Maƙala
Shin methylene blue yana cire karafa masu nauyi ko yana aiki a matsayin detox?
Methylene blue ba tabbataccen magani ba ne na cire karafa masu nauyi daga jiki. Majiyoyin asibiti da binciken da aka duba don wannan labarin ba su gano shaidar ɗan Adam da ke nuna cewa yana ƙara fitar da gubar dalma, mercury, cadmium, ko arsenic a ma'ana tare da inganta sakamakon guba ba. Wannan iyaka ce ta shaidar da aka samu, ba hujjar cewa an kawar da yiwuwar duk wata mu'amalar sinadarai ba.
Sau da yawa ana haɗa maganganu uku daban-daban cikin kalmar “detox”: samfur yana da ƙarancin gurɓatawa, wani abu yana sauya martanin ƙwayoyin halitta ga matsin lamba, kuma wani magani yana cire wani abu mai guba daga mutum. Shaida ga ɗaya ba ta tabbatar da sauran ba.
Samfur mai tsabta sakamakon inganci ne
Gwajin karafa masu nauyi yana bincika samfurin da aka miƙa. Zai iya bayar da rahoton adadin gubar dalma, mercury, cadmium, da arsenic, tare da raka'a, hanyoyin gwaji, da iyakokin bayar da rahoto. Arsenic metalloid ne, duk da cewa ana yawan saka shi cikin gwaje-gwajen da ake kira gwajin karafa masu nauyi.
Hanyoyin nazarin abubuwa na FDA suna nuna aikin nazari: auna takamaiman abubuwa a cikin wani abu da aka ayyana ta amfani da hanyoyin da aka tabbatar. Sakamako da yake ƙasa da iyakar bayar da rahoto yana nufin dakin gwaje-gwaje bai iya bayar da rahoton adadin da ya wuce wannan iyaka a ƙarƙashin waɗannan yanayi ba. Ba yana nufin abin ba ya nan kwata-kwata a lissafi ba.
Ga methylene blue, wannan yana amsa ko samfurin da aka gwada yana ƙunshe da gurɓataccen abu da aka auna. Ba ya faɗin komai game da cire gurɓatar da ta riga ta shiga jiki. Takardar shaida da ke nuna ƙarancin gubar dalma ba za ta iya tabbatar da aikin chelation na gubar dalma ba, kamar yadda gwajin ruwa ba ya tabbatar da yadda magani yake aiki.
Jagorarmu kan karafa masu nauyi, Azure B, da sauran gurɓatattun abubuwan methylene blue yana bayyana dalilin da ya sa gwajin abubuwa shi ma yake barin wasu tambayoyin inganci ba tare da amsa ba. Tabbatar da asalin samfur, gurɓatattun abubuwan da suka shafi rini, da gurɓatattun abubuwan elemental suna buƙatar shaidar nazari daban-daban.
Mene ne cire karafa zai buƙata a zahiri?
Chelation yana nufin sinadari ya ɗaure ion na ƙarfe. A magani, tambaya mai amfani ita ce ko wannan mu'amala tana taimaka wa jiki ya fitar da ƙarfen da ake magana a kai tare da haɗarin da za a iya karɓa. Ɗaurewa a cikin bututun gwaji kaɗai ba zai iya tabbatar da cewa wani abu ya isa nama da ya dace, ya riƙe ƙarfen yayin safara, ko ya samar da fa'idar asibiti ba.
Bayanin FDA game da chelation na likitanci yana bambanta magungunan takardar sayan magani da ake kulawa da su daga kayayyakin da ba a amince da su ba da ake tallatawa don detox a gida. Ya bayyana cewa babu wani samfurin chelation da FDA ta amince da shi don amfani ba tare da takardar sayan magani ba.
Da'awar cewa methylene blue yana cire ƙarfe cikin sahihanci za ta buƙaci a fayyace ƙarfen, a gano irin fallasar, a ayyana formulation da hanyar ba da shi, a samu ƙungiyoyin kwatanci da suka dace, da kuma auna abubuwa a tsawon lokaci. Masu bincike za su buƙaci bambanta ƙarin fitarwa daga sake rarrabawa tsakanin jini da nama ko rage ci gaba da fallasa. Sakamakon lafiya da illolin da ba a so suna da muhimmanci tare da ƙimomin dakin gwaje-gwaje.
“Yana tallafawa hanyoyin detox” ba ya samar da waɗannan ma'aunai da suka ɓace. Haka kuma tsarin ɗaurewa da ake zato mai alaƙa da sulfur wanda aka hasashe daga tsarin kwayar halitta ba ya yin hakan.
Teburin da'awa-da-shaida
Yi amfani da wannan teburin don gano abin da rahoto yake auna a zahiri kafin ka amince da da'awar da ke tare da shi.
| Claim or observation | Evidence that addresses it | What it cannot establish by itself |
|---|---|---|
| “Wannan batch ɗin yana da ƙarancin gurɓatar karafa masu nauyi” | Sakamakon elemental da aka haɗa da batch, raka'a, iyakokin bayar da rahoto, asalin samfur, da ingantacciyar hanyar da aka tabbatar | Cire karafa daga mutum; rashin duk wani nau'in gurɓataccen abu |
| “Methylene blue yana rage oxidative stress” | Ma'aunai masu sarrafawa na ƙwayoyin halitta ko dabbobi kan takamaiman redox endpoints, tare da kulawar assay da ta dace | Ɗaure ƙarfe, ƙara fitar da ƙarfe, ko ingancin magani a cikin mutane |
| “Wani ƙarfe yana ɗaurewa a gwajin dakin gwaje-gwaje” | Ma'aunin ɗaurewa kai tsaye a ƙarƙashin yanayin sinadarai da aka bayyana | Dorewar ɗaurewa a cikin jiki, safara mai aminci, ko fitarwa |
| “Jiki yana fitar da ƙarin ƙarfe” | Ingantattun ma'aunai na takamaiman ƙarfe tare da lokacin tattara samfur da ya dace, masu kwatanci, da fassara | Cewa guba ta kasance, cewa jimillar nauyin da ke cutarwa a nama ya ragu, ko cewa lafiya ta inganta |
| “Methylene blue yana detoxifying karafa masu nauyi” | Shaidar maganin ɗan Adam da ke haɗa fallasa, intervention, yadda ƙarfe ke rarrabuwa, sakamako masu ma'ana, da illa | Wannan faffadan da'awa ba ta tabbata da shaidar da aka samu don wannan labarin ba |
| “Fitsari ya koma shuɗi ko kore” | Shaidar canjin launi da ya shafi rini | Ma'aunin cire gubar dalma, mercury, arsenic, ko cadmium |
Teburin kayan taimako ne wajen karanta shaida, ba tsarin gwaji ko magani ba.
Tasirin antioxidant ba ya auna fitar da ƙarfe
Methylene blue yana shiga cikin sinadaran oxidation-reduction. Saboda haka gwaji zai iya bincika yadda yake sauya martanin ƙwayar halitta ga rauni ba tare da nuna cewa yana cire abin da ya jawo raunin ba.
Misali, binciken 2009 Striatal neuroprotection with methylene blue ya binciki berayen da aka bai wa rotenone, wani toxin na mitochondrial, kai tsaye cikin wani yanki na kwakwalwa, tare da ko ba tare da methylene blue da aka ba a wurin ba. Masu bincike sun tantance girman lesion, oxidative metabolism, oxidative stress, da halayen motsi. Kariyar da aka bayar da rahoto ta shafi raunin nama na gwaji. Rotenone ba ƙarfe mai nauyi ba ne, kuma wannan ba gwajin fitar da ƙarfe a cikin mutane ba ne.
Akwai kuma tsohuwar takardar 1980 kan aikin enzyme a berayen da aka sa wa gubar dalma. Rikodinta na PubMed yana nuna wannan batu na gwaji amma bai bayar da abstract ba. Rikodin kaɗai ba zai iya tabbatar da tasirin magani, cire ƙarfe, ko shawara ga mutane ba. Taken da ke ɗauke da “lead poisoning” ba isasshiyar shaida ba ce ga da'awar detox ta intanet.
Waɗannan bambance-bambancen suna aiki a duk faɗin shaidar ɗan Adam kan fa'idodin methylene blue. Dakin karatu na bincike yana tsara bincike bisa ainihin al'ummar da aka yi nazari a kansu da endpoints ɗinsu.
Gajerun hanyoyi biyu masu iya ruɗarwa
Na farko, maganin methemoglobinemia ba chelation na ƙarfe ba ne. Bayanan rubuta magani na PROVAYBLUE na intravenous suna bayyana rawar methylene blue wajen canza ƙarfen hemoglobin daga yanayin ferric zuwa ferrous. Karfen yana sauya oxidation state yayin da yake ci gaba da zama wani ɓangare na hemoglobin. Wannan ba ya nuna cire ƙarfe ko wasu karafa daga jiki.
Na biyu, nazarin “cirewa” na muhalli na iya juya rawar da masu karatu suke zato. Takarda mai taken Removal of mercury and methylene blue from aqueous solution tana binciken functionalized graphene-oxide adsorbent. Mercury da methylene blue su ne abubuwan da ake cirewa daga ruwa. Methylene blue ba shi ne maganin da ke cire mercury daga mara lafiya ba.
Idan kana zargin ainihin fallasa
Ka fara da abin da aka fallasa gare shi, tushen sa, lokacin faruwar sa, da hanyar fallasar. Ka kai kwandon samfur, bayanan wurin aiki, ko rahoton dakin gwaje-gwaje da ya dace ga likita ko sabis na guba. Zaɓi da fassarar gwaji sun dogara da ƙarfen da ake zargi da yanayin fallasar.
Kada ka sha chelator don samar da gwajin fitsari mai positive. Matsayin American College of Medical Toxicology kan provoked urine testing ya bayyana cewa chelators na iya ƙara fitar da ƙarfe a cikin mutanen da ke da guba da waɗanda ba su da ita. Kwatanta waɗannan sakamakon da reference ranges na yau da kullum waɗanda ba a provoke ba na iya haifar da kuskuren ganewar asali da maganin da ba dole ba.
Methylene blue kuma yana da nasa illolin gefe da contraindications, ciki har da muhimman mu'amalar magunguna da haɗari ga masu G6PD deficiency. Jin rashin lafiya bayan shan sa ba shaida ba ce cewa ana motsa karafa daga wurarensu.
Idan ana zargin guba mai tsanani ta gaggawa, tuntuɓi sabis na guba cikin hanzari. Jagorar gaggawa ta Poison Control tana umartar a nemi taimakon gaggawa nan take idan mutum ya fadi, ya samu seizures, yana wahalar numfashi, ko ba za a iya tashe shi ba. A Amurka, Poison Control shi ne 1-800-222-1222 kuma lambar gaggawa ita ce 911; a wasu wurare, yi amfani da sabis na gida. Kada a jinkirta tantancewa domin gwada tsarin detox na methylene blue.