Shuɗin methylene don rage nauyi: nazarin shaidun bincike

Ba a tabbatar da shuɗin methylene a matsayin maganin rage nauyi mai tasiri da ake sha ta baki a mutane ba. Nazarin da aka samu don wannan maƙala ba su ƙunshi gwajin mutane mai rukunin kwatantawa da ya nuna cewa shansa yana haifar da raguwar kitse mai ɗorewa ba. Sun ƙunshi gwaje-gwajen sarrafa kuzari, sakamakon nauyin dabbobi, da nazarin ƙiba a mutane inda sinadarin launin yake da wata rawa dabam.

Waɗannan bambance-bambance suna sauya amsar. Ƙwayar hanta da ke amfani da ƙarin oxygen wani abin lura ne game da hanyar aiki. Alade da nauyinsa ya ƙaru da kaɗan bayan wata hanyar gwaji a ciki yana nuna sakamakon jiyya a dabba. Mutum da ya rasa kitse bayan jiyyar balon ciki yana nuna sakamako a mutum, amma hakan bai ware tasirin sinadarin launin da ke cikin balon ba.

Me zai zama shaida ta rage nauyi?

Nauyin jiki ya haɗa da kitse, sassan jiki marasa kitse, ƙashi, ruwa, da abubuwan da ke cikin ciki da hanji. Ƙarancin lambar da ma'aunin nauyi ya nuna ba ya bayyana wane ɓangare ne ya sauya. Auna abubuwan da jiki ya ƙunsa, kamar aunawa ta shan hasken X mai matakan kuzari biyu (DXA), yana taimakawa wajen rarrabe nauyin kitse daga laushin sassan jiki marasa kitse da ma'adanai na ƙashi. Ko da haka, sassan jiki marasa kitse ba tsokokin da ke haɗe da ƙashi kaɗai ba ne.

Nazarin kula da nauyi mai gamsarwa zai kwatanta takamaiman jiyya a mutane masu halaye makamanta, ya auna sauyi a cikin lokaci mai ma'ana, ya yi la'akari da abinci da sauran matakan jiyya, sannan ya bayar da rahoton illoli da waɗanda suka janye daga binciken. Zai bambanta rage nauyin da ake da shi daga hana ƙarin nauyi, da kuma raguwar farko daga kiyaye wannan raguwar.

Alamomin sarrafa kuzari suna amsa tambayoyi masu taƙaitaccen fanni. Kitsen hanta yana bayyana taruwar kitse a wata gaɓa ta musamman. Jin tasirin insulin yana bayyana yadda jiki ke amsa insulin. Amfani da oxygen a ƙwayoyin halitta yana bayyana wani ɓangare na sarrafa kuzari a ƙarƙashin yanayin gwajin. Babu ɗayansu da zai maye gurbin raguwar kitsen jikin mutum mai ɗorewa da aka auna.

Kwatanta da'awa da nazari

Wannan kwatantawa tana rarrabe sakamakon da aka auna daga da'awar da mai karatu zai iya fahimta daga gare shi. Hanyoyin haɗin nazarin suna kaiwa ga rahotannin asali ko bayanansu a PubMed.

Da'awar da ake tantancewa	Nazari da matakin jiyya	Abin da aka auna ko aka bayar da rahotonsa	Abin da sakamakon ke goyon baya
“Yana kunna sarrafa kuzari, don haka yana ƙona kitsen jiki.”	Shin da abokan aiki, 2014: gwaje-gwajen ƙwayoyin hanta da samfurin ƙananan beraye da aka ciyar da abinci mai kitse da yawa; an haɗa ba da shuɗin methylene ta baki.	Isar da saƙonni masu alaƙa da SIRT1/AMPK, ma'aunan mitochondria, da raguwar taruwar kitsen hanta da kumburin hanta mai alaƙa da kitse a samfurin dabbobin.	Hasashe game da sarrafa kuzari a hanta. Ba ya tabbatar da rage nauyi mai ɗorewa a mutane.
“Wani nazarin ƙiba ya tabbatar da cewa shuɗin methylene yana rage nauyi.”	Lee da abokan aiki, 2022: na'urar cikin ciki da aka lulluɓe da shuɗin methylene tare da jiyyar sinadarin da hasken laser ke kunnawa a aladu.	A mako guda, ƙarin nauyin jiki da aka bayar da rahotonsa ya kasance 12% tare da jiyyar sinadarin da haske ke kunnawa, idan aka kwatanta da 24% a rukunin kwatantawa; matakan ghrelin ma sun yi ƙasa.	Raguwar ƙarin nauyi bayan haɗaɗɗiyar hanyar jiyya a dabbobi. Dukkan sauye-sauyen nauyin da aka bayar da rahotonsu ƙari ne.
“Shuɗin methylene ya rage nauyin jiki ba tare da rage yawan abincin da aka ci ba.”	Yang da abokan aiki, 2023: shuɗin methylene kai tsaye a ɓangaren farko na ƙaramin hanji tare da jiyyar sinadarin da haske ke kunnawa; taƙaitaccen bayanin ya bayyana manyan beraye da aka ciyar da abinci mai kitse da yawa don gwajin tasiri.	Nauyin jiki ya yi ƙasa da na rukunin jiyyar kwaikwayo a kwanaki 30, ma'aunan da suka shafi glucose sun inganta, kuma babu bambanci mai muhimmanci a ƙididdiga wajen yawan abincin da aka ci.	Sakamakon wata hanyar jiyya ta hanji kafin gwajin mutane, ba shaida ta haɗiye shuɗin methylene a matsayin ƙarin abinci ba.
“Nazarin mutane sun auna raguwar kitse tare da shuɗin methylene.”	Nazarin bibiyar rukuni na balon ciki na watanni shida: balon ya ƙunshi ruwan gishiri da shuɗin methylene; mahalarta 39 cikin 50 sun kammala bibiyar.	DXA ya nuna raguwar nauyin kitse da nauyin sassan jiki marasa kitse bayan jiyyar balon.	Sauyin abubuwan da jikin mutum ya ƙunsa bayan jiyya da na'ura. Ba a gwada tasirin sinadarin launin shi kaɗai ba.
“Wani gwajin rage nauyi da aka raba mahalarta bisa bazuwar zaɓi ya haɗa da sinadarin launin.”	Gwajin balon na musayar jiyya da aka kwatanta da jiyyar kwaikwayo: lokutan jiyyar balon da na jiyyar kwaikwayo, tare da tsarin jiyya ta abinci.	Raguwar BMI da kason raguwar nauyin da ya wuce kima.	Shaida game da haɗaɗɗen tsarin jiyyar balon. Rarraba mahalarta bisa bazuwar zaɓi ba ya sa kowane kayan da aka yi amfani da shi a hanyar jiyya ya zama abin da ke haifar da tasirin jiyyar.

Dalilin da hanyar aikin sarrafa kuzari ba ta warware tambayar ba

Nazarin hanta na 2014 mafari ne mai ma'ana ga hasashen ilimin halitta. A ƙwayoyin hanta, shuɗin methylene ya sauya rabon NAD+/NADH da hanyoyin da suka shafi aikin mitochondria da sarrafa kitse. Gwajin ƙananan berayen ya ƙunshi ciyarwa da abinci mai kitse da yawa na makonni takwas, kuma ya gano raguwar taruwar kitse fiye da kima a hanta.

Wannan shaida ce ta gwaji mai amfani game da wani takamaiman sashe na jiki da samfurin cuta. Amma yanke hukunci cewa hakan zai rage kitsen dukkan jiki yana buƙatar ƙarin matakai: dole tasirin ya bayyana a matakin da mutum zai iya jurewa, ya ci gaba yayin cin abinci da ayyukan yau da kullum, ya sauya adadin kuzarin da jiki ke tarawa bayan cire wanda yake amfani da shi, kuma ya samar da sakamakon jiyya mai amfani. Auna matakin farko ba zai tabbatar da na baya ba.

“Ƙarin ATP” ma ba cikakkiyar hujja ba ce ta rage nauyi. ATP wata ƙwayar sinadari ce da ƙwayoyin halitta ke amfani da ita wajen miƙa kuzari. Samar da ita, makamashin da ake buƙata don samar da ita, da jimillar kuzarin da ake kashewa kullum suna da alaƙa amma ma'aunai ne daban-daban. Da'awa game da ingancin aikin mitochondria tana buƙatar aunawa kai tsaye kafin ta zama da'awa game da adadin kalororin da aka kashe ko kitsen da aka rasa.

Bayaninmu na fa'idodin shuɗin methylene a binciken mutane yana amfani da wannan bambanci tsakanin hanyar aiki mai yiwuwa da fa'idar da aka gani a majiyyaci.

Hanyoyin jiyya da haske ke kunnawa wani fannin bincike ne dabam

Jiyyar sinadarin da haske ke kunnawa tana haɗa sinadari mai jin tasirin haske da hasken da aka haska domin samar da tasirin ilimin halitta a wani takamaiman wuri. A nazarin aladu na 2022, an saka shuɗin methylene a cikin na'urar ciki kuma an kunna shi da hasken laser. Matakin jiyyar ya haɗa da na'urar, taɓawar da take yi da sassan jiki, sinadarin launin, da haskakawa. Cire waɗannan abubuwa yana sauya jiyyar da ake magana a kanta.

Rahoton ɓangaren farko na ƙaramin hanji na 2023 ya nazarci jiyya a wani takamaiman wurin hanji kuma ya bayar da rahoton sauye-sauye na ɗan lokaci a ƙananan tsiron bangon wannan ɓangaren hanjin. Taken ya ce “samfurin ƙananan beraye,” yayin da taƙaitaccen bayaninsa ya bayyana manyan beraye da aka ciyar da abinci mai kitse da yawa don gwajin tasiri kan sarrafa kuzari. Wannan bayani a rahoton wani dalili ne na karanta hanyoyin binciken maimakon hasashen gwajin daga take. Waɗannan sakamakon ba za su iya zama hujjar haɗa sinadarin launin da ake sha ta baki da allon jan haske a gida ba.

Aunawar raguwar kitsen mutane tana buƙatar danganta ta da dalilin da ya dace

Nazarin bibiyar rukuni na balon na watanni shida yana bayyana matsaloli biyu daban-daban na fassara. A cikin mahalartan da suka kammala bibiyar, matsakaicin nauyi ya ragu da 11.7 kg. DXA ya rubuta matsakaicin raguwa na 7.53 kg a nauyin kitse da 3.70 kg a nauyin sassan jiki marasa kitse. Saboda haka, sauyin da ma'aunin nauyi ya nuna ba kitse kaɗai ba ne.

Matsala ta biyu ita ce danganta sakamako da dalilinsa. Waɗannan mutane sun sami balon ciki mai ɗauke da ruwan gishiri da aka saka wa launi. Ba a raba su bisa bazuwar zaɓi zuwa masu shan shuɗin methylene ta baki da masu shan maganin kwaikwayo ba. Aunawar abubuwan da jiki ya ƙunsa bayanai ne na gaske daga mutane, amma danganta waɗannan sauye-sauyen da shuɗin methylene zai zama amsa tambayar da nazarin bai gwada ba. Ma'ajiyar bincike tana tsara nazarin bisa matakin jiyya da sakamako domin waɗannan bambance-bambance su kasance a bayyane.

Shin shaidun sun ba da hujjar shansa don rage nauyi?

Shaidun da aka duba a nan ba su tabbatar da wata fa'idar rage nauyi da za a iya auna ta da haɗarin ci gaba da shansa ta baki ba. Alamar tasiri kan sarrafa kuzari a dabba ba za ta iya bayyana adadin da zai yi tasiri a mutum ko tsawon lokacin amfani ba, kuma hanyar jiyya da na'ura ba za ta iya bayyana tsarin shan magani ta baki ba.

Bayanin rubuta maganin Provayblue na jijiya a Amurka ya bayyana methemoglobinemia da aka samu daga baya a matsayin dalilin amfani da shi. Ya yi gargaɗi game da matsanancin ciwon taruwar serotonin idan aka haɗa shi da magungunan da ke shafar serotonin da opioids, kuma ya haramta amfani da shi a masu ƙarancin G6PD saboda haɗarin ƙarancin jini sakamakon lalacewar jajayen ƙwayoyin jini. Waɗannan gargaɗin na asibiti ba tabbatar da amincin kayayyakin da masu saye ke sha ta baki ba ne. Suna nuna dalilin da ya sa amfani don rage nauyi da ba a tabbatar ba har yanzu yake buƙatar kula da ilimin aikin magunguna.

Ga wanda yake tunanin amfani da shuɗin methylene saboda nauyinsa ya sauya bayan fara wani magani, tantance magungunan ya fi amfani fiye da ƙara wani sinadarin gwaji. Duba shaidun illoli, yanayin da ya hana amfani, da hulɗar magunguna tare da ƙwararren ma'aikacin lafiya ko masanin harhaɗa magunguna. Da'awar da ta cancanci a ɗauki mataki a kanta tana buƙatar takamaiman matakin jiyya a mutane, sakamakon kitse ko nauyi da aka auna, da bibiyar da ke nuna ko fa'idar tana ɗorewa.