Methylene blue nekurara: zvakanyorwa mumiedzo, nezvisina kuyerwa nemunhu

Mutsara mumwe chete mutafura yezviitiko zvisingadiwi ndiwo humbowo hukuru hwekurara huripo muboka iri remishonga. Mumuedzo wemavhiki 52 une kugoverwa kumapoka nemukana wefrontotemporal dementia inonyanya kuchinja maitiro, kutadza kurara kwakashumwa nevarwere 3 pa110 vaitora 8 mg pazuva uye nevarwere 7 pa108 vaitora 200 mg pazuva. Vanyori vanonyora kutadza kurara pakati pezviitiko zvisingadiwi zvakawedzera nedosi, pamwe nekushomeka kweropa, manyoka, kusvotwa, kurwadziwa pakuita weti, kuita weti kakawanda uye kurutsa.

Dosi yakakura zvakapetwa makumi maviri neshanu yakaburitsa kutadza kurara kwakawanda zvakapetwa kanenge kaviri nechidimbu. Icho chiratidzo chiduku mutafura duku, uye chinonanga kudivi rakapesana nechikonzero chinoita kuti vanhu vakawanda vatsvage nyaya iyi.

Hapana muedzo wemethylene blue une kugoverwa kumapoka nemukana, kana wechimiro chayo chakaderedzwa, hydromethylthionine mesylate, wakayera kurara semugumisiro. Kutsvaga kwakaitwa nokuda kwechinyorwa ichi hakuna kuwana ongororo yaishandisa gwaro remibvunzo pamusoro pekurara, actigraphy, kana husiku murabhoritari yekurara. Chiripo ndechezvakangoitika kuti murwere ataure uye chiremba anyore muchikamu chezviitiko, inova nzira isina kusimba sekuonekwa kwainoita.

Zvakanyorwa muzvirongwa zvemiedzo ine kugoverwa kumapoka nemukana

Miunganidzwa mitatu yemashoko ine zvese zvakanyorwa zvine chekuita nekurara zvakawanikwa. Miviri yacho miedzo yehydromethylthionine ine kugoverwa kumapoka nemukana, chimiro chakaderedzwa chehwaro humwe chete hwephenothiazine, chakadzikamisirwa semunyu. Wechitatu mashoko ekuUS ekunyora mushonga unopinzwa mutsinga.

Zvinhu zviviri mumutsara wechipiri zvinokosha kupfuura nhamba. Chekutanga, boka rekuenzanisa rakapiwa methylthioninium chloride, chinhu chimwe chete chinotengeswa semethylene blue, pa4 mg kaviri pavhiki, ichipiwa sechinopa weti ruvara chisina chinangwa chekurapa kuitira kuti vatori vechikamu vasakwanise kuziva musiyano wemapoka maviri nokutarisa mukati mechimbuzi. Chechipiri, hapana pazviitiko zvisere zvekutadza kurara mumapoka aiwana mushonga unoshanda zvakatongwa nemuongorori sezvine chekuita nemushonga. Zviitiko zvitatu zvekukotsira pa332 ndizvo zvakatongwa saizvozvo.

Chiitiko chisingadiwi hakusi kuyerwa. Chinhu chakataurwa nemumwe munhu, chakanyorwa nemazwi akasiyana neanoshandiswa nemuverengi, muboka revanhu vane chirwere chinoramba chichikuvadza masero etsinga, vakawanda vavo vachitorawo mishonga inonyaradza nemishonga yekuora mwoyo. Kuverenga “hazvina kunyorwa” mumutsara wechitatu sekuti “hazviitiki” kungava kukanganisa nokuda kwechikonzero chakapesana: varwere 31 iboka duku zvekuti rinogona kutadza kuratidza chero chinhu, uye mashoko ekunyora mushonga anotaura pachena kuti hukama pakati pehuwandu hwemushonga hunosvika mumuviri nemhinduro yemuviri, pamwe nekuchengeteka, hahuzivikanwi.

Kunobva zvinotaurwa nezvekurara

Chinenge chinyorwa chese, vhidhiyo, uye peji rechigadzirwa chinobatanidza chinhu ichi nekurara chinozopedzisira chanongedzera kumugumisiro mumwe chete. Muna 2007, Oxenkrug nevamwe vake vakayera kushanda kwemonoamine oxidase nemaindole mupineal gland yemakonzo mushure medosi rimwe chete rakapiwa pasi peganda.

Methylene blue yaidzivisa monoamine oxidase yerudzi A ichikwikwidzana nezvimwe zvinhu, uye kudzivisa uku kwaigona kudzokera shure, paKi yeanenge 180 nanomoles; yerudzi B yaidziviswa paanenge 1,400 nanomoles, zvichiratidza kuda rudzi A zvakapetwa kanenge kasere. Makonzo mashanu paboka, 10 mg/kg pasi peganda, mapineal gland akabviswa mushure memaminitsi 90. Melatonin yakakwira kubva pa0.17 kusvika pa0.71 nanograms pagland. N-acetylserotonin, chinhu chinotangira melatonin zvakananga pakugadzirwa kwayo, yakabva pachiyero chakanga chiri pasi pemuganhu unogona kuonekwa kusvika pa0.86. Serotonin yemupineal yakakwira kubva pa79 kusvika pa118, uye 5-HIAA, chigadzirwa chekuputswa kwayo, yakadzika kubva pa10.9 kusvika pa4.1.

Kufunga kunotevera kwakavakirwa pakemisitiri yakarurama. Serotonin ndiyo inoshandiswa kugadzira melatonin, uye noradrenaline inokurudzira danho reacetylation rinoshandura serotonin kuita N-acetylserotonin. Kana enzyme inoputsa zvese izvi ikavharirwa, pineal inenge iine zvakawanda zvekushandisa pakugadzira munguva yechiedza uye zvinhu zvakawanda zvinotangira melatonin kana nguva yerima yasvika.

Asi izvi zvichiri kure zvikuru nekuti munhu arare zviri nani. Chinoyerwa ndezviri mugland remhuka iri pasi peanaesthesia panguva imwe chete, uye hapana mugadziriro iyoyo chinonyora kuti gonzo rakarara kwenguva yakareba sei, rakakurumidza sei kubatwa nehope, kana kuti rakanzwa sei mangwanani akatevera. Pepa racho rakanyorwa pamusoro pemaitiro emishonga yekuora mwoyo, uye hurukuro yaro inopa pfungwa yekuti kuwedzera melatonin masikati kungagadzirisa mutinhimira wemuviri wezuva nehusiku wakachinja muvarwere vane kuora mwoyo. Iyi ipfungwa ichiri kuda kuedzwa iri muchikamu chehurukuro, uye ndiyo yakabereka zvinotaurwa nezvekurara.

Zvinotaurwa nezvezviroto zvakajeka hazvina kwakabva kwakabudiswa

Kutsvaga kwakaitwa nokuda kwechinyorwa ichi hakuna kuwana mushumo wemurwere mumwe, miunganidzwa yemishumo yevarwere, zvakanyorwa mumuedzo, kana ongororo umo methylene blue yakabatanidzwa nezviroto zvakajeka, zviroto zvinotyisa, kana kuchinja kwekuyeuka zviroto. Zvinotaurwa izvi zviri muhurukuro dzepamhepo, kwete muzvinyorwa zvesainzi.

Humbowo hweboka remishonga iyi hunonanga kudivi rakapesana panguva yekurapwa. Apo clorgyline nepargyline, zvinodzivisa zvakasarudzika monoamine oxidase yemhando A neB, zvakapiwa kwemavhiki mana kuvarwere vane matambudziko emanzwiro, kurara kweREM kwakadzvinyirirwa kunenge zvachose uye nguva yese yekurara yakaderera. Ongororo yakarongeka yemishonga yekuora mwoyo nekurota, yaibatanidza ongororo dzevarwere 21 nemishumo yevarwere 25, yakawana kuti kuyeuka zviroto kunoitika zvishoma pakushandisa phenelzine, mushonga unozivikanwa zvikuru unodzivisa monoamine oxidase. Zviroto zvinotyisa muzvinyorwa izvozvo zvinoonekwa pakurega mushonga, apo kurara kweREM kunodzoka kwakawedzera, kwete mushonga uchiri kutorwa.

Saka maitiro anowanzotaurwa sechikonzero chezviroto zvakajeka anofanotaura kurara kweREM kushoma uye kuyeuka zviroto kushoma mumamiriro akajairika, zvichiteverwa nekudzoka kusingafadzi kana mushonga wamiswa. Kuti methylene blue inoita chimwe cheizvi mumunhu hakuna kuedzwa. Kudzivisa kwayo kunogona kudzokera shure, inodzivisa zvisina kusimba zvakanyanya kana ichienzaniswa nephenelzine, uye ongororo dzevanhu dzaizopindura mubvunzo uyu hadzina kumbobvira dzaitwa.

Zvinotaurwa nezvejet lag zvine kwakabva chaiko

Pepa rimwe chete ndiro riri shure kwazvo. Oxenkrug naRequintina vakagadzira muenzaniso wejet lag mumakonzo nokuchinja kutenderera kwechiedza, ndokuyera serotonin, N-acetylserotonin nemelatonin yemupineal vachishandisa high-performance liquid chromatography ine kuona nefluorescence.

Zvakawanikwa zviviri zvakashumwa. Majekiseni emelatonin pakutanga kwenguva itsva yerima akakurumidzisa kudzoka kwemitinhimira yeN-acetylserotonin nemelatonin. Uye N-acetylserotonin nemethylene blue, yakatsanangurwa mupepa sechinodzivisa monoamine oxidase A, zvakaderedza kuvhiringidzwa kweN-acetylserotonin kwaikonzerwa nechiedza, asi kwete kwemelatonin.

Verenga izvozvo zvakanyatsonaka. Mumuenzaniso wemhuka wemamiriro chaiwo ari kutaurwa, methylene blue yakachinja chiratidzo chimwe chechinhu chinotangira melatonin uye haina kuchinja mutinhimira wemelatonin. Mhedziso dzepepa pacharo dziri pamusoro penguva yekusvika iri nani parwendo rwendege rwekuenda kumabvazuva uye pamusoro penguva inofanira kupiwa melatonin. Haripi pfungwa yekushandisa methylene blue semushonga wejet lag, uye hapana ongororo yevanhu yakaiyedza saizvozvo.

Kunyimwa hope mumakonzo maduku hakusi kuyerwa kwekurara

Kuedza kunowanzotaurwa sehumbowo hwekuti methylene blue inobatsira pakunyimwa hope hakuna kuyera kurara. Marzabadi nevamwe vake vakaisa makonzo maduku echirume 60 erudzi BALB/c mugadziriro yakagadziridzwa yemapuratifomu akawanda, umo mhuka inoiswa papuratifomu yakamanikana inomanikidzwa kuramba yakamuka, vakaenzanisa boka repuratifomu yakafara nemhuka dzakanyimwa hope, methylene blue yoga, laser inopuruzira ye810-nanometre yoga, uye zviviri izvi zvakabatanidzwa.

Methylene blue yakabaiwa pa0.5 mg/kg pamazuva gumi akatevedzana kunyimwa hope kusati kwatanga, laser ichishandiswa zuva rimwe richisvetukwa. Kudzidza nekuyeuka kwakapiwa zvibodzwa pachishandiswa T-maze, muedzo wekudyidzana nedzimwe mhuka uye shuttle box, uye huwandu hwePSD-95, GAP-43 nesynaptophysin muhippocampus hwakayerwa pashure.

Kunyimwa hope kwakaderedza mwero wekuchinjana pakati penzira, kuda kudyidzana, kufarira mhuka itsva uye chiyero chekuyeuka. Hapana kurapwa kumwe chete kwakadzorera zvizhinji zvezviyero izvozvo. Kubatanidzwa kwacho kwakazvidzorera, uye kwakawedzera zvese zviratidzo zvitatu zvesynapse. Zvakawanikwa ndezvekuti kubatanidza marapirwo pamberi pekunyimwa hope kwakachengetedza kuyeuka mumhuka dzine kurara kwakavhiringidzwa. Kunyimwa hope ndiko kukuvadzwa kwakaitwa mugadziriro yacho, kwete mugumisiro waiyerwa. Hapana nguva yekubva pakuedza kurara kusvika pakubatwa nehope, nguva yakareba yekurara kana marongerwo ezvikamu zvekurara zvakanyorwa, uye kuverenga pepa iri sehumbowo hwekuti munhu anorara zvakanaka zvakadii kunopindurudza zvarakayera.

Mangwanani kana husiku: nhamba hadzipedzi nyaya

Mazano pamusoro penguva yekutora anoramba achidzokororwa nechivimbo uye haana kumbobvira aedzwa. Hapana muedzo wakaenzanisa kutora mangwanani nemanheru, muboka ripi neripi revanhu, uchiyera mugumisiro upi noupi wekurara.

Chakayerwa ndechekuti chinhu ichi chinofamba zvishoma sei mumuviri. Muongororo yedosi rimwe chete muvanhu vane utano vakazvipira, 200 mg yakatorwa nemuromo mushure mekugadzirira ura yakaita kuti huwandu hwayo muropa hukwire kwemaawa gumi nemaviri, huchisvika pakakwirira panguva yepakati yemaawa 16. Nguva yekuti huwandu hwacho hudzikire nehafu yaiva pakati pemaawa 14 ne27 padosi iroro uye pakati pemaawa 6 ne26 pa400 mg. Chigadzirwa chinopinzwa mutsinga chiri mumashoko ekunyora mushonga chine nguva yekudzikira nehafu yeanenge maawa 24, uye anenge 40% anobudiswa muweti asina kuchinjwa, huwandu hunosvika mumuviri huchiwedzera zvakanyanya kana itsvo dzisingashandi zvakanaka.

Saka dosi rinotorwa nemuromo pakudya kwemangwanani rinosvika pahuwandu hwaro hwepamusoro hwakayerwa panenge pakati pehusiku. Izvi zvinoda kufungisiswa, nokuti mazano maviri anowanzoparadzirwa anoenderana nekuti izvi hazvisi zvechokwadi. “Itore mangwanani kuti isavhiringidza kurara” zvinofungidzira kuti kushanda kwayo kunenge kwapera panguva yekurara. “Itore husiku nokuti inopera kushanda nokukurumidza” zvinofungidzira zvakapesana. Ongoro imwe chete iripo yevanhu yekufamba kwemushonga mumuviri haitsigiri kushanda kwenguva pfupi manheru, uye kuedza kwemakonzo kuri shure kwenyaya yemelatonin kunotsigira kutora pakutanga kwenguva yechiedza nokuda kwechikonzero chakasiyana zvachose, chekuwedzera chinhu chinotangira melatonin masikati. Pane gwaro rakasiyana rinotsanangura kuti chinhu ichi chinogara mumuviri kwenguva yakareba sei kana nhamba dzekubviswa kwacho mumuviri dziri idzo dzawakavinga.

Mhinduro yakatendeseka kumubvunzo wenguva ndeyekuti hapana anoziva, uye huwandu hwakayerwa hunopikisa kunyepedzera kuti tinoziva.

Mushumo mumwe chete wevanhu wekuchinja kwedambudziko rekurara

Pane chinyorwa chimwe chete chevanhu chakawanikwa umo methylene blue yakapiwa munhu ane dambudziko rekurara, uye chinotaura nezvemurwere mumwe chete.

Mushumo wemurwere wa2021 muCureus unotsanangura mukomana aiva nemakore 15 ane Kleine-Levin syndrome, mamiriro asingawanzoitiki ezvikamu zvinodzokororwa zvekurara zvakanyanya zvinotora mazuva kusvika kumavhiki, zvichiperekedzwa nekuvhiringidzika, kunzwa sokuti zvakamupoteredza hazvisi zvechokwadi uye kuchinja kwemaitiro. Akanga arapwa nelithium kwemakore matatu, uye modafinil, methylprednisolone, mishonga yeatypical antipsychotics neamantadine zvakanga zvisina kuunza kuvandudzika. Pa18 akapinda muchikamu chakatora inenge mwedzi mitanhatu. Nevabereki vabvuma, akapiwa 10 mg yemethylene blue nemuromo awa imwe asati apiwa chiedza chitsvuku chemukati memhino kwemaminitsi 25 husiku hwega hwega pa633 nanometres, 11.4 joules per square centimetre. Mukati mevhiki, kurara kwakanyanya nezviratidzo zvemaitiro zvakapera. Makore maviri gare gare akanga asina kudzokerwa uye aisatora mumwe mushonga.

Vanyori vanotaura muganhu wacho ivo pachavo: munhu mumwe chete, isiri ongororo yekutevera munhu kwenguva refu, uye zvikamu zveKleine-Levin zvinozivikanwa kuti zvinova zvishoma nokufamba kwemakore, zvichiita kuti zvisakwanisike kuti kupora kwacho kunzi kwakakonzerwa nekurapwa. Pane muganhu wechipiri wavasingasimbisi. Zvakapiwa zvaiva marapirwo maviri panguva imwe chete, uye rimwe racho raiva chiedza chitsvuku chaiendeswa mukati memhino pamwe nechinhu chine kushandiswa kwacho kwese kwephotodynamic kunoenderana nekuti chiedza chichiita kuti chishande. Muverengi haakwanisi kupatsanura dhayi nechiedza uye nekufamba kwenguva, uye mushumo uyu hausi chikonzero chekuedza methylene blue nokuda kwedambudziko rekurara.

Divi rine mashoko akayerwa muvanhu nderekudzikamisa kunokotsirisa

Panowanikwa zviyero zvevanhu zvehurongwa hukuru hwetsinga, zvakawanda zvacho zvinonongedzera kukudzikamisa kunokotsirisa kwete kukuwedzera kusvinura.

Ongororo ya2008 muAnaesthesia yakaenzanisa varwere 11 vakapiwa methylene blue pachine nguva nevarwere 11 vekuenzanisa vaiva nemamiriro anoenderana, panguva yekutanga anaesthesia nekuvhiyiwa, ichishandisa Bispectral index uye kupinzwa kwepropofol kwaidzorwa kuti kusvike pachinangwa chakatarwa. Pahuwandu hwepropofol hwaifungidzirwa panzvimbo yainoshanda hwe2 micrograms per millilitre, zvibodzwa zvekudzikamiswa nezviyero zveindex zvakanga zvakaderera zvakakosha muboka rakarapwa. Mukati mekuvhiyiwa, varwere vakapiwa mushonga pachine nguva vaida propofol iri pasi neavhareji ye50% kuti vasvike pakudzika kumwe chete kweanaesthesia. Pepa racho rinotanga nokucherechedza kuti kunonoka kubuda muanaesthesia nekuvhiringidzika kwekushanda kwetsinga zvakanga zvatove zvakashumwa muvarwere vaivhiyiwa parathyroid vakapiwa methylene blue pachine nguva, uye rinopedzisa nokukurudzira kugadzirisa dosi nokungwarira pose panopinzwa mushonga uyu panguva yakapoteredza kuvhiyiwa.

Mashoko ekunyora mushonga anotaura chinhu chimwe chete nemamwe mazwi. Kurapwa kunogona kukonzera kuvhiringidzika, dzungu nematambudziko ekuona, uye varwere vanokurudzirwa kusatyaira kana kushandisa michina ine ngozi kusvikira izvi zvapera, murayiro usina hukama huri pachena nechinhu chinotengeswa sechinobatsira kurara.

Zvino panewo kushandiswa kunorapa mamiriro akafanana nekurara. Ifosfamide, mushonga wechemotherapy, unogona kukonzera encephalopathy ine zviratidzo zvikuru zvekukotsira kwakanyanya, kusagadzikana nekuvhiringidzika, zvichisvika pakoma. Methylene blue mumwe wemishonga inopiwa nokuda kwayo. Muongororo yezviitiko 24 paMD Anderson Cancer Center, varwere 20 vakapiwa methylene blue uye zviratidzo zvakapera mu19, zvikadzoka muvatatu pavashanu vakazoedzwazve neifosfamide vachipiwa methylene blue sokudzivirira.

Mushonga unowedzera kudzika kweanaesthesia, unokonzera dzungu nekuvhiringidzika, uye unoshandiswa kudzorera mamiriro ekukotsira zvakanyanya anokonzerwa nechemotherapy hausi pachena kuti chinhu chinobatsira kurara. Mushonga une zvainoita chaizvo pahurongwa hukuru hwetsinga, uye kwazvinonanga kunoenderana nezvimwe zviri mumuviri.

Mishonga yehusiku, nekufema husiku

Zvinhu zviviri zvakanyorwa mumashoko ekunyora mushonga zvinoda kucherechedzwa nemunhu wese anotora methylene blue manheru pamwe nechimwe chinhu.

Chekutanga rondedzero yemishonga inopindirana nayo. Mashoko ari pachigadzirwa anoti SSRIs, SNRIs, MAOIs, bupropion, buspirone, clomipramine, mirtazapine, linezolid, opioids nedextromethorphan, uye anokurudzira kusatora chero mushonga unoshanda paserotonin mukati memaawa 72 mushure medosi rekupedzisira. Zviviri zvacho zvinowanikwa pamatafura epadivi pemibhedha. Mirtazapine mushonga wekuora mwoyo unokotsirisa unowanzotorwa husiku. Dextromethorphan ndiyo inodzvinyirira chikosoro mumishonga yedzihwa yehusiku, uye inotengeswa pasina gwaro rachiremba. Hapana pakubatanidzwa uku panongova nepfungwa isina kumboitika: mashoko ari pachigadzirwa anonyora zviitiko zveserotonin syndrome kubva muzvigadzirwa zveboka remethylene blue, uye zvimwe zvacho zvakauraya. Mushumo wakabudiswa wechiitiko panguva yakapoteredza kuvhiyiwa unotsanangura murume aiva nemakore 67 ane kusagadzikana, kubvunda kwetsandanyama kunodzokororwa uye kupisa kwemuviri kwakanyanya zvakazoonekwa chete paakanga obuda muanaesthesia yekuvhiya, mushure mekunge methylene blue yapiwa panguva yekuvhiyiwa.

Melatonin, benzodiazepines, z-drugs akadai sezopiclone, uye diphenhydramine hazvishandi paserotonin, saka chiri kunetsa ipapo haisi serotonin syndrome. Ndiro dambudziko rakayerwa neongororo yeanaesthesia, rokudzikamisa kunokotsirisa kunowedzerana padosi risina munhu ati anyatsotsanangura.

Chechipiri chakanyorwa chine chekuita nekufema. Pakati pezvinoitika zvisingadiwi zvakashumwa pamusoro pezvigadzirwa zveboka remethylene blue, mashoko ekunyora mushonga anonyora kuvharika kwemhino, kurwadziwa mumuromo nepahuro, kubuda mvura mumhino uye kuhotsira. Iyi mishumo yakangoendeswa isina kurongwa, isina mwero wekuitika uye isina nzira yakataurwa yekupiwa mushonga, uye izvi zvichinja zvinogona kuoneka sokumuka nemuromo wakaoma uye kunzwa sekuti kufema nemumhino kwakanga kwakasiyana husiku. Mushumo mumwe wemuverengi wekuchinja kamwe kamwe achitanga kufema nemuromo akarara uri muhurukuro yepaforamu pasina kuongororwa, nhoroondo yemishonga kana kuyerwa kupi zvako, izvo zvinongoratidza kuti mushumo wakaitwa, hapana chimwe.

Munhu wese ane dambudziko rekurara riri kuridza ngonono, kumbomira kufema kunoonekwa nevamwe, kana kukotsira masikati kwakanyanya zvekubatwa nehope achityaira anofanira kutarisa mubvunzo wekumira kufema pakurara pane kutarisa chinowedzerwa pakudya. Apnoea inogona kuongororwa, inogona kurapwa, uye hapana humbowo huri pamusoro hunotaura nezvayo.

Hunhu hwechinhu chacho hunosiyanawo pano

Madosi muongororo dzese dziri pamusoro aiva huwandu hwakayerwa hwechinhu chakatsanangurwa kubva kumugadziri wemishonga, aine chitupa cheongororo chinotsigira. Bhodhoro rinobva kumutengesi asina kusimbiswa harisi chinhu ichocho, uye musiyano wacho hausi wekunze chete. Chiratidzo cheUSP ndiwo muyero unogona kutariswa nemutengi, uye chinhu chisingaenderani nawo chingangova chemhando yekushandisa pamachira, chinogona kuva nezvinhu zvisina kuchena zveorganic zvakadai seAzure B, zvasara zvezvinonyungudutsa uye simbi dzinorema pamwero unoganhurirwa nezvinodiwa zvemishonga.

Vatengesi vakawanda vanotsanangura chigadzirwa sechakaedzwa neimwe sangano rakazvimirira vanongotarisa simbi dzinorema, vachiratidza ongororo imwe chete iyoyo sokutevedzera zvese zvinodiwa. Blupreme inoedza zvese zvinodiwa neUSP: kuzivikanwa kwechinhu, kuchena, zvinhu zvisina kuchena zveorganic, zvasara zvezvinonyungudutsa, zvinhu zvisina kuchena zvemaelement, zvasara mushure mekupiswa, miganhu yezvipenyu zvidukuduku uye endotoxins dzemabhakitiriya. Boka rega rega rinogadzirwa rinotumirwa rine chitupa cheongororo, uye kuchiverenga nemazvo kunoreva kuenzanisa nhamba yeboka rakagadzirwa nerabhoritari nebhodhoro riri muruoko rwako.

Hapana pane izvozvo chinogadzira rubatsiro pakurara, uye handicho chikonzero chekutora chinhu ichi. Kana ukachitora zvakadaro, kuziva zviri mukapisi ndiyo nhanho yepasi inodiwa, uye gwaro rekuchengeteka pamwe negwaro rekupindirana kwemishonga anobata mibvunzo inouya pamberi pehurukuro ipi neipi yenguva yekutora.

Pfupiso

Hapana muedzo une kugoverwa kumapoka nemukana wakayera kurara panguva yekurapwa nemethylene blue. Zvakanyorwa zvekurara chete muzvinyorwa zvemiedzo iyoyo mitsara yezviitiko zvisingadiwi, uye mukuenzanisa kukuru kwemadosi kuripo, mwero wekutadza kurara waiva 2.7% pa8 mg pazuva uchienzaniswa ne6.5% pa200 mg pazuva.

Zvinotaurwa nezvezviroto zvakajeka hazvina kwakabva kwakabudiswa, uye zvinyorwa zvemonoamine oxidase zvinofanotaura zvakapesana panguva yekurapwa. Mubvunzo wemangwanani kana husiku hauna kumbobvira waedzwa, uye dosi rinotorwa nemuromo rinosvika pahuwandu hwepamusoro muropa panguva yepakati yemaawa 16, iri pedyo nepakati pehusiku kupfuura nenguva yekudya kwemasikati kune wese anoritora pakudya kwemangwanani. Kuedza kwekunyimwa hope kunoparadzirwa sehumbowo iongororo yekuyeuka umo pasina kurara kwakanyorwa, uye mushumo mumwe chete wevanhu wekuvandudzika kwedambudziko rekurara ndewemurwere mumwe chete aiziva kurapwa kwaaipiwa, achiwana marapirwo maviri panguva imwe chete.

Pfupiso yehumbowo hwevanhu inounganidza zvinonyatsoratidzwa nemiedzo iyi, ongororo yekuyeuka nekuisa pfungwa pachinhu inotsanangura zviyero zvekufunga zviri pedyo zvikuru nekurara muongororo idzodzo, uye raibhurari yetsvakurudzo inoronga mapepa ari shure kwezvese zvinotaurwa papeji ino.