Te kikorangi metilīni mō te ADHD: he aha ngā mea kua rangahaua?

Kāore anō kia whakaūngia te kikorangi metilīni hei maimoatanga whai hua mō te ADHD. Kāore ngā rapunga mō tēnei arotake i kite i tētahi whakamātau e tirotiro ana mēnā ka whakapai ake taua matū i ngā tohumate ADHD o ngā tāngata i whakaurua nā te mea kua tautohua taua mate ki a rātou. Ko ngā whakamātau tangata e kōrerotia nuitia ana e pā ana ki te mahara, ngā mahi aro i te taiwhanga, ngā whakaahua roro rānei i ētahi atu rōpū. Kāore aua kitenga e whakaū ana ka āwhina te kikorangi metilīni i tētahi tangata ki te whakahaere i te mahi ohorere kāore e āta whakaarohia, ki te ū ki tana mahi, ki te pai ake rānei tana whakatutuki i ngā mahi ahakoa te ADHD.

He mea nui anō taua wehewehenga mō te haumaru. He aukatinga tō ētahi rongoā ADHD mō te whakamahi tahi me ngā aukati monoamine oxidase, arā, te kāwai rongoā e hāngai ana ki te tūraru pāhekoheko o te kikorangi metilīni. Ahakoa kāore i te tino mōhiotia te painga, ehara tērā i te tohu kāore he kino o te whakakotahitanga whakamātau.

Ehara te whakamātautau aro i te whakamātau maimoatanga ADHD

Ka uru ki te ADHD ngā tohumate mau tonu me te whakararu i te āhei ki te mahi i ngā taiao huhua. E whakaahua ana te whakamārama a te CDC mō te tautohu mate i tētahi aromatawai haumanu e whai whakaaro ana ki te hītori, te whanonga i ngā taiao rerekē, me ētahi atu whakamārama ka taea. Kāore te urupare pōturi i tētahi mahi rorohiko e whakaū i te tautohunga mate. Kāore hoki te urupare tere ake i muri i tētahi wawaotanga e whakaū, ko ia anake, i te angitu o te maimoatanga.

Me whakauru te whakamātau ADHD i tētahi rōpū kua tika te tautohu i tō rātou mate, me ine hoki i ngā putanga e hāngai ana. Ka uru pea ki ēnei ngā whakatauranga tohumate kua whakamanahia me te āhei ki te mahi i te kura, i te wāhi mahi, i te kāinga rānei. Me wehe hoki ngā pānga o te wawaotanga i ngā huringa o te moe, ngā rongoā o nāianei, ngā tūmanako, me te whakaharatau tukurua.

Whakaarohia ēnei pātai e rua: ka taea rānei e te tangata te tika ake o tana mōhio ki tētahi whakaahua kātahi anō ka whakaaturia, ā, ka taea rānei e taua tangata te whakarite me te whakaoti i ngā mahi o ia rā i ngā wā katoa? E whai wāhi ana te hinengaro ki ngā mea e rua. Engari ehara ēnei i ngā putanga ka taea te whakakapi tētahi ki tētahi. Ka whakamahia taua wehewehenga puta noa i ngā painga e marohitia ana i tā mātou tirohanga whānui ki ngā taunakitanga mō te kikorangi metilīni i te tangata.

He aha ngā kitenga tūturu o te whakamātau ki ngā pakeke hauora?

I tātari te rangahau whakaahua roro matapōkere a Rodriguez me ōna hoa i te tau 2016 i ngā pakeke hauora 26, mai i te 22 ki te 62 tau te pakeke. I whakatauritea tētahi hoatutanga kotahi mā te waha o te kikorangi metilīni kounga USP ki tētahi rongoā horihori kua whakakikorangingia. Ko ngā whakamātautau i mua i te hoatutanga, ā, tata ki te kotahi hāora i muri mai, he mahi aro mau tonu, he mahi mahara wā poto, me te MRI mahi. Ko ngā mate hinengaro me te whakamahi rongoā hinengaro i ngā wā tata nei ētahi paearu hei aukati i te whakaurunga.

I rerekē ngā urupare i ngā whakaahua roro i ētahi rohe. Me āta tirotiro ake ngā hua whanonga: kāore te whakataurite i te wā urupare aro i waenga i ngā rōpū i roto i te wā i whai hiranga tauanga, arā, P = .43. I pūrongo te pepa i tētahi whakapainga tata ki te 7% o ngā whakautu mahara tika i roto i te rōpū kikorangi metilīni, engari kāore hoki te pāhekoheko hāngai i waenga i ngā rōpū i whai hiranga tauanga, arā, P = .09.

Ki te whai hiranga tauanga tētahi hua i mua, i muri hoki i roto i te rōpū kotahi, kāore tērā e whakaū i tētahi painga maimoatanga whai hiranga tauanga ki runga ake i tētahi atu rōpū. Ka tautoko ēnei kitenga i te rangahau anō, engari kāore e whakaatu ana i tētahi painga mō te ADHD. Kāore hoki e taea e tēnei whakamātau te whakautu i ngā pātai mō te whakamahi tukurua, ngā tamariki, ngā whakakotahitanga rānei me ngā rongoā ADHD.

He rārangi rangahau ka taea te rapu, tae atu ki ngā taunakitanga e ngaro ana

Whakatuwheratia te rārangi rangahau ka taea te rapu hei tātari i ngā pūkete mā te rōpū tāngata, te putanga, te kaituhi, te āputa taunakitanga rānei. Kei roto ngā hononga ki ngā mātāpuna, ā, ka wehewehea ngā whakamātau horopaki e hāngai ana i tētahi hua rapu kāore e hāngai ana.

I tohaina matapōkeretia e te whakamātau a Telch ngā pakeke 42 he kaha tō rātou wehi ki ngā wāhi kōpani ki te kikorangi metilīni, ki te rongoā horihori rānei, i muri i te whakangungu mā te whakapā atu ki te mea e wehingia ana. I hāngai ngā aromatawai mahara me tētahi aromatawai wehi i te kotahi marama ki te ako me te mau tonu o te wehi. I whakawhirinaki ngā hua wehi ki te angitu o te mutunga o taua wātū whakapā. Ehara tēnei i te whakamātau tohumate ADHD, ā, kāore e whakaū ana i tētahi painga whānui mō te aro.

E whakaatu ana tētahi hua rapu he aha e kore ai e ranea te tatau pepa rangahau. I te pūrongo kēhi methemoglobinemia kua whakarārangitia hei PMID 27099330, i puta te ADHD i te hītori hauora o te tūroro. I karohia te kikorangi metilīni nā te whakapae he hapa G6PD, ā, i whakaūngia taua hapa i muri mai. Ka taea e te pūkaha rapu te kimi i ngā kupu e rua ahakoa kāore he whakamātau maimoatanga i te pepa e hono ana i aua mea.

Ka tuhia e te rārangi tētahi rapunga whāiti i te 12 o Hepetema, 2026, mā ngā kupu “methylene blue”, “methylthioninium” rānei, me “ADHD”, “attention deficit hyperactivity disorder” rānei. I whakahokia mai e PubMed taua pūrongo kēhi; kāore a ClinicalTrials.gov i whakahoki mai i ngā pūkete e ōrite ana. Nā ngā rapunga whānui ake i kitea ai ngā rangahau hinengaro hei horopaki. He arowhai taunakitanga tēnei e whai rā ana, ehara i te taunaki kua kitea ngā rangahau katoa kāore anō kia whakaputaina, kua whakarārangitia rerekētia rānei. Kei te whare pukapuka rangahau te horopaki rangahau whānui ake.

Ka panonihia te pātai ā-mahi e ngā pāhekoheko rongoā

Ka taea e te kikorangi metilīni te aukati i te monoamine oxidase. E whakatūpato ana tōna tapanga mō te rongoā werohanga me whai whakahaunga mō te huinga tohumate serotonin ina whakamahia me ngā rongoā pā-serotonin me ngā opioids. Mō te tangata whai ADHD, he mea nui te rārangi rongoā katoa, tae atu ki ngā maimoatanga mō te mate pōuri, te māharahara rānei e noho tahi ana.

1. Ngā hua amphetamine: ka aukati te tapanga Adderall XR i te whakamahi tahi me ngā aukati MAO, ā, ka whakaingoatia māriretia te kikorangi metilīni ka hoatu mā te ia toto. Ko tētahi māharahara kua tohua ko te pikinga mōrearea o te pēhanga toto.
2. Methylphenidate: ka aukati hoki te tapanga Ritalin i te maimoatanga tukutahi me ngā aukati MAO nā te tūraru o te pikinga mōrearea o te pēhanga toto.
3. Atomoxetine: ka whakaingoatia e te tapanga Strattera te kikorangi metilīni ka hoatu mā te ia toto i roto i tana aukatinga mō ngā aukati MAO, ā, ka whakaahuahia ngā tauhohenga ka tino kino pea.

Ehara ēnei tapanga i ngā whakamātau o ia hanganga hua mā te waha e hokona ana ki ngā kiritaki. Kāore hoki e whakaū ana he haumaru tētahi whakakotahitanga mā te waha. Ka kōrero motuhake te whakatūpato a te TGA o Ahitereiria mō ngā hua kikorangi metilīni mā te waha kāore i rēhitatia mō ngā pāhekoheko rongoā mōrearea. Kawea te hua tonu, tōna kukūtanga me te rārangi rongoā katoa ki te kaiwhakahaunga rongoā, ki te kaimātai rongoā rānei, i mua i te whakaaro ki te whakamahi. Kaua e whakamutu i te maimoatanga ADHD kua whakahaungia hei whakahaere i tāu ake whakamātau kikorangi metilīni.

Ki te whai mai te kirikā, te tino pōkaikaha, te rangirua rānei, te mārō o ngā uaua, tētahi tauhohenga e tere kino haere ana rānei i muri i te pānga ki taua matū, rapua he tiaki hauora ohotata. Ka whakamārama te tirohanga whānui ki te haumaru i ētahi atu aukatinga me ngā mōhiohio mō te pānga ki taua matū e tika ana kia tuhia.

He aha ngā taunakitanga ka huri i te whakautu?

Ko tētahi rangahau whai take e whai ake nei ka whakamātau i tētahi hanganga hua kua āta tautuhia ki ngā kaiuru kua tautohua he ADHD, ka whakamahi i tētahi mea whakataurite, ka tautuhi i mua i ngā putanga mō ngā tohumate ADHD me te āhei ki te mahi, ā, ka aroturuki i ngā pānga kino mō tētahi wā e whai kiko ana. Me whai taunakitanga motuhake ngā pātai mō ngā pakeke me ngā tamariki. Kāore tētahi whakamārama mō te tikanga mahi o ngā mitochondria e whakakī i aua āputa.

Kei ngā tiaki kua whakaūngia kē ngā ara aromatawai me te aroturuki kua whakaritea, pēnei i ērā o ngā tūtohutanga ADHD a NICE. Ki te kore e pai te whakahaere i ngā tohumate, he take tērā kia arotake anō i taua tiaki me te mātanga haumanu e tiaki ana i a koe. Kāore ngā rangahau i arotakengia i konei e tautoko ana i te whakakapi ki te kikorangi metilīni. Me whai ake ngā kerēme mō ngā āhuatanga whanaketanga e pā tata ana i ō rātou ake arowhai mō te rōpū tāngata me te wawaotanga, pērā i te whakamārama i tā mātou arotake o ngā rangahau mō te kikorangi metilīni me te takiwātanga.