Inyandiko
Ese methylene blue ikuraho ibyuma biremereye cyangwa ikora nk'ikuraho uburozi?
Methylene blue ntabwo ari uburyo bwemewe kandi bwashimangiwe bwo gukuraho ibyuma biremereye mu mubiri. Inkomoko z'ubuvuzi n'ubushakashatsi zasuzumwe kuri iyi ngingo ntizagaragaje ibimenyetso byo ku bantu byerekana ko yongera ku buryo bufatika isohorwa rya lead, mercury, cadmium, cyangwa arsenic kandi igatuma ingaruka z'uburozi zirushaho kuba nziza. Ibi ni imipaka y'ibimenyetso byabonetse, si gihamya ko imikoranire yose ishoboka hagati y'ibinyabutabire yamaze guhakanywa.
Amagambo atatu atandukanye akunze guhurizwa mu ijambo “detox”: ko igicuruzwa kirimo imyanda mike, ko ikinyabutabire gihindura uburyo utugingo twitabira stress, no ko uburyo bwo kuvura bukuraho ikinyabutabire cy'uburozi mu muntu. Ibimenyetso bishyigikira kimwe muri ibyo ntibihamya ibindi.
Igicuruzwa gisukuye ni igisubizo kijyanye n'ubuziranenge
Panel y'ibyuma biremereye isuzuma sample y'igicuruzwa yoherejwe. Ishobora gutanga ingano za lead, mercury, cadmium, na arsenic, hamwe n'ibipimo, uburyo bwakoreshejwe, n'imipaka yo gutanga raporo. Arsenic ni metalloid, nubwo ikunze gushyirwa muri panel zisobanurwa nk'ibizamini by'ibyuma biremereye.
Uburyo bwa FDA bwo gusesengura elements bwerekana icyo iri sesengura risaba: gupima elements zihariye mu kintu cyasobanuwe hifashishijwe uburyo bwemejwe. Igisubizo kiri munsi y'umupaka wo gutanga raporo bivuze ko laboratoire itashoboye gutanga ingano iri hejuru y'uwo mupaka muri ibyo bihe. Ntibivuze ko iyo element idahari na mba mu mibare.
Kuri methylene blue, ibi bisubiza ikibazo cyo kumenya niba sample yapimwe izana contaminant yapimwe. Ntacyo bivuga ku gukuraho contamination isanzwe iri mu mubiri. Certificate igaragaza lead nke ntishobora kwemeza ko hari ibikorwa byo guhuza no gukuraho lead, nk'uko ikizamini cy'amazi kidashobora kugaragaza uburyo umuti ukora.
Igitabo cyacu ku byuma biremereye, Azure B, n'indi myanda ya methylene blue gisobanura impamvu panel ya elements na yo idasubiza ibindi bibazo by'ubuziranenge. Kumenya umwirondoro w'igicuruzwa, imyanda ijyanye n'irangi, na contaminants za elements bisaba ibimenyetso bitandukanye by'isesengura.
Gukuraho ibyuma mu by'ukuri byasaba iki?
Chelation ibaho igihe ikinyabutabire gifata ion y'icyuma. Mu buvuzi, ikibazo cy'ingenzi ni ukumenya niba iyo mikoranire ifasha umubiri gusohora icyuma bireba ku rwego rufite ingaruka zemewe. Kuba ikinyabutabire gifata icyuma mu kizamini cyo muri laboratoire gusa ntibihagije kwemeza ko kigera mu tissue ikwiye, ko gikomeza gufata icyo cyuma mu gihe cyo kugitwara, cyangwa ko gitanga inyungu yo kwa muganga.
Ibisobanuro bya FDA ku bijyanye na chelation yo kwa muganga bitandukanya imiti yandikwa na muganga ikoreshwa ikurikiranwa n'abaganga n'ibicuruzwa bitemewe bicuruzwa nk'ibyo gukorera detox mu rugo. Bivuga ko nta gicuruzwa cya chelation cyemewe na FDA ngo gikoreshwe umuntu atagiherewe prescription.
Ikirego cyizewe kivuga ko methylene blue ikuraho ibyuma cyasaba kuvuga icyuma runaka, exposure izwi, formulation n'inzira yo kuyitanga byasobanuwe, amatsinda yo kugereranya akwiye, n'ibipimo bifatwa uko igihe kigenda. Abashakashatsi bagomba gutandukanya kongera isohorwa ry'icyuma no kugihindurira aho kiba hagati y'amaraso na tissues cyangwa kugabanya exposure ikomeza. Ibisubizo ku buzima n'ingaruka mbi bigomba gusuzumwa hamwe n'agaciro k'ibipimo bya laboratoire.
Kuvuga ngo “ishyigikira inzira za detox” ntibitanga ibyo bipimo bibura. N'igitekerezo cy'uburyo bwo gufata ibyuma bushingiye kuri sulfur gishingiye gusa ku miterere ya molecule ntikibitanga.
Imbonerahamwe ihuza ikirego n'ibimenyetso
Koresha iyi mbonerahamwe kugira ngo umenye icyo raporo ipima mu by'ukuri mbere yo kwemera ikirego kijyana na yo.
| Ikirego cyangwa ibyo byagaragaye | Ibimenyetso bibisuzuma | Ibyo bidashobora kwemeza byonyine |
|---|---|---|
| “Iyi batch ifite contamination nke y'ibyuma biremereye” | Ibisubizo bya elements bihujwe na batch, units, reporting limits, umwirondoro wa sample, n'uburyo bukwiye kandi bwemejwe | Gukuraho ibyuma mu muntu; kutagira indi myanda iyo ari yo yose |
| “Methylene blue igabanya oxidative stress” | Ibipimo bigenzurwa ku tugingo cyangwa ku nyamaswa by'endpoints za redox zasobanuwe, hamwe n'igenzura rikwiye ry'ibizamini | Gufata ibyuma, kongera isohorwa ry'ibyuma, cyangwa imikorere y'ubuvuzi ku bantu |
| “Icyuma gifatwa mu kigeragezo cya laboratoire” | Ibipimo bitaziguye byo gufatana mu bihe by'ibinyabutabire byasobanuwe | Gufatana ku buryo burambye mu mubiri, gutwarwa neza, cyangwa gusohorwa |
| “Umubiri urimo gusohora icyuma kinshi” | Ibipimo byemejwe byihariye kuri icyo cyuma, bifite igihe gikwiye cyo gukusanya samples, comparators, n'isesengura rikwiye | Ko uburozi bwari buhari, ko umutwaro wose wangiza uri muri tissues wagabanutse, cyangwa ko ubuzima bwateye imbere |
| “Methylene blue ikora detox y'ibyuma biremereye” | Ibimenyetso byo kuvura ku bantu bihuza exposure, intervention, uko icyuma kigenda mu mubiri, ibisubizo bifatika, n'ingaruka mbi | Iki kirego kigari nticyemejwe n'ibimenyetso byabonetse kuri iyi ngingo |
| “Inkari zahindutse ubururu cyangwa icyatsi” | Ibimenyetso by'ibara rituruka ku irangi | Igipimo cyo gukuraho lead, mercury, arsenic, cyangwa cadmium |
Iyi mbonerahamwe ni ubufasha bwo gusoma ibimenyetso, si protocol y'ibizamini cyangwa iy'ubuvuzi.
Ingaruka za antioxidant ntizipima isohorwa ry'ibyuma
Methylene blue igira uruhare muri chemistry ya oxidation-reduction. Bityo, ikigeragezo gishobora gusuzuma uburyo ihindura uko akagari kitwara ku kwangirika, ariko ntikigaragaze ko ikuraho icyateye uko kwangirika.
Urugero, ubushakashatsi bwo mu 2009 Striatal neuroprotection with methylene blue bwasuzumye imbeba zahawe rotenone, toxin ya mitochondria, mu gice cy'ubwonko ku buryo butaziguye, bamwe bahabwa na methylene blue muri ako gace abandi ntibayihabwe. Abashakashatsi basuzumye ingano ya lesion, oxidative metabolism, oxidative stress, n'imyitwarire y'imigendere. Uburinzi bwatangajwe bwari bujyanye no kwangirika kwa tissue mu kigeragezo. Rotenone si icyuma kiremereye, kandi ubu ntabwo bwari ubushakashatsi ku bantu bwo gusohora ibyuma.
Hari kandi inyandiko yo mu 1980 ku mikorere ya enzymes mu mbeba zahawe uburozi bwa lead. Record yayo ya PubMed igaragaza iyo ngingo y'ikigeragezo ariko nta abstract itanga. Iyo record yonyine ntishobora kwemeza ingaruka z'ubuvuzi, gukuraho ibyuma, cyangwa recommendation ku bantu. Kuba umutwe w'inyandiko urimo “lead poisoning” ntibihagije nk'ibimenyetso byo gushyigikira ikirego cya detox cyo kuri internet.
Iri tandukaniro rinareba ibimenyetso byo ku bantu ku nyungu za methylene blue. Ububiko bw'ubushakashatsi butondeka ubushakashatsi hakurikijwe populations n'endpoints byabwo nyakuri.
Inzira ebyiri z'ubusamo ziyobya
Icya mbere, kuvura methemoglobinemia si metal chelation. Amakuru yo kwandika no gukoresha PROVAYBLUE itangwa mu mutsi asobanura uruhare rwa methylene blue mu guhindura iron iri muri hemoglobin ikava muri ferric state ikajya muri ferrous state. Iron ihindura oxidation state ariko igakomeza kuba igice cya hemoglobin. Ibi ntibigaragaza ko iron cyangwa ibindi byuma bikurwamo mu mubiri.
Icya kabiri, ubushakashatsi bwo mu bidukikije bukoresha ijambo “removal” bushobora kuba buhindura inshingano abasomyi bakeka. Inyandiko yitwa Removal of mercury and methylene blue from aqueous solution isuzuma adsorbent ya graphene oxide yahinduwe kugira ngo ikore umurimo runaka. Mercury na methylene blue ni byo bintu birimo gukurwa mu mazi. Methylene blue si uburyo bwo kuvura bukuraho mercury mu murwayi.
Niba ukeka exposure nyakuri
Tangira umenya ikinyabutabire, aho cyaturutse, igihe exposure yabereye, n'inzira cyanyuzemo. Jyana container y'igicuruzwa, amakuru yo ku kazi, cyangwa raporo ya laboratoire bireba ku muganga cyangwa ku rwego rushinzwe uburozi. Guhitamo no gusobanura ibizamini biterwa n'icyuma gikekwa n'uko exposure yabaye.
Ntufate chelator kugira ngo uteze igisubizo positive mu kizamini cy'inkari. Umwanzuro wa American College of Medical Toxicology ku bizamini by'inkari byatewe na chelator usobanura ko chelators zishobora kongera isohorwa ry'ibyuma ku bantu bafite uburozi no ku batabufite. Kugereranya ibyo bisubizo na reference ranges zisanzwe z'ibizamini bitatewe na chelator bishobora gutanga diagnosis iyobya no gutuma habaho ubuvuzi budakenewe.
Methylene blue na yo ifite ingaruka mbi n'ibihe itagomba gukoreshwamo, harimo imikoranire ikomeye n'imiti n'ingaruka ku bantu bafite G6PD deficiency. Kumva utameze neza nyuma yo kuyifata si gihamya ko ibyuma birimo gukurwa aho byari biri mu mubiri.
Ku burozi bukaze bukekwa, hamagara serivisi y'uburozi vuba. Amabwiriza yihutirwa ya Poison Control ategeka gushaka ubufasha bwihutirwa ako kanya mu gihe umuntu aguye hasi, agize seizures, agira ikibazo cyo guhumeka, cyangwa adashobora gukanguka. Muri United States, Poison Control ni 1-800-222-1222 kandi nimero y'ubutabazi ni 911; ahandi, koresha serivisi z'aho uri. Ntutinde gusuzumwa kugira ngo ubanze ugerageze regimen ya methylene blue detox.