Te kikorangi metilīni me POTS: he aha ngā tukanga o ngā ia toto e kore ai e whakaū i tētahi maimoatanga

Kāore anō te kikorangi metilīni kia whakaūngia hei maimoatanga mō te huinga tohumate o te tere rawa o te manawa ina tū, arā, ko POTS. I te rapunga tuhinga rangahau mō tēnei tuhinga, kāore i kitea he whakamātautau haumanu whai rōpū whakataurite e whakaatu ana ka whakapai ake tēnei matū i ngā tohumate o POTS, i te āhei rānei ki te mahi i ngā mahi o ia rā. He pātai kē ka whakautua e ngā rangahau mō te ru nā te whakapokenga me ngā whakamātautau ki ngā ia toto.

Ko te whakapae e rata ai te tangata, e pā ana a POTS ki te rere toto, ka taea e te kikorangi metilīni te whakahē i ētahi tohu e whakangāwari ana i ngā ia toto, nō reira me whakapai ake te kikorangi metilīni i a POTS. Me āta tirotiro ia wāhanga o taua whakapae. Ko te pānga o tētahi rongoā ki tētahi ara koiora o ngā ia toto e kore e whakaū ko taua ara te pūtake o ngā tohumate o tētahi tangata, ka āwhina rānei te whakarerekē i taua ara kia hāneanea tana tū.

Ngā mea me wehewehe i te tuatahi

Ko te kore e taea te noho tū he tohumate e pā ana ki te tū, ki te noho tika rānei. Ko POTS tētahi huinga tohumate kua tautuhia i roto i taua raruraru whānui ake. He whānui ake anō te raruraru o te pūnaha io motuhake, e pā ana ki ngā mate o te whakahaere aunoa i ngā mahi o te tinana; ehara tēnei i te ingoa mō tētahi tauira kotahi o te pēhanga toto.

E whakamārama ana te pūrongo whakaaetanga a ngā mātanga NIH mō POTS i te pikinga pūmau o te auau manawa, kia 30 neke atu ngā patuki i te meneti i roto i te 10 meneti o te tū, kia 40 neke atu rānei mō te hunga 12–19 tau. Me whai hoki he tohumate roa ina tū, he pai ake ina takoto, me te kore o te hekenga pūmau o te pēhanga toto ina tū. Me toru marama neke atu te roa o ngā tohumate, ā, me whakakore ētahi atu whakamārama mō te tere rawa o te manawa. E kore tētahi inenga mai i te matawā anake e whakaū i taua huinga āhuatanga.

He inenga tautuhi kē tō te pēhanga toto iti ina tū o te momo matarohia: e ai ki te tautuhinga whakaaetanga a ngā rōpū mātanga o te pūnaha io motuhake, me heke pūmau te pēhanga toto kia 20 mmHg neke atu mō te pēhanga i te kukūtanga o te manawa, kia 10 mmHg neke atu rānei mō te pēhanga i te whakangā o te manawa, i roto i te toru meneti o te tū, o te honga rānei kia whakarunga te māhunga. Ko te ru nā te ngaronga o te tōnuitanga o ngā ia toto he ngaronga ohotata o te kukūtanga taketake o ngā ia toto, he nui rawa kia mōrearea te rere toto. Kāore e tautuhia mā tētahi whakamātautau tū.

Whakatauritenga: te mate, te putanga, me te āputa taunakitanga

Ka wehewehe tēnei whakatauritenga i ngā pātai rangahau; ehara i te pepa mahi hei tautuhi mate. Tīkina te whakatauritenga o ngā mate me ngā pātai whakawhiti kōrero kia noho tahi ai ēnei rerekētanga. He mea whai take anō ēnei ina whakamāramatia te kikorangi metilīni me ngā panonitanga o te pēhanga toto.

He aha tonu te mea i whakamātauria i te whakamātautau mō te ru

I te whakamātautau tohatoha matapōkere a Ibarra-Estrada me ōna hoa i te tau 2023, i whiwhi ngā pakeke he ru tō rātou nā te whakapokenga ki te kikorangi metilīni mā te ia toto, ki te wairewa tote hei rongoā horihori rānei, i te taha o te maimoatanga tiaki tūroro tino māuiui. E 91 ngā tūroro i roto i te tātaritanga, e 45 i whiwhi ki te kikorangi metilīni, e 46 ki te rongoā horihori. I uru ki te maimoatanga ngā tuku rongoā āta rere i roto i ngā rā e toru, ā, i aromatawaia ngā putanga tae noa ki te 28 rā.

Ko te putanga matua ko te wā kia taea ai te whakamutu i ngā rongoā whakapiki pēhanga toto. He rongoā ēnei hei tautoko i te pēhanga toto i te wā o te ru. Ko te tau waenga o taua wā he 69 hāora mō te kikorangi metilīni, he 94 hāora mō te rongoā horihori. He ōrite te auau matenga me te roa o te whakamahi mīhini whakahā i waenga i ngā rōpū.

He taunakitanga tēnei mō tētahi maimoatanga āpiti i te wā o te kore e tika ohotata o te rere toto e pā ana ki te whakapokenga. Kāore e whakaatu ana mā te kikorangi metilīni ka horomia e whakaiti te tere rawa o te manawa ina tū, e ārai te tata hemo, e whakapai ake rānei te taenga ki te kura mō te hunga whai POTS. He rerekē katoa ngā tūroro, te ara tuku rongoā, ngā maimoatanga i te taha, te roanga o te wā, me te putanga matua. Ka tirotiro te arotake motuhake mō ngā whakamātautau o te kikorangi metilīni mō te ngaronga o te tōnuitanga o ngā ia toto me te ru nā te whakapokenga i aua taunakitanga tiaki tūroro tino māuiui i tō rātou ake horopaki.

He aha te whakamārama mō te waikura hauota e kore ai e oti

Ka whai wāhi te waikura hauota ki te whakangāwari i ngā ia toto, tae atu ki te tuku tohu mā te guanylate cyclase wairewa me te GMP porohita. Ka taea e te kikorangi metilīni te whakararu i ēnei tukanga koiora, engari mā te whakaahua noa hei aukati waikura hauota ka huna ngā rerekētanga o ngā whakamātautau.

Hei tauira, i te whakamātautau ia toto a Wolin me ōna hoa i te tau 1990, i whakapāngia te kikorangi metilīni ki tētahi wāhi o te pūnaha ia toto ririki o te uaua kōhiwi i huraina i ngā kiore i raro i te rehunga. I whakaiti tēnei i te whakawhānui o ngā ia toto nā te acetylcholine me te waikura hauota. Nā te superoxide dismutase i ārai taua aukatinga, e tautoko ana i tētahi tukanga superoxide i waho i ngā pūtau i taua whakaritenga whakamātautau. He whakamātautau tēnei ki ngā ia toto ririki o tētahi wāhi, ehara i te rangahau maimoatanga mā te waha mō te hunga whai POTS. Kāore tōna kitenga e whakaū i te painga haumanu, i te wharanga io rānei mō aua tūroro.

Kāore hoki e mārama te whakapae mō te taha mate. I whakataurite tētahi rangahau o te tau 2005 mō ngā urupare o ngā ia toto ririki i POTS i ngā kaiuru 15 he POTS rere toto iti tō rātou, ngā kaiuru 17 he POTS rere toto noa tō rātou, me ngā kaiuru hauora 13 hei whakataurite, e 14–22 tau te pakeke. I ine ngā kairangahau i te rere toto o te kiri i te wā e whakamātauria ana ngā urupare o ngā ia toto o tētahi wāhi. I tohu ā rātou kitenga he iti ake te tukunga waikura hauota e whakawhirinaki ana ki te rere toto i te rōpū rere toto iti. Kāore rātou i whakamātau i te kikorangi metilīni hei maimoatanga.

Ka wero tēnei kitenga i te whakaaro he waikura hauota nui rawa te āhuatanga o ngā momo POTS katoa, ā, me pēhi taua waikura hauota. Kāore hoki e whakaū ana he iti rawa te waikura hauota o ia tangata whai POTS. E ai ki te arotake haumanu a Mar rāua ko Raj, ka taea e te wharanga wāhanga o ngā io motuhake, te iti o te rōrahi toto e rere ana, me te kaha ake o ngā mahi adrenergic te whai wāhi mai i roto i ngā ara e īnaki ana. He mea whai take ngā rerekētanga i waenga i NOS, cGMP, me te tuku tohu i ngā ia toto, nā te mea ehara te ingoa o tētahi ara koiora i te tautuhinga mate mō tētahi tūroro ake.

He aha ngā pūrongo taupatupatu a ngā tūroro e whakaatu mai ai

Kei roto i tētahi kōrerorero o Phoenix Rising he pūrongo mō te tino kino ake o POTS i te wā e whakamahia ana te kikorangi metilīni. Engari, kei roto i tētahi kōrerorero mō POTS i Reddit he pūrongo mō te pai ake tonu o te auau manawa, e whakapaetia ana nā te kikorangi metilīni. He wheako me ngā pātai ka whakaahuatia e ēnei kōrero; kāore e whakaū ana i te pūtake o te pai ake, o te kino ake rānei.

He pātai whāiti ngā pātai whai take. I inea ngā tohumate i te tūnga kotahi o te tinana? I panoni te pēhanga toto me te auau manawa? I panonitia ngā rongoā, ētahi atu tāpiringa rānei? He pai ake te rongo o te tangata mō te wā poto noa iho, i hoki mai rānei tōna āhei ki te tū mō tētahi wā whai take i ngā rā o muri mai? Ko tētahi kōrero kāore aua taipitopito e kore e taea te wehewehe i te pānga o te rongoā i ngā panonitanga i taua wā anō, i ngā rerekētanga noa rānei o ngā tohumate.

Mō te hunga whai ME/CFS hoki, ko te rongo tonu i te kaha ake e kore e whakautu mēnā nā te mahi i puta ai he kino ake i muri mai. Ka kōrero ME/CFS, te kikorangi metilīni, me te māuiui i muri i te whakapau kaha mō taua putanga motuhake. Kāore ngā pūrongo whakahihiko, ngā pūrongo whakamataku rānei e whai take ai tētahi kawa whakamātau i te kāinga.

He aha ngā mea e whakapono ai te tangata ki tētahi kerēme mō POTS?

Ka whakauru tētahi rangahau whai take i ngā tūroro kua tuhia ōkawatia te tautuhinga mate, ka tautuhi i te whakaritenga o te rongoā me te ara tuku, ka whakamahi i tētahi maimoatanga whakataurite pono, ā, ka ine i ngā tohumate me te āhei ki te mahi. Me aromatawai ngātahi te auau manawa me te pēhanga toto. Me roa rawa te aroturuki kia tirohia ai te painga pūmau me ngā pānga kino, kaua e whakaarohia ko tētahi inenga pai kotahi he whakaoranga. He whakaritenga ēnei hei whakamātau i te kerēme, ehara i te taunakitanga e whai hua ana te maimoatanga.

He mea whai take te haumaru ki tēnei tono ake. E whakatūpato ana ngā mōhiohio tuku rongoā o Amerika mō ProvayBlue mā te ia toto mō te huinga tohumate serotonin ka mate pea te tangata ina pāhekoheko ki ētahi atu rongoā, ā, e aukati ana i te whakamahinga mō te hunga he ngoikoretanga G6PD tō rātou nā te mōrea o te anemia ka hua mai i te pakaru o ngā pūtau toto whero. Ko tōna whakamahinga kua whakaaetia ko te methemoglobinemia kua riro mai, ehara ko POTS. Kāore taua tapanga e whakamana i tētahi hōtaka rongoā mā te waha mō ngā tohumate ina tū.

Kawea te kerēme motuhake, te hua, te rārangi rongoā e whakamahia ana i tēnei wā, me te putanga e whāia ana ki tētahi mātanga haumanu e mōhio ana ki ō tohumate ina tū. Ka āwhina ngā pātai hei ui i mua i te whakaaro ki te kikorangi metilīni ki te whakarite i taua kōrerorero. Ko te pātai kāore anō kia whakautua, mēnā ka hua mai he painga whai take, pūmau hoki mō ngā tūroro whai POTS, ehara mēnā ka taea e tēnei matū te whakarerekē i ngā ia toto i tētahi atu horopaki.