Methylene Blue Idan Aka Kwatanta da Methylfolate da Methyl-B12

Methylene blue ba methylfolate ba ne, kuma ba methyl-B12 ba ne. Methylfolate wani nau'in bitamin B9 ne; methyl-B12 kuwa methylcobalamin ne, wani nau'in bitamin B12. Suna shiga cikin martani guda na sinadarai a jiki. Methylene blue rini ne na roba kuma sinadarin magani ne mai tsarin sinadarai dabam. Ba sinadarin gina jiki mai bayar da methyl ba ne, kuma ba madadin ɗaya daga cikin waɗannan bitamin ba ne.

Kamanceceniyar sunayen tana sa ikirari marar hujja ya zama kamar mai yiwuwa: idan wani abu yana ɗauke da “methyl,” wataƙila yana inganta “methylation.” Sunan sinadari ba zai iya tabbatar da wannan aiki ba. Tambayoyin da suka dace su ne abin da ƙwayar sinadarin ke yi a wani takamaiman martani, da ko an nuna cewa wannan aikin yana da amfani ga mutumin da ke tunanin amfani da shi.

Kwatanta abin da sinadarin yake kafin kwatanta amfaninsa

PubChem ya bayyana methylene blue a matsayin methylthioninium chloride, wani rini na phenothiazinium. Takardar bayanai ta NIH kan folate ta bayyana methylfolate a matsayin 5-methyltetrahydrofolate, wanda aka fi taƙaitawa da 5-MTHF. Takardar bayanai ta NIH kan bitamin B12 ta bambanta methylcobalamin da sauran nau'ikan B12. Waɗannan bayanai sun bayyana kwatancen da ke ƙasa.

Tambaya	Methylene blue	Methylfolate	Methyl-B12
Mene ne shi?	Methylthioninium chloride, wani rini na roba	5-MTHF, wani nau'in folate	Methylcobalamin, wani nau'in B12 mai ɗauke da cobalt
Bitamin ne?	A'a	Wani nau'in bitamin B9	Wani nau'in bitamin B12
Aikinsa a martanin sinadarai na jiki	Zai iya karɓa da miƙa electrons ta hanyar martanin redox	Yana bayar da rukunin methyl a martanin methionine synthase	Sinadarin taimako da ke haɗe da enzyme, wanda yake shiga cikin miƙa wannan rukuni zuwa homocysteine
Wane bambanci ne yake da muhimmanci?	Aikin magani ya bambanta da maye gurbin sinadarin gina jiki	Yanayin sinadaran folate ya bambanta da na B12	Sinadarin taimako ba enzyme ɗin kansa ba ne
Me sunansa bai tabbatar ba?	Aiki a matsayin madadin folate ko maganin methylation	Cewa kowa yana buƙatar wannan takamaiman nau'in folate	Cewa wannan nau'in ƙarin bitamin shi ne mafi kyau ga kowace matsala da ta shafi B12

Wannan kwatancen ayyuka ne, ba jera su bisa fifiko ba. Wani samfur ba zai iya maye gurbin sinadarin gina jiki kawai saboda ana bayyana su duka da kalmomi kamar “kuzari” ko “lafiyar ƙwaƙwalwa” ba. Don ƙarin bayani kan abin da sinadarin yake da yadda ake amfani da shi, duba mene ne methylene blue.

Abin da folate da B12 suke yi tare a zahiri

Tsarin sarrafa raka'o'in carbon guda ɗaya a jiki yana motsa waɗannan raka'o'i ta jerin martanai masu alaƙa. Raka'ar carbon tana haɗe da ƙwayar sinadari mai ɗaukarta; ba ta yawo a matsayin “mai ƙara methylation” mai zaman kansa ba.

Enzyme na MTHFR yana sauya 5,10-methylenetetrahydrofolate zuwa 5-methyltetrahydrofolate. Kalmomin da suke kama da juna a nan suna nufin nau'ikan folate guda biyu. Babu ɗayansu da yake methylene blue.

A cikin martanin methionine synthase, rukunin methyl daga 5-MTHF yana bi ta sinadarin taimako na B12 da ke cikin enzyme zuwa homocysteine, yana samar da methionine. Saboda haka, folate da B12 suna da ayyuka masu alaƙa amma daban-daban: ɗaya yana bayar da rukunin, ɗayan kuma yana shiga cikin miƙa shi. Daga baya ana iya amfani da methionine don samar da S-adenosylmethionine, ko SAM, wanda yake bayar da rukunonin methyl a wasu martanai da yawa.

Wannan jerin matakai kuma yana bayyana dalilin da ya sa “ƙarin rukunonin methyl” ba cikakkiyar hujjar magani ba ce. Hanyar martanin sinadarai a jiki ta ƙunshi sinadaran da ake aiki a kansu, enzymes, sinadaran taimako da tsarin daidaitawa. Nuna inda sinadarin gina jiki yake shiga ba ya tabbatar da ƙarancinsa, dalilin wata alama, ko amfanin ƙara shi.

B12 yana da wani nau'i mai aiki, adenosylcobalamin, wanda yake taimakawa wani martanin enzyme dabam da ya shafi methylmalonyl-CoA. Kiran methylcobalamin “B12 mai aiki” ba yana nufin shi kaɗai ne nau'in B12 mai amfani ba. Kwatancen NIH na nau'ikan B12 da ake ɗauka a matsayin ƙari bai tabbatar da wani nau'i da ya fi sauran gaba ɗaya ga kowa ba.

Dalilin da ya sa methylene blue ba madadin methylation ba ne

Bayanan rubuta maganin PROVAYBLUE suna bayar da takamaiman misali na aikin redox na methylene blue. A wajen magance methemoglobinemia da aka samu ba ta gado ba, ana sauya methylene blue zuwa leucomethylene blue ta hanyar karɓar electrons a wani tsari da ya dogara da NADPH. Nau'in da ya karɓi electrons yana taimakawa sauya ƙarfen hemoglobin daga yanayin ferric zuwa yanayin ferrous. Wannan martanin miƙa electrons ne, ba isar da rukunin methyl zuwa homocysteine ba.

Tsarin methylene blue yana ɗauke da rukunonin methyl. Kasancewarsu ba ya sa waɗannan rukunoni su zama masu amfani a hanyar folate/B12. Ikirarin cewa shi “mai bayar da methyl” ne yana buƙatar hujjar ainihin martanin miƙawar; nuna sunansa ko tsarinsa bai isa ba.

Haka kuma, sakamakon MTHFR ba ya nuna cewa methylene blue yana kauce wa wani martani da ya samu tangarɗa ko yana inganta sakamakon lafiya mai alaƙa da shi. Bayanin maganin ya tabbatar da amfani da shi wajen magance methemoglobinemia da aka samu ba ta gado ba, ba magance bambance-bambancen MTHFR na gama-gari ba. Hujjojin amfanin methylene blue daga nazarin ɗan Adam masu faɗi suna buƙatar tantancewa dabam ga kowane sakamako.

Abin da sakamakon MTHFR yake faɗa maka da abin da ba ya faɗa maka

MTHFR wani gene ne, kuma abin da yake samarwa enzyme ne. Bambance-bambancensa na gama-gari irin su C677T sun bambanta da bambance-bambance masu wuya waɗanda suke haifar da cuta mai tsanani ta gado. Rahoton gwajin kwayoyin halitta na mai amfani bai kamata ya haɗa waɗannan rukunai zuwa ikirarin cewa “methylation ya lalace” a jikin mutum ba.

Bayani na CDC kan bambance-bambancen MTHFR na gama-gari ya bayyana cewa mutanen da suke da waɗannan bambance-bambancen za su iya sarrafa folic acid a jikinsu. Samun bambancin gama-gari shi kaɗai ba dalili ba ne na guje masa. Bayanin CDC na fannin aikin asibiti kuma bai ba da shawarar sauya yawan folate da ake ɗauka bisa nau'in kwayoyin halittar MTHFR kaɗai ba.

Nau'in kwayoyin halitta ba ma'aunin sinadarin gina jiki ba ne. Homocysteine ma ba cikakken “ma'aunin methylation” ba ne: ƙarancin folate, ƙarancin B12 da aikin koda na iya shafarsa. Tantancewa dole ne ta danganta wani takamaiman sakamako da yanayin sinadaran gina jiki na mutum, alamominsa da sauran abubuwan da aka gano. Ba za a iya maye gurbin wannan hujja da daidaita sunan gene da sunan samfur ba.

Ƙamus na kalmomin da ake yawan rikicewa da su

Kalma	Ma'ana	Rikicewar da aka saba yi wadda ya kamata a guje wa
Rukunin methyl	Atom ɗin carbon da ya haɗu da atoms na hydrogen guda uku, ana rubuta shi CH₃, kuma yana haɗe a cikin ƙwayar sinadari	Kasancewarsa ba ya sa sinadari ya zama mai bayar da shi a jiki kai tsaye
Mai bayar da methyl	Ƙwayar sinadari da take bayar da rukunin methyl a wani takamaiman martani	Wannan aikin yana buƙatar a bayyana martanin da yake faruwa a cikinsa
Methylation	Ƙara rukunin methyl ga ƙwayar sinadari	Ba aiki guda ɗaya ba ne a duk jiki mai matakin “mafi dacewa” guda ɗaya ga kowa
Folate	Rukunin bitamin B9	Folic acid da 5-MTHF nau'ika ne daban-daban
MTHFR	Sunan gene da taƙaitaccen sunan methylenetetrahydrofolate reductase	Ba taƙaitaccen sunan methylene blue ba ne
Sinadarin taimako	Wani ɓangare da ba furotin ba wanda ake buƙata don aikin enzyme	B12 yana taimakawa enzyme; ba shi ne methionine synthase kansa ba
Redox	Haɗaɗɗun martanan rasa da karɓar electrons	Miƙa electrons da miƙa rukunin methyl matakai ne daban-daban
Methyl blue	Wani rini mai suna dabam	Duba kwatancen rinayen shuɗi masu sunaye masu kama kafin maye gurbin sinadaran gwaji na ɗakin gwaje-gwaje

Dalilin da ya sa wannan bambanci yake sauya shawarar lafiya

Ba za a iya musanya folate da B12 ba ko da sakamakon gwajin jini iri ɗaya ya bayyana a ƙarancin kowannensu. NIH ya bayyana cewa ɗaukar folate mai yawa na iya inganta ƙarancin jinin da ƙarancin B12 ya haifar ba tare da magance lalacewar jijiyoyi da ya haifar ba. Saboda haka, magance abin da aka kira “matsalar methylation” na iya sa a kasa gano ainihin matsalar.

Methylene blue yana kawo wasu damuwa dabam. Bayanin maganinsa na takardar likita ya ƙunshi gargaɗi mai tsanani kan hulɗar da za ta iya haifar da ciwon serotonin syndrome, da kuma hana amfani da shi ga masu ƙarancin G6PD saboda haɗarin lalacewar jajayen ƙwayoyin jini. Haɗa shi da bitamin ba ya kawar da waɗannan halaye. Ikirari game da tasirinsa ga sinadaran isar da saƙo na jijiyoyi ko haɗa shi da hanyoyin NAD+ suna buƙatar hujjojinsu na yadda suke aiki da na nazarin asibiti.

Yayin tantance ikirari, gano takamaiman sinadarin, martanin da ake cewa yana yi, matsalar da ake son magancewa da sakamakon da aka auna a ɗan Adam. Idan bayanin ya tashi kai tsaye daga kamanceceniyar suna zuwa shawarar magani, to babu hujjar da ake buƙata.