Shuɗin methylene da autism: tantance binciken

Ba a tabbatar da shuɗin methylene a matsayin maganin autism ba. Majiyoyin da aka duba don wannan maƙala ba su haɗa da gwajin marasa lafiya mai rukunin kwatantawa da ya nuna cewa shuɗin methylene shi kaɗai yana inganta gudanar da ayyukan yau da kullum na masu autism ko sakamakon da suka shafi autism ba. Sun haɗa da gwajin na'urar haske, binciken ɗakin gwaje-gwaje da na lura, da rahoton mutum ɗaya da aka ba magunguna da dama. Waɗannan bayanai suna amsa tambayoyi daban-daban.

Matakin farko mai amfani shi ne karanta sashen takardar binciken da aka ambata wanda ya bayyana abin da aka yi wa mahalarta. Wata wallafa na iya ambaton shuɗin methylene ba tare da an ba wani mahalarci shi ba. Mutum na iya samun shuɗin methylene saboda wata matsalar lafiya dabam ba tare da hakan ya zama binciken maganin autism ba.

Gwajin haske bai gwada shuɗin methylene ba

Binciken 2024 a yara masu shekaru biyu zuwa shida, wanda aka raba su zuwa rukuni bisa bazuwar zaɓi tare da rukunin kwatantawa da aka yi wa abin kwaikwayo, ya gwada photobiomodulation ta cikin ƙoƙon kai: an isar da haske mai kusa da infrared zuwa fatar kai ta amfani da na'urar da ake bincike a kanta. Yara talatin sun shiga shirin na tsawon makonni takwas. Abin da aka yi musu bai haɗa da shuɗin methylene ba.

Masu binciken sun ba da rahoton bambancin maki 7.23 tsakanin rukunonin a sauyin da aka gani a Childhood Autism Rating Scale, da tazarar amincewa ta 95% daga 2.357 zuwa 12.107. Wannan sakamako ne na ma'aunin kimantawa daga ƙaramin gwaji. Bai tabbatar da tasirin shuɗin methylene ba, ko an yi amfani da shi shi kaɗai ko tare da haske. Marubutan sun bayyana iyakokin binciken, ciki har da ƙarancin mahalarta, ficewar mahalarta da maye gurbinsu, da rashin tabbas game da tasirin dogon lokaci.

Me ya sa takardar za ta iya bayyana a tattaunawar shuɗin methylene? Majiyoyin da ta ambata sun haɗa da wata takardar bita game da hanyoyin da wannan rini ke shafar tafiyar sinadarai a tsarin jijiyoyi. Majiyar da aka ambata tana tallafa wa bayanin tushe; ba ta canza abin da aka ba mahalarta ba. Bambancin photobiomodulation da halayen sinadaran shuɗin methylene a ƙarƙashin haske yana da muhimmanci duk lokacin da wata hanyar haɗaka ta dogara da sakamako daga binciken haske kaɗai.

Teburin bibiyar ikirari zuwa bincike

Yi amfani da wannan tebur don kwatanta ikirari da bayanin binciken da za a iya ambata don tallafa masa. “An wallafa” yana nuna cewa binciken yana samuwa, ba hujjar tasirinsa ba.

Ikirarin da ake tantancewa	Ainihin abin da aka yi ko aka auna	Mahalarta ko samfurin gwaji	Sakamakon da aka ruwaito	Matsayin wallafa da fassarar sakamako
“Gwajin autism yana tallafa wa shuɗin methylene.”	Haske mai kusa da infrared idan aka kwatanta da abin kwaikwayo; babu shuɗin methylene	Yara 30 masu shekaru 2–6	Sauyi a ma'aunin kimanta autism; ma'aunan EEG na binciken farko	An wallafa gwajin na'urar haske a 2024; ba zai iya tabbatar da tasirin magani ba
“Shuɗin methylene yana yaƙi da alamomin autism da ke da alaƙa da endotoxin.”	An yi allurar shuɗin methylene kafin gwajin fallasa wa LPS ko gwajin ɗabi'a	Beraye maza a samfurin gwajin baƙin ciki mai tsanani	Yawancin matsalolin ɗabi'a da aka haddasa sun ragu; an tantance heme oxygenase-1 a ruwan jini	An wallafa gwajin dabbobi a intanet a 2018 kuma a fitowar mujalla ta 2019; babu sakamakon marasa lafiya masu autism
“Endotoxin shi ne sanadin autism.”	Auna endotoxin da alamomin garkuwar jiki a ruwan jini; babu magani	Manya 22 da aka bayyana suna da autism mai tsanani; mahalarta 28 na rukunin kwatantawa da aka daidaita da su	Yawan endotoxin ya fi girma, kuma an ga alaƙa da ma'aunan mu'amalar zamantakewa	An wallafa binciken lura a 2010; bai tabbatar da sanadi ko amfanin magani ba
“Abubuwan da aka gano game da mitochondria sun tabbatar da dalilin amfani da shuɗin methylene a matsayin magani.”	Ma'aunan mitochondria na ƙwayoyin jini; babu maganin shuɗin methylene	Yara 10 masu autism masu shekaru 2–5 da mahalarta 10 na rukunin kwatantawa	Bambance-bambance a aikin mitochondria da ma'aunan DNA	An wallafa binciken farko a 2010; babu ma'aunin sakamakon ingancin magani
“Rahoton mutum ɗaya ya tabbatar cewa shuɗin methylene yana aiki.”	Shirye-shiryen magungunan yaƙi da ƙananan halittu da ake sauyawa, ciki har da shuɗin methylene, tare da hanyoyin tallafi	Matashi ɗaya da aka gano yana da matsalolin lafiya da dama	Sauye-sauyen alamomi da iyaye suka rubuta da ingantuwar kimantawar ilimi	An wallafa rahoton mutum ɗaya a 2023; ba zai iya ware gudummawar shuɗin methylene ba
“An sanar da bincike, don haka an nuna amfaninsa.”	Dole a duba abin da aka shirya yi a cikin ainihin tsarin binciken	Sharuɗɗan cancanta suna bayyana waɗanda ake nufin su shiga	Sakamakon da aka shirya auna ba sakamakon da aka gani ba ne	Sanarwa ko rajista kaɗai ba ta ba da bayanan sakamakon marasa lafiya ba

Abin da gwajin endotoxin ya nuna a zahiri

Tattaunawar dandalin da ta haɗa shuɗin methylene, autism, da endotoxin tana nuna yadda ake iya haɗe ikirari da dama. Tushe ce na tambayoyin masu karatu, ba hujjar asibiti ba.

Ɗaya daga cikin takardun da suka dace shi ne gwajin Yin da abokan aikinsa a beraye kan matsalolin ɗabi'a da LPS ya haddasa. An yi amfani da LPS, wato lipopolysaccharide, don haddasa martanin kumburi a samfurin gwajin baƙin ciki mai tsanani. Masu binciken sun ba da shuɗin methylene ta allura a cikin kogon ciki kafin fallasar ko gwajin ɗabi'a. Sun auna ɗabi'a a gwaje-gwajen tilasta iyo da ratayewa da wutsiya, fifita sucrose, gane abubuwa, da wata alama a jini.

Wannan tsarin yana tambayar ko ba da magani kafin fallasa yana canza martani ga lahani da aka haddasa ta gwaji. Ba ya tambayar ko shuɗin methylene da aka sha ta baki yana taimaka wa babba mai autism da gajiya, yana rage alamomin ciki da hanji na yara, ko yana canza autism. Haka kuma ba ya gwada tsarin abinci “marar endotoxin” ko tabbatar da cewa rinin yana kawar da ƙwayoyin bakteriya na hanji masu samar da endotoxin.

Alaƙar da aka gani a mutane wani sakamako ne dabam. Emanuele da abokan aikinsa sun auna endotoxin a manya 22 masu autism da mahalarta 28 na rukunin kwatantawa, inda suka gano matakai mafi girma a rukunin masu autism da alaƙa da ma'aunan mu'amalar zamantakewa. Ba a gwada wani maganin rage endotoxin ba. Bambanci tsakanin rukuni bai warware tambayoyin wane abu ne ke haifar da wane ba, da sauran abubuwan da ke da tasiri, da ko sauya wannan ma'auni zai taimaka wa kowa. Bincike kan shuɗin methylene da tarin ƙananan halittun hanji yana buƙatar irin wannan bambantawa tsakanin ma'aunan halittu da amfanin da marasa lafiya ke samu.

Hasashen mitochondria da rahoton mutum ɗaya da aka ba magunguna da dama

Mitochondria suna shiga samar da kuzari a ƙwayoyin jiki. Wannan yana sa su zama abin bincike mai ma'ana, amma abin bincike mai ma'ana ba dalili ne da aka tabbatar na amfani da magani ba. A binciken farko na Giulivi da abokan aikinsa, masu binciken sun kwatanta mitochondria na ƙwayoyin lymphocyte daga yara 10 masu autism da na mahalarta 10 na rukunin kwatantawa. Sun gano bambance-bambance a ma'aunan aiki da dama da na DNA na mitochondria. Ba su ba da shuɗin methylene ba ko tabbatar da lahani guda ɗaya a mitochondria da duk masu autism suke da shi.

Wani nau'in hujja dabam ya fito daga rahoton 2023 na matashi ɗaya da ya samu magungunan yaƙi da ƙananan halittu. Shuɗin methylene yana ɗaya daga cikin abubuwa da dama da aka shigar cikin shirye-shiryen magani da ake sauyawa saboda zargin cututtukan da halittu masu ɗaukar cuta ke yaɗawa. Marubutan sun bayyana ingantuwa a alamomin da iyaye suka rubuta da kimantawar ilimi. Babu rukunin kwatantawa da ba a ba magani ba, kuma an sauya hanyoyin da dama a tsawon lokaci. Rahoton ba zai iya nuna mana abin da zai faru ba tare da magani ba ko wane ɓangare ne ya ba da gudummawa. Bai tabbatar da kamuwa da cuta a matsayin bayanin autism gaba ɗaya ba.

Ƙayyade sakamakon da ake nema kafin la'akari da magani

Mutum mai autism da ke neman sauƙi daga gajiya, rashin barci, ciwo, damuwa, ko alamomin ciki da hanji ya cancanci a tantance wannan takamaiman matsalar. Ingantuwar barci na iya zama mai muhimmanci sosai ba tare da nuna sauyi a autism kansa ba. A ɗaya ɓangaren kuma, sauyin ƙimar gwajin ɗakin gwaje-gwaje na iya zama ba shi da wani tasiri da za a lura da shi a rayuwar mutum.

Ga kowane sabon ikirari, rubuta sakamakon da ake nema, wanda ya auna shi, abin da aka yi kwatantawa da shi, da tsawon lokacin da ingantuwar ta ɗauka. Bambanta burin mutum kansa da ingancin rayuwarsa daga ra'ayin wani mai lura cewa ɗabi'arsa ta fi kama da ta mafi yawan mutane. Tantance tsarin amfani da shuɗin methylene na intanet kuma yana nufin tabbatar da cewa an yi bincike a kan cikakken haɗin abubuwan da ke cikinsa.

Sanarwa tana bayyana binciken da ake niyyar yi. Bayanin rajista na iya bayyana shirin ɗaukar mahalarta da sakamakon da ake shirin aunawa. Babu ɗayansu da zai maye gurbin sakamakon da ke nuna mutane nawa aka ba magani, abin da ya faru a kowane rukuni, da abubuwan cutarwa da suka faru. Ko binciken da aka yi wa alamar an kammala na iya rasa sakamakon da aka bayyana ga jama'a.

Bayanin rubuta magani na yanzu a Amurka don ProvayBlue da ake ba ta cikin jijiya ya shafi methemoglobinemia da aka samu bayan haihuwa, ciki har da amfani da shi ga yara. Bai samar da tsarin magani don autism ba. Yana gargaɗi game da mummunar matsalar serotonin idan aka haɗa shi da magungunan da ke shafar serotonin da opioids, kuma ya hana amfani da shi ga masu ƙarancin G6PD saboda haɗarin anemia sakamakon rushewar jajayen ƙwayoyin jini. Waɗannan batutuwa suna buƙatar tantance magunguna da tarihin lafiya, ba lissafin adadin magani a intanet ba.

Kada a rage tsarin amfani na babba don walwala domin a ba yaro. Hujjoji game da shuɗin methylene a yara dole ne su dace da matsalar da aka gano, nau'in haɗin maganin, hanyar ba da shi, da rukunin shekaru. Binciken da aka bibiyi a nan bai tabbatar da adadin maganin autism na musamman ga yara ko maganin shuɗin methylene don gajiyar da ke faruwa tare da autism ba.