Chinyorwa
Bvunzo yemaasidhi eoganik ingaratidza here kana uchida methylene blue?
Bvunzo yemaasidhi eoganik haigoni, iri yoga, kuratidza kuti unoda methylene blue. Maasidhi eoganik ari muweti mametabolite anogona kuyerwa uye anoshandiswa zvakakodzera pakuongorora zvirwere zvekushandurwa kwezvinhu mumuviri. Asi kuyera chinhu nemazvo, kuziva chinokonzera mugumisiro usiri wenguva dzose, uye kufanotaura kubatsirwa nemushonga mabasa matatu akasiyana.
Zvinyorwa zvakaongororwa pakugadzira gwaro iri hazvina kuratidza maitiro akasimbiswa emaasidhi eoganik ari muweti anogona kushandiswa kusarudza vanhu vokurapwa nemethylene blue. Saka mushumo unogona kuratidza kusiyana chaiko nezvinotarisirwa, asi kurapwa kunokurudzirwa zvichibva pauri kuchiri kusina humbowo hunokutsigira.
Zvinoyerwa nebvunzo yemaasidhi eoganik
Maasidhi eoganik anosanganisira zvinhu zvepakati pamwe nezvinobva pakuputswa kwezvinhu munzira dzekushandurwa kwezvinhu mumuviri. Bvunzo yeweti inoongorora zvinosvika mumuenzaniso wakaunganidzwa. Haiyeri zvakananga kugadzirwa kweATP mukati metsandanyama dzako kana kufambiswa kwemaerekitironi mukati meuropi hwako.
Bvunzo yemaasidhi eoganik yeMayo Clinic Laboratories inoshandisa gas chromatography pamwe nemass spectrometry, ichipa dudziro yemhando yekusiyana kwemazinga emaasidhi eoganik nezvinotarisirwa pakuferefeta kukanganisika kwekushandurwa kwezvinhu mumuviri kunoberekwa nakwo. Mayo inotaura kuti dudziro inoenderana nemamiriro akadai sekurwara kunongoerekana kwatanga, zvinowedzera pakudya, uye kuti muviri uri kuvaka matishu here kana kuputsa dura resimba.
Kushandiswa uku mukurapa hakusimbisi dudziro dzose dzinopiwa neboka rose rebvunzo rinotengeswa. Bvunzo inotengeswa ichinzi “OAT” inogona kuzivisa zvinhu zvakasiyana, kushandisa miganhu yakasiyana yezvinotarisirwa, kana kuwedzera zvirevo pamusoro pezvinovaka muviri, tupukanana, kana zvinhu zvinotakura mashoko pakati pemasero etsinga. Nzira chaiyo inoshandiswa uye chinangwa chebvunzo zvinokosha kupfuura chidimbu chezita rayo.
Mucherechedzo unoratidza kuenzanisa, kwete kuzivikanwa kwechirwere
Tanga nemushumo wakazara: zita rechinhu chiri kuyerwa, muenzaniso wakashandiswa, mayuniti, miganhu yezvinotarisirwa, mamiriro ekuunganidzwa, uye dudziro yerabhoritari. Kuwanda kwechinhu muuwandu hwakati hwemvura uye nhamba inoratidzwa ichienzaniswa necreatinine iri muweti zviyero zvakasiyana. Migumisiro haifaniri kuenzaniswa kubva mumishumo yakasiyana pasina kutanga waongorora hwaro hwekuziviswa kwayo.
Miganhu yezvinotarisirwa inotsanangura boka revanhu rinoshandiswa nerabhoritari pakuenzanisa mumamiriro akatarwa. Haingovi yega muganhu unoshandiswa kutanga kurapwa. Mugumisiro wakakwira zvishoma unoita kuti pabvunzwe chikonzero chekuti nhamba iyi yakasiyana; hauzivisi chikonzero uri woga. Muganhu unonzi “wakanakisisa” wakatetepa kupfuura werabhoritari unoda tsananguro yawo inoutsigira.
Tsananguro yeFDA-NIH yekusimbiswa kwezviratidzo zvebiolojiki inosiyanisa kusimbiswa kwekuyera, kunoratidza kana bvunzo ichiyera chinhu chayakanangana nacho, nekusimbiswa mukurapa, kunoratidza kana mugumisiro uchitsigira dudziro yezvekurapa iri kutaurwa. Kuyera kwakanaka murabhoritari hakuiti kuti zvirevo zvose zvinozoitwa zvichibva pazviri zvive zvakarurama.
Somuenzaniso, mugumisiro wemalate wakakwira ungaita kuti nyanzvi yezvekurapa iongorore maitiro emametabolite ose pamwe chete, zviratidzo zvemunhu, uye dzimwe tsananguro dzinobvira. Kudhirowa mutsetse unobva pamalate iri pamufananidzo wenzira yekushandurwa kwezvinhu uchinanga pakuti munhu anonzi anoda methylene blue kunodarika kuongorora uku. Pakuenzanisa, zviyero zvemitochondria muzviedzo zvinoongorora zvinhu zvakasiyana mumamiriro anodzorwa.
Zvakawanikwa chaizvo netsvakurudzo yemitochondria yakapihwa
Mutsvakurudzo yaBruce Barshop ya2004 yakatarisa zvakanga zvaitika kare, vatsvakurudzi vakaongorora ongororo dzeweti 3,646, dzaisanganisira mienzaniso 258 kubva kuvarwere 67 vaiva nezvirwere zvaizivikanwa zvekushandiswa kweokisijeni mumitochondria, uye mienzaniso 176 kubva kuvarwere 21 vaiva neorganic acidemias. Aya manhamba emienzaniso nemanharamba evarwere, kwete hukuru hwemapoka ekutsvakurudza hunogona kutsinhaniswa.
Lactate yeweti uye zvinhu zvizhinji zvepakati mudenderedzwa reKrebs zvakanga zvisinganyatsobatsiri kusiyanisa mapoka. Fumarate nemalate zvakapa ruzivo rwakawanda, asi pamiganhu yakasarudzwa mutsvakurudzo iyi zvakangosiyanisa vanenge 25–30% vevarwere vane zvirwere zvemitochondria, paine 5% yevanhu vasina chirwere vakaratidzwa sevainacho zvisirizvo. Miganhu iyi yetsvakurudzo haisi miganhu yekuziva chirwere inoshanda pese paboka rebvunzo remazuva ano.
Iyi yaiva tsvakurudzo yehukama pakati pezviyero nekuzivikanwa kwechirwere mumienzaniso yakatumirwa kunoongororwa. Haina kupa methylene blue, kuienzanisa neplacebo, kana kuyedza kana maitiro eweti aifanotaura kuvandudzika. Inotsigira kuongororwa kwemiganhu yedudziro yemametabolite, kwete kushandisa mugumisiro kusarudza chirongwa chekurapwa.
Lactate inoda mamiriro ayo anotsanangura mugumisiro
Lactate iri muweti, lactate iri muropa, uye chiyero chelactate nepyruvate muropa zvinhu zvakasiyana zvinoonekwa. Mucherechedzo welactate muweti haugoni kutsiva zviyero zveropa rakaunganidzwa nemazvo.
Chirevo chekubvumirana cheMitochondrial Medicine Society chinotsanangura kuti lactate yeropa inogona kukwira nekuda kwekukanganisa kunokonzerwa nekuunganidzwa kweropa kana mamiriro asiri chirwere chinotangira mumitochondria. Chiyero chelactate nepyruvate chinopa ruzivo chete kana lactate yakakwira. Lactate iri pamwero wenguva dzose hainawo kuvimbika pakuratidza kuti hapana chirwere chemitochondria.
Chirevo chimwe chete ichi chinoisa maasidhi eoganik ari muweti mukati mekuongorora kwakakura kunogona kusanganisira bvunzo dzeropa uye kuongororwa kwemajini. Basa rekusimbisa rinotsamira pachirwere chiri kufungidzirwa uye pane zvakawanikwa pakuongorora murwere. Kudzokorora kuunganidza muenzaniso usingavimbiki kungabvisa kumwe kusava nechokwadi; kusimbisa mashandiro anoita chirwere kungada bvunzo yakasiyana zvachose. Hapana padanho iri panongofanotaura pega kupindura kwemunhu kumethylene blue.
“Zviratidzo zvezvinhu zvinotakura mashoko pakati pemasero etsinga” zvinoda kushandiswa kwekurapa kwakatarwa
Homovanillic acid, kana kuti HVA, imetabolite yedopamine. Hukama uhwu hwemakemikari emumuviri hahuiti kuti mugumisiro weHVA yeweti uve chiyero chakananga chedopamine yeuropi kana kurayirwa kwemushonga unokanganisa kushandurwa kwemonoamine mumuviri.
Bvunzo yeHVA yeweti yeMayo ine mashandisirwo akatarwa, anosanganisira kuongorora mapundu anobudisa catecholamine uye zvimwe zvirwere zvinogarwa nhaka zvekushandurwa kwecatecholamine mumuviri. Inozivisawo kukanganiswa kwemigumisiro nemishonga. Aya mamiriro chaiwo ekuongorora chirwere, kwete kusimbiswa kwetsananguro inoshandiswa pese yekuti “zvinhu zvinotakura mashoko pakati pemasero etsinga zvakaderera” ndizvo zvinokonzera kuneta kana zviratidzo zvine chekuita nemanzwiro.
Bvunza kuti mucherechedzo uri mumushumo unofanirwa kuziva chirwere chipi, kuti dudziro iyoyo yakasimbiswa sei muvarwere vakafanana, uye kuti chii chingaisimbisa. Nzira yekushandurwa kwezvinhu ine zita inopa fungidziro yekuongorora. Haitsananguri zvakasimbiswa zvinorehwa mukurapa nenhamba imwe chete yakaderera kana yakakwira.
Rondedzero yekuongorora humbowo hunobatanidza bvunzo nekurapwa
Shandisa tafura iyi paunenge uchiongorora kurapwa kunokurudzirwa zvichibva pabvunzo. Nyora gwaro kana tsvakurudzo chaiyo inotsigira mhinduro imwe neimwe. Mhinduro isingazivikanwi inoramba isingazivikanwi; ichi hachisi chiyero chinobvumidza munhu kurapwa.
| Chikamu chehumbowo | Mibvunzo chaiyo | Chii chingatsigira chirevo? | Chii chinoramba chisina kusimbiswa? |
|---|---|---|---|
| Kururama kwekuyera | Chinhu chipi chaicho, nzira ipi, mayuniti api, uye muenzaniso upi zvakashandiswa? Kuongororwa kwemabatirwo emuenzaniso nezvinokanganisa kuyera kwakazadziswa here? | Magwaro enzira yerabhoritari, kudzora kunaka kwebasa, uye kusachinja-chinja kwezviyero pamwero wakaziviswa | Chikonzero chemugumisiro kana kubatsira kwemushonga |
| Dudziro yezvinotarisirwa | Miganhu yacho yakakodzera zera remunhu uye hwaro hwekuziviswa kwemugumisiro here? Kusiyana kwacho kunowanikazve here kana kudzokorora kwakakodzera mukurapa? | Miganhu yerabhoritari uye dudziro yemaitiro ose pamwe chete ichifunga nezvemamiriro acho | Kuti mucherechedzo wose unomirira chirwere kana kuti unoda kugadziriswa |
| Kururama kwekuziva chirwere | Chirwere chipi chiri kufungidzirwa? Chinhu ichi chinowanikwa kangani mune mamwe mamiriro kana pasina chirwere chacho? | Tsvakurudzo muboka revarwere rakanangwa pamwe nebvunzo dzakakodzera dzekusimbisa dzemakemikari emumuviri, majini, kana dzimwe | Kuti chirwere chakazivikanwa chinofanotaura kubatsirwa nemethylene blue |
| Kururama kwekufanotaura | Vanhu vane maitiro ebvunzo aya vakabatsirwa zvikuru nemethylene blue kana ichienzaniswa nechimwe chinhu kupfuura vanhu vasina maitiro acho here? | Ongororo yechiratidzo chebiolojiki yakatarwa pachine nguva, ine kuenzanisa pakati peboka rinorapwa neboka rekudzora | Kuti hukama hunongoonekwa hunozivisa vanhu vanopindura kurapwa |
| Kubatsira mukurapa | Kurapwa kwakatungamirirwa nebvunzo kwakavandudza zviratidzo, kugona kuita mabasa, kana mumwe mugumisiro unokosha, paine kukuvadza kunogamuchirika here? | Humbowo hwemigumisiro yevarwere hunobva muzviedzo zvine mapoka ekudzora, hwechirongwa chaicho chekurapwa nekuyedzwa | Kuti kuderera kwemetabolite kwega kunoreva utano huri nani |
Tsananguro yeFDA-NIH yechiratidzo chebiolojiki chinofanotaura inotsanangura kuti nei kuenzanisa kurapwa kuchikosha. Migumisiro iri nani pakati pevanhu vanorapwa vane mucherechedzo inogona kuratidza zvaitotarisirwa pamafambiro echirwere chavo. Kusimbisa kufanotaura kunowanzoda kuenzanisa kurapwa neboka rekudzora mumapoka akasiyana emicherechedzo. Kunyange muyedzo wakabudirira wakanyoresa varwere vane mucherechedzo chete haungaratidzi, uri woga, kuti mucherechedzo wacho unodiwa kusarudza vanhu vanopindura kurapwa.
Zvekuita kana kurapwa kwakurudzirwa
Enda nemushumo wakazara uye tsvakurudzo yakataurwa kunyanzvi yezvekurapa iri kuongorora zviratidzo zvacho. Bvunza kuti humbowo hunozadzisa chikamu chipi chaizvo cherondedzero yekuongorora. Shandisa gwaro rekuongorora chirongwa chekurapwa paindaneti kutarisa kana gwaro rekuziva chirwere rakaratidzwa sehumbowo hwekurapwa.
KuME/CFS, mugumisiro unobatsira ungada kutarisa chirwere nemigumisiro yacho pakugona kuita mabasa, kusanganisira kunzwa kusagadzikana mushure mekushandisa simba. Kuchinja kwemugumisiro weweti kana kunzwa simba kwenguva pfupi hazvipinduri mubvunzo iwoyo.
Boka rebvunzo dzeweti hariratidziwo kuti mishonga inogona kushandiswa pamwe chete zvakachengeteka. Ruzivo rwekurayira PROVAYBLUE runozivisa kudyidzana kwakakomba kune chekuita neserotonin uye runorambidza kushandiswa kana paine kushomeka kweG6PD. Nyaya idzi dzinoda kuongororwa kwakasiyana nenyanzvi yezvekurapa, sezvakatsanangurwa mumibvunzo yokubvunza usati wafunga nezvemethylene blue.
Udza rabhoritari nezvekusangana kupi zvako nemethylene blue. Kukanganiswa kwebvunzo dzerabhoritari kwakanyorwa kunoenderana nenzira inoshandiswa; kukanganiswa kwebvunzo yeweti inoshandisa kamutsetse kanonyikwa muweti hakuratidzi kuti bvunzo dzose dzemass spectrometry dzinokanganiswa. Nyanzvi yezvekurapa yakakumbira bvunzo nerabhoritari vanofanira kusarudza kana mugumisiro uchigona kududzirwa uye kuti kumwe kuunganidzwa kwemienzaniso kungarongwa sei.