Maqaal
Methylene blue ma ka saartaa biraha culus ama ma u shaqaysaa sidii sun-saarid?
Methylene blue ma aha daaweyn la xaqiijiyey oo biraha culus jirka lagaga saaro. Ilaha caafimaad iyo cilmi-baarista loo eegay maqaalkan lagama helin caddayn bini'aadam oo muujinaysa inay si macno leh u kordhiso ka saarista lead, mercury, cadmium, ama arsenic isla markaana wanaajiso natiijooyinka sumowga. Tani waa xaddidaad ku jirta caddaynta la helay, mana aha caddayn ah in dhammaan isdhexgallada kiimikaad ee suurtagalka ahi meesha ka baxeen.
Saddex hadal oo kala duwan ayaa inta badan lagu soo koobaa erayga “sun-saarid”: badeecaddu waxay leedahay wasakh yar, walaxdu waxay beddeshaa jawaabaha unugyada ee culayska, iyo daaweyntu waxay qofka ka saartaa walax sun ah. Caddaynta midkood ma xaqiijinayso kuwa kale.
Badeecad nadiif ahi waa natiijo tayo
Guddi baaritaan biraha culus ah wuxuu baaraa muunadda badeecadda ee la gudbiyey. Waxa laga yaabaa inuu soo sheego qaddarka lead, mercury, cadmium, iyo arsenic, iyadoo ay la socdaan unugyada cabbirka, hababka, iyo xuduudaha warbixinta. Arsenic waa metalloid, inkastoo inta badan lagu daro guddiyada lagu tilmaamo baaritaanka biraha culus.
Hababka FDA ee falanqaynta curiyeyaasha waxay muujinayaan hawsha falanqaynta: in curiyeyaal gaar ah lagu cabbiro walax si cad loo qeexay iyadoo la adeegsanayo habraacyo la ansixiyey. Natiijo ka hooseysa xadka warbixinta waxay ka dhigan tahay in shaybaarku aanu xaaladahaas ku soo sheegi karin qaddar ka sarreeya xadkaas. Taas macnaheedu ma aha in curiyuhu xisaab ahaan gebi ahaan maqan yahay.
Marka laga hadlayo methylene blue, tani waxay ka jawaabaysaa in muunadda la baaray ay keento wasakh la cabbiray iyo in kale. Waxba kama sheegayso ka saarista wasakh hore ugu jirtay jirka. Shahaado muujinaysa lead hoose ma xaqiijin karto awoodda chelation-ka lead, si la mid ah sida baaritaanka biyuhu aanu u caddayn sida dawo u shaqayso.
Hagahayaga ku saabsan biraha culus, Azure B, iyo wasakhooyinka kale ee methylene blue wuxuu sharxayaa sababta guddi curiyeedku sidoo kale uga jawaabi waayo su'aalaha kale ee tayada. Aqoonsiga badeecadda, wasakhooyinka la xiriira dheeha, iyo wasakhooyinka curiyeyaashu waxay u baahan yihiin caddayn falanqayn oo kala duwan.
Maxay ka saarista biruhu dhab ahaan u baahan tahay?
Chelation-ku wuxuu ku lug leeyahay kiimiko ku xirmaysa ion bir ah. Daaweynta caafimaadka, su'aasha faa'iidada leh waa in isdhexgalkaasi ka caawiyo jirka inuu saaro birta khuseysa iyadoo khataruhu yihiin kuwo la aqbali karo. Ku-xirasho ka dhacda tuubo shaybaar oo keliya ma xaqiijin karto in walaxdu gaadho nudaha saxda ah, birta sii haysato inta lagu jiro gaadiidka, ama keento faa'iido caafimaad.
Sharaxaadda FDA ee chelation-ka caafimaad waxay kala saartaa daaweynta rijeetada ee kormeerka leh iyo badeecooyinka aan la ansixin ee loo suuq-geeyo sun-saarid guriga lagu sameeyo. Waxay sheegaysaa in aanu jirin wax badeecad chelation ah oo FDA u ansixisay isticmaalka aan rijeetada u baahnayn.
Sheegasho lagu kalsoonaan karo oo ku saabsan in methylene blue ay bir ka saarto waxay u baahan lahayd bir si gaar ah loo magacaabay, soo-gaadhis la aqoonsaday, qaab-dhismeed iyo waddo qaadasho oo la qeexay, kooxo isbarbardhig ku habboon, iyo cabbirro lagu sameeyo waqtiyo kala duwan. Cilmi-baarayaashu waxay u baahan lahaayeen inay kala saaraan ka saarista kordhay iyo dib-u-qaybsanaanta u dhexeysa dhiigga iyo nudaha ama yaraanshaha soo-gaadhista sii socota. Natiijooyinka caafimaadka iyo waxyeellooyinka ayaa muhiim la ah qiyamka shaybaarka.
“Waxay taageertaa dariiqyada sun-saaridda” ma bixiso cabbirradaas maqan. Sidoo kale ma bixiso hab la soo jeediyey oo ku-xirasho la xiriirta sulfur, kaas oo laga soo qaatay qaab-dhismeedka molecule-ka.
Jadwalka sheegashooyinka iyo caddaynta
Isticmaal jadwalkan si aad u garato waxa warbixin dhab ahaan cabbirayso ka hor intaadan aqbalin sheegashada la socota.
| Sheegasho ama indha-indhayn | Caddaynta ka hadlaysa | Waxa aanay keligeed xaqiijin karin |
|---|---|---|
| “Dufcaddani waxay leedahay wasakh biraha culus oo hooseysa” | Natiijooyinka curiyeyaasha ee ku xiran dufcadda, unugyada cabbirka, xuduudaha warbixinta, aqoonsiga muunadda, iyo hab la ansixiyey oo ku habboon | Ka saarista biraha qof; maqnaanshaha dhammaan wasakhooyinka kale |
| “Methylene blue waxay yaraysaa culayska oksaydhaynta” | Cabbirro unug ama xayawaan oo la xakameeyey oo ku saabsan bartilmaameedyo redox gaar ah, iyadoo ay jiraan kontaroollo tijaabo oo ku habboon | Ku-xirashada biraha, kordhinta saarista biraha, ama waxtarka daaweynta ee bini'aadamka |
| “Bir ayaa ku xirmaysa tijaabo shaybaar” | Cabbirro toos ah oo ku-xirasho ah iyadoo lagu jiro xaalado kiimikaad oo la sheegay | Ku-xirasho deggan oo jirka ka dhacda, gaadiid ammaan ah, ama ka saarid |
| “Jirku wuxuu saaraya bir badan” | Cabbirro bir gaar ah oo la ansixiyey oo leh waqtiga ururinta ku habboon, waxyaabo lagu barbar dhigo, iyo fasiraad | In sumow jiray, in culayska guud ee waxyeellada leh ee nuduhu yaraaday, ama in caafimaadku hagaagay |
| “Methylene blue waxay sun-saarid ku samaysaa biraha culus” | Caddayn daaweyn oo bini'aadam ah oo isku xiraysa soo-gaadhista, faragelinta, sida birta jirku ula macaamilo, natiijooyin macno leh, iyo waxyeellooyin | Sheegashadan ballaaran laguma xaqiijin caddaynta loo helay maqaalkan |
| “Kaadidu waxay isu beddeshay buluug ama cagaar” | Caddayn ku saabsan midab uu dheehu sababay | Cabbir ka saarista lead, mercury, arsenic, ama cadmium |
Jadwalku waa qalab lagu akhriyo caddaynta, mana aha habraac baaritaan ama daaweyn.
Saameynta ka-hortagga oksaydhayntu ma cabbirto ka saarista biraha
Methylene blue waxay ka qaybqaadataa kiimikada oxidation-reduction. Sidaas darteed tijaabo ayaa baari karta sida ay u beddesho jawaabta unugga ee dhaawaca iyadoo aan muujin inay meesha ka saarayso sababta dhaawacaas.
Tusaale ahaan, daraasaddii 2009 ee Striatal neuroprotection with methylene blue waxay baaraysay jiir la siiyey sunta mitochondrial-ka rotenone oo si toos ah loogu duray qayb maskaxda ka mid ah, iyadoo methylene blue gudaha meeshaas laga siiyey ama aan laga siin. Cilmi-baarayaashu waxay qiimeeyeen cabbirka dhaawaca, dheef-shiidka oksaydhaynta, culayska oksaydhaynta, iyo dhaq-dhaqaaqa. Ilaalinta la soo sheegay waxay khusaysay dhaawac nudeed oo tijaabo ah. Rotenone ma aha bir culus, taniina ma ahayn tijaabo bini'aadam oo cabbiraysa saarista biraha.
Waxa kale oo jira maqaal 1980 ah oo ku saabsan hawsha enzyme-ka ee jiirarka ku sumoobay lead. Diiwaankiisa PubMed wuxuu tilmaamayaa mawduuca tijaabadaas laakiin ma bixiyo abstract. Diiwaanka keligiis lagama xaqiijin karo saameyn daaweyn, ka saarista biraha, ama talo bini'aadam. Cinwaan ay ku jirto “lead poisoning” ma aha caddayn ku filan sheegasho sun-saarid oo internetka lagu sameeyo.
Kala duwanaanshahan wuxuu khuseeyaa dhammaan caddaynta bini'aadamka ee faa'iidooyinka methylene blue. Maktabadda cilmi-baarista waxay daraasadaha u habaysaa iyadoo lagu salaynayo dadka dhab ahaan la baaray iyo natiijooyinka la cabbiray.
Laba jid-gaaban oo marin-habaabinaya
Marka koowaad, daaweynta methemoglobinemia ma aha chelation biraha ah. Macluumaadka rijeetada ee PROVAYBLUE xididka lagu duro wuxuu sharxayaa doorka methylene blue ee u beddelidda birta hemoglobin-ka xaaladda ferric una beddelidda ferrous. Birtu waxay beddeshaa xaaladdeeda oksaydhaynta iyadoo weli qayb ka ah hemoglobin-ka. Tani ma muujinayso in birta ama biro kale jirka laga saaro.
Marka labaad, daraasadaha deegaanka ee “ka saarista” waxay rogi karaan doorarka uu akhristuhu filayo. Maqaal cinwaankiisu yahay Removal of mercury and methylene blue from aqueous solution wuxuu baaraa walax graphene-oxide ah oo shaqaynaysa sida adsorbent. Mercury iyo methylene blue ayaa ah walxaha biyaha laga saarayo. Methylene blue ma aha daaweynta mercury ka saaraysa bukaan.
Haddii aad ka shakisan tahay soo-gaadhis dhab ah
Ka bilow walaxda, isha, waqtiga, iyo waddada soo-gaadhista. Weelka badeecadda, macluumaadka goobta shaqada, ama warbixin shaybaar oo khuseysa u gee dhakhtar ama adeegga sunta. Doorashada iyo fasiraadda baaritaanku waxay ku xiran yihiin birta laga shakisan yahay iyo duruufaha soo-gaadhista.
Ha qaadan chelator si aad u abuurto baaritaan kaadi oo togan. Mowqifka American College of Medical Toxicology ee baaritaanka kaadida ee la kiciyey wuxuu sharxayaa in chelators-ku kordhin karaan saarista biraha dadka sumaysan iyo kuwa aan sumaysnayn labadaba. Isbarbardhigga natiijooyinkaas iyo xuduudaha tixraaca caadiga ah ee kaadi aan la kicin waxay keeni kartaa ogaansho marin-habaabin ah iyo daaweyn aan loo baahnayn.
Methylene blue sidoo kale waxay leedahay waxyeellooyin iyo xaalado aan lagu habboonayn, oo ay ku jiraan isdhexgallo dawo oo muhiim ah iyo khataro la xiriira yaraanta G6PD. Inaad xanuun dareento ka dib qaadashadeeda ma aha caddayn in biraha la dhaqaajinayo.
Haddii laga shakiyo sumow daran, si degdeg ah ula xiriir adeegga sunta. Tilmaamaha degdegga ah ee Poison Control waxay farayaan in gargaar degdeg ah isla markiiba la raadiyo haddii qofku dhaco, suuxdin yeesho, neefsashadu ku adkaato, ama aan la toosin karin. Gudaha Maraykanka, Poison Control waa 1-800-222-1222 lambarka degdegga ahna waa 911; meelaha kale, isticmaal adeegyada deegaanka. Ha dib u dhigin qiimaynta si aad u tijaabiso hab sun-saarid oo methylene blue ah.