Nkhani
Methylene blue ndi migraine: zonena za chithandizo poyerekeza ndi kupweteka kwa mutu pambuyo poigwiritsa ntchito
Methylene blue si chithandizo chovomerezeka cha migraine. Zolemba za kafukufuku wa zachipatala zimene zinapezeka pa kuwunikaku zilibe kafukufuku wokhala ndi gulu loyerekezera wosonyeza kuti imathetsa migraine ikayamba, imaipewa, kapena imachiza aura. Malipoti oti mutu unachepa ndi malipoti oti mutu unayamba pambuyo poigwiritsa ntchito angakhalepo onse popanda kutsimikizira mmene methylene blue imakhudzira migraine imene yatsimikiziridwa ndi dokotala.
Chifukwa chimodzi cha chisokonezochi n’chakuti mutu ungachepe ngati chimene chikuyambitsa mutuwo chachizidwa. Methylene blue imagwiritsidwa ntchito m’zipatala pochiza methemoglobinemia yobwera pambuyo pobadwa. Matendawa pawokha angayambitse mutu waukulu wofanana ndi migraine. Chithandizo chikapambana pa matendawa chimayankha funso losiyana ndi lakuti kodi munthu amene ali ndi migraine ayenera kumwa methylene blue.
Pezani chithandizo chadzidzidzi ngati mutu wayamba mwadzidzidzi ndipo ukupweteka kwambiri, ngati mwayamba kufooka kapena kuvutika kulankhula, ngati mwakomoka, kapena ngati mutu ukupweteka pamodzi ndi kuvutika kupuma komanso milomo yabuluu kapena ya imvi. Musaganize kuti zizindikirozi ndi kusintha kwachibadwa kwa thupi pozolowera methylene blue. Malangizo a NHS okhudza kupweteka kwa mutu amatchula kupweteka kwambiri kwadzidzidzi ndi zizindikiro zokhudza ubongo ndi mitsempha ngati zinthu zofuna chithandizo chadzidzidzi.
Zimene zonena zokhudza migraine zimasonyeza kwenikweni
Zokambirana zomwe zaperekedwa zikusonyeza zochitika zotsutsana: zokambirana zina pa intaneti zimanena za kupweteka kwa mutu pambuyo pogwiritsa ntchito methylene blue, pamene zina zili ndi zonena kuti mutu unachepa migraine itangoyamba. Izi ndi zimene owerenga anaona, osati deta ya zachipatala yotsimikizira kuti mankhwalawa amagwira ntchito. Zokambirana zachiwirizi zimafotokozanso kuti kuchuluka kwa methylene blue m’madzimadzimo sikunali kodziwika bwino, zomwe zimapangitsa kukhala kovuta kumvetsetsa kuchuluka kumene munthu analandira.
Kafukufuku wothandiza wa chithandizo uyenera kutsimikizira kuti munthu ali ndi migraine, kufotokoza mtundu wa mankhwala ndi njira yoperekera, kuyerekezera ndi gulu lina, ndi kuyeza zotsatira monga kutheratu kwa kupweteka pa nthawi yoikidwiratu kapena kusintha kwa masiku a migraine pa mwezi. Kuchepa kwa mutu wa munthu mmodzi sikungapereke kuyerekezera kumeneku komwe kulibe. Migraine imasinthasintha, anthu nthawi zambiri amamwa mankhwala ena, ndipo chithandizo chingagwiritsidwe ntchito pamene migraine yayamba kale kusintha.
Kafukufuku wa nitric oxide amapereka chifukwa cha mmene thupi limagwirira ntchito chofufuzira njira zoyambitsira mutu, koma satsimikizira kuti methylene blue ndi chithandizo. Mu kafukufuku wa migraine wa Lassen ndi anzake wa 1998, L-NMMA, mankhwala oletsa nitric oxide synthase operekedwa kudzera mumtsempha, anachepetsa mutu patatha maola awiri mwa anthu 10 mwa 15 amene analandira mankhwalawo, poyerekeza ndi 2 mwa 14 m’gulu loyerekezera. Komabe, anthu atatu okha amene analandira placebo anasankhidwa mwachisawawa mu kafukufukuyu; anthu khumi ndi mmodzi a m’gulu loyerekezera anatengedwa ku kafukufuku wakale. Chofunika kwambiri n’chakuti L-NMMA ndi mankhwala ena osiyana. Zotsatira zake sizingagwiritsidwe ntchito potsimikizira methylene blue kapena zinthu zogulitsidwa zoti munthu amwe.
Kusiyana komweku kumagwiranso ntchito pa kafukufuku wa methylene blue pa mitundu ina ya ululu. Njira yochizira ululu wa pamalo enaake kapena kafukufuku wa matenda a mitsempha sizitsimikizira kuti methylene blue ndi yoyenera kuchiza migraine.
Tebulo la umboni: siyanitsani zochitika za kupweteka kwa mutu
| Zochitika | Zimene umboni ukukhudza kwenikweni | Zimene sungatsimikizire |
|---|---|---|
| Migraine yotsimikiziridwa ndi dokotala, yokhala ndi aura kapena yopanda aura | Zochitika zofotokozedwa pa intaneti ndi mfundo zokhudza mmene mankhwala angagwirire ntchito; pa kuwunikaku sipanapezeke kafukufuku wa methylene blue pochiza migraine wokhala ndi gulu loyerekezera | Ndondomeko yothandiza yochizira migraine, phindu popewa migraine, kapena zotsatira zodalirika pa aura |
| Kafukufuku woyesera mankhwala pa migraine | Kafukufuku waung’ono wa L-NMMA yoperekedwa kudzera mumtsempha pa migraine yopanda aura, wokhala ndi magulu owonjezera a placebo ochokera ku kafukufuku wakale | Kugwira ntchito kwa methylene blue, yomwe ndi chinthu china chosiyana |
| Mutu womwe akuti wabwera chifukwa cha methemoglobinemia | Kuwunika kofalitsidwa komwe kuli ndi nkhani ya mutu waukulu, khungu kusintha kukhala labuluu, ndi zizindikiro zina zomwe zinatha pambuyo pa chithandizo | Phindu pa migraine yoyambirira mwa munthu amene alibe methemoglobinemia |
| Mutu pambuyo pa jakisoni wa methylene blue woperekedwa motsatira malangizo a dokotala | Kupweteka kwa mutu kuli m’gulu la zotsatira zosafunika zomwe zalembedwa pa malangizo a jakisoniyo | Kuchuluka kwa anthu amene mutu umawapweteka ndi mankhwala omwedwa, kapena kuti mutu uliwonse pambuyo pokhudzidwa ndi mankhwalawa umayambitsidwa ndi utotowu |
| Mutu watsopano pambuyo pokhudzidwa ndi methylene blue popanda malangizo a dokotala | Mbiri ya zachipatala yofuna kuwunika nthawi yomwe zinachitika, chinthu chomwe chinagwiritsidwa ntchito, mankhwala ena, ndi zizindikiro zomwe zinatsagana nazo | Kuyeza serotonin, kutsimikizira matenda potengera nthawi yokha, kapena chifukwa chogwiritsiranso ntchito chinthucho |
Tebeloli limasiyanitsa magulu a anthu omwe anafufuzidwa ndi mavuto a zachipatala. Silisanja mwayi woti munthu wina aliyense angakhale ndi mavutowo.
Chifukwa chake nkhani ya methemoglobinemia si kafukufuku wa chithandizo cha migraine
Gwero la kafukufuku lomwe laperekedwa, Kupweteka kwa Mutu ndi Methemoglobinemia la Khan ndi anzake, linaonekera pa intaneti mu 2019 ndi m’magazini ya January 2020. Limawunika mutu wobwera chifukwa cha vuto lina ndipo limaphatikizapo wodwala amene mutu wake wonse unkapweteka kwambiri, ankakhala ndi kumva kubayidwa mozungulira pakamwa, milomo ndi manja zabuluu, nseru, komanso kuvutika kupuma pochita zolimbitsa thupi. Zizindikirozo zinatha pambuyo pa chithandizo cha methylene blue.
Methemoglobinemia imasintha hemoglobin moti magazi sangathe kupereka mpweya wa oxygen monga mwachibadwa. Kuchiza vuto la magazi limeneli kungachepetse zizindikiro zake. Lipotilo limachenjeza kuti zizindikiro zake zingaganizidwe molakwika ngati migraine yokhala ndi nkhawa kapena kupuma mofulumira kwambiri. Silinasankhe mwachisawawa anthu okhala ndi migraine yoyambirira kuti alandire methylene blue kapena placebo, ndipo mmene wodwalayo anasinthira pambuyo pa chithandizo sikutsimikizira kupewa kapena kuchepetsa migraine wamba. Kufotokozera kwatsatanetsatane kwa chithandizo cha methemoglobinemia m’chipatala kumafotokoza ntchito imeneyi.
Kwa owerenga amene akufufuza makamaka za “methylene blue ndi aura ya migraine,” kalata ina yofalitsidwa pambuyo pake imafotokoza methemoglobinemia yooneka ngati migraine yokhala ndi aura ya maso. Uku ndi kufanana kwa zizindikiro komwe kungasokoneze kuzindikira matenda, osati umboni wochizira aura ndi methylene blue. Zolemba zomwe zikupezeka pa PubMed zilibe chidule cha nkhaniyo, choncho tsatanetsatane wa chithandizo cha wodwalayo sangadziwike potengera mutu wa nkhaniyo.
Mutu pambuyo pokhudzidwa ndi methylene blue si mayeso a serotonin
Malangizo operekera PROVAYBLUE amatchula kupweteka kwa mutu pakati pa zotsatira zosafunika zomwe zanenedwa. Deta imeneyi ikukhudza mankhwala operekedwa kudzera mumtsempha motsatira malangizo a dokotala kwa odwala amene ali ndi methemoglobinemia. Sikuyeza kuopsa kwa mankhwala omwedwa omwe ali ndi zosakaniza zosiyana komanso kuchuluka kosiyana komwe thupi limalandira.
Nthawi zina, mutu watsopano ungakhale zotsatira zosafunika, migraine yomwe munthu amazolowera, vuto lina la mutu, kapena mbali ya matenda ena. Nthawi ndi yofunika, koma kunena kuti zinachitika “pambuyo pa” sikokwanira kutsimikizira kuti zinachitika “chifukwa cha.” Lembani zimene zinachitika ndipo funsani upangiri musanagwiritsenso ntchito chinthu chomwe sichinaperekedwe ndi dokotala. Musachigwiritsenso ntchito kuti muyese ngati ndicho chinayambitsa mutu, kapena kuwonjezera mankhwala ena kuti muthetse zotsatira zake.
Nkhawa yokhudza kugwirizana kwa mankhwala ilidi ndi maziko: mayeso pogwiritsa ntchito ma enzyme a anthu omwe ayeretsedwa amasonyeza kuti methylene blue imalepheretsa monoamine oxidase A. Koma kupweteka kwa mutu sikusonyeza kuchuluka kwa serotonin m’thupi la munthu. Kuchepa kwa mutu atagwiritsa ntchito chinthu china kapena kusapweteka kwa mutu sizingatsimikizire kapena kuchotsa kuthekera kwa vuto la serotonin yochuluka kwambiri.
Onani mankhwala enieni a migraine
Chithandizo cha migraine chingaphatikizepo mankhwala ochokera m’magulu angapo. Malangizo a sumatriptan amaletsa kugwiritsa ntchito mankhwalawa nthawi imodzi ndi mankhwala oletsa MAO-A. Mankhwala ena ogwiritsidwa ntchito popewa migraine, kuphatikizapo mankhwala a matenda a kukhumudwa, amafunikanso kuunikidwa. Malangizo a jakisoni wa methylene blue amachenjeza za serotonin syndrome akagwiritsidwa ntchito ndi mankhwala okhudza serotonin ndi opioids. Katswiri wa mankhwala amafunika mayina enieni a mankhwalawo, osati kungoti “mankhwala a migraine.”
Pezani chithandizo chamankhwala mwachangu pambuyo pokhudzidwa ndi methylene blue ngati kusakhazikika kapena kusokonezeka maganizo kwachitika pamodzi ndi kutentha thupi, kutuluka thukuta kwambiri, kunjenjemera, kuuma kwa minofu, kapena kusuntha kwadzidzidzi kwa thupi. Kuphatikizana kwa zizindikirozi n’kodetsa nkhawa kwambiri kuposa mutu wokha. Musasiye mankhwala opewera migraine omwe dokotala wakupatsani kuti mugwiritse ntchito methylene blue, kapena kukonza nokha nthawi yodikira kuti mankhwala achoke m’thupi. Buku lothandiza pa kugwirizana kwa mankhwala limafotokoza magulu oyenera kuganiziridwa; kusapezeka pa mndandanda waung’ono sikutanthauza kuti ndi otetezeka kugwiritsa ntchito pamodzi.
Lembani zimene zinachitika popanda kuchedwetsa chithandizo
Tsitsani fomu yolembera mbiri ya zizindikiro kuti mupite nayo kukaonana ndi katswiri wa zachipatala. Imathandiza kulemba zimene zinachitika, osati kutsimikizira matenda kapena kupereka malangizo a chithandizo.
Fotokozani ngati kupwetekaku kukufanana ndi mutu umene mumazolowera, kuti kunayamba liti poyerekeza ndi nthawi yomwe munagwiritsa ntchito methylene blue, zomwe munamwa, ndi zizindikiro zina zomwe zinachitika. Phatikizanipo kusintha kwa mankhwala a mutu omwe mumagwiritsa ntchito nthawi zonse ndi kuchuluka kwa nthawi zomwe mumagwiritsa ntchito mankhwala ochepetsa mutu ukayamba. Kugwiritsa ntchito pafupipafupi pakokha kungapangitse kuwunika mutu kukhala kovuta.
Malangizo a NICE owunika kupweteka kwa mutu amalimbikitsa kulemba kuchuluka kwa nthawi zomwe mutu umapweteka, nthawi yomwe umakhala ukupweteka, kuopsa kwake, zizindikiro zotsagana nawo, mankhwala, ndi zinthu zomwe zingauyambitse. Amasiyanitsanso aura wamba yomwe imayamba pang’onopang’ono ndipo imatha, ndi zizindikiro zomwe zimafuna kuwunika kwina. Vuto la maso kapena la ubongo ndi mitsempha lomwe lachitika koyamba kapena losiyana kwambiri ndi lozolowera siliyenera kutchedwa “aura chabe” potengera zimene zalembedwa ndi munthu pa intaneti.
Ngati muli ndi mutu watsopano kapena wosatha pambuyo pokhudzidwa ndi methylene blue, pitani ndi chidebe chake kapena chithunzi chomveka bwino cha lebulo, pamodzi ndi fomuyo, kwa katswiri wa zachipatala kapena wa mankhwala. Buku lofotokoza chitetezo mwatsatanetsatane ndi mafunso oti mukambirane ndi katswiri wa zachipatala amathandiza kukonza zokambiranazo potengera chinthu chenicheni ndi ntchito yomwe mukufuna kuchigwiritsira.