Uvavanyo lweeasidi ze-organic ne-methylene blue: zithetha ntoni iziphumo

Uvavanyo lweeasidi ze-organic alunakumisela, ngokwalo, ukuba uyayidinga i-methylene blue. Iiasidi ze-organic ezisemchameni ziimveliso zemetabolism ezinokulinganiswa, ezisetyenziswa ngokufanelekileyo ekuphandeni izifo zemetabolism. Kodwa ukulinganisa into ngokuchanekileyo, ukuchonga unobangela wesiphumo esingaqhelekanga, nokuqikelela inzuzo enokuvela kwiyeza yimisebenzi emithathu eyahlukeneyo.

Imithombo ehlolwe kwesi sikhokelo ayizange imisele ipateni eqinisekisiweyo yeeasidi ze-organic ezisemchameni ekhetha abantu abafanele unyango lwe-methylene blue. Ngoko ke ingxelo inokuquka into engaqhelekanga yokwenene, kodwa isincomo sonyango esinxulunyaniswe nayo sihlale singenabungqina busixhasayo.

Oko kulinganiswa luvavanyo lweeasidi ze-organic

Iiasidi ze-organic ziquka izinto eziphakathi nezo ziveliswa kukuqhekeka kwezinto kwiindlela zemetabolism. Uhlalutyo lomchamo luhlola oko kufikelela kwisampulu eqokelelweyo. Alulinganisi ngokuthe ngqo ukuveliswa kwe-ATP ngaphakathi kwizihlunu zakho okanye ukuthuthwa kwee-electron ngaphakathi kwingqondo yakho.

Uvavanyo lokuhlola iiasidi ze-organic lweMayo Clinic Laboratories lusebenzisa i-gas chromatography kunye ne-mass spectrometry, luze lunike ingcaciso yohlobo lokungaqheleki kumanqanaba eeasidi ze-organic ukuze kuphandwe ukuphazamiseka kwem metabolism umntu azalwa nako. IMayo iphawula ukuba ukutolikwa kweziphumo kuxhomekeke kwiimeko ezifana nesigulo esibukhali, izongezelelo, nokuba umzimba wakha izicubu okanye uqhekeza oovimba bamandla.

Olo setyenziso lwezonyango aluqinisekisi yonke ingcaciso enikwa yiyo yonke ipaneli yovavanyo ethengiswayo. Uvavanyo oluthengiswa njenge-“OAT” lunokunika ingxelo ngeekhompawundi ezahlukeneyo, lusebenzise uluhlu olwahlukileyo lwamaxabiso okubhekiswa kuwo, okanye longeze amabango ngezondlo, iintsholongwane, okanye izithunywa zemichiza zemithambo-luvo. Indlela echanekileyo esetyenziswayo nenjongo yovavanyo zibaluleke ngaphezu kwesifinyezo.

Uphawu lwesiphumo esingaqhelekanga luthelekiso, hayi uxilongo

Qala ngengxelo epheleleyo: igama lento ehlalutywayo, isampulu, iiyunithi, uluhlu lwamaxabiso okubhekiswa kuwo, iimeko zokuqokelelwa kwesampulu, nengcaciso yelabhoratri. Uxinzelelo lwento kumchamo nexabiso elichazwe ngokuthelekiswa ne-creatinine yomchamo zizilinganiso ezahlukeneyo. Iziphumo zeengxelo ezahlukeneyo akufanele zithelekiswe kungakhange kuhlolwe isiseko ezichazwe ngaso.

Uluhlu lwamaxabiso okubhekiswa kuwo luchaza iqela labantu elisetyenziswa yilabhoratri ukuthelekisa phantsi kweemeko ezichaziweyo. Alubi ngokuzenzekelayo ngumda wokuqalisa unyango. Isiphumo esiphakame kancinane sifuna kubuzwe ukuba kutheni ixabiso lahlukile; asichongi unobangela ngokwaso. Uluhlu olubizwa ngokuba “lolona lufanelekileyo” nolumxinwa kunolwelabhoratri lufuna ubungqina balo bokuluthethelela.

Ingcaciso ye-FDA-NIH ngokuqinisekiswa kwezikhombisi zebhayoloji yahlula phakathi kokuqinisekiswa kokuchaneka kohlalutyo, oko kukuthi, ukuba uvavanyo lulinganisa into olujoliswe kuyo, nokuqinisekiswa kokutolikwa kwezonyango, oko kukuthi, ukuba isiphumo siyayixhasa na ingcaciso yezonyango ecetywayo. Umlinganiselo olungileyo welabhoratri awenzi onke amabango alandelayo abe semthethweni.

Umzekelo, isiphumo se-malate esiphezulu sinokukhokelela ugqirha ukuba ahlole ipateni iyonke yeemveliso zemetabolism, iimpawu, nezinye iingcaciso ezinokwenzeka. Ukudibanisa i-malate ekumzobo wendlela yemetabolism nemfuno ekuthiwa ikhona ye-methylene blue kutsiba olo phando. Xa kuthelekiswa, imilinganiselo ye-mitochondria eyenziwa kuvavanyo lophando ihlola iziphumo ezahlukeneyo phantsi kweemeko ezilawulwayo.

Oko kwafunyanwa ngokwenene luphando lwe-mitochondria olunikiweyo

Kuphando lukaBruce Barshop lwango-2004 olwahlola idatha yangaphambili, abaphandi bahlola uhlalutyo lomchamo oluyi-3,646, kuquka iisampulu eziyi-258 ezivela kwizigulana eziyi-67 ezineziphazamiso ezaziwayo ze-oxidation kwi-mitochondria, neesampulu eziyi-176 ezivela kwizigulana eziyi-21 ezine-organic acidemias. La ngamanani eesampulu namanani ezigulana, hayi ubungakanani beesampulu obunokutshintshwa kusetyenziswe obunye endaweni yobunye.

I-lactate yomchamo nezinto ezininzi eziphakathi kumjikelo weKrebs zazingakwazi kakuhle ukwahlula amaqela. I-fumarate ne-malate zazinolwazi oluthe kratya, kodwa kwimida ekhethwe luphando zahlula kuphela malunga ne-25–30% yezigulana ezinesifo se-mitochondria, ngezinga le-5% leziphumo ezibonisa isifo ngempazamo. Loo mida yophando ayiyomida yoxilongo esebenza kuyo yonke ipaneli yovavanyo yanamhlanje.

Olu yayiluphando lonxulumano loxilongo kwiisampulu ezithunyelwe ukuba zihlolwe. Aluzange lunike i-methylene blue, luyithelekise ne-placebo, okanye luvavanye ukuba ipateni yomchamo yayiqikelela ukuphucuka na. Luxhasa ukuphanda imida yokutolikwa kweemveliso zemetabolism, hayi ukusebenzisa isiphumo ukukhetha isicwangciso sonyango.

I-lactate ifuna owawo umxholo

I-lactate yomchamo, i-lactate yegazi, nomlinganiselo we-lactate ne-pyruvate egazini zizinto ezahlukeneyo eziqwalaselwayo. Uphawu lwe-lactate engaqhelekanga emchameni alunakuthatha indawo yemilinganiselo yegazi eqokelelwe ngokuchanekileyo.

Ingxelo yemvumelwano yeMitochondrial Medicine Society ichaza ukuba i-lactate yegazi inokunyuka ngenxa yokuphazamiseka okubangelwa yindlela yokuqokelela isampulu okanye ngenxa yeemeko ezingesosifo esiphambili se-mitochondria. Umlinganiselo we-lactate ne-pyruvate unika ulwazi kuphela xa i-lactate iphakanyisiwe. I-lactate eqhelekileyo nayo ayikukhupheli ngaphandle ngokuthembekileyo ukuba nesifo se-mitochondria.

Kwale ngxelo ibeka iiasidi ze-organic zomchamo ngaphakathi kophando olubanzi olunokuquka iimvavanyo zegazi nohlalutyo lwemfuza. Umsebenzi wokuqinisekisa uxhomekeke kwisiphazamiso esikrokrelwayo noko kufunyenwe ekuhlolweni kwezonyango. Ukuphinda kuhlolwe isampulu ethandabuzekayo kunokusombulula ukungaqiniseki okuthile; ukuqinisekisa indlela esenzeka ngayo isifo kunokufuna uvavanyo olwahluke ngokupheleleyo. Akukho nalinye kula manyathelo eliqikelela ngokuzenzekelayo impendulo kwi-methylene blue.

“Izikhombisi zezithunywa zemichiza zemithambo-luvo” zifuna ukusetyenziswa kwezonyango okuchaziweyo

I-homovanillic acid, okanye i-HVA, yimveliso yemetabolism ye-dopamine. Olo nxulumano lwebhayokhemistri alwenzi isiphumo se-HVA yomchamo sibe ngumlinganiselo othe ngqo we-dopamine engqondweni okanye sibe sisigunyaziso sokunikwa iyeza elichaphazela imetabolism yee-monoamine.

Uvavanyo lwe-HVA yomchamo lweMayo luneendlela zokusebenzisa ezichaziweyo, kuquka ukuhlolwa kwamathumba akhupha ii-catecholamine neziphazamiso ezithile ezizuzwe njengelifa zemetabolism yee-catecholamine. Lukwachaza nemiphumo enxulumene namayeza kwiziphumo. Ezi ziimeko ezithile zoxilongo, hayi ukuqinisekiswa kwengcaciso jikelele “yezithunywa zemithambo-luvo eziphantsi” malunga nokudinwa okanye iimpawu zesimo sengqondo.

Buza ukuba sisiphi isiphazamiso ekufanele sichongwe sisikhombisi esikwingxelo, ukuba loo ngcaciso yaqinisekiswa njani kwizigulana ezinokuthelekiswa, nokuba yintoni enokuyiqinisekisa. Indlela yemetabolism enegama inika ingcinga ekufuneka iphandwe. Ayimiseli intsingiselo yezonyango yexabiso elinye eliphantsi okanye eliphezulu.

Uluhlu lokuhlola ubungqina obudibanisa uvavanyo nonyango

Sebenzisa le theyibhile xa uhlola isincomo esisekelwe kuvavanyo. Bhala uxwebhu okanye uphando lokwenene oluxhasa impendulo nganye. Impendulo engaziwayo ihlala ingaziwa; olu ayilogqaku eliqinisekisa ukuba umntu angafumana unyango.

Inqanaba lobungqina	Imibuzo ethile	Yintoni enokuxhasa ibango?	Yintoni engakaqinisekiswa?
Ukuchaneka kohlalutyo	Yeyiphi kanye into ehlalutywayo, indlela, iiyunithi nesampulu ezisetyenzisiweyo? Ngaba iimfuneko zokuphathwa kwesampulu nokuhlolwa kokuphazamiseka zafezekiswa?	Amaxwebhu endlela yelabhoratri, ulawulo lomgangatho, nokuchaneka kwinqanaba elichaziweyo	Unobangela wesiphumo okanye ukuba luncedo kweyeza
Ukutolikwa kwamaxabiso okubhekiswa kuwo	Ngaba uluhlu lufanelekile kwiminyaka yomntu nakwisiseko sokuchazwa kweziphumo? Ngaba ukutenxa kuyaphindeka xa ukuphinda uvavanyo kufanelekile ngokwezonyango?	Uluhlu lwelabhoratri nokutolikwa kwepateni epheleleyo kuthathelwa ingqalelo umxholo	Ukuba lonke uphawu lubonisa isifo okanye lufuna ukulungiswa
Ukuthembeka koxilongo	Loluphi uxilongo olucetywayo? Kufunyanwa kangaphi oku kwezinye iimeko okanye kubantu abangenaso isifo?	Uphando kwiqela lezigulana ekujoliswe kulo kunye neemvavanyo ezifanelekileyo zokuqinisekisa zebhayokhemistri, zemfuza, okanye ezinye	Ukuba uxilongo luqikelela inzuzo ye-methylene blue
Ukuthembeka koqikelelo	Ngaba abantu abanale pateni yovavanyo bazuze ngakumbi kwi-methylene blue xa ithelekiswa nolunye unyango okanye nolawulo kunabantu abangenayo?	Uhlalutyo lwesikhombisi sebhayoloji oluchazwe kwangaphambili, olunothelekiso phakathi konyango nolawulo	Ukuba unxulumano oluqwalaselweyo luchonga abantu abaza kuphendula kunyango
Inzuzo yezonyango	Ngaba ukhathalelo olukhokelwa luvavanyo luphucule iimpawu, ukusebenza, okanye esinye isiphumo esibalulekileyo, ngeengozi ezamkelekileyo?	Ubungqina obulawulwayo beziphumo zezigulana malunga nonyango lokwenene nesicwangciso sovavanyo	Ukuba ixabiso eliphantsi lemveliso yemetabolism lilodwa lithetha impilo engcono

Inkcazelo ye-FDA-NIH yesikhombisi sebhayoloji esiqikelelayo ichaza ukuba kutheni uthelekiso lonyango lubalulekile. Iziphumo ezingcono phakathi kwabantu abanyangiweyo abanesikhombisi zinokubonisa uqikelelo lwangaphambili lwendlela imeko yabo enokuqhubeka ngayo. Ukumisela amandla okuqikelela kudla ngokufuna ukuthelekiswa konyango nolawulo kumaqela ahlukeneyo ngokwesikhombisi. Nkqu nolingo oluphumelelayo olubhalisa kuphela izigulana ezinesikhombisi alunakuqinisekisa, ngokwalo, ukuba isikhombisi siyafuneka ukukhetha abantu abaza kuphendula kunyango.

Omawukwenze ngesincomo

Yisa ingxelo epheleleyo nophando olucatshuliweyo kugqirha ohlola iimpawu. Buza ukuba yeyiphi inxalenye yoluhlu lokuhlola ezalisekiswa bubungqina ngokwenene. Sebenzisa isikhokelo sokuqinisekisa iprothokholi ekwi-intanethi ukuze uhlole ukuba iphepha loxilongo liye laboniswa njengobungqina bonyango na.

Kwi-ME/CFS, isiphumo esiluncedo kuya kufuneka sijongane nesigulo neziphumo zaso ekusebenzeni komntu, kuquka ukungaziva kakuhle emva kokuzibhokoxa. Isiphumo somchamo esitshintshileyo okanye ukuziva unamandla okwethutyana akuwuphenduli loo mbuzo.

Ipaneli yovavanyo lomchamo nayo ayimiseli ukuba amayeza ayahambelana na. Ulwazi lokumisela iPROVAYBLUE luchaza intsebenziswano eyingozi echaphazela i-serotonin kwaye luyakwalela ukusetyenziswa xa kukho ukunqongophala kwe-G6PD. Le miba ifuna uhlolo lwezonyango olwahlukileyo, njengoko kuchaziwe kwimibuzo omawuyibuze ngaphambi kokucinga nge-methylene blue.

Yazisa ilabhoratri ngayo nayiphi na imeko apho uye wachanabeka kwi-methylene blue. Ukuphazamiseka kovavanyo lwelabhoratri okubhalwe phantsi kuxhomekeke kwindlela esetyenziswayo; ukuphazamiseka kovavanyo lomchamo ngomcu ofakwa emchameni akuqinisekisi ukuphazamiseka kwalo lonke uvavanyo lwe-mass spectrometry. Ugqirha ocele uvavanyo kunye nelabhoratri bafanele bagqibe ukuba isiphumo sinokutolikwa na nokuba ukuqokelelwa kwezinye iisampulu kufanele kulungiselelwe njani.