.

Zvinotaurwa hazvina chigadzirwa chakasimbiswa

Ongororo imwe neimwe iongororo yebhodhoro, uye zviri mukati zvinoyerwa zvinowanzosiyana nezviri pachiratidzo. Kuongororwa kwezvigadzirwa 30 zvemelatonin kwakawana kuti zvinopfuura 71% zvaiva kunze kwemuganhu we10% weuwandu hwakataurwa, kubva pa83% pasi pehwakataurwa kusvika pa478% pamusoro pahwo, nekusiyana pakati pemabatch kuchisvika 465%, uye serotonin yaiva muzvisere zvacho. Mumuunganidzwa wezvinowedzerwa mukudya nezvemishonga yemiti 272 zvakabatanidzwa nekukuvara kwechiropa, 51% zvaiva nezviratidzo zvine mashoko asiri iwo, zvichikwira kusvika pa82% pakati pezvigadzirwa zvesteroid.

Methylene blue ine zviyero zvayo pachayo, uye yakagadzirirwa kudhaya haisungirwi kuzvitevedzera. Chigadzirwa chinoenderana negwaro rezviyero remubhuku remishonga chinoongororwa kuti chizivikanwe, kuchena kwacho, tsvina yezvinhu zveorganic yakadai seAzure B, zvasara zvezvinonyungudutsa, tsvina yemaelement, zvinosara pakupiswa, miganhu youtachiona, uye endotoxin dzemabhakitiriya. Chinyorwa chetsvina nenzira dzekuyedza chinoratidza bvunzo idzodzo uye zvinofukidzwa nezvisingafukidzwi nemhedzisiro yakabudiswa yemasampuli emethylene blue.

Ichi ndicho chikamu chechisarudzo chekutenga chinogona kusimbiswa nemuverengi. Vatengesi vazhinji vemethylene blue vanoshambadza kuti inoenderana neUSP vanongoongorora masimbi anorema, vozvitsanangura sekutevedzera zvizere. Blupreme inoshanda nemugadziri wemethylene blue yemishonga uye inobudisa zvitupa zvekuongorora zvakanangana nebatch imwe neimwe, zvichibatanidza nhamba yebatch iri pabhodhoro nebatch yezvinhu zvakashandiswa yakaongororwa. Peji rinotsanangura zita reUSP rinotsanangura zvinofukidzwa nezviyero zvacho, uye nhungamiro yekuverenga chitupa chekuongorora inoratidza maenzanisire aungaita gwaro nebatch yawakagamuchira.

Kuziva zvaiva mubhodhoro kunobvisa chimwe chinhu chinovhiringidza mhedziso. Hakushanduri zvinotaurwa nemunhu mumwe aiziva zvaaitora kuva uchapupu hwokuti chigadzirwa ndicho chakakonzera shanduko.

Zvinotaurwa zvichiri kukodzera kuverengwa

Nyaya dzevanhu uchapupu husina kusimba hwebhenefiti, asi uchapupu hunonzwisisika hwechimwe chinhu: dambudziko rinogona kuvapo. Kana vanhu vanoverengeka vakazvimiririra vachitsanangura kuita kumwe chete kwemuviri kwakasiyana nezvakajairika, ihwohwo fungidziro yokuti nyanzvi yezveutano iongorore, uye pfupiso yemigumisiro isingadiwi inotsanangura matauriro aungaita kuti wakasangana nechinhu chakawanda sei uye kuti kuita kwemuviri kwaunofungidzira kungaziviswa kupi. Nhungamiro yekutora zvakawandisa nekuiswa muchetura inofukidza divi rinoda kukurumidzirwa.

Zvinotaurwa zvinokuudzawo mibvunzo yaunofanira kubvunza. Hurukuro yevanhu vasingabvumirani pamusoro pekuti methylene blue yakabatsira kurara kwavo here chiratidzo chokuti zvakakodzera kutsvaga nezvekurara muzvinyorwa zvemiedzo, kwete chiratidzo chokuti methylene blue inobatsira kurara. Ongororo yeuchapupu muvanhu inoratidza zviri muzvinyorwa izvozvo, uye raibhurari yetsvakurudzo inounganidza miedzo yacho.

Kuverenga hurukuro usingazvinyengedzi

Nzira yacho ipfupi. Kopa zvinonzi zvakaitika sezvazviri. Patsanura zvakacherechedzwa nemunhu nemhedziso yaakaita. Zvadaro nyora tsananguro dzinogona kuva dzechokwadi uye bvunza kuti ndeipi inobviswa nezvinotaurwa izvi. Kazhinji mhinduro yechokwadi ndeyokuti hapana, uye mamiriro ezvinotaurwa acho ndeekuti hazvisati zvagadziriswa, kwete kuti ichokwadi kana kuti inhema.

Dhawunirodha pepa rekuongorora nyaya dzemunhu mumwe kuti uite ongororo iyoyo pahurukuro yakatarwa. Rinonyora zvikamu zvinowanzoshaikwa, nzvimbo yekunyora dzimwe tsananguro dzinokwikwidzana, uye marongerwo egwaro rekunyora zvinoitika kune ani zvake anosarudza kuedza chimwe chinhu zvakadaro.

Kana ukaedza chimwe chinhu pauri pachako, sarudzo ina dzinoita kuti zvinyorwa zvako zvibatsire kupfuura chinyorwa chakajairika: sarudza zvaunoda kuyera nechiyero chacho usati watora uwandu hwekutanga, chengeta zvinyorwa zvemamiriro ekutanga kwenguva yakakwana kuratidza mashandukiro anowanzoita chiratidzo, chinja chinhu chimwe chete panguva, uye nyora mazuva akafamba zvakaipa. Nhungamiro yekutarisa chirongwa chakawanikwa paindaneti inoshandisa kungwarira kumwe chete kumirayiridzo pane kuzvinosangana nevanhu.

Zvinhu zviviri zvinoenderana zvinopedzisa nharo iyi. Kunzwa zviri nani hakusimbisi kuti chigadzirwa ndicho chakakonzera kuvandudzika, uye kusanzwa chinhu hakusimbisi kuti chigadzirwa hachina zvachinoita pauwandu hupi zvahwo kana muchimiro chipi zvacho. Zvikanganiso zvose zviri zviviri zvinobva pakutora chinhu chimwe chakacherechedzwa nemunhu aiziva zvaaitora semhedzisiro yakasimbiswa. Zvinogona kuwedzerwa neongororo chikonzero chokutsvaga, uye yambiro yakakodzera kutorwa matanho.