Chinyorwa
Zvakanakira methylene blue: zvinotsigirwa netsvakurudzo muvanhu
Methylene blue ine mashandisirwo ekurapa akaratidzwa, asi izvozvo hazviisimbisi sechinowedzerwa pakudya cheutano hwose. Tsvakurudzo muvanhu inosanganisira miedzo midiki yendangariro nemashandisirwo esimba muuropi, zvidzidzo mumapoka akasarudzwa evarwere, nemigumisiro isingaenderani nezvinowanzotaurwa nezvekuwedzera simba. Mubvunzo unobatsira ndewekuti: inobatsira munhu upi, uye zvinoyerwa nemugumisiro upi?
Mushonga unogona kugadzirisa muitiro wechimwe chirwere usinganatsiridzi hurongwa hwemuviri hwagara huine utano. Kuchinja kunoonekwa pamufananidzo weuropi kunogona kuratidza kuti chinhu chiri kushanda pasina kuratidza kuti munhu ava kufunga zvakajeka. Kuchengeta misiyano iyoyo kunochinja manzwisisirwo ehumbowo.
Ndechipi chakanakira methylene blue chakatosimbiswa?
MuUnited States, ruzivo rwekunyorera varwere ProvayBlue inopinzwa mutsinga runoti inoshandiswa kurapa methemoglobinemia inowanikwa mushure mekuzvarwa muvanhu vakuru nevana. Pachirwere ichi, oxidation inochinja hemoglobin zvokuti haichakwanisi kutakura okisijeni sezvainowanzoita. Methylene blue inobatsira kushandura hemoglobin iyoyo kuti idzokere kuchimiro chinokwanisa kushanda.
Uku kurapa kwakanangana nechirwere chakati, kuine musanganiswa wemushonga, nzira yekuupinza mumuviri, kuonekwa kwechirwere, uye kutariswa kwemurwere zvakanyatsotsanangurwa. Hazvirevi kuti mvura yemushonga inotengeswa kuti inwiwe inowedzera kuendeswa kweokisijeni kana kunatsiridza utano mumunhu asina methemoglobinemia. Musiyano uyu uri pane zvakaratidzwa, kwete pakuti chinhu ichi chine zvachinoita mumuviri here.
Tafura yehumbowo hwechimwe nechimwe chinonzi chinobatsira
Tafura iyi inopatsanura migumisiro kuvarwere kubva pane zvakayerwa mumiedzo. Irondedzero yehumbowo hwakasarudzwa, kwete runyorwa rwekushandiswa kwese kwakarongwa. Zvakawanikwa zvinoratidza kubatsira zvinoshanda pamamiriro echidzidzo akaratidzwa.
| Zvinonzi zvinobatsira | Vanhu vakadzidzwa nemamiriro echidzidzo | Chakayerwa nezvakawanikwa | Chinonyanya kuganhurira humbowo |
|---|---|---|---|
| Kurapa methemoglobinemia inowanikwa mushure mekuzvarwa | Vanhu vakuru nevana vanopiwa mushonga unonyorerwa nachiremba unopinzwa mutsinga | Kudzorerwa kwehemoglobin inokwanisa kushanda ndiko kwakavakirwa kushandiswa kwakatenderwa kwataurwa pamusoro | Kurapa kwakanangana nechirwere chakati, kwete humbowo hwekunatsiridza utano hwose |
| Kunatsiridza ndangariro kana kutarisisa | Muedzo wa2016 wakagovera vanhu mumapoka zvisina kurongwa: vanhu vakuru 26 vane utano; kupiwa mushonga kamwe chete nemuromo kuchienzaniswa nechinotsiva mushonga chisina mushonga chaiwo; kuedzwa awa imwe gare gare | Mashandiro europi ane chokuita nebasa akachinja; mhinduro dzakarurama pakurangarira dzakavandudzika neinenge 7% mukati meboka remethylene blue | Kuenzanisa kuchinja kwekuita nebasa zvichienderana nemushonga nenguva hakuna kusvika pachiyero chinokosha pahuwandu, P = .09; nguva yekupindura pabasa rekutarisisa haina kuvandudzika |
| Kuwedzera simba reuropi | Muedzo wa2023 umo vatori vechikamu vakachinjana kurapwa: vakadzi vasere vane utano; methylene blue yakapinzwa mutsinga pamwero miviri yekuwanikwa kwayo mumuviri, nechinotsiva mushonga chisina mushonga chaiwo pamazuva akasiyana | Kuyerera kweropa muuropi nemashandisirwo eokisijeni akafungidzirwa zvakaderera | Chidzidzo chidiki chemashandiro emuviri enguva pfupi; hausi muedzo weutano hwose wemushonga unopiwa nemuromo uye hausi humbowo hwekukuvadza kana kubatsira pakurapa |
| Kunatsiridza kuora mwoyo kana kufunganya | Muedzo waAlda nevamwe wechirwere chebipolar: vatori vechikamu 37 vaitora lamotrigine; kuchinjana kurapwa kwemwedzi mitanhatu kuchienzanisa mwero mikuru nemidiki yemushonga unopiwa nemuromo | Zviratidzo zvekuora mwoyo nekufunganya zvakanga zvasara zvakaderera; migumisiro pakufunga haina kusvika pachiyero chinokosha pahuwandu | Kurapa kwekuwedzera muboka rakasarudzwa revarwere; mushonga chaiwo wemwero mudiki ndiwo wakashandiswa pakuenzanisa; hazvikwanisi kusimbisa kunatsiridzwa kwemanzwiro kuvanhu vose |
| Kurapa chirwere cheAlzheimer | Muedzo weLMTM wechikamu 3 wa2016: varwere 891 vane chirwere chisina kunyanya kusimba kana chiri pakati nepakati; mwedzi 15 | Ongororo huru dzakagara dzarongwa hadzina kuwana kubatsira pakufunga kana pamabasa ezuva nezuva pamwero mikuru kana ichienzaniswa neboka rekuenzanisa raipiwa mwero mudiki | LMTM musanganiswa wakasiyana wemethylthioninium iri muchimiro chakadzikiswa nechiitiko chemakemikari; migumisiro yayo haigoni kusimbisa madonhwe emethylene blue anotengeswa muzvitoro |
| Kunatsiridza kupora kubva mushock inokonzerwa nesepsis | Muedzo wa2023 wakaitwa panzvimbo imwe: varwere 91 vakaongororwa; kurapa kunopinzwa mutsinga kwakawedzerwa pakuchengetwa kwevarwere vanorwara zvakanyanya kuchienzaniswa nechinotsiva mushonga chisina mushonga chaiwo | Nguva yepakati kusvika pakumiswa kwemishonga inosimudza BP yaiva maawa 69 ichienzaniswa ne94 | Huwandu hwevakafa hwakanga hwakafanana; muedzo wakanga usina ukuru hwakakwana kusimbisa kubatsira pakurarama; kurapa kwakaitwa muchipatara |
| Kunonotsa kuchembera kweganda | Miedzo ya2017 yemasero efibroblast neganda rakavakwazve: masero evanhu akarimwa murabhoritari nemienzaniso yematishu ane mativi matatu | Kuchinja kwaisanganisira kuderera kwekushushikana kwemasero kunokonzerwa neoxidation uye kuwedzera kwemvura neukobvu muganda remuenzaniso | Zvinhu zvakabva mumuviri wemunhu hazvisi muedzo muvanhu; hapana humbowo pano hwokuti kunwa methylene blue kunoderedza kuunyana kweganda |
| Kurebesa upenyu hwevanhu | Ongororo ya2021 yekudzivisa kuchembera inokurukura nzira dzemashandiro, miedzo yemasero, tsvakurudzo mumhuka, netsvakurudzo yekurapa yakasarudzwa | Kugoneka kwemashandiro aya mumuviri nemigumisiro ine chokuita nekuchembera yakaonekwa mumiedzo | Ongororo iyi haisi muedzo weurefu hweupenyu hwevanhu; zvakawanikwa zvinotaurwa hazvisimbisi kuti vanhu vanorarama nguva yakareba |
Chidzidzo chendangariro chinoratidza zvakadii?
Nhamba ye7% inofanira kutaurwa pamwe chete nechainenge ichienzaniswa nacho. Kuvandudzika kuchienzaniswa nemamiriro eboka pacharo pakutanga hakuna kufanana nekuratidzwa kwekubatsira kupfuura chinotsiva mushonga chisina mushonga chaiwo. Kudzokorora basa kunogona kuvandudza kuita nekuti munhu anenge ava kurijaira, ndicho chimwe chikonzero chinoita kuti boka rekuenzanisa rikoshe.
Mumuedzo uri pamusoro, kuenzanisa kwehuwandu kwekuchinja mumapoka hakuna kusvika pachiyero chinowanzoshandiswa kuratidza kukosha kwemugumisiro. Izvozvo hazviratidzi kuti hapana chakaitika. Zvinoita kuti zvakawanikwa pakuita basa zvive humbowo hwekutanga hunoda kusimbiswa. Uyewo kuwedzera kwemashandiro anoonekwa pamifananidzo yeuropi ane chokuita nebasa hakusimbisi kunatsiridzwa kwekutarisisa muupenyu hwezuva nezuva, kuita basa, kana kudzivirirwa pakuderera kwendangariro nekufunga. Ona ongororo yehumbowo hwendangariro nekufunga kuti uwane kuongororwa kunoenderana nemugumisiro mumwe nomumwe.
Methylene blue inowedzera simba here?
“Simba” rinogona kureva kunzwa kusaneta zvakanyanya, kugadzira ATP yakawanda mumasero, kushandisa okisijeni yakawanda, kana kuita maekisesaizi kwenguva yakareba. Izvi zvinhu zvakasiyana zvinoyerwa. Humbowo hwechimwe hahugoni kungoshandiswa panzvimbo pehwechimwe pasina kutsanangura.
Chidzidzo chevakadzi vasere chinonyanya kupa ruzivo nokuti vaongorori vaitarisira kuwedzera kwemashandisirwo esimba muuropi asi vakaona zvakasiyana nazvo. Miedzo yakasiyana mumakonzo yakawanawo kuderera kwekuyerera kweropa nemashandisirwo eglucose mumamiriro akaedzwa. Vanyori vakakurukura migumisiro inoenderana nemwero wemushonga uye mukana wokuti uropi hune utano hunopindura zvakasiyana nehurongwa hwakakanganisika.
Izvi hazviratidzi mumwe mwero wekuwanikwa kwemushonga mumuviri unovandudza simba nenzira yakavimbika. Kupinza mushonga mutsinga nekuupa nemuromo kunoitawo kuti huwandu hunowanikwa mumuviri nekuchinja kwahwo nekufamba kwenguva zvisiyane. Chidzidzo chinotsigira kuyedza nzira yemashandiro zvakananga pane kungofungidzira kuti mashandiro emitochondria anogara achiwedzera. Ongororo yedu yehumbowo hwemitochondria inoongorora musiyano iwoyo zvakadzama.
Nei migumisiro yemumhuka nemumasero isingapedzi mibvunzo yezvinonzi zvinobatsira utano
Miedzo inoitwa vanhu vasati vaedzwa inobatsira kuziva nzira dzemashandiro uye kusarudza zvinofanira kuedzwa muvanhu. Inogona kudzora chaizvo kuwanda kwechinhu chakapoteredza sero, kukonzera kukuvara kwakati mumhuka, kana kuyera kuchinja kwematishu kusingagoni kudzidzwa zviri nyore muvanhu.
Zvakanakira miedzo izvi ndizvowo zvinoganhurira kushandisa migumisiro yayo muvanhu. Kudzivirira sero rakaiswa pasi pekushushikana mumuedzo hakuratidzi kuti munhu mukuru ane utano achanzwa zviri nani. Muenzaniso weganda rakavakwazve haudzokorori kutenderera kweropa kwemunhu, mashandisirwo ezvinhu mumuviri wake, kushandisa kwake mishonga, kana makore aanenge achisangana nechinhu ichi. Chidzidzo cheganda muenzaniso wakajeka: kuti zvinhu zvacho zvakabva muvanhu hazvishanduri zviyero zvematishu emurabhoritari kuva migumisiro yerunako yakaonekwa pakuongorora vanhu.
Saizvozvowo, ongororo ine mashoko okuti “kudzivisa kuchembera” mumusoro wayo inogona kupfupisa miedzo inopa tariro pasina kusimbisa upenyu hwakareba. Patsanura mugumisiro uri kutarisirwa kubva pane wakanyatsoyerwa. Ongororo yehumbowo hwekurarama kwenguva refu nekudzivisa kuchembera inotevera mubvunzo iwoyo mutsvakurudzo dzakasiyana.
Zvakanakira methylene blue zvinosiyana kuvarume nevakadzi here?
Zvidzidzo zviripo hazvisimbisi zvakanakira utano hwose zvakasiyana zvichienderana nokuti munhu murume kana mukadzi. Boka revakadzi chete rakadzidzwa mashandiro emuviri rinotiudza kuti ndiani akapinda muchidzidzo; pasina kuenzanisa nevarume, harigoni kuratidza mhinduro yemuviri yakanangana nevakadzi chete. Zvidzidzo zvinosanganisira varume nevakadzi zvinodawo huwandu hwakakwana hwevanhu uye kuenzanisa kwakagara kwarongwa zvisati zvatsigira zvinotaurwa nezvemigumisiro yakasiyana.
Kuvarume, tsvakurudzo yakaongororwa pano haisimbisi kubatsira patestosterone, pakukwanisa kubereka, kana pakuita zvepabonde. Kuvakadzi, haisimbisi kuderedzwa kwezviratidzo zvekuguma kuenda kumwedzi kana kuenzaniswa kwemahomoni. Kutsvaga kwakanyatsonangana nemiedzo yetestosterone nekuguma kuenda kumwedzi hakuna kuwana humbowo hunogutsa hwekurapa muvanhu hunotsigira zvinotaurwa izvi. Izvi zvinotsanangura humbowo hwakawanikwa, hazvisi humbowo hwokuti migumisiro yose ingangovapo yakatobviswa pamikana.
Pamuviri panoshandura kuongororwa kwenjodzi: mashoko emushonga unonyorerwa nachiremba anoyambira nezvekukuvadza mwana ari mudumbu kungangoitika. Mashoko anongoti “zvakanakira vakadzi” haagoni kubvisa kunetseka ikoko.
Yakakunakira here?
Hapana kubatsira kwakaratidzwa kunoshanda kuvanhu vose kunopindura mubvunzo uyu kumuverengi wese. Mugumisiro unotarisirwa, mamiriro eutano, nzira yekupinza mushonga mumuviri, nemimwe mishonga zvose zvinokosha. Mashoko emushonga unonyorerwa nachiremba anorambidza kushandiswa muvanhu vane kushomeka kweG6PD nokuda kwenjodzi yeanemia inokonzerwa nekuparara kwemasero matsvuku eropa, uye anoyambira nezveserotonin syndrome yakakomba kana uchishandiswa pamwe nemishonga inokanganisa serotonin nemaopioid. Verenga pfupiso yemigumisiro isingadiwi nemamiriro anorambidza kushandiswa pamwe nechero zvinotaurwa nezvekubatsira kwawo.
Usati watora chidzidzo chinoratidza kubatsira sekurudziro yakanangana newe, ziva vanhu vakadzidzwa, chakaenzaniswa, mugumisiro wakayerwa, nenguva yavakateverwa. Bvunza kana mugumisiro wacho une chokuita nezviratidzo kana kugona kuita mabasa ezuva nezuva, kana kuti unongova chiyero chemurabhoritari. Uya nechidzidzo chaicho neruzivo rwechigadzirwa kuhurukuro nachiremba uchishandisa iyi mibvunzo yokubvunza nezvemethylene blue. Usachinja mishonga yawakanyorerwa kuti ugone kutanga chirongwa cheutano chiri kungoedzwa.