Ingredient batch is identified
The sample is linked to the methylene blue ingredient batch it came from before the test results are interpreted.
Quality testing,
documented by batch.
Blupreme’s quality standard is built around batch-specific records. The shared Dropbox records link the Blupreme batch number on the bottle to the methylene blue ingredient batch number and its laboratory certificate of analysis (COA).
Traceable from bottle to COA.
Use the shared batch records to find the ingredient batch associated with the batch number on your bottle. Then open that ingredient batch’s COA. The COA shows the tested material, specifications, dates, and results.
- Batch records
- Product batch number → ingredient batch number
- Laboratory
- Named on the report
- Test date
- Reported per batch
- Methods
- Shown with each result
What does USP-grade methylene blue mean?
USP stands for United States Pharmacopeia, and NF stands for National Formulary. Together, USP–NF publishes pharmaceutical quality standards, including specifications for the identity, strength, quality, and purity of materials.
A USP-grade claim means the material meets all applicable USP–NF requirements. For methylene blue, this includes the applicable monograph and general requirements, not just a heavy-metal screening panel. Review the specifications and batch documentation to understand what was tested.
Read the USP–NF General Notices and RequirementsWhat we test.
Every batch is evaluated against the same defined identity, composition, impurity, and contaminant specifications. Batch-specific records are available through the shared data folder.
TestWhat it evaluatesSpecification
IdentityConfirms the tested material is methylene blue.HPLC and IR identification
Assay, dried basisMeasures methylene blue content on the dried basis.97.0%–103.0%
Azure BMeasures the dye impurity Azure B.NMT 2.5%
Unspecified impurityLimits the amount of any single unspecified related impurity.NMT 0.10%
Total impurities excluding Azure BLimits the total amount of related impurities other than Azure B.NMT 0.5%
Loss on dryingChecks mass loss associated with water and hydrates.8.0%–24.0%
Residue on ignitionChecks non-volatile inorganic residue after ignition.NMT 0.15%
Elemental impurities: cadmium (Cd) / lead (Pb) / arsenic (As) / mercury (Hg)Measures cadmium, lead, arsenic, and mercury by ICP–MS.NMT 0.5 / 0.5 / 1.5 / 3.0 ppm
How each batch is documented.
The Dropbox batch records link each Blupreme product batch to its ingredient batch and the reviewed test results for that ingredient batch.
Methods are applied
Tests cover identity, assay, organic impurities, and the contaminants listed in the testing specification.
Results are reviewed
Reported values are reviewed against the ingredient specifications for that batch.
The COA is linked to the product batch
The Dropbox batch records link the approved ingredient COA to the Blupreme product batch.
Find your methylene blue certificate of analysis
Open the shared Dropbox folder. Use the batch records to find the ingredient batch number associated with the batch number on your bottle. Then open the certificate of analysis for that ingredient batch.
Read the Blupreme batch number
Find the Blupreme batch number on the bottle or packaging.
Find the ingredient batch number
Find your Blupreme batch number in the Dropbox batch records. Note the associated methylene blue ingredient batch number.
Open the matching COA
Open the COA with that ingredient batch number.
What a certificate of analysis should tell you.
What is a COA?
A certificate of analysis, or COA, is a batch-specific laboratory document. It identifies the tested material, batch number, quality specifications, test results, and whether the batch met the stated requirements.
A useful COA identifies
- 01 Tested material
- The methylene blue ingredient tested
- 02 Ingredient batch
- The ingredient batch associated with the batch number on the bottle
- 03 Lab and date
- Who tested it and when
- 04 Specifications
- The limits used for review
- 05 Results and status
- Test results and whether the batch met the stated requirements
Documents that answer different questions
Certificate of analysis
The tested material’s identity, batch number, specifications, test results, methods, and whether the ingredient batch met the stated specifications.
Safety data sheet
Hazards, first aid, storage, handling, transport, and disposal information.
Quality standard
Which tests are performed, why they are needed, how often they are performed, and who performs them.
Find the quality records
for your batch.
Use the Dropbox batch records to find the ingredient COA associated with the Blupreme batch number on your bottle.
Always check that the COA is associated with the batch number on your bottle.