Ukusebenzisana kwe-Methylene Blue namayeza kunye nesifo se-Serotonin

I-methylene blue inokubangela ukusebenzisana okuyingozi namayeza achaphazela i-serotonin. Ulwazi lokumisela i-PROVAYBLUE efakwa emthanjeni lunesilumkiso esibiyelwe ngebhokisi esiphathelele isifo se-serotonin esinokubulala xa isetyenziswa namayeza achaphazela i-serotonin kunye nee-opioid. Imveliso ethathwa ngomlomo ayikhululekanga ngokuzenzekelayo kuloo nkxalabo.

Ngaphambi kokongeza i-methylene blue, cela usokhemesti okanye umntu omisela amayeza ahlole uluhlu olupheleleyo lwamayeza, kuquka amayeza athathwa ngamaxesha athile, iimveliso zokukhohlela, izongezelelo, kunye nohlobo lwemveliso ye-methylene blue oceba ukuyisebenzisa. Musa ukuyeka iyeza osele ulisebenzisa ukuze uqalise yona. Umbuzo oluncedo kukuba loo mxube uthile ufanelekile na kuloo mntu, kungekhona ukuba umntu othile kwi-intanethi ukhe wawuzama na.

Kutheni idayi isebenzisana namayeza oxinzelelo lwengqondo

I-serotonin sisithunywa semichiza. Iziphumo zayo zixhomekeke ngokuyinxenye kwisantya iiseli eziyifunxa kwakhona nezziyicubungula ngaso. Amayeza athintela ngokukhethekileyo ukufunxwa kwakhona kwe-serotonin, okanye ii-SSRI, anciphisa ukufunxwa kwayo kwakhona. I-monoamine oxidase A, efinyezwa ngokuthi MAO-A, yi-enzayim ebandakanyekayo ekuchithweni kwe-serotonin. Ukuthintela zombini ezi nkqubo kunokubangela umsebenzi ogqithisileyo we-serotonin.

Kuphando lwee-enzayim luka-Ramsay, u-Dunford, no-Gillman lwango-2007, i-methylene blue yayithintela ngamandla i-MAO-A yomntu ecociweyo. Isilinganiso esisisigxina sokuthintela esixeliweyo sasimalunga ne-27 nanomolar. I-MAO-B yayifuna amaxinaniso aphezulu kakhulu. Olu yayiluvavanyo lwaselebhu, hayi ulingo olumisela umthamo owamkelekileyo othathwa ngomlomo okanye olulinganisa amathuba okusebenzisana kwamayeza.

Ukuthintela kwakunokubuyiselwa umva. Oko kuchaza ukusebenzisana ne-enzayim; akuthethi ukuba impendulo engathandekiyo iya kuba buthathaka okanye ikhuseleke ukuba ilawulwe ekhaya. Okufunyenwe elebhu kuchaza indlela esebenza ngayo ebangela iingxelo zekliniki, kodwa akuniki mda wokhuseleko womntu ngamnye.

Itheyibhile yokusebenzisana: udidi, indlela yokungenisa emzimbeni, nobungqina

Itheyibhile yahlula isilumkiso seklinikhi kwindlela enokwenzeka yokusebenza nakukungabikho kobungqina obuthe ngqo obaneleyo. Imizekelo ayiquki onke amayeza akudidi ngalunye. Ikholam yendlela yokungenisa emzimbeni ibhekisa kwi-methylene blue, ngaphandle kokuba kuchazwe enye indlela.

Udidi lwamayeza okanye umbuzo	Ubungqina obungqamene nendlela yokungenisa emzimbeni	Intsingiselo yoko kufunyenweyo
Amayeza oxinzelelo lwengqondo achaphazela i-serotonin: ii-SSRI, ii-SNRI, ne-clomipramine	Ileyibhile ye-IV ilumkisa ngokuwasebenzisa kunye. Iingxelo zekliniki ezipapashiweyo ziquka ukufakwa emzimbeni ngaphandle kokudlula kwinkqubo yokwetyisa; ikwakhona nengxelo yemeko yemveliso exutyiweyo ethathwa ngomlomo.	Le yinkxalabo eqinisekisiweyo yokusebenzisana okuyingozi, hayi nje umbuzo wethiyori wokuba ayahambelana na.
Amayeza athintela i-MAO, kuquka ii-MAOI ezisetyenziswa kunyango lwengqondo ne-linezolid	Ileyibhile ye-IV iwabiza la mayeza phakathi kwemixube ekufuneka iphetshwe.	I-methylene blue yongeza ukuthintelwa kwe-MAO; injongo eqhelekileyo yeyeza ayibonisi yonke imingcipheko yalo yokusebenzisana namanye.
I-bupropion, kuquka i-Wellbutrin	Ileyibhile ye-bupropion ijongana ngokukhethekileyo ne-methylene blue ye-IV kunye neempendulo zokunyuka koxinzelelo lwegazi.	Ukungabi kudidi lwee-SSRI akubonisi ukuba amayeza ayahambelana.
Izivuseleli ze-amphetamine, kuquka i-Adderall XR	Iileyibhile zangoku ze-amphetamine ziquka i-methylene blue ye-IV kuthintelo lokusetyenziswa kunye nee-MAOI ngenxa yomngcipheko wokunyuka koxinzelelo lwegazi okuyingozi kakhulu.	Ityhefu echaphazela intliziyo nemithambo yegazi ibalulekile kunye netyhefu ye-serotonin. Loo magama abhekisa kwi-IV awaqinisekisi ukuba ukusetyenziswa kunye ngomlomo kukhuselekile.
Ii-opioid, kuquka i-buprenorphine/naloxone okanye i-Suboxone	Ileyibhile ye-SUBOXONE ichonga i-methylene blue ye-IV phakathi kwamayeza achaphazela i-serotonin asebenzisana nayo, kwaye ixoxa ngetyhefu yee-opioid enxulumene nee-MAOI.	Iyeza elivuselela ngokuyinxenye ii-receptor zee-opioid lisafuna uhlolo lokusebenzisana namanye. Esi silumkiso asithethi ukuba zonke ii-opioid zinomngcipheko ofanayo.
Amanye amayeza achaphazela i-serotonin, kuquka i-buspirone ne-dextromethorphan	Ileyibhile ye-methylene blue ye-IV iwabiza ngokuthe ngqo la mayeza.	Iyeza lexhala okanye isithako seyeza lokukhohlela elingadingi myalelo kagqirha sinokubaluleka njengeyeza loxinzelelo lwengqondo.
I-gabapentin nemibuzo enxulumene namayeza okuthintela ukuxhuzula	Iforam ichaza iimpawu emva kokusetyenziswa kunye. Olu ayilophando lweklinikhi oluqinisekisiweyo lokusebenzisana olungqamene nendlela yokungenisa emzimbeni.	Impendulo exeliweyo ifanelwe luhlolo; ayingqini ukuba i-gabapentin yabangela isifo se-serotonin.
Amayeza athintela i-PDE5, kuquka i-sildenafil okanye i-Viagra	Okufunyenwe kuvavanyo lwendlela ye-nitric oxide kunika umxholo wendlela yokusebenza, hayi ulingo lokhuseleko lomxube othathwa ngomlomo ngabantu.	Indlela yokusebenza iyodwa ayiqinisekisi utshintsho oluqikelelweyo kwisiphumo okanye ibango lokuhambelana.
I-ivermectin neminye imixube engaphandwanga ngokwaneleyo	Akukho phando olulawulwayo lokusebenzisana kubantu lufunyenweyo kwimithombo ehlolwe kweli nqaku.	Lo mxube awukaqondwa ngokwaneleyo. Ukungafumani nto xa kukhangelwa ukusebenzisana akubobungqina bokhuseleko.

Icandelo lokusebenzisana kwileyibhile ye-IV likwabiza i-mirtazapine ne-bupropion. Uluhlu olujonga kuphela amayeza anamagama ebrendi aqhelekileyo amayeza oxinzelelo lwengqondo luya kuphoswa ngamayeza abalulekileyo.

Yintoni etshintshayo xa i-methylene blue iginywa?

Indlela yokungenisa emzimbeni itshintsha indlela umzimba ochanabeka ngayo, ngoko ingxelo ye-IV ayinakunikeza uqikelelo lwamanani lomngcipheko wesisombululo esithathwa ngomlomo. Nesigqibo esijonge kwelinye icala asisebenzi: iingxelo ezimbalwa zokusetyenziswa ngomlomo aziqinisekisi ukuba umxube othathwa ngomlomo ukhuselekile.

Ingxelo ka-Zuschlag noogxa bakhe yango-2018 ichaza isifo se-serotonin esasikrokrelwa emva kokuqaliswa kweyeza lentlungu yendlela yomchamo elithathwa ngomlomo neliqulethe i-methylene blue kumntu owayethatha amayeza aliqela achaphazela i-serotonin. Uphononongo oluhamba naloo ngxelo lwachonga iimeko ezingama-50 zangaphambili ezaziquka i-methylene blue efakwe emzimbeni ngaphandle kokudlula kwinkqubo yokwetyisa kunye namayeza oxinzelelo lwengqondo achaphazela i-serotonin awayesetyenziswa ngaxeshanye.

Loo mahluko uluncedo. Imeko yokusetyenziswa ngomlomo yayiquka iyeza elinezithako ezixutyiweyo, hayi uvavanyo olulawulwayo lwesisombululo somthengi esinesithako esinye. Ayinakusixelela ukuba ibhotile ethile ibangela ukusebenzisana kangaphi. Noko ke, iyaphikisana nebango lokuba ukuginya i-methylene blue kwenza ityhefu ye-serotonin ingenzeki. Iingxelo zeemeko zichonga iingozi; ngaphandle kwenani kunye neempawu zabo bonke abachanabekileyo, azilinganisi ukuba iimeko zenzeka kangaphi.

I-Wellbutrin, izivuseleli, ne-Suboxone zifuna ukuqwalaselwa ngokwahlukeneyo

I-Wellbutrin yi-bupropion, ayiyo-SSRI. Ulwazi lwayo lokumisela luchonga umngcipheko wempendulo yokunyuka koxinzelelo lwegazi xa isetyenziswa ne-methylene blue ye-IV. Ngoko ke, ukuthi “ayisebenzi ikakhulu nge-serotonin” akuyompendulo yaneleyo kumbuzo wokusebenzisa la mayeza kunye.

Kwizivuseleli, ileyibhile ye-ADDERALL XR iquka ngokucacileyo i-methylene blue ye-IV kuthintelo lwayo lokusetyenziswa kunye nee-MAOI. Impendulo enkulu yoxinzelelo lwegazi yinkxalabo eyahlukileyo kwindlela yokusebenza kwe-serotonin echazwe ngasentla. Amayeza ezivuseleli ahlukeneyo asafuna ukuhlolwa ngalinye.

I-Suboxone iqulethe i-buprenorphine ne-naloxone. Itheyibhile yayo yokusebenzisana ichaza isifo se-serotonin kunye netyhefu yee-opioid enxulumene nee-MAOI, kuquka ukucinezeleka kokuphefumla okanye ikhoma. Ubukho be-naloxone abuqinisekisi ngokubanzi ukuba akukho mngcipheko wokusebenzisana. Abantu abafumana unyango lokuphazamiseka kokusebenzisa ii-opioid bafanele babandakanye iqela labo lonyango ngaphambi kokongeza i-methylene blue.

I-gabapentin: ingxelo yempendulo ayikokuxilongwa

Umbuzo okwiforam ye-Phoenix Rising malunga ne-gabapentin ne-methylene blue uchaza ukudideka nokuvuseleleka ngokugqithisileyo kwezivamvo. Umbhali wayezibuza ukuba isifo se-serotonin sasibangela oko na. Lo mbuzo awunakuphendulwa ngeso sithuba: asiquki uhlolo lweklinikhi okanye inkcazelo eqinisekisiweyo yeempawu.

Indlela i-gabapentin esebenza ngayo emzimbeni yahlukile kweye-SSRI. Ileyibhile yayo ichaza ukunamathela kwinxalenye ye-alpha-2-delta yemijelo ye-calcium evulwa ngamandla ombane, ngoxa ivuma ukungaqiniseki ngendlela kanye esebenza ngayo kunyango. Lo mahluko uthintela ukuyibeka kudidi olungachanekanga; awungqini ukuba ukongeza i-methylene blue akunabungozi. Musa ukuphinda unyango lokuhlangula olucetyiswe kwiforam ukuze uvavanye ukuba yintoni eyabangela impendulo.

I-sildenafil ne-ivermectin: iindlela zokusebenza azigqibi ngombuzo wokuhambelana

I-sildenafil ixhasa indlela ye-nitric oxide/cyclic GMP ngokuthintela i-PDE5. Ingxoxo yenzululwazi ye-EMA nge-Viagra ichaza le ndlela kunye nokusetyenziswa kwe-methylene blue kuvavanyo. Kuvavanyo lwemithambo eyahluliweyo nolwee-enzayim ezicociweyo, i-methylene blue yaphazamisa ukuthunyelwa kwemiqondiso ye-nitric oxide, ineziphumo ezahlukeneyo kwiindawo ezijoliswe kuzo nakumaxinaniso ahlukeneyo.

Oku kuqatshelweyo kwenza amabango malunga notshintsho olunokwenzeka kwisiphumo se-sildenafil aqondakale ngokwebhayoloji. Akuqinisekisi isiphumo esinokuqikelelwa ebantwini, umxube okhuselekileyo, okanye indlela yokulinganisa iyeza elinye nelinye. Imibuzo yamayeza athintela i-PDE5 ikwicandelo lendlela amayeza achaphazela ngayo intliziyo nemithambo yegazi, ayiweli ngokuzenzekelayo kudidi olunye lobungqina njengokusebenzisana ne-SSRI.

Kwi-ivermectin, ukungabikho kophando olulawulwayo lokusebenzisana kwimathiriyeli efunyenweyo kushiya umsantsa kubungqina. Amaphepha ophando lwaselebhu akhankanya zombini ezi khompawundi asenokuba ayazithelekisa okanye asebenzisa enye njengesilinganiso sokuthelekisa kuvavanyo. Oko akulolingelo lwabantu abazithatha kunye. Ngokufanayo, iingxoxo ezingekho sikweni ngamava aziniki imbali yamayeza kunye nolandelelo olucwangcisiweyo olufunekayo ukuze kuqinisekiswe ukuba umxube ungamkeleka.

Iimpawu ezifuna uhlolo olungxamisekileyo

Ityhefu ye-serotonin inokuquka indibaniselwano yokuphazamiseka okanye ukudideka, umkhuhlane okanye ukubila kakhulu, ukubetha kwentliziyo ngokukhawuleza, ukungcangcazela, ukuqina kwemisipha, kunye nokuxhuzula kwemisipha okungalawulekiyo. Ezi mpawu zivela kwisilumkiso sesifo se-serotonin esikwileyibhile ye-amphetamine. Aziloluhlu lokuzixilonga ekhaya.

Emva kokuchanabeka okukrokrelwa ukuba kubandakanya amayeza asebenzisanayo, iimpawu ezintsha zifuna ingcebiso yonyango ngokukhawuleza. Ukudideka kakhulu, umkhuhlane ophezulu, ukuxhuzula, ukuwa, okanye ubunzima bokuphefumla kufuna unyango olungxamisekileyo ngoko nangoko. Nika ipakethe yemveliso, uluhlu lwamayeza, indlela yokuwangenisa emzimbeni, isixa, kunye nexesha; musa ukuthatha enye i-methylene blue ngoxa ufuna ingcebiso.

Xa uceba ukuhlolwa kwamayeza, sebenzisa imibuzo yokubuza ingcali yezonyango nge-methylene blue. Isikhokelo esibanzi sokhuseleko lwe-methylene blue sichaza imingcipheko engaphaya kokusebenzisana, kuquka umba owahlukileyo wokunqongophala kwe-G6PD nokutshatyalaliswa kweeseli ezibomvu zegazi. Uhlolo olupheleleyo lufuna uluhlu lwamayeza kunye nembali yempilo yomntu echaphazelekayo.