Ndemanga za Methylene Blue ndi Malipoti a pa Reddit: Mmene Mungawerengere

Lembani “ndemanga za methylene blue” m'bokosi losakira ndipo malipoti amafika mayesero asanafike. Munthu wina amalemba kuti anayambanso kusangalala ndi nthawi zake za masana. Wina amalemba kuti palibe chomwe chinachitika. Wachitatu amafotokoza usiku wovuta ndipo amasiya kulemba. Zomwe zimakopa ndi kuwawerengera: ngati anthu okwanira akufotokoza kusintha komweko, ndiye kuti payenera kukhala chinachake.

Malipoti a anthu omwe asonkhanitsidwa si mayesero ang'onoang'ono azachipatala. Ndi chinthu cha mtundu wina, chopangidwa ndi anthu omwe sanavomerezepo kukhala gulu loimira ena.

Zomwe lipoti limodzi limakhala nazo

Ganizirani zolemba zomwe munthu angalembedi: “Masabata awiri ndikumwa methylene blue, madontho khumi m'madzi m'mawa uliwonse. Kusaganiza bwino kwatha, ndikumvanso ngati mmene ndinalili kale.”

Mawu atatu amenewo ali ndi zonena zinayi. Panali chinthu, panagwiritsidwa ntchito kuchuluka kwake, panadutsa nthawi, ndipo china chake chinasintha. Timawerenga chonena chomalizacho n'kuona zitatu zoyambazo ngati zokongoletsa, pamene ndi zomwe zimaika malire pa lipotilo. Chinthucho ndi chilichonse chomwe chinali m'botolo. Kuchulukako ndi chiwerengero cha madontho, chomwe sichili muyeso. Kusinthako ndi mmene munthuyo akumvera, koyesedwa ndi munthu amene amayembekezera kuti chinachake chichitike, popanda choyerekezerapo kapena mbiri ya mmene zinthu zinalili asanayambe. Ichi ndi chochitika chimodzi chomwe munthu waona, ndipo ndi chenicheni, chifukwa munthuyo anamvadi mosiyana. Koma sichinafotokoze chifukwa chake.

Zifukwa zina zinayi zikugwirizananso bwino ndi mawu omwewo: kuyembekezera, china chake chomwe chinasintha nthawi yomweyo, kusinthasintha kwa chizindikirocho pawokha, ndi kusintha kwa mmene kuyeza kukuchitikira. Palibe mwa izi chomwe chingachotsedwe pa zifukwa zomwe zingakhale zitayambitsa kusinthako pogwiritsa ntchito lipotilo lokha.

Anthu omwe sanamve kusintha ali ndi chifukwa chochepa cholembera

Umboni womveka bwino kwambiri woti malipoti a pa intaneti ndi zitsanzo zokondera umachokera pa kafukufuku wa mu 2014 woyerekezera ndemanga 1,901 za pa Amazon zokhudza njira zochepetsera thupi ndi mankhwala othandizira kubereka ndi zotsatira za mayesero. Pambuyo pa miyezi isanu ndi umodzi akutsatira zakudya za Atkins, 93% ya olemba ndemanga pa intaneti (64 mwa 69) ananena kuti achepa osachepera 10 kg, pamene 27% ya otenga nawo mbali m'mayesero (19 mwa 71) anapeza kusintha komweko. Mawu omaliza a olembawo ndi amene tiyenera kukumbukira: “Ndemanga za pa intaneti zimakokomeza phindu la chithandizo chamankhwala, mwina chifukwa anthu omwe apeza zotsatira zoipa safuna kwambiri kuuza ena zimene zawachitikira.” Munthu amene wakhala bwino ali ndi nkhani yoti afotokoze; munthu amene watha masabata asanu ndi limodzi akumvabe chimodzimodzi alibe choti anene.

Kukonderako sikumakhala mbali imodzi nthawi zonse, ndipo zimenezi zimatiphunzitsa. Kafukufuku wa mu 2025 wa zolemba 369 za pa Reddit zokhudza zowonjezera zakudya zothandizira kubereka anapeza kuti zinthu zinali mosiyana: mwa olemba 279 omwe ananena kuti akumwa zowonjezera zakudya, 9.3% anafotokoza kusintha kwabwino komwe anaona ndipo 12.9% anafotokoza koipa, pamene 21.1% anapempha malangizo. Pa bwalo lopangidwa kuti anthu athandizane kuthetsa mavuto, zimenezi ndi zomwe tingayembekezere. Kafukufuku wina anapeza kuti odwala omwe analowa m'gulu la zokambirana zaumoyo pa intaneti anali ndi miyezo ya matenda ovutika maganizo ndi nkhawa yokwera kuposa ya osakhala m'gululo.

Kusakanikirana kwa malipoti kumasonyeza khalidwe la gululo, osati kuwerengera zotsatira za anthu onse.

Kuyembekezera ndi chimodzi mwa zinthu zomwe zimakhudza zotsatira

Mawu omwe anthu amakonda kutsutsa nawo amakhala okhudza iwowo: “Ine sindine munthu amene amapusitsidwa ndi kuyembekezera.”

Mu 2010, gulu lotsogozedwa ndi ofufuza a ku Harvard linapatsa anthu 80 omwe anali ndi matenda a m'matumbo otchedwa irritable bowel syndrome mapiritsi a placebo omwe anawauza moona kuti analibe mankhwala ogwira ntchito, kapena silinawapatse chithandizo chilichonse, ndipo magulu onse awiri anali ndi nthawi yofanana yokumana ndi wopereka chithandizo. Pa masabata atatu, miyezo ya kusintha kwa thanzi lonse inali 5.0 ± 1.5 m'gulu la placebo lomwe linkadziwa zomwe likumwa, poyerekeza ndi 3.9 ± 1.3 m'gulu losalandira chithandizo. Pambuyo pake, kusanthula kophatikiza mayesero khumi ndi limodzi okhala ndi anthu 654 kunapeza zotsatira zophatikizidwa za 0.72 pa muyeso wa kupatuka kokhazikika. Munthu amene akumwa methylene blue sali ngakhale m'malo mwa amene wauzidwa moona kuti akumwa placebo: amakhulupirira kuti ikugwira ntchito, anaisankha, analipira, ndipo ndi iyeyo amene akulemba zotsatira.

Zoyezera ntchito za m'thupi zimasinthanso. Mu kafukufuku wa othamanga amene anayerekezera zomwe anapatsidwa ndi zomwe anauzidwa kuti apatsidwa, nthawi zothamangira mtunda wa 1000-metre zinakhala bwino pokhapokha otenga nawo mbali atakhulupirira kuti amwa caffeine, kaya caffeine inalidi mu kapisozi kapena ayi: kukula kwa zotsatira kunali 0.43 pa gulu lomwe linauzidwa zosiyana ndi zomwe linapatsidwa, poyerekeza ndi 0.42 pa gulu lomwe linalandira yeniyeni. Kuuzidwa kuti amwa placebo sikunabweretse kusintha kulikonse ngakhale atalandira caffeine.

Palibe amene angabise mtundu wake

Pa zowonjezera zakudya zambiri, mnzanu angakonze makapisozi ofanana. Pa methylene blue sizingatheke: ikamwedwa pakamwa, imasandutsa mkodzo kukhala wabuluu kapena wobiriwira, ndipo nthawi zina ndowe.

Mayesero a mu 2016 omwe anagawa anthu m'magulu mwachisawawa, ofalitsidwa mu Radiology, anayesetsa kusamalira nkhaniyi. Otenga nawo mbali analandira mwina 280 mg ya methylene blue ya mulingo wa USP yomwedwa pakamwa kapena utoto wa zakudya wa FD&C Blue No. 2 m'makapisozi ofanana osalowetsa kuwala, ndipo anapemphedwa kukodza asanamwe koma osakodzanso mpaka kujambula zithunzi za m'thupi kutatha, kuti mtundu wa mkodzo usawulule gulu lawo. Kuyesetsa kumeneku kunalembedwa, komanso kulephera kwake: onse omwe analandira methylene blue ananena kuti mkodzo wawo unakhala wabuluu pambuyo pake, ndipo palibe m'gulu la placebo amene ananena zimenezo. Olembawo anati kusintha kwa mtunduwo kunali “chizindikiro chochedwa chotsimikizira kuti analandira mankhwalawo.”

Chitsanzo chachikulu chimasonyeza mtengo wake. Mayesero a gawo 3 a LMTM a mu 2016 anagawa mwachisawawa odwala 891 omwe anali ndi matenda a Alzheimer's ndipo analibe gulu la placebo n'komwe. Gulu lake loyerekezera linalandira 4 mg kawiri patsiku, kuchuluka komwe kunasankhidwa, malinga ndi olembawo, “kuti asadziwe gulu lawo chifukwa cha kusintha kwa mtundu wa mkodzo kapena ndowe.” Piritsi lopanda mankhwala ogwira ntchito likanadziwika m'chimbudzi. Kafukufuku wa matenda a bipolar omwe otenga nawo mbali anasinthana pakati pa njira zoyesedwa, wokhala ndi odwala 37 ndipo wotchula gulu la 15 mg kuti “placebo”, anachitanso zimenezi poyerekeza ndi gulu lolandira 195 mg yogwira ntchito.

Werengani mapangidwe a mayeserowo ngati chenjezo pa kuyesa kwa munthu payekha. Ngati odwala mazana ambiri m'mayesero olandira ndalama, okhala ndi makapisozi osalowetsa kuwala ndi mndandanda wa katswiri wa ziwerengero wogawa anthu mwachisawawa, akanathabe kuzindikira gulu lawo, ndiye kuti munthu amene akuwerengera madontho m'kapu ya madzi kunyumba akudziwa kale zomwe akumwa. Kubisa zimenezi sikungoti n'kovuta pano. N'kosatheka.

Chizindikirocho chimatsatira nthawi yake

Anthu sayamba kumwa chowonjezera chakudya nthawi zambiri pa sabata yabwino. Amayamba pa sabata yoipa, zomwe zimayambitsa kubwerera ku mlingo wapakati: miyezo yokwera kwambiri kapena yotsika kwambiri imayambanso kuyandikira ya pakati kaya pachitidwa chinachake kapena ayi.

Kubwererako kungayezedwe. M'gulu la odwala ululu wa m'munsi mwa msana wokhalitsa omwe sanalandire chithandizo, ululu wapakati pa sikelo ya 0 mpaka 100 unachoka pa 56 paulendo woyamba kufika pa 54 patadutsa miyezi iwiri ndi 46 patadutsa miyezi inayi. Olembawo amati mbali ina ya kusinthako inachitika chifukwa cha chidwi chomwe odwalawo analandira pokhala m'kafukufuku, chifukwa china chomwe chimakhalaponso pa kuyesa kulikonse kwa munthu payekha.

Kukhala bwino popanda chithandizo chapadera kumachitika kawirikawiri pa mavuto omwe anthu amatchula pokambirana za methylene blue. Mwa odwala 79 omwe anali ndi matenda a kutopa kosatha kwa nthawi yosakwana zaka ziwiri, popanda chithandizo chokhazikika, 46% ananena kuti akhala bwino pakatha chaka chimodzi. M'gulu la anthu 1,266 omwe anagonekedwa m'chipatala ndi COVID-19, pafupifupi 65% ya omwe ananena kuti akulephera kuganiza bwino, kukumbukira, kapena kuika maganizo awo pa chinthu pa nthawi yapakati ya miyezi 8.4 sananenenso zimenezo pa miyezi 13.2, pamene ena anayamba kukhala ndi chizindikirocho panthawi yomweyo. Pa anthu a m'zipatala za chisamaliro choyamba omwe anali ndi matenda aakulu ovutika maganizo osalandira chithandizo, akuti 23% zizindikiro zawo zimatha mkati mwa miyezi itatu ndipo 53% mkati mwa chaka.

Palibe mwa izi chomwe chikutanthauza kuti methylene blue sichichita chilichonse. Zikufotokoza mlingo woyambira womwe lipoti la munthu lilibe, ndipo kukula kwa kusintha komwe kumafotokozedwa nthawi zambiri m'mabwalo okambirana kumakhala mkati mwa kusintha komwe kumachitika pawokha.

Zotsatira za mayeso zimatsatira nthawi yake

Kuyeza mobwerezabwereza kumasintha zomwe zikuyesedwa. Akuluakulu athanzi omwe anachita mayeso ambiri a ntchito za ubongo ndi maganizo kasanu ndi kawiri m'chaka chimodzi anachita bwino chifukwa cha kubwereza kokha: zotsatira za kuzolowera mayeso zinali 0.36 mpaka 1.19 pa muyeso wa kupatuka kokhazikika pamene ankayesedwa pafupipafupi mpaka mwezi wachitatu, ndipo pambuyo pake kuchita kwawo kunasiya kukwera. Kukwera kwakukulu kwambiri kunachitika pa mayeso achiwiri. Kukwera kwa zotsatira pa masabata atatu a mayeso a tsiku ndi tsiku ophunzitsa ubongo ndi zomwe zingayembekezeredwe chifukwa chochita mayesowo masabata atatu motsatizana.

Sikelo zomwe munthu amagwiritsa ntchito kudziyesa sizitetezedwa ku zimenezi. Kupereka mayeso a Beck Depression Inventory mobwerezabwereza kwa gulu la ophunzira kunabweretsa kutsika kwa zotsatira ndi 40% pa masabata asanu ndi atatu chifukwa cha kuyeza mobwerezabwereza kokha, kufotokoza pafupifupi 10% ya kusiyana kwa zotsatira. “Ndakhala ndikuyesa mmene ndikumvera m'mawa uliwonse ndipo zotsatira zikukwera” ndi mawu okhudza kuyeza komanso mmene munthu akumvera.

Nthawi zambiri china chake chinasinthanso nthawi yomweyo

Anthu ambiri omwe amalemba lipoti la methylene blue anali atasinthanso zinthu zina: kugona, kuchita masewera olimbitsa thupi, mowa, chowonjezera chakudya china, kuwala kwa masana, kapena ntchito yopanikiza yomwe inatha. Lipotilo limatchula chinthucho chifukwa ndi chatsopano kwambiri pa mndandandawo, osati chifukwa ndi chokhacho.

Lipoti silikhala ndi kuchuluka kotsimikizidwa

Madontho ndiwo muyeso womwe umagwiritsidwa ntchito kwambiri m'ndemanga za methylene blue, koma si muyeso wokhazikika. Kafukufuku wa mabotolo 19 okhala ndi chodonthozera cha kugwiritsa ntchito mobwerezabwereza anapeza kuti dontho limodzi linali pakati pa 33.8 ndi 63.4 microlitres, kusiyana kwa pafupifupi kawiri pakati pa mabotolo, ndipo kupendeketsa botolo pang'ono kunatulutsa madontho ang'onoang'ono. “Madontho khumi” a m'botolo limodzi angakhale pafupifupi kawiri “madontho khumi” a m'botolo lina, ndipo zolembazo nthawi zambiri sizitchula ndende ya methylene blue m'madzimo, motero ngakhale voliyumu yoyezedwa bwino singasinthidwe kukhala kulemera. Malangizo a mayunitsi a kuchuluka komwedwa amafotokoza zomwe zikufunika kuti musinthe muyesowo.

Kuchuluka kumakhudzanso zotsatira m'njira yosadziwika mosavuta, chifukwa ubale wa kuchuluka ndi zotsatira si mzere wowongoka. M'mayesero a makoswe, 4 mg/kg inathandiza kuzolowera zinthu pa khalidwe lawo ndi kuzindikira zinthu, 50 mpaka 100 mg/kg inachepetsa kuthamanga pa gudumu, ndipo ndende zotsika zinawonjezera kugwiritsa ntchito mpweya wa oxygen mu ubongo m'mayesero a kunja kwa thupi komanso pambuyo popatsa makoswe amoyo. Olembawo anafotokoza khalidwe limeneli kuti zotsatira zake zimadalira kuchuluka m'njira zonse ziwiri. Nkhani yowunika kukumbukira ndi kuika maganizo pa chinthu imasiyanitsa kafukufuku wa anthu malinga ndi kuchuluka komwedwa pachifukwa chomwecho. Choncho ndemanga yabwino siimasonyeza kuchuluka komwe kungakugwirireni ntchito, ndipo nkhani ya munthu amene sanamve kusintha siimachotsa kuthekera kwa kusintha pa kuchuluka kwina.

Palinso kusiyana pakati pa kuchuluka komwedwa ndi kuchuluka komwe kumafika m'thupi. Mu kafukufuku wa akuluakulu 16 athanzi omwe anasinthana pakati pa njira zoyesedwa, gawo lapakati la methylene blue yosungunulidwa m'madzi ndi yomwedwa pakamwa lomwe linafika m'magazi linali 72.3%, ndi kupatuka kokhazikika kwa 23.9 pa zana. Anthu awiri omwe akumwa kuchuluka koyezedwa kofanana sangakhale ndi ndende yofanana m'magazi, monga momwe nkhani yowunika kuyamwidwa ndi kufalikira m'thupi imafotokozera.

Lipoti silikhala ndi chinthu chotsimikizidwa

Ndemanga iliyonse ndi ndemanga ya botolo, ndipo zomwe zili m'botolomo zikayezedwa nthawi zambiri zimasiyana ndi zomwe zili pa chizindikiro chake. Kusanthula zinthu 30 za melatonin kunapeza kuti zoposa 71% zinali kunja kwa kusiyana kwa 10% ndi kuchuluka komwe kunalembedwa, kuyambira pa 83% kuchepera mpaka 478% kuposa zomwe zinanenedwa, ndi kusiyana pakati pa magulu opangidwa kufika pa 465%, komanso serotonin m'zinthu zisanu ndi zitatu. M'gulu la zinthu 272 za zitsamba ndi zowonjezera zakudya zomwe zinakhudzidwa ndi kuvulala kwa chiwindi, 51% zinali ndi zilembo zosalondola, ndipo zinakwera kufika pa 82% pakati pa zinthu za steroid.

Methylene blue ili ndi zofunikira zakezake, ndipo yopangidwira kupaka utoto siyenera kukwaniritsa zofunikira zimenezo. Chinthu chomwe chikutsatira zofunikira za m'buku la miyezo ya mankhwala chimayesedwa kuti atsimikizire chomwe chili, chiyero chake, zonyansa za organic monga Azure B, zotsalira za zosungunulira, zonyansa za maelementi, zotsalira chikawotchedwa, malire a tizilombo, ndi poizoni wa endotoxin wochokera ku mabakiteriya. Nkhani ya zonyansa ndi njira zoyesera imasonyeza mayeso amenewo ndi zomwe zotsatira zofalitsidwa za zitsanzo za methylene blue zimaphimba ndi zomwe siziphimba.

Iyi ndi mbali ya chisankho chogula yomwe wowerenga angatsimikizire. Ogulitsa ambiri a methylene blue omwe amalengeza kuti ikukwaniritsa USP amayesa zitsulo zolemera zokha ndipo amati zimenezo ndi kukwaniritsa zonse. Blupreme imagwira ntchito ndi wopanga methylene blue wa mankhwala ndipo imafalitsa zikalata za kusanthula za gulu lililonse lopangidwa, zolumikiza nambala ya gulu pa botolo ndi gulu la chophatikizira lomwe linayesedwa. Tsamba la kutchulidwa kwa USP limafotokoza zomwe zofunikirazo zimaphimba, ndipo malangizo owerenga chikalata cha kusanthula amasonyeza mmene mungafanizire lipoti ndi gulu lopangidwa lomwe mwalandira.

Kudziwa zomwe zinali m'botolo kumachotsa chifukwa chimodzi chosokoneza kumvetsetsa zotsatira. Sikumasandutsa lipoti la munthu mmodzi amene akudziwa zomwe watenga kukhala umboni woti chinthucho ndi chimene chinayambitsa kusinthako.

Malipoti omwe ndi ofunikabe kuwerenga

Nkhani za anthu pa zomwe zawachitikira ndi umboni wofooka wa phindu, koma ndi umboni woyenera wa chinthu china: vuto lomwe lingakhalepo. Ngati anthu angapo, mosadalirana, afotokoza zomwezo zosiyana ndi zachizolowezi zomwe zawachitikira, limenelo ndi lingaliro loti katswiri wa zachipatala afufuze, ndipo nkhani yachidule ya zotsatira zosafunika imafotokoza mmene munganenere zomwe mwatenga ndi kumene munganenere zomwe mukukayikira kuti zachitika chifukwa chake. Malangizo okhudza kumwa mopitirira muyeso ndi kuipitsidwa ndi poizoni amafotokoza mbali yofunika kuchitapo kanthu mwamsanga.

Malipoti amakuuzaninso mafunso oti mufunse. Mndandanda wa zokambirana za anthu osagwirizana pa nkhani yoti methylene blue inawathandiza kugona ndi chizindikiro choti n'koyenera kufufuza nkhani ya kugona m'mabuku a mayesero, osati chizindikiro choti methylene blue imathandiza kugona. Nkhani yowunika umboni wa anthu imasonyeza zomwe mabuku amenewo ali nazo, ndipo laibulale ya kafukufuku imasonkhanitsa mayeserowo.

Kuwerenga zokambirana popanda kudzipusitsa

Njira yake ndi yachidule. Koperani zomwe zanenedwa ndendende. Siyanitsani zomwe munthuyo anaona ndi zomwe anaganiza kuti zikutanthauza. Kenako lembani zifukwa zomwe zingafotokoze zimenezo ndipo funsani kuti ndi chifukwa chiti chomwe lipotili likuchotsa. Nthawi zambiri yankho loona mtima ndi lakuti palibe, ndipo lipotilo ndi losadziwika chifukwa chake osati loona kapena labodza.

Tsitsani pepala lowunikira nkhani ya zomwe munthu wakumana nazo kuti mugwiritse ntchito njira imeneyi pa zokambirana zinazake. Limatchula mfundo zomwe nthawi zambiri zimasowa, malo olembera zifukwa zina zomwe zingafotokoze zomwe zinachitika, ndi ndondomeko yolembera zochitika kwa aliyense amene wasankha kuyesa chinthu ngakhale zili choncho.

Ngati mukuyesa chinthu pa inu nokha, zisankho zinayi zimapangitsa mbiri yanu kukhala yothandiza kuposa zolemba zambiri: sankhani zotsatira zomwe mudzayese ndi sikelo yoyezera musanamwe koyamba, sungani mbiri ya mmene zinthu zilili musanayambe kwa nthawi yokwanira kuonetsa mmene chizindikirocho chimasinthira nthawi zonse, sinthani chinthu chimodzi pa nthawi, ndipo lembani masiku omwe zinthu sizinayende bwino. Malangizo owunikira ndondomeko yopezeka pa intaneti amagwiritsa ntchito kusamala komweku pa malangizo m'malo mwa zomwe anthu akumana nazo.

Mfundo ziwiri zofanana zimatseka nkhaniyi. Kumva bwino sikutsimikizira kuti chinthu chinayambitsa kukhala bwino, ndipo kusamva kusintha sikutsimikizira kuti chinthucho sichichita chilichonse pa kuchuluka kulikonse kapena m'njira iliyonse. Zolakwa zonse ziwiri zimachokera pa kuona chochitika chimodzi, chomwe munthu akudziwa zomwe watenga, ngati zotsatira zotsimikizidwa. Zomwe ndemanga zingawonjezere ndi chifukwa chofufuzira, ndi chenjezo loyenera kuchitapo kanthu.