Methylene blue yeADHD: chii chakanyatsoongororwa?

Hazvisati zvasimbiswa kuti methylene blue mushonga unoshanda pakurapa ADHD. Kutsvaga kwakaitwa pakuongorora uku hakuna kuwana muyedzo waiongorora kana ichivandudza zviratidzo zveADHD muvanhu vakapinzwa muchidzidzo mushure mekuonekwa vaine chirwere ichi. Miedzo muvanhu inowanzotaurwa nezvayo ine chekuita nekurangarira, mabasa ekutarisisa emurabhoritari, kana kutorwa kwemifananidzo yeuropi mumamwe mapoka evanhu. Zvakawanikwa izvi hazvigoni kusimbisa kuti methylene blue inobatsira munhu kudzora kuita zvinhu asina kufunga, kuramba achishanda, kana kuita mabasa ake zviri nani aine ADHD.

Musiyano iwoyo unokoshawo pakuchengeteka. Mishonga yakati wandei yeADHD hairambidzwi kushandiswa pamwe chete nemishonga inodzivisa monoamine oxidase pasina chikonzero; boka iri remishonga rine chekuita nenjodzi yekudyidzana kwemishonga yemethylene blue. Batsiro isina chokwadi haiiti kuti kusanganisa mishonga kuchiri kuedzwa kusava nenjodzi.

Bvunzo yekutarisisa haisi muyedzo wekurapa ADHD

ADHD inosanganisira zviratidzo zvinoramba zviripo uye kuvhiringidzika kwekuita mabasa munzvimbo dzakasiyana. Tsananguro yeCDC yekuongorora ADHD inotsanangura kuongororwa nachiremba kunotarisa nhoroondo, maitiro munzvimbo dzakasiyana, uye zvimwe zvinogona kutsanangura zviratidzo. Kunonoka kupindura pabasa repakombiyuta hakugoni kusimbisa kuti munhu ane ADHD. Kupindura nokukurumidza mushure mechinhu chaedzwa hakugoniwo, pachako, kusimbisa kuti kurapa kwabudirira.

Muyedzo weADHD waizofanira kupinza vanhu vakanyatsoongororwa vakawanikwa vaine ADHD uye kuyera migumisiro ine chekuita nayo. Izvi zvingasanganisira zviyero zvezviratidzo zvakatosimbiswa kuti zvakavimbika, uye kugona kuita mabasa kuchikoro, kubasa, kana kumba. Waizofanirawo kusiyanisa migumisiro yechinhu chiri kuedzwa neyekuchinja kwekurara, mishonga iri kutoshandiswa, zvinotarisirwa nevatori vechikamu, uye kudzokorora mabasa kuti vajaire.

Funga nezvemibvunzo miviri: munhu anogona kuziva mufananidzo waachangoratidzwa nomazvo zvikuru here, uye munhu iyeye anogona kugara achironga nokupedza mabasa ezuva nezuva here? Zvose zvine chekuita nokushanda kwepfungwa. Asi hazvisi migumisiro inogona kutsivaniswa. Pfupiso yedu yehumbowo hwemethylene blue muvanhu inoshandisa musiyano iwoyo pakutarisa mabatsiro anofungidzirwa.

Zvakanyatsowanika muyedzo wevanhu vakuru vane utano

Chidzidzo cha2016 chaRodriguez nevamwe chekutora mifananidzo yeuropi, chakagovera vatori vechikamu mumapoka zvisina kurongwa, chakaongorora vanhu vakuru 26 vane utano, vane makore 22 kusvika 62. Chakaenzanisa kupiwa methylene blue yemhando yeUSP nemuromo kamwe chete nekupiwa placebo ine ruvara rwebhuruu. Bvunzo dzakaitwa vasati vapiwa uye anenge awa imwe chete mushure mekupiwa dzaisanganisira basa rekuchengetedza kutarisisa, basa rekurangarira kwenguva pfupi, uye MRI inoratidza kushanda kweuropi. Vanhu vaiva nezvirwere zvepfungwa kana vakanga vachangobva kushandisa mishonga yezvirwere zvepfungwa havana kubvumirwa kupinda muchidzidzo.

Shanduko dzakaonekwa mumifananidzo yekushanda kweuropi munzvimbo dzakati wandei. Zvakabuda pamaitiro zvinoda kunyatsotariswa: kuenzaniswa kwenguva yekupindura pabasa rekutarisisa pakati pemapoka nekufamba kwenguva hakuna kuratidza musiyano une kukosha kwechiverengero, paine P = .43. Pepa rechidzidzo rakashuma kuvandudzika kunenge 7% kwemhinduro dzakarurama pabasa rekurangarira muboka remethylene blue, asi kuenzaniswa kweshanduko iyi pakati pemapoka hakuna kuratidzawo musiyano une kukosha kwechiverengero, paine P = .09.

Musiyano une kukosha kwechiverengero pakati pezvakaitika kurapa kusati kwaitwa uye mushure mekuitwa muboka rimwe hausimbisi kuti kurapa kwacho kuri nani pane kweboka rimwe nenzira ine kukosha kwechiverengero. Zvakawanikwa izvi zvinotsigira kumwe kuongorora, asi hazviratidzi batsiro paADHD. Muyedzo uyu haugoniwo kupindura mibvunzo pamusoro pekushandisa kakawanda, vana, kana kusanganisa nemishonga yeADHD.

Rondedzero yezvidzidzo inotsvakika, kusanganisira humbowo husipo

Vhura rondedzero yezvidzidzo inotsvakika kuti usefe zvinyorwa maererano neboka revanhu, mugumisiro, munyori, kana humbowo husipo. Inosanganisira zvinongedzo kune kwakabva mashoko uye inosiyanisa miedzo inokodzera kupa ruzivo rwekumashure nechinyorwa chakawanikwa pakutsvaga chisina chekuita nenyaya.

Muyedzo waTelch wakagovera vanhu vakuru 42 vaitya zvikuru nzvimbo dzakavharika mumapoka zvisina kurongwa kuti vapiwe methylene blue kana placebo mushure mekudzidziswa nekusangana nezvinotyisa. Kuongororwa kwekurangarira uye kuongororwa kwekutya mushure memwedzi mumwe chete zvaiva zvine chekuita nekudzidza uye kuramba kwekutya. Zvakabuda pakutya zvaienderana nokuti chikamu chekudzidziswa nekusangana nezvinotyisa chakanga chapera zvakanaka zvakadii. Uyu wakanga usiri muyedzo wezviratidzo zveADHD, uye hausimbisi batsiro yekutarisisa inoshanda mumamiriro ose.

Chimwe chinyorwa chakawanikwa pakutsvaga chinoratidza kuti kuverenga mapepa chete hakuna kukwana. Munyaya yemurwere ane methemoglobinemia yakanyorwa pasi pePMID 27099330, ADHD yakataurwa munhoroondo yemurwere yezveutano. Methylene blue haina kushandiswa nekuti kushomeka kweG6PD kwaifungidzirwa, uye kwakazosimbiswa. Injini yekutsvaga inogona kuwana mazwi ose ari maviri kunyange pepa risina muyedzo wekurapa unoabatanidza.

Rondedzero iyi inonyora kutsvaga kwakanangana nenyaya iyi kwakaitwa musi wa12 Gunyana, 2026, pachishandiswa “methylene blue” kana “methylthioninium” pamwe chete ne“ADHD” kana “attention deficit hyperactivity disorder.” PubMed yakaburitsa nyaya yemurwere iyoyo; ClinicalTrials.gov haina kuburitsa zvinyorwa zvinoenderana nekutsvaga. Kutsvaga kwakafara kwakapa zvidzidzo zvekushanda kwepfungwa zvinopa ruzivo rwekumashure. Uku kuongororwa kwehumbowo kwepanguva yakatarwa, kwete uchapupu hwekuti chidzidzo chose chisina kuburitswa kana chakanyorwa pasi pemamwe mazwi chakawanikwa. Raibhurari yetsvakurudzo inopa mamwe mashoko ezvidzidzo zvine chekuita nenyaya iyi.

Kudyidzana kwemishonga kunochinja mubvunzo wekushandisa

Methylene blue inogona kudzivisa monoamine oxidase. Mashoko ekushandiswa kwejekiseni rayo rinopiwa nechinyorwa chachiremba anoyambira nezveserotonin syndrome kana ichishandiswa pamwe nemishonga inokanganisa serotonin uye maopioid. Kumunhu ane ADHD, rondedzero yose yemishonga inokosha, kusanganisira mishonga yekuora mwoyo kana kuzvidya mwoyo kunoitika pamwe neADHD.

1. Mishonga ine amphetamine: mashoko ari paAdderall XR anorambidza kushandiswa pamwe nemishonga inodzivisa MAO uye anonyatsodoma methylene blue inopiwa mutsinga. Kukwira kwakanyanya kweBP kunotaurwa senjodzi.
2. Methylphenidate: mashoko ari paRitalin anorambidzawo kurapwa pamwe chete nemishonga inodzivisa MAO nekuda kwenjodzi yekukwira kwakanyanya kweBP.
3. Atomoxetine: mashoko ari paStrattera anodoma methylene blue inopiwa mutsinga pamushonga unorambidzwa pamwe nemishonga inodzivisa MAO uye anotsanangura zvinogona kuitika zvakakomba.

Mashoko aya haasi miedzo yemhando dzose dzemishonga inonwiwa inotengeswa kuvatengi. Haasimbisiwo kuti kusanganisa mishonga inonwiwa kwakachengeteka. Yambiro yeTGA yeAustralia pamusoro pemishonga yemethylene blue inonwiwa isina kunyoreswa inonyatsotaura nezvekudyidzana kwemishonga kune njodzi. Usati wafunga kuishandisa, ratidza chigadzirwa chaicho, uwandu hwemethylene blue huri machiri, uye rondedzero yakazara yemishonga kuna chiremba anonyora mishonga kana mufamasisti. Usarega kurapwa kweADHD kwawakanyorerwa kuti uzviedzere methylene blue wega.

Kana mushure mekushandisa methylene blue ukava nefivha, kusagadzikana kwakanyanya kana kuvhiringidzika kwepfungwa, kuomarara kwemhasuru, kana kuita kwemuviri kuri kukurumidza kuipa, tsvaga rubatsiro rwekurapa rwechimbichimbi. Pfupiso yekuchengeteka inotsanangura mamwe mamiriro anorambidza kushandiswa kwayo uye mashoko pamusoro pekushandiswa ayo zvakakosha kunyora.

Humbowo hupi hungachinja mhinduro?

Chidzidzo chinotevera chinobatsira chaizoedza mushonga une magadzirirwo akatsanangurwa muvanhu vakaonekwa vaine ADHD, choshandisa chimwe chinhu chekuenzanisa nacho, chofanotsanangura migumisiro yezviratidzo zveADHD nekugona kuita mabasa ichayerwa, uye chotevera zvinokanganisa utano kwenguva yakakwana. Mibvunzo pamusoro pevanhu vakuru nevana yaizoda humbowo hwakasiyana. Tsananguro yekuti mitochondria inoshanda sei haigoni kuzadza kushomeka kwehumbowo uku.

Kurapa kwakatosimbiswa kwatova nenzira dzakarongwa dzekuongorora nekutevera mamiriro emurwere, dzakadai sedziri mumazano eNICE eADHD. Kusadzorwa kwezviratidzo zvinogutsa chikonzero chekuongororazve kurapa ikoko pamwe nachiremba ari kukurapa. Zvidzidzo zvaongororwa pano hazvitsigiri kutsiva kurapa ikoko nemethylene blue. Zvinotaurwa pamusoro pemamwe mamiriro ane chekuita nekukura zvinoda kuongororwa kwemapoka evanhu uye zvinhu zvakaedzwa zvakanangana nawo, sezvinotsanangurwa muongororo yedu yetsvakurudzo yemethylene blue neautism.