Imibuzo ebuzwa rhoqo.

IMethylene Blue yeBlupreme inokuthengwa ngqo ku-blupreme.com nakubathengisi abagunyazisiweyo abadweliswe kwiwebhusayithi yethu.

IBlupreme ivavanywa ngokwemonografi epheleleyo esebenzayo ye-USP–NF yeMethylene Blue, ngokweemfuno ezifanelekileyo zezinyibilikisi ezishiyekileyo nakwezinye iimfuno zomgangatho. Isisombululo sokugqibela esiyi-1% senziwa size sifakwe ezibhotileni eLithuania phantsi kwemigangatho ye-GMP, yaye sine-methylene blue ekumgangatho we-USP namanzi ahlambulukileyo ngaphandle kwezongezelelo okanye izigcini.

I-USP–NF ngumgangatho owaziwayo womgangatho wamayeza. Ibango elixhaswayo lomgangatho we-USP lifuna ukuthotyelwa kwazo zonke iimfuno ezifanelekileyo zemonografi neziqhelekileyo, kuquka isazisi, uvavanyo lomxholo, ukungcola kwezinto eziphilayo nolunye ulawulo lomgangatho olufanelekileyo, hayi iphaneli yokuhlola izinyithi ezinzima kuphela.

Umgubo unokubiza kancinci ukupakisha nokuthutha, kodwa ufuna ukulinganiswa kobunzima ngokuchanekileyo, ukulinganiswa kolwelo nokuxutywa. Isisombululo samanzi seBlupreme esiyi-1% sele silungisiwe, ngoko akukho mfuneko yokulinganisa umgubo okanye ukulungisa isisombululo.

Isisombululo se-1% sobunzima ngomthamo sinegram e-1 ye-methylene blue kwi-100 mL yesisombululo. Oku kulingana ne-10 mg kwimililitha nganye.

Isisombululo se-0.1% sobunzima ngomthamo sinegram e-1 ye-methylene blue kwilitha enye yesisombululo. Isisombululo se-methylene blue seBlupreme sixinene nge-1%, hayi nge-0.1%.

Gcina ibhotile ime nkqo, ikhuselekile ekukhanyeni kwaye ingaphantsi kwe-25 °C. Yigcine kude nabantwana uze uyisebenzise ngaphambi komhla wokuphelelwa ochwethezwe ekupakishweni.

Ewe. Ibhotile nganye iza nedropha yokulinganisa enamanqaku emilinganiselo ye-0.25 mL, 0.5 mL ne-1 mL ukuze ulawule isixa osikhuphayo. Akukho mfuneko yokuthenga idropha eyahlukileyo.

Malunga namathontsi amabini ane-1 mg ye-methylene blue, kwaye amathontsi alishumi anamalunga ne-5 mg. Ubungakanani bethontsi bunokwahluka ngokwendlela idropha ebanjwa nesetyenziswa ngayo.

I-methylene blue ifunxa ukukhanya ngamandla. Oku kunokwenza isisombululo esiluhlaza ngokunzulu sibonakale siphantse sibe mnyama ngaphakathi ebhotileni.

Isatifikethi sohlalutyo, okanye i-COA, luxwebhu lwelabhoratri lwebhetshi ethile. Sichaza isithako esivavanyiweyo, inombolo yebhetshi, imigaqo yomgangatho, iziphumo zovavanyo nokuba ibhetshi ihlangabezene kusini na neemfuno ezichaziweyo.

Vula iphepha loVavanyo loMgangatho uze ulandele imiyalelo yeerekhodi zebhetshi. Thelekisa inombolo yebhetshi ekwibhotile yakho nebhetshi yesithako edwelisiweyo kunye nesatifikethi sayo sohlalutyo. Qhagamshelana nathi ukuba awuyifumani irekhodi.

Ewe. Iphepha loVavanyo loMgangatho lichaza iimvavanyo ezenziweyo, imigaqo esebenzayo noko kuboniswa ziziphumo.

Ewe. Ibhetshi nganye ivavanywa ngokwemigaqo echaziweyo yesithako neyemveliso egqityiweyo ngaphambi kokukhutshwa.

Uvavanyo lwenziwa liqabane lethu lelabhoratri eLithuania kusetyenziswa iindlela nemida yokwamkelwa echaziweyo.

Ukuhlolwa kwezinyithi ezinzima kulinganisa ezinye izinto ezingcolisayo eziziziqalelo kodwa akuniki nkcazelo ngovavanyo lomxholo, i-Azure B, okunye ukungcola kwezinto eziphilayo, izinyibilikisi ezishiyekileyo, amanqanaba eentsholongwane okanye ii-endotoxin zebhaktiriya. Uvavanyo olupheleleyo luvavanya isithako ngokweemfuno ezibanzi zesazisi, umxholo we-methylene blue, ubunyulu nomgangatho weentsholongwane.

I-Azure B kukungcola kwezinto eziphilayo okuchaziweyo nemveliso engafunekiyo evela ekwenziweni kwe-methylene blue. IMonografi ye-USP–NF ibeka owona mda uphezulu uthile. Uvavanyo lwezinyithi ezinzima alukwazi ukufumanisa i-Azure B. Ukulinganisa i-Azure B kunika inkcazelo ngokuhlanjululwa engafumanekiyo kuvavanyo lwezinyithi ezinzima.

Ukungcola kwezinto eziphilayo zizinto ezinxulumene ngokwekhemikhali ezinokuvela xa kusenziwa isithako okanye xa sibola. Uvavanyo luquka ukungcola okuchaziweyo njenge-Azure B, ukungcola ngakunye okungachazwanga nesixa sisonke sokunye ukungcola.

Izinyibilikisi ezishiyekileyo ziikhemikhali eziguqukayo ezinokusala emva kokwenziwa kwesithako. Uvavanyo lumisela ukuba izinyibilikisi ezichaziweyo zikhona kusini na nokuba amanqanaba azo ahlala ngaphakathi kwemida echaziweyo.

Uvavanyo lwentsalela emva kokutshiswa, olukwabizwa ngokuba luvavanyo lothuthu oluneesulfate, lulinganisa izinto ezingaphiliyo nezingaguqukiyo ezisala emva kokutshiswa kwesampuli phantsi kweemeko ezilawulwayo. Lwahlukile kuvavanyo lwezinyibilikisi ezishiyekileyo.

Uvavanyo lweBlupreme lokungcola kweziqalelo luquka ilothe, i-arsenic, i-cadmium nemekyuri. Ezi ziphumo ziyinxalenye enye yovavanyo lomgangatho lulonke.

Uvavanyo lweentsholongwane lulinganisa amanani ewonke eentsholongwane ezisebenzisa ioksijini, i-yeast nokungunda. Lukwajonga iintsholongwane ezithile njenge-E. coli.

Ii-endotoxin zebhaktiriya zizinto ezinxulumene neenwebu zangaphandle zeebhaktiriya ezithile. Uvavanyo lwee-endotoxin lufumanisa ungcoliseko olusenokungafunyanwa luvavanyo oluqhelekileyo lokubala iintsholongwane.

Uvavanyo lomxholo lulinganisa ubungakanani be-methylene blue ekwisithako esivavanyiweyo luze luthelekise isiphumo noluhlu lokwamkelwa olusebenzayo lwe-USP–NF.

Eli gama ngamanye amaxesha lisetyenziswa ngaphandle kobungqina bovavanyo olupheleleyo lwe-USP–NF. Ibango elifanelekileyo kufuneka lixhaswe ziziphumo ezibonisa ukuthotyelwa kwazo zonke iimfuno ezifanelekileyo zemonografi neziqhelekileyo, hayi udidi olunye olukhethiweyo lwezinto ezingcolisayo kuphela.

INdlela Elungileyo Yokwenza yinkqubo elawulwayo yemveliso equka abasebenzi, amaziko, izixhobo, izithako, iirekhodi, ucoceko, ulawulo lomgangatho, ukuphambuka nokukhutshwa kwebhetshi. Ukwenziwa ngokwemigangatho ye-GMP akuthathi indawo yovavanyo lwemveliso. Zombini ziyafuneka.

Isisombululo se-methylene blue seBlupreme sinamanzi ahlambulukileyo alungiselelwe ukwenziwa kwemveliso okulawulwayo navavanywe ngokwemida yeekhemikhali neyeentsholongwane echaziweyo. Umxube awunatywala, izinongo, izimuncumuncu, izongezelelo okanye izigcini.

Okwangoku asinaso isiqinisekiso seqela lesithathu sokuba iBlupreme ayiyo-GMO.

Hayi. Gcina ibhotile ime nkqo, ikhuselekile ekukhanyeni kwaye ingaphantsi kwe-25 °C. Musa ukuyibeka elangeni ngqo okanye kufutshane nomthombo wobushushu.

Gcina ibhotile ivalwe nkqi uze uyisebenzise ngaphambi komhla wokuphelelwa ochwethezwe ekupakishweni. Okwangoku asichazi xesha limiselweyo elahlukileyo lokusebenzisa isisombululo emva kokuvula ibhotile. Silahle ukuba itywina lokuqala lonakele okanye isisombululo sitshintsha inkangeleko ngendlela engalindelekanga.

Ubushushu obude, ukukhanya okuthe ngqo okanye ukukhenkceza kunokuchaphazela ibhotile okanye umgangatho wemveliso. Gcina iBlupreme ingaphantsi kwe-25 °C kwaye musa ukuyikhenkcezisa.

Musa ukuvumela idropha ichukumise izandla, umlomo, imiphezulu yokusebenza okanye ezinye izinto. Yibuyisele ebhotileni ngokukhawuleza emva kokuyisebenzisa uze uyivale nkqi ibhotile.

Funxa ulwelo oluchithekileyo ngoko nangoko ngesixhobo esilahlwayo, hlamba umphezulu ochaphazelekileyo ngamanzi abandayo uze uwucoce ngesicoci esifanelekileyo. Musa ukuxuba iikhemikhali zokucoca. Vavanya nayiphi na indlela kwindawo engabonakaliyo kuba i-methylene blue inokushiya ibala elingasuswayo.

Ewe. I-methylene blue yidayi enamandla kwaye inokushiya amabala eluswini, empahleni, kumphezulu wokusebenza, kwigrout nakwezinye izinto ezinemingxuma. Yiphathe ngononophelo ibhotile uze ukhusele imiphezulu ejikelezileyo.

Ibhotile eyi-100 mL ihlangabezana nomda oqhelekileyo we-EU wesikhongozeli esinye solwelo kumthwalo wesandla. Yigcine ivalwe nkqi ekupakishweni kwayo kwasekuqaleni uze uqinisekise iimfuno zangoku zesikhululo seenqwelo-moya nezomthuthi-moya ngaphambi kokuhamba.

I-methylene blue sisithinteli esinamandla nesibuyisekayo se-monoamine oxidase. Ukuyidibanisa namayeza anyusa i-serotonin kunokubangela i-serotonin syndrome.

Kubantu abanokusilela kwe-glucose-6-phosphate dehydrogenase (G6PD), i-methylene blue inokubangela ukutshatyalaliswa kweeseli ezibomvu zegazi, okubizwa ngokuba yi-haemolysis. I-methylene blue yamayeza evunyiweyo ayifanele isetyenziswe ngabantu abanokusilela kwe-G6PD.

Ngezixa ezikhulu, qhagamshelana nathi kule dilesi: support@blupreme.com, uze uchaze isixa esifunekayo, ilizwe ekuthunyelwa kulo neemfuno zokuhanjiswa.

Ungabonisa amaxabiso uze uhlawule nge-EUR, USD, GBP, CAD, AUD, CHF, JPY, PLN, SEK, NOK, DKK okanye NZD. Imali ekhethiweyo netotali yokugqibela ziboniswa ngaphambi kokuhlawula.

Iindleko zokuthumela zibalwa kwiphepha lokuhlawula ngokwendawo ekuthunyelwa kuyo nenkonzo yokuhanjiswa efumanekayo.

Iindlela zokuhlawula ezifumanekayo ziboniswa kwiphepha lokuhlawula. Kuboniswa kuphela iindlela ezifumanekayo zaloo odolo, ilizwe nemali.

Hlola iinkcukacha zekhadi nedilesi yokuhlawulisa, emva koko ubuze ibhanki yakho ukuba iyivalile na intengiselwano. Ukuba ibhanki iqinisekisa ukuba akukho sithintelo, qhagamshelana nathi kule dilesi: support@blupreme.com.

Faka imveliso kwinqwelo yakho, dlulela kwiphepha lokuhlawula, faka inkcazelo yokuhanjiswa, khetha indlela yokuhlawula ngekhadi efumanekayo uze ugqibe iodolo emva kokuhlola itotali neenkcukacha zokuhanjiswa.

Ewe. Amazwe esithumela kuwo ngoku adweliswe kwiphepha lokuhlawula. Ukufumaneka kuxhomekeke kwinkonzo yangoku yomthwali nakwizithintelo zendawo.

Iiodolo ezihamba phakathi kwamazwe angamalungu e-EU azihlawuliswa rhafu yesithethe yokungenisa impahla. Imithetho eyahlukileyo inokusebenza kwimimandla engaphandle kwendawo yesithethe ye-EU.

Inkcazelo yokulandelela ithunyelwa nge-imeyile emva kokuthunyelwa kwephakheji. Sebenzisa ikhonkco elikuloo imeyile ukulandela ukuthunyelwa.

Ukuhanjiswa ngaphakathi kwe-EU kudla ngokuthatha iintsuku ezi-3 ukuya kwezi-4. Ukuhanjiswa ngaphandle kwe-EU kuthatha malunga neentsuku ezili-10. Olu luqikelelo, alusosiqinisekiso.

Ewe. Sithengisela abathengi ngabanye namashishini.