Genzura Porotokole ya Methylene Blue yo Kuri Interineti

Tangira n'ikintu kimwe kivugwa, hanyuma ushake inyandiko yatangajwe bivugwa ko igishyigikira. Gahunda irambuye, amagambo ya siyansi, n'urutonde rurerure rw'inkomoko ntibihamya ko hari uwigeze agerageza porotokole yatanzwe.

Porotokole yo kuri interineti akenshi ihuza ibivugwa bitandukanye: methylene blue ihindura uburyo runaka bw'imikorere y'umubiri; iyo mpinduka ituma indwara irushaho kugenda neza; ikindi gikorwa cyongera iyo ngaruka; kandi igicuruzwa runaka kigatanga ibyagaragaye mu bushakashatsi. Buri kimwe muri ibyo kivugwa gikeneye ibimenyetso byacyo. Kwemeza icya mbere ntibyemeza ibindi bitatu.

Ikibazo cy'ingirakamaro ni iki: Ese ubu bushakashatsi bwagerageje iki gikorwa, kuri iri tsinda ry'abantu, kandi bupima inyungu irimo kwizezwa?

Shaka inyandiko iri inyuma y'inkomoko yatanzwe

Koporora umutwe, abanditsi, ikinyamakuru cya siyansi, umwaka, na DOI cyangwa nimero ya PubMed ubishyire mu nyandiko yawe. Fungura iyo nimero ukwazo maze ugereranye buri mwirondoro. Nimero nyayo yashyizwe ku mutwe utari wo ni inkomoko idakwiye, nubwo aho ikujyana haba havuga kuri methylene blue.

Niba nta nimero ihari, shakisha umutwe wose uko wakabaye, hanyuma ushakishe amagambo awutandukanya n'indi mitwe hamwe n'izina ry'umwanditsi. Reba urubuga rw'ikinyamakuru cya siyansi kimwe na PubMed. Kuba gushakisha rimwe kutagize icyo kubona si gihamya ko inyandiko yahimbwe: imitwe ishobora guhinduka, inkomoko zishobora kuba zirimo amakosa, kandi PubMed ntirimo buri nyandiko yose yatangajwe. Andika igisubizo nka ntikiragenzurwa kugeza habonetse inyandiko bihuye.

Ku ncamake yakozwe na AI, koresha uburyo bumwe neza. Saba inkomoko ishobora kongera kuboneka, hanyuma ugenzure inyandiko yatangajwe ukwazo. Kubaza sisitemu imwe niba inkomoko yayo ari yo ntibitanga igenzura ryigenga.

Genzura n'uwanditse urupapuro. Ikiganiro cy'umurwayi kiri ku rubuga rw'ibitaro kiracyari ikiganiro cy'umurwayi keretse niba cyaranditswe cyangwa cyarasuzumwe ku mugaragaro nk'amabwiriza y'ubuvuzi. Imfashanyigisho ya NCCIH yo gusuzuma amakuru y'ubuzima yo kuri interineti itandukanya ibibazo bijyanye n'inkomoko, ukuri, isuzuma ry'impuguke, igihe amakuru yavugururiwe, n'inkunga y'amafaranga. Kuba urubuga rumenyerewe bisubiza igice kimwe gusa cy'iryo suzuma.

Huza igerageza n'icyo risezeranya

Andika muri make ikintu cyakoreshejwe mu bushakashatsi, uko cyateguwe, itsinda ryakoreweho ubushakashatsi, uburyo cyatanzwe, igihe cyamaze, icyo cyagereranyijwe na cyo, n'igisubizo cyapimwe. Ibi ubisome mu nyandiko y'ubushakashatsi ubwayo, aho kubisoma mu nyandiko iyivuga. Imfashanyigisho yo gusoma inyandiko y'ubushakashatsi kuri methylene blue isobanura uburyo bwo gusuzuma imiterere y'ubushakashatsi mu buryo burambuye.

Reka turebe urugero nyarwo. Ubushakashatsi bwa 2016 bwakorewe ku bantu 26 bazima hakoreshejwe uburyo bwo kubagabanya mu matsinda ku buryo bw'amahirwe bwasuzumye amashusho y'ubwonko, ubushobozi bwo gukomeza kwitondera ikintu, n'ububiko bw'amakuru bw'igihe gito mbere no mu isaha imwe nyuma yo gufata methylene blue mu kanwa cyangwa placebo. Bwatangaje impinduka mu bisubizo by'amashusho y'ubwonko no kwiyongera kw'ibisubizo by'ukuri mu gihe cyo kwibuka amakuru.

Ibyo ni ibimenyetso bifitanye isano n'imirimo yapimwe muri ibyo bihe. Ntibihamya kuvura indwara idakira y'ibihaha, inyungu zimara amezi, cyangwa ingaruka zo kongeramo ogisijeni cyangwa urumuri. Ibyo ni ibibazo bitandukanye, nubwo igika cyo kwamamaza cyabihuza gikoresheje amagambo ajyanye na mitochondria.

Nanone, tandukanya icyitegererezo cy'indwara mu nyamaswa n'abarwayi bafite iyo ndwara. Kuba hari ijambo rimwe rikoreshwa mu gusuzuma indwara ntibituma ayo matsinda ashobora gufatwa nk'aho angana. Andika kwimura umwanzuro uwo ari wo wose hagati y'amoko, uburyo bwo gutanga, cyangwa ibisubizo nk'igereranya rirenze ibimenyetso byakoreweho ubushakashatsi, hanyuma ushake ibimenyetso bishyigikira iryo yimurwa.

Ntutandukanye ibipimo n'ingano bipima

Ibipimo bisobanura icyo umubare upima. Milligrams zipima uburemere; milliliters zipima ingano y'amazi; milligrams per milliliter zipima concentration; milligrams per kilogram zipima uburemere bugereranyijwe n'uburemere bw'umubiri. Gukoporora umubare ugakuraho ikigabanya cyawo bihindura icyo usobanura.

Ku rugero rw'imibare rutari urw'ubuvuzi, kuvuga 4 mg/mL ntibisobanura 4 mg hatari ingano y'amazi bijyana. Mu buryo bumwe, 4 micrograms na 4 milligrams bitandukanywa n'inshuro 1,000. Izi ngero zerekana uburyo bwo kugenzura amakosa yo gukoporora, si ingano zo gukoresha.

Ntugerageze gukosora porotokole ikemangwa ubara gahunda nshya yo kuyikoresha. Garagaza aho bidahuye maze usubire ku nkomoko. N'imibare ibazwe neza rwose ntishobora guhamya ko ingano yakoreshejwe ku nyamaswa, concentration yo muri laboratwari, cyangwa formulation iterwa inshinge ikwiye umuntu ukoresha igicuruzwa gifatwa mu kanwa.

Urupapuro rw'imyitozo rwo kugenzura ibyavuzwe

Ibyavuzwe hepfo ni ingero zakozwe nkana zigamije kwigisha, si ibyifuzo nyakuri by'ubuvuzi. Inyandiko ya PubMed ni nyayo; ibivugwa byahimbwe byayometseho si ukuri. Koporora imiterere y'iyi mbonerahamwe igihe ugenzura inyandiko yo kuri interineti.

Ikivugwa cyangwa ikosa ry'urugero	Intambwe yo kugenzura	Icyabonetse n'umwanzuro ushobora gushyigikirwa
Inkomoko yahimbwe: umutwe wahimbwe uvuga gukiza indwara idakira y'ibihaha hakoreshejwe ikomatanywa runaka womekwa kuri PMID 27351678.	Fungura PMID maze ugereranye umutwe, abitabiriye, n'igikorwa cyakoreweho ubushakashatsi.	Iyo nyandiko ni ubushakashatsi bw'amashusho y'ubwonko bwakorewe ku bantu bazima bwasobanuwe haruguru. Nimero ni nyayo, ariko ntabwo yemeza inkomoko yahimbwe cyangwa ibivugwa.
Itsinda ridahuye: igisubizo cyo mu igerageza ry'imbeba gisobanurwa nk'inyungu yamaze kugaragazwa ku barwayi.	Menya ubwoko bw'inyamaswa bwakoreshejwe, hanyuma ushake ubushakashatsi butandukanye bwakorewe ku bantu ku nyungu ivugwa.	Inyandiko y'inyamaswa igaragaza icyakoreweho ubushakashatsi muri icyo cyitegererezo. Ibivugwa ku barwayi bikeneye ibindi bimenyetso.
Ibipimo bidahuye: incamake ikoporora agaciro ka concentration nk'aho ari uburemere.	Andika ingano zombi zose, harimo ibigabanya n'ingano y'amazi bijyana.	Ibyanditswe byombi bisobanura ingano zitandukanye. Incamake ntishobora kwizerwa uko yanditswe.
Icyuho mu ikomatanywa: inyandiko imwe yiga methylene blue, indi nyandiko itandukanye ikiga ikindi gikorwa.	Genzi niba kimwe muri ubwo bushakashatsi kirimo ubuvuzi bukomatanyije bwatanzwe n'icyo bugereranyijwe na cyo gikwiye.	Ubushakashatsi butandukanye ntibugaragaza inyungu z'ikomatanywa, inyungu y'inyongera, cyangwa umutekano waryo.
Gusimbuza igisubizo: impinduka ku kimenyetso cyo muri laboratwari ihinduka isezerano ry'imikorere myiza mu buzima bwa buri munsi.	Shaka endpoint nyayo, uburyo bwo kuyipima, n'igihe cyo gukurikirana.	Igisubizo cy'ikimenyetso gishyigikira gusa ibivugwa kuri icyo kimenyetso. Inyungu ku mikorere isaba igipimo kibijyanye.

Genza ikomatanywa nk'igikorwa cyihariye

Ku bivugwa ko kongeramo B bituma ubuvuzi A burushaho gukora, shaka itsinda ryahawe A hamwe na B ugereranye n'itsinda ryahawe A. Ikomatanywa ryagereranyijwe na placebo gusa rishobora kugaragaza itandukaniro rusange ridashobora kumenya icyo B yongeyeho. Ibivugwa bikomeye kurushaho ko ibintu byombi bikorana bikongerana bisaba imiterere y'ubushakashatsi n'isesengura bishobora gutandukanya imikoranire yabyo n'ingaruka za buri kimwe ukwacyo.

Andika buri gice ukwacyo aho gukoresha izina ry'ipaki. Ku bivugwa kuri ogisijeni n'urumuri, ibi bikubiyemo uburyo nyabwo ogisijeni yatanzwe n'ingano y'urumuri byakoreshejwe mu bushakashatsi. Inyandiko ivuga kuri methylene blue hamwe na hyperbaric oxygen isuzuma iki kibazo cy'ibimenyetso byihariye ku ikomatanywa.

Umutekano na wo ugomba kugenzurwa ukwawo. Amakuru ya PROVAYBLUE yo kwandikirwa imiti ariho ubu arebana n'igicuruzwa gitangwa mu mutsi kigenewe acquired methemoglobinemia. Araburira ku serotonin syndrome ikomeye cyangwa ishobora kwica mu gihe ikoreshanyijwe n'imiti ya serotonergic n'opioids, kandi abuza kuyikoresha ku bafite G6PD deficiency kubera ibyago bya hemolytic anemia. Gahunda yo ku rubuga rw'ibiganiro si isuzuma ry'imikoranire y'imiti. Jyana ibivugwa n'urutonde rw'imiti ukoresha ku muganga cyangwa undi muntu ubifitiye ubumenyi n'ububasha; ntuhindure ubuvuzi wandikiwe kugira ngo buhuze na porotokole yo kuri interineti.

Andika umwanzuro mbere yo gusuzuma ugurisha

Genza niba umwanditsi agurisha icyo gicuruzwa, ahabwa amafaranga yo kohereza abakiriya, cyangwa atanga porogaramu y'ivuriro ivugwa. Amabwiriza ya NCCIH ku matangazo agaragazwa nk'amakuru asobanura impamvu gusa kuba inyandiko isa n'iy'ubwanditsi bitayigira iyo kwizerwa. Inyungu z'ubucuruzi ni amakuru y'ingenzi ajyanye n'aho ibintu bihagaze, ariko si gihamya ihita yerekana ko ibivugwa ari ibinyoma. Inyandiko z'igicuruzwa zigomba gusuzumwa ukwazo mu isuzuma ry'ibimenyetso by'ubuziranenge.

Soza inyandiko yawe n'ibintu bitatu: icyo inkomoko ishyigikira, icyo porotokole yongeraho, n'ibitarasobanuka. Bika ibivugwa by'umwimerere, URL y'inkomoko, n'itariki. Ibi biha muganga cyangwa umushakashatsi itandukaniro ryihariye ryo gusuzuma, aho kumuha porotokole ndende ifite ibitekerezo byafashwe nk'ukuri byihishe mu mabwiriza yayo.