Te puru metilīni mō te mutu hā i te moe me te ngongoro: te whakamātau kerēme

Kei ngā huinga kōrero mō te moe tētahi kerēme e horapa ana, he āhua pēnei tōna. E kī ana te tangata ka whakapai ake te puru metilīni i te whakamahinga hāora i roto i ngā pūtau, ā, i muri i ētahi rā e kai ana i taua matū, ka mutu tā rātou ngongoro, ka mutu te oho me te kapo hā, ka tīmata hoki te hā puta noa i te pō me te kore kanohi ārai. Ehara te mātauranga rongoā e herea ana ki taua kerēme i te mea tito noa. Ka pāhekoheko tonu te puru metilīni ki te whakawhitinga irahiko i roto i ngā mitokōria. Engari e tīpokatia ana tētahi takahanga e taua tohenga: ko te mutu hā i te moe he rahunga ā-tinana o te arahau o runga, ā, kāore te whakarerekē i te whakamahinga hāora a tētahi pūtau e whakarerekē mēnā ka noho tuwhera tonu te korokoro.

Ka wehe tēnei āputa i ngā mea e toru e kōrerotia ana me he mea kotahi: te mate, ngā inenga e tautuhi ana i taua mate, me te wheako kua pūrongotia o tētahi pō pai ake.

He raruraru paipa tēnei mate

I te wā e moe ana, ka whakangā ngā uaua e pupuri ana i te korokoro kia tuwhera. Ki ētahi tāngata, ka tino whāiti te arahau, ā, ka whakatītakataka te hau e rere ana i roto i ngā kiko ngohengohe; ko taua tītakataka te ngongoro. Ki ētahi atu, ka kati rawa te arahau mō te tekau hēkona, neke atu rānei, arā, he mutu hā, ka whāiti rānei kia heke te rere hau me te hāora, arā, he iti hā. Ka mutu taua takahanga ina whakaoho poto te hekenga o te hāora me te pikinga o te hauhā i te tangata, ka hoki mai te tōnuitanga o ngā uaua, ka tuwhera te arahau, ā, ka hoki anō te tangata ki te moe.

Ko ngā taurangi e hāngai ana he mea ā-hanganga tinana, ā-whanonga hoki. Ko te āhua o te kauae, te pūtake o te arero, te paenga o te kakī, te tuwheratanga o te ihu, te takotoranga o te tinana, te waipiro, ngā rongoā whakarokiroki me te hōhonutanga o te moe, ka whakarerekē katoa i te auau o te kati o te arahau. Kāore tētahi rongoā e whakarerekē ana i te whakamahinga hāora a tētahi pūtau e uru ki taua rārangi. Koia te take e kore ai e hāngai te whakamārama ā-tukanga, ahakoa te tika o ōna wāhanga. He whakaahuatanga tērā o tētahi pūnaha kē.

Ngā mea ka tatauria e tētahi rangahau moe, me ngā mea kāore e tatauria

Ka tuhi tētahi rangahau moe ā-pūrere maha i te rere hau i te ihu me te waha, te whakapau kaha ki te hā mā ngā tātua huri noa i te uma me te puku, te kukū hāora mā tētahi pūoko maihao, te tangi ngongoro, te takotoranga o te tinana, me te mahi hiko o te roro. Ka whai hongere hoki mō ngā karu me ngā uaua kauwae, kia taea ai te whakarōpū i ngā wāhanga moe me ngā oho poto. Ka whakaitihia ēnei e tētahi whakamātautau mutu hā i te moe ki te kāinga, ko te tikanga ki te rere hau, te whakapau kaha ki te hā, te ine hāora me te takotoranga.

Ka puta mai ngā tau i aua hongere. Ko te taupū mutu hā–iti hā te tatauranga o ngā mutu hā me ngā iti hā ia hāora moe. Ka tatau te taupū hekenga kukū hāora i ngā hekenga o te kukū ia hāora. Ka tatau te taupū oho poto i ngā whakararutanga moe ia hāora. Hei tāpiri ki ēnei, ka pūrongo te rangahau i te tapeke o te wā moe, te pai o te whakamahi i te wā mō te moe, te wā oho i muri i te tīmatanga o te moe, me te wā i ia wāhanga moe.

Anei te wāhanga nui mō te aromatawai i tētahi kerēme maimoatanga. Ka ine ia tau i tētahi mea i tupu i tētahi pō motuhake. Kāore tētahi o aua tau e ine ana i te tūponotanga ka hinga, ka kati te arahau. Ka whakatau tatahia taua tūponotanga mai i taua pō, ā, ka tika noa taua whakatau ki te whānuitanga e whakaata ana taua pō i ngā pō noa.

Kāore hoki ngā tatauranga takahanga e pūmau. Ka iti ake ngā takahanga ka tatauria mō te tangata ka nui ake te wā o te pō e takoto ana ki tōna taha. Ko te takotoranga o te tinana, te wāhanga moe, te ihu puru, te waipiro i inumia tata nei, te panoni taumaha, te momo pūoko rere hau me ngā ture tatauranga, ka whakarerekē katoa i te hua. I te nuinga o te wā, he kino ake te pō tuatahi i tētahi taiwhanga i te pō tuarua. Ahakoa he aha atu ngā mea e hiahiatia ana e tētahi kerēme maimoatanga, me whai hoahoa e tū tonu ai ahakoa ka rerekē ngā hua o ngā pō e rua e whai ana tētahi i tētahi mō te tangata kotahi kāore anō kia maimoatia.

Ehara te pō pai ake i te panonitanga kua inea

Ko ngā tohumate e whakatau mahi ai te tangata he whakaaro nō tōna wheako: kua iti iho te ngongoro, kua mutu te kapo hā, kua pai ake taku moe, kua nui ake taku kaha. He wheako tūturu ēnei, engari he inenga ngoikore hoki mō te ārainga o te arahau.

Ka tono te Tauine Hiamoe Epworth kia whakatauria e te tangata tōna tūponotanga ki te parangia i ngā āhuatanga e waru o ia rā. Ka ui te Taupū Kounga Moe Pittsburgh mō te marama kua pahure. He kōrero ēnei e rua nā te tangata mōna anō. Nā tēnei ka ngāwari te whakakī, ka ngāwari hoki te huri ahakoa kāore te raruraru taketake i panoni. Ka rapu maimoatanga te tangata ina tino kino tōna āhua, nō reira kua tītaha kē te inenga tuatahi ki te pito kino, ā, nā taua take anake ka āhua pai ake te inenga e whai ake ana. Ka tūmanako te tangata ki te pai ake mēnā e mōhio ana ia kua whiwhi ia i tētahi maimoatanga.

He ara mārama e pai ake ai tētahi pō, me te kore panoni ki te arahau. Ka puta pea tētahi oho poto e wāwāhi ana i te moe me te kore hekenga nui o te kukū hāora, ā, ka iti ake aua oho i tētahi pō moe hōhonu. Ka iti ake ngā takahanga ka tatauria mō te tangata i tūpono takoto ki tōna taha i taua pō. Ehara ēnei i te tinihanga; koia te take noa e rerekē ai ngā pūrongo whaiaro me ngā rangahau kua tatauria ō rātou takahanga.

Te wāhi e mahi tūturu ai te puru metilīni

He waikano hāora-tango, hāora-tuku te puru metilīni. Ka tango, ka tuku hoki i ngā irahiko, ā, ka taea e ia te kawe mai i ngā wāhanga o te mekameka kawe irahiko ki te sitokirōma c. I roto i ngā mitokōria roro kua wehea, i whakapiki i te whakaputanga ATP, i whakahoki hoki i te pūmanawa hiko o te kiriuhi i te wā i āraia ai te matatini I, te matatini III rānei. I ngā pūtau ate kiore iti, i tiaki i ngā pūtau i āraia ai te kawe irahiko e ngā rongoā e rua; i ngā pūtau astrosaita i tangohia ai te kūhuka me te hāora, i whakapai ake i te tukanga hā o ngā pūtau.

Ka pānui ana i ngā taipitopito, ka rerekē te āhua o te kōrero. I aua mitokōria roro anō, i whakapiki te puru metilīni i te whakaputanga hauwai perōkai, i whakapiki hoki i te kohi hāora i te wā whakatā, engari kāore i panoni te tukanga hā i whakaohohia e te ADP. Ehara te nui ake o te hāora e kohia ana i te wā e noho whakatā ana tētahi mitokōriona i te nui ake o te pūngao e whakaputaina ana. I ngā mitokōria ate kiore nui kua wehea, nā ngā kukūtanga e piki ana i whakaheke ngā ōwehenga whakahaere hā, i whakatupu hoki te pupuhi. I whakaahuatia tēnei e ngā kaituhi hei momotutanga o te whakahōtuitui pūhui ūkuikui mā te hāora. Kāore te puru metilīni e whakapai noa i te tōtika o te tukanga hā; ka whakarerekē i te hononga i waenga i te kohi hāora me te whakaputanga ATP, ā, ka whakawhirinaki te ahunga o taua panoni ki te kukūtanga.

Kāore hoki te putanga matarohia o te kōrero — arā, ka ārai te puru metilīni i te tuku tohu a te hauota waikura — i te tino māmā pērā i te nuinga o ngā kōrero mōna. I ngā pūtau uaua maheni o ngā ia tuku pūkahukahu i whakatipuria, ko te ārainga i te whakaeminga GMP porohita nā ngā matū whakaroha ia toto e tuku ana i te hauota waikura, me te tauwehe whakangā i takea mai i te endothelium, i tāruaruatia mā te whakaputa superoxide. Nā te puru metilīni anō i whakaputa te superoxide. I ngā pūtau endothelium i whakatipuria me te kore kūhuka, ko ngā kukūtanga kei runga ake i te āhua 5 micromolar i whakapiki i te ahotea hāora-whakapiri i roto i ngā pūtau. Ka whakaahua tētahi arotake o ngā tuhinga mō te hononga horopeta–urupare i taua tauira hei urupare hormesis: ka whakapiki ngā horopeta waenga i te mahi a te sitokirōma oxidase, ā, ka whakaheke ngā horopeta teitei ake i taua mahi. Ka huri kōaro te ahunga o te pānga i te pikinga o te horopeta.

E rua atu ngā inenga e whakaatu ana i taua aronga anō. I ngā kurī, i whakarerekē te puru metilīni i te ōwehenga lactate ki te pyruvate i ngā ia tuku, he tohu mō te āhua hāora-tango, hāora-tuku o ngā kiko, ā, kāore i tino whakarerekē i te whakaputanga toto a te manawa, te auau manawa, me te pēhanga o ngā ia tuku. I ngā tūao tangata i tukuna ai te puru metilīni mā te ia toto, i heke te rere toto puta noa i te roro, kāore i piki. He uaua te whakahāngai i tēnei ki te whakaaro ka tukuna e taua rongoā he hāora nui ake ki te roro.

Ko te panonitanga matū-koiora ka taea te ine, me te kore panonitanga mahi e hāngai ana, te tauira me wikitoria e tētahi kerēme; ehara i te taunakitanga kua whakapūmautia kētia taua kerēme.

E toru ngā tohenga kāore e kati i te āputa

Ko te tuatahi e pā ana ki te ihu. Ka akiaki te ihu puru i te tangata kia hā mā te waha, ā, ka kino ake te ngongoro i te hā mā te waha. Nō reira he ngāwari te hiahia ki te maimoa i ngā tohumate ihu, me te tūmanako ka pai ake te raruraru katoa. He take kotahi te tuwheratanga o te ihu e whai wāhi ana ki te hā raruraru i te moe. Ehara tēnā i te hinganga o te arahau. Ka puta te ārainga o te mutu hā i te moe ki muri i te ngao ngohengohe me te pūtake o te arero, kei tua atu i te ihu i te ara rere hau, ā, kāore tētahi mea i ngā rangahau kua whakaputaina mō te puru metilīni e whakaatu ana ka whakatuwheratia e ia aua hanganga.

Ko te tuarua te tohenga mitokōria, koinei te mea e tino rangona ana. Ko te kōrero mō ngā pūtau e tōtika ake ana te whakamahi hāora, he kōrero mō te pākia o ngā kiko. Ko te mutu hā he kōrero mō te rere. I tētahi takahanga ārainga, ka heke te hāora i ngā ia tuku nā te mea kua mutu te rere o te hau, ehara nā te mea kua kore ngā pūtau e whakamahi i taua hāora. Kāore te pai ake o te whakawhiti irahiko i roto i tētahi mitokōriona e whakatuwhera anō i te korokoro kua kati. Ā, mēnā ka whakapiki te puru metilīni i te kohi hāora i te wā whakatā me te kore panoni i te tukanga hā kua tūhonotia ki te whakaputanga pūngao, ko te pātai ka ara ake i tētahi pō hāora iti e pā ana ki te nui e hiahiatia ana, ehara i te nui e tukuna ana.

Ko te tuatoru te kōrero wheako takitahi. Kāore e taea e te tangata e whakamātau ana i te puru metilīni te whakahaere i tētahi whakamātautau matapō mōna anō, ā, he tino taumaha tēnei raruraru mō tēnei rongoā: he waikano kaha te tae. Ka puru te mimi, ā, ka pērā hoki pea te werawera me ngā roimata. Ko te puru metilīni hoki he kaiārai kaha, ka taea te whakahoki, o te monoamine oxidase A. Ka whakarerekē tēnei i te tukatuka a te whēkau i ngā amine o te kai ina kainga mā te waha, ā, he mōrearea pāhekoheko kua tuhia ki ngā rongoā e pā ana ki te serotonin. Ka ngāwari te whakamāori i tētahi pānga whakaohooho pēnei hei pai ake o te moe, ahakoa kāore he panoni ki te arahau.

Kāore ēnei kōrero e mea ana kei te hē te tangata mō ōna ake pō. E mea ana me whai inenga ki te taha o te pūrongo mō tētahi pō pai ake, i mua i tōna noho hei kerēme mō te mutu hā.

Ngā mea me whakaatu e te kerēme

Ki te whakatakotoria kia mārama, koinei te āhua o tētahi kerēme e tika ana kia whakaponohia.

He tātaritanga mate kua whakaūngia e tētahi rangahau moe kua tatauria ōna takahanga i mua i te tīmatanga o te maimoatanga, me te whakaatu i te taumaha o te mate, kia whai mea hei whakataurite.
He rōpū whakataurite e whai wāhi ana i taua wā tonu, kua tohaina matapōkeretia. Nā te mea ka panoni noa iho ngā tatauranga takahanga, kāore e taea e tētahi raupapa inenga i mua, i muri hoki, me te kore rōpū whakataurite, te wehe i te pānga maimoatanga i taua panoni. He ātaahua te hoahoa whakawhiti maimoatanga, engari he raruraru anō ōna: he tohu kaha te tae o te mimi mō te wāhanga e uru ana te kaiuru.
He whakamārama pono mō te huna i te tohanga maimoatanga. Me kī tētahi whakamātautau o tētahi pūhui whai tae ka kitea, i pēhea tana whakahaere i te āhuatanga ka taea e ngā kaiuru te kite kei tēhea rōpū rātou. Ko tētahi ara, he rongoā horihori kua whakahāngaitia tōna tae.
He putanga matua ka taea te ine me te kore whakawhirinaki ki te whakaaro whaiaro: te panoni mai i te tīmatanga i ngā takahanga ia hāora, i te taupū hekenga kukū hāora rānei. Me noho ngā kaute uiui ki te rārangi tuarua, kia taea ai te pūrongo pono me te kore e waiho mā aua kaute e tautoko te kerēme matua.
Kia rawaka ngā pō kua tuhia hei whakatau i ngā rerekētanga mai i tētahi pō ki tētahi pō, ko te tikanga he nui ake i te pō kotahi mō ia āhuatanga.
Kia inea te ū ki te maimoatanga, kaua e whakapaetia noa.
He pūrongo haumaru e hāngai ana ki te taupori, tae atu ki ngā tāngata e kai ana i ngā rongoā e pā ana ki te serotonin.
He mahere putanga me te tātari kua whakatauria i mua i te kohinga raraunga.

Kei tēnei tuhinga tētahi pepa mahi ka taea e koe te whakakī mō tētahi kerēme motuhake: pepa mahi whakataurite putanga. Ka mahi tuimotu hoki te kōnae HTML motuhake nei ina tiakina, ka whakatuwheratia ki tētahi pūtirotiro.

Mēnā ka pūrongo tētahi whakamātautau i tētahi hekenga whai tikanga o ngā takahanga ia hāora mō ngā tāngata kua whakaūngia tō rātou mate, he hua whakamīharo tērā. Me whai whakamārama hoki mō te ara i tae atu ai tētahi pūhui e mahi ana ki te whakawhitinga irahiko ki te korokoro.

He pānuitanga e pā ana i tēnei raupapa: ngā taunakitanga mō te puru metilīni me te moe, e kōrero ana mō te kore moe me te wā kai horopeta, me te take ōrite mō te puru metilīni i te COPD me te hāora iti. E rua ngā whārangi nui mēnā kei te whakamahi koe i tēnei i roto i ngā mahi: ngā pānga o te puru metilīni ki te ine kukū hāora mā te manawa me ngā whakamātautau taiwhanga, nā te mea ka whakarerekē tētahi waikano i te toto i ngā pūrongo a ētahi pūrere, me te rārangi pātai hei tuku ki tētahi mātanga hauora mō te puru metilīni.

Ngā mahi kē hei whai, me tētahi mea e tika ana kia tirohia

Kāore tētahi kōrero i runga ake nei e noho hei take kia whakamutua te maimoatanga pēhanga tōrunga ki te arahau, kia kaua rānei e whai rangahau moe mō te tātaritanga mate. Ko ēnei tonu te paerewa tohutoro, ā, ka whakaputa tētahi pō i runga i tētahi mīhini i ngā inenga kāore e taea e tētahi tāpiringa.

Mēnā kei te kai koe i te puru metilīni mō tētahi take kē, ā, kei te kino tō moe, me ine te moe, kaua e whakatau tata noa. Tonoa ngā tau: e hia ngā takahanga ia hāora, te taupū hekenga kukū hāora, te roa o te wā i raro iho te kukū i te iwa tekau ōrau, me te taupū oho poto. Ko aua uara ngā mea me whakarerekē e tētahi maimoatanga.

Ko te taurangi kotahi ka taea e te kaihoko te manatoko ko ngā matū kei roto i te hua. Ko te parakore te rerekētanga i waenga i tētahi matū e hāngai ana ki tētahi whakaritenga pukapuka paerewa rongoā me tētahi kāore e hāngai ana. Ko te ara whaihua ki te parakore teitei rawa e wātea ana, ko te ū ki te tuhinga paerewa a te United States Pharmacopeia mō te puru metilīni. He maha ngā kaihoko e kerēme ana i taua ū, engari ka whakamātau mō ngā konganuku taumaha anake, ka mutu i reira. Ka mahi tahi a Blupreme me tētahi kaihanga rongoā, ka whakamātau i te whakaritenga katoa, tae atu ki te tuakiri, te parakore, ngā poke waro, ngā toenga whakarewa, ngā poke huānga, te toenga i muri i te tahu, ngā tepenga moroiti me ngā endotoxin huakita, ā, ka whakaputa i te tiwhikete tātari katoa mō taua huinga whakaputanga. Ka whakaatu aua tuhinga i ngā mea kei roto i te matū. Kāore e whakaatu ana ka maimoatia te mutu hā i te moe e taua matū.