Frequently asked questions.

Blupreme Methylene Blue can be purchased directly from blupreme.com and from authorised retailers listed on our website.

Blupreme is tested against the full applicable USP–NF Methylene Blue monograph, relevant residual-solvent requirements, and additional quality requirements. The finished 1% solution is manufactured and bottled in Lithuania under GMP standards and contains USP-grade methylene blue and purified water without additives or preservatives.

USP–NF is a recognised pharmaceutical quality standard. A supported USP-grade claim requires compliance with all applicable monograph and general requirements, including identity, assay, organic impurities, and other relevant quality controls, not only a heavy-metal screening panel.

Powder may cost less to package and transport, but it requires accurate weighing, liquid measurement, and mixing. Blupreme’s 1% aqueous solution is ready-made, so no powder weighing or solution preparation is required.

A 1% weight-per-volume solution contains 1 gram of methylene blue per 100 mL of solution. This is equivalent to 10 mg per millilitre.

A 0.1% weight-per-volume solution contains 1 gram of methylene blue per litre of solution. Blupreme’s methylene blue solution has a concentration of 1%, not 0.1%.

Store the bottle upright, protected from light, and below 25 °C. Keep it out of reach of children and use it before the best-before date printed on the packaging.

Yes. Each bottle is supplied with a graduated dropper pipette marked at 0.25 mL, 0.5 mL, and 1 mL for controlled dispensing.

Approximately two drops contain 1 mg of methylene blue, and ten drops contain approximately 5 mg. Drop size can vary depending on how the dropper is held and used.

Methylene blue absorbs light strongly. This can make the dark blue solution appear almost black inside the bottle.

A certificate of analysis, or COA, is a batch-specific laboratory document. It identifies the tested material, batch number, quality specifications, test results, and whether the batch met the stated requirements.

Open the Quality Testing page and follow the batch-record instructions. Match the batch number on your bottle to the listed ingredient batch and its certificate of analysis. Contact us if you cannot find the record.

Yes. The Quality Testing page explains the tests performed, the applicable specifications, and what the results demonstrate.

Yes. Each batch is tested against defined ingredient and finished-product specifications before release.

Testing is performed by our laboratory partner in Lithuania using defined methods and acceptance limits.

Heavy-metal screening measures selected elemental contaminants but provides no information about assay, Azure B, other organic impurities, residual solvents, microbial levels, or bacterial endotoxins. Full testing assesses the material against the broader requirements for identity, methylene blue content, purity, and microbiological quality.

Azure B is a named organic impurity and unwanted manufacturing by-product in methylene blue. The USP–NF monograph sets a specific maximum limit. Heavy-metal testing cannot detect Azure B. Measuring Azure B provides information about purification that heavy-metal testing cannot provide.

Organic impurities are chemically related substances that can arise during ingredient manufacturing or degradation. Testing covers specified impurities such as Azure B, unspecified individual impurities, and the total amount of other impurities.

Residual solvents are volatile chemicals that may remain after ingredient manufacturing. Testing determines whether specified solvents are present and whether their levels remain within defined limits.

The residue on ignition test, also called the sulfated ash test, measures non-volatile inorganic material remaining after a sample is burned under controlled conditions. It is different from residual-solvent testing.

Blupreme elemental-impurity testing covers lead, arsenic, cadmium, and mercury. These results form one part of the overall quality assessment.

Microbial testing measures the total counts of aerobic microorganisms and of yeasts and moulds. It also checks for specified organisms such as E. coli.

Bacterial endotoxins are substances associated with the outer membranes of certain bacteria. Endotoxin testing detects contamination that may not be identified through ordinary microbial-count testing.

The assay measures how much methylene blue is present in the tested ingredient and compares the result with the applicable USP–NF acceptance range.

The term is sometimes used without evidence of complete USP–NF testing. A proper claim should be supported by results demonstrating compliance with all applicable monograph and general requirements, not only one selected category of contaminants.

Good Manufacturing Practice is a controlled production system covering personnel, facilities, equipment, materials, records, hygiene, quality control, deviations, and batch release. GMP manufacturing does not replace product testing. Both are required.

Blupreme’s methylene blue solution contains purified water prepared for controlled product manufacturing and tested against defined chemical and microbiological limits. The formulation contains no alcohol, flavourings, sweeteners, additives, or preservatives.

We do not currently have third-party non-GMO certification for Blupreme.

No. Store the bottle upright, protected from light, and below 25 °C. Do not place it in direct sunlight or near a heat source.

Keep the bottle securely closed and use it before the best-before date printed on the packaging. We do not currently specify a separate time limit for using the solution after opening the bottle. Discard it if the original seal was damaged or the solution develops an unexpected change in appearance.

Prolonged heat, direct light, or freezing can affect the bottle or product quality. Store Blupreme below 25 °C and do not freeze it.

Do not allow the dropper to touch your hands, mouth, work surfaces, or other objects. Return it to the bottle immediately after use and close the bottle securely.

Absorb a spill immediately with disposable material, rinse the affected surface with cold water, and clean it with an appropriate detergent. Do not mix cleaning chemicals. Test any method on an inconspicuous area because methylene blue can stain permanently.

Yes. Methylene blue is a strong dye and can stain skin, clothing, worktops, grout, and other porous materials. Handle the bottle carefully and protect surrounding surfaces.

A 100 mL bottle meets the standard EU limit for an individual liquid container in hand luggage. Keep it tightly closed in its original packaging and confirm current airport and airline requirements before travelling.

Methylene blue is a potent reversible monoamine oxidase inhibitor. Combining it with medicines that increase serotonin can cause serotonin syndrome.

In people with glucose-6-phosphate dehydrogenase (G6PD) deficiency, methylene blue can cause the destruction of red blood cells, called haemolysis. Approved pharmaceutical methylene blue is contraindicated in people with G6PD deficiency.

For bulk quantities, contact support@blupreme.com with the required quantity, destination country, and delivery requirements.

You can display and pay in EUR, USD, GBP, CAD, AUD, CHF, JPY, PLN, SEK, NOK, DKK, or NZD. The selected currency and final total are shown before payment.

Shipping costs are calculated at checkout based on the destination and available delivery service.

Available payment methods are displayed at checkout. Only payment options available for the order, country, and currency are shown.

Check the card details and billing address, then ask your bank whether it blocked the transaction. If the bank confirms there is no restriction, contact support@blupreme.com.

Add the product to your cart, proceed to checkout, enter your delivery information, select an available card payment method, and complete the order after reviewing the total and delivery details.

Yes. The countries we currently ship to are listed at checkout. Availability depends on current carrier service and destination restrictions.

Orders moving between EU member states are generally not subject to import customs duties. Different rules may apply to territories outside the EU customs area.

Tracking information is sent by email after dispatch. Use the link in that email to follow the shipment.

EU delivery typically takes 3 to 4 days. Delivery outside the EU is approximately 10 days. These are estimates, not guarantees.

Yes. We sell to both individual customers and businesses.