Ese isuzuma rya aside ngenga rishobora kwerekana ko ukeneye methylene blue?

Isuzuma rya aside ngenga ntirishobora, ryonyine, kwemeza ko ukeneye methylene blue. Aside ngenga zo mu nkari ni ibikomoka ku ihinduramatwara bishobora gupimwa kandi bifite akamaro kemewe mu iperereza ku ndwara z'ihinduramatwara. Ariko gupima ikinyabutabire neza, kumenya impamvu y'igisubizo kidasanzwe, no guteganya inyungu y'umuti ni imirimo itatu itandukanye.

Inyandiko zasuzumwe mu gutegura iyi nyobora ntizagaragaje imiterere yemejwe y'aside ngenga zo mu nkari ikoreshwa mu guhitamo abantu bahabwa ubuvuzi bwa methylene blue. Raporo ishobora rero kugaragaza ikintu kidasanzwe koko, ariko icyifuzo cy'ubuvuzi kiyiherekeza kigakomeza kuba kidafite ibimenyetso bigishyigikira.

Icyo isuzuma rya aside ngenga ripima

Aside ngenga zirimo ibinyabutabire byo hagati mu nzira z'ihinduramatwara n'ibikomoka ku isenyuka ry'ibinyabutabire muri izo nzira. Isuzuma ry'inkari rireba ibyageze mu cyitegererezo cyafashwe. Ntiripima mu buryo butaziguye ikorwa rya ATP mu mikaya yawe cyangwa itwarwa rya elegitoroni mu bwonko bwawe.

Isuzuma rya aside ngenga rya Mayo Clinic Laboratories rikoresha kromatografiya ya gazi hamwe na sipetrometiriya y'uburemere, rigatanga isesengura ry'imiterere y'ibipimo bidasanzwe bya aside ngenga mu iperereza ku nenge z'ihinduramatwara umuntu avukana. Mayo ivuga ko gusobanura ibisubizo biterwa n'ibintu nk'uburwayi butunguranye, inyunganiramirire, ndetse no kuba umubiri uri kubaka inyama zawo cyangwa gusenya ububiko bw'ingufu.

Ikoreshwa ry'iryo suzuma mu buvuzi ntiryemeza buri gisobanuro gitangwa na buri tsinda ry'ibizamini rigurishwa. Isuzuma ryamamazwa nka “OAT” rishobora gutanga ibipimo by'ibinyabutabire bitandukanye, gukoresha intera z'ibipimo fatizo zitandukanye, cyangwa kongeraho ibivugwa ku ntungamubiri, utunyabuzima dutoya, cyangwa ibinyabutabire bitwara ubutumwa hagati y'uturemangingo tw'imyakura. Uburyo nyabwo bwo gupima n'icyo isuzuma rigenewe birushaho kugira akamaro kurusha impine y'izina ryaryo.

Ikimenyetso cy'igisubizo kidasanzwe ni igereranya, si icyemezo cy'indwara

Tangirira kuri raporo yuzuye: izina ry'ikinyabutabire gipimwa, icyitegererezo, ibipimo byakoreshejwe, intera y'ibipimo fatizo, uko icyitegererezo cyafashwe, n'igisobanuro cya laboratwari. Ingano y'ikinyabutabire mu rugero runaka rw'inkari n'agaciro kagaragazwa ugereranyije na kireyatinine yo mu nkari ni ibipimo bitandukanye. Ibisubizo byo muri raporo zitandukanye ntibigomba kugereranywa utabanje kureba ishingiro ryakoreshejwe mu kubitanga.

Intera y'ibipimo fatizo isobanura ibipimo by'itsinda laboratwari ikoresha mu kugereranya, mu bihe byagenwe. Ntabwo ihita iba umupaka wo gutangiriraho ubuvuzi. Igisubizo kiri hejuru ho gato gisaba kubaza impamvu agaciro gatandukanye n'ibisanzwe; nticyerekana impamvu ubwacyo. Intera yitwa “nziza kurusha izindi” ariko ikaba nto kurusha intera ya laboratwari ikeneye ibisobanuro byayo biyishyigikira.

Igisobanuro cya FDA-NIH ku kwemeza ibipimo biyobora isuzuma gitandukanya kwemeza ubushobozi bw'isuzuma bwo gupima icyo rigenewe, no kwemeza ko igisubizo gishyigikira igisobanuro gitangwa mu buvuzi. Gupima neza muri laboratwari ntibituma ibyo byose bivugwa hashingiwe ku gisubizo biba ibyemejwe.

Urugero, igisubizo cya malate kiri hejuru gishobora gutuma inzobere mu buvuzi ireba imiterere rusange y'ibikomoka ku ihinduramatwara, ibimenyetso by'uburwayi, n'izindi mpamvu zishoboka. Guhuza malate iri ku gishushanyo cy'inzira y'ihinduramatwara n'ibivugwa ko umuntu akeneye methylene blue bisimbuka iryo perereza. Mu kugereranya, ibipimo bya mitokondiriya mu bushakashatsi bw'igerageza bisuzuma ibintu bitandukanye mu bihe bigenzurwa.

Icyo ubushakashatsi bwatanzwe kuri mitokondiriya bwabonye koko

Mu bushakashatsi bwa Bruce Barshop bwo mu 2004 bwasubiye ku makuru yari asanzwe ahari, abashakashatsi basuzumye ibizamini by'inkari 3,646, birimo ibyitegererezo 258 by'abarwayi 67 bari bazwiho indwara zibangamira ibikorwa bya okisidasiyo muri mitokondiriya, n'ibyitegererezo 176 by'abarwayi 21 bari bafite indwara zitera kwiyongera kwa aside ngenga mu maraso. Iyi ni imibare y'ibyitegererezo n'imibare y'abarwayi; ntishobora gusimburana nk'aho yose ivuga umubare umwe w'abitabiriye ubushakashatsi.

Lactate yo mu nkari n'ibinyabutabire byinshi byo hagati mu ruziga rwa Krebs ntibyashoboraga gutandukanya neza abarwayi n'abatari bafite izo ndwara. Fumarate na malate byatangaga amakuru arushijeho kuba ingirakamaro, ariko ku mipaka y'ibipimo yatoranyijwe muri ubwo bushakashatsi, byagaragazaga gusa hafi 25–30% by'abarwayi bafite indwara za mitokondiriya, hamwe na 5% by'ibisubizo byagaragazaga indwara itari ihari. Iyo mipaka y'ibipimo yakoreshejwe mu bushakashatsi si imipaka rusange yo kwemeza indwara mu matsinda y'ibizamini akoreshwa muri iki gihe.

Ubu bwari ubushakashatsi ku masano hagati y'ibipimo n'indwara mu byitegererezo byoherejwe kugira ngo bisuzumwe. Ntibwatanze methylene blue, ntibwayigereranyije n'umuti udafite ikinyabutabire kivura, kandi ntibwagerageje kumenya niba imiterere y'ibipimo byo mu nkari yashoboraga guteganya ko umuntu azamera neza. Bushyigikira iperereza ku mbibi zo gusobanura ibipimo by'ibikomoka ku ihinduramatwara, si ugukoresha igisubizo mu guhitamo gahunda y'ubuvuzi.

Lactate ikeneye amakuru ayikikije yihariye

Lactate yo mu nkari, lactate yo mu maraso, n'igipimo cya lactate ugereranyije na pyruvate mu maraso ni amakuru atandukanye. Ikimenyetso cy'uko lactate yo mu nkari idasanzwe ntigishobora gusimbura ibipimo by'amaraso yafashwe mu buryo bukwiye.

Inyandiko y'ubwumvikane bwa Mitochondrial Medicine Society isobanura ko lactate yo mu maraso ishobora kwiyongera kubera ibibazo byatewe n'uburyo amaraso yafashwe cyangwa izindi mpamvu zitari indwara zituruka muri mitokondiriya ubwayo. Igipimo cya lactate ugereranyije na pyruvate gitanga amakuru y'ingirakamaro gusa iyo lactate yazamutse. Lactate iri mu bipimo bisanzwe na yo ntishobora kwemeza neza ko indwara ya mitokondiriya idahari.

Iyo nyandiko ishyira aside ngenga zo mu nkari mu iperereza ryagutse rishobora kubamo ibizamini by'amaraso n'isesengura ry'ingirabuzimafatizo. Ibizamini byo kwemeza indwara biterwa n'indwara ikekwa n'ibyagaragaye mu isuzuma ry'umurwayi. Kongera gufata icyitegererezo giteye gushidikanya bishobora gukemura ikintu kimwe kitazwi neza; kwemeza uburyo indwara ibaho bishobora gusaba ikizamini gitandukanye rwose. Nta na kimwe muri ibyo gihita giteganya uko umuntu azitabira methylene blue.

“Ibipimo by'ibinyabutabire bitwara ubutumwa mu myakura” bisaba ikoreshwa ryagenwe mu buvuzi

Aside homovanillic, cyangwa HVA, ni ikinyabutabire gikomoka ku ihinduramatwara rya dopamine. Iyo sano y'ibinyabutabire ntituma igisubizo cya HVA yo mu nkari kiba igipimo kiziguye cya dopamine yo mu bwonko cyangwa icyemezo cyo kwandika umuti ugira ingaruka ku ihinduramatwara rya monoamine.

Ikizamini cya Mayo cya HVA yo mu nkari gifite imikoreshereze yagenwe, irimo gusuzuma ibibyimba bisohora catecholamine n'indwara zimwe na zimwe z'ihinduramatwara rya catecholamine zikomoka ku ruhererekane rw'ingirabuzimafatizo. Kigaragaza kandi ingaruka imiti ishobora kugira ku bisubizo. Ibi ni ibihe byihariye byo gusuzuma indwara, si ukwemeza igisobanuro rusange cy'uko “ibinyabutabire bitwara ubutumwa mu myakura biri hasi” ari byo bitera umunaniro cyangwa ibimenyetso bifitanye isano n'uko umuntu yiyumva.

Baza indwara icyo gipimo kiri muri raporo kigomba kugaragaza, uko icyo gisobanuro cyemejwe mu barwayi bagereranywa n'uwo bireba, n'icyakwemeza ko ari cyo. Kuvuga izina ry'inzira y'ihinduramatwara bitanga igitekerezo cyo gusuzuma. Ntibyemeza icyo agaciro kamwe kari hasi cyangwa hejuru gasobanura mu buvuzi.

Urutonde rwo kugenzura ibimenyetso bihuza isuzuma n'ubuvuzi

Koresha iyi mbonerahamwe igihe usuzuma icyifuzo cy'ubuvuzi gishingiye ku kizamini. Andika inyandiko cyangwa ubushakashatsi nyabwo bushyigikira buri gisubizo. Igisubizo kitazwi gikomeza kuba kitazwi; uru si urutonde rw'amanota rwemeza ko umuntu ashobora guhabwa ubuvuzi.

Igisobanuro cya FDA-NIH cy'igipimo ndangamubiri giteganya igisubizo ku buvuzi gisobanura impamvu kugereranya uburyo bw'ubuvuzi ari ngombwa. Ibisubizo byiza kurushaho mu bantu bavuwe bafite igipimo runaka bishobora guterwa n'uko uburwayi bwabo bwari busanzwe buteganyijwe kugenda. Kwemeza ubushobozi bwo guteganya igisubizo ku buvuzi muri rusange bisaba kugereranya ubuvuzi n'itsinda rigenzura mu matsinda atandukanye ashingiye kuri icyo gipimo. Ndetse n'igerageza ryagenze neza ryakiriye gusa abarwayi bafite icyo gipimo ntiryakwemeza, ryonyine, ko icyo gipimo gikenewe mu guhitamo abazitangira igisubizo cyiza ku buvuzi.

Icyo wakora ku cyifuzo cy'ubuvuzi

Shyira raporo yuzuye n'ubushakashatsi bwavuzwe inzobere mu buvuzi isuzuma ibimenyetso byawe. Baza igice cy'urutonde rwo kugenzura ibimenyetso bihari byuzuza koko. Koresha inyobora yo kugenzura gahunda y'ubuvuzi kuri interineti kugira ngo urebe niba inyandiko yerekeye kwemeza indwara yaragaragajwe nk'ikimenyetso gishyigikira ubuvuzi.

Ku bijyanye na ME/CFS, igisubizo cy'ingirakamaro cyagombye kwita ku burwayi n'ingaruka zabwo ku bushobozi bwo gukora, harimo kumererwa nabi nyuma yo gukoresha imbaraga. Igisubizo cy'inkari cyahindutse cyangwa kumva ufite ingufu mu gihe gito ntibisubiza icyo kibazo.

Itsinda ry'ibizamini by'inkari na ryo ntiryemeza ko imiti ishobora gukoreshwa hamwe. Amakuru yo kwandika PROVAYBLUE agaragaza imikoranire ikomeye n'imiti igira ingaruka kuri serotonine kandi abuza kuyikoresha igihe hari ibura rya G6PD. Ibi bibazo bisaba isuzuma ryihariye ry'inzobere mu buvuzi, nk'uko bisobanuwe mu bibazo byo kubaza mbere yo gutekereza gukoresha methylene blue.

Menyesha laboratwari niba hari methylene blue yigeze kwinjira mu mubiri wawe. Kubangamira ibizamini bya laboratwari byanditswe mu nyandiko biterwa n'uburyo bukoreshwa; kubangamira isuzuma ry'inkari rikoresha agapapuro gapima ntibyemeza ko buri suzuma rya sipetrometiriya y'uburemere na ryo ribangamirwa. Inzobere mu buvuzi yasabye ikizamini na laboratwari ni bo bagomba kwemeza niba igisubizo gishobora gusobanurwa n'uko gufata ikindi cyitegererezo byategurwa.