Nkhani
Kodi methylene blue imachotsa zitsulo zolemera kapena imagwira ntchito ngati yoyeretsa thupi?
Methylene blue si chithandizo chokhazikitsidwa chochotsera zitsulo zolemera m'thupi. Magwero azachipatala ndi kafukufuku amene anawunikidwa m'nkhaniyi sanapeze umboni wa anthu wosonyeza kuti imawonjezera kwambiri kuchotsedwa kwa lead, mercury, cadmium, kapena arsenic ndiponso kusintha zotsatira za poizoni. Imeneyi ndi malire a umboni womwe unapezeka, osati umboni wakuti kulumikizana kulikonse komwe kungatheke pakati pa mankhwala kwakanidwa.
Mawu atatu osiyana nthawi zambiri amaphatikizidwa kukhala mawu oti “detox”: mankhwala ali ndi zodetsa zochepa, chinthu chimasintha momwe maselo amayankhira kupsinjika, ndipo chithandizo chimachotsa chinthu cha poizoni mwa munthu. Umboni wa chimodzi sutsimikizira zina.
Mankhwala oyera ndi zotsatira za khalidwe labwino
Kuyesa kwa zitsulo zolemera kumawunika chitsanzo cha mankhwala chomwe chaperekedwa. Kungafotokoze kuchuluka kwa lead, mercury, cadmium, ndi arsenic, limodzi ndi mayunitsi, njira, ndi malire operekera lipoti. Arsenic ndi metalloid, ngakhale nthawi zambiri imaphatikizidwa m'mayeso omwe amatchedwa kuyezetsa zitsulo zolemera.
Njira za FDA zowunikira maelementi zimasonyeza ntchito ya kusanthula imeneyi: kuyeza maelementi enieni m'chinthu chodziwika bwino pogwiritsa ntchito njira zotsimikiziridwa. Zotsatira zomwe zili pansi pa malire operekera lipoti zikutanthauza kuti labotale sinathe kunena kuchuluka kopitirira malirewo pansi pa mikhalidwe imeneyo. Sizikutanthauza kuti elementi imeneyo kulibe kwenikweni mwa masamu.
Kwa methylene blue, izi zimayankha ngati chitsanzo choyezedwacho chimabweretsa chodetsa chomwe chayezedwa. Sizikunena chilichonse chokhudza kuchotsa zodetsa zomwe zili kale m'thupi. Satifiketi yosonyeza lead yochepa siingatsimikizire ntchito yomanga lead kuti ichotsedwe, monganso kuyezetsa madzi sikungatsimikizire momwe mankhwala amagwirira ntchito.
Buku lathu lofotokoza zitsulo zolemera, Azure B, ndi zodetsa zina za methylene blue limafotokoza chifukwa chake kuyezetsa maelementi sikuyankhanso mafunso ena a khalidwe la mankhwala. Kuzindikiritsa mankhwala, zodetsa zokhudzana ndi utoto, ndi zodetsa za maelementi zimafunikira umboni wosiyana wa kusanthula.
Kodi kuchotsa zitsulo kungafune chiyani kwenikweni?
Chelation imaphatikizapo mankhwala omanga ayoni ya chitsulo. Pa chithandizo chamankhwala, funso lofunika ndi ngati kulumikizana kumeneko kumathandiza thupi kuchotsa chitsulo chomwe chikukhudzidwa popanda chiopsezo chosavomerezeka. Kungomanga chitsulo mu chubu choyesera sikungatsimikizire kuti chinthucho chimafika m'malo oyenera m'thupi, chimapitiriza kugwira chitsulo pamene chikuyendetsedwa, kapena chimabweretsa phindu lachipatala.
Kufotokozera kwa FDA za chelation yachipatala kumasiyanitsa chithandizo cha mankhwala operekedwa ndi dokotala omwe amayang'aniridwa ndi zinthu zosavomerezedwa zomwe zimagulitsidwa kuti zigwiritsidwe ntchito pa detox kunyumba. Limanena kuti palibe mankhwala a chelation omwe avomerezedwa ndi FDA kuti agwiritsidwe ntchito popanda mankhwala olembedwa ndi dokotala.
Chonena chodalirika chakuti methylene blue imachotsa zitsulo chingafune kutchula chitsulo chenicheni, kudziwika kwa mmene munthu anakumana nacho, mawonekedwe ndi njira yoperekera mankhwala yomwe yafotokozedwa, magulu oyenerera oyerekezera, ndi miyeso yopangidwa pakapita nthawi. Ofufuza angafunike kusiyanitsa kuwonjezeka kwa kuchotsedwa kwa chitsulo ndi kusamutsidwa kwake pakati pa magazi ndi minofu kapena kuchepa kwa kupitiriza kukumana nacho. Zotsatira pa thanzi ndi zotsatira zosafunika ndizofunikanso pamodzi ndi ziwerengero za labotale.
Mawu oti “imathandiza njira za detox” sapereka miyeso yomwe ikusowayo. Chimodzimodzinso ndi njira yomwe akuganiza kuti imamangirira chifukwa cha sulfur yomwe yatengedwa kuchokera ku kapangidwe ka molekyulu.
Tebulo la zonena ndi umboni
Gwiritsani ntchito tebulo ili kuti muzindikire zomwe lipoti likuyeza kwenikweni musanavomereze chonena chomwe chili nacho.
| Chonena kapena zomwe zawonedwa | Umboni womwe umafotokoza zimenezi | Zomwe sungathe kutsimikizira paokha |
|---|---|---|
| “Batch iyi ili ndi zodetsa zochepa za zitsulo zolemera” | Zotsatira za maelementi zolumikizidwa ndi batch, mayunitsi, malire operekera lipoti, kuzindikiritsa chitsanzo, ndi njira yoyenera yotsimikiziridwa | Kuchotsa zitsulo mwa munthu; kusakhala ndi zodetsa zina zonse |
| “Methylene blue imachepetsa oxidative stress” | Miyeso yoyendetsedwa bwino ya maselo kapena nyama ya zotsatira zenizeni za redox, yokhala ndi zowongolera zoyenera za kuyesa | Kumanga zitsulo, kuwonjezeka kwa kuchotsedwa kwa zitsulo, kapena mphamvu ya chithandizo mwa anthu |
| “Chitsulo chimamangirirana mu kuyesa kwa labotale” | Miyeso yeniyeni ya kumangirirana pansi pa mikhalidwe ya mankhwala yomwe yafotokozedwa | Kumangirirana kokhazikika m'thupi, kuyendetsedwa kotetezeka, kapena kuchotsedwa |
| “Thupi likutulutsa chitsulo chochuluka” | Miyeso yotsimikiziridwa ya chitsulo chenicheni yokhala ndi nthawi yoyenera yosonkhanitsira, zoyerekezera, ndi kutanthauzira | Kuti poizoni analipo, kuti kuchuluka konse koopsa m'minofu kunachepa, kapena kuti thanzi linasintha |
| “Methylene blue imachotsa poizoni wa zitsulo zolemera” | Umboni wa chithandizo cha anthu wolumikiza kukumana ndi chitsulo, chithandizo, mmene chitsulo chimayendera m'thupi, zotsatira zofunika, ndi zoopsa | Chonena chachikulu chimenechi sichinatsimikizidwe ndi umboni womwe unapezeka pa nkhaniyi |
| “Mkodzo wasanduka wabuluu kapena wobiriwira” | Umboni wa mtundu wokhudzana ndi utoto | Muyeso wa kuchotsedwa kwa lead, mercury, arsenic, kapena cadmium |
Tebuloli ndi chithandizo chowerengera umboni, osati njira yoyezera kapena yochizira.
Zotsatira za antioxidant siziyesa kuchotsedwa kwa zitsulo
Methylene blue imatenga nawo mbali mu chemistry ya oxidation-reduction. Choncho, kuyesa kungawunike momwe imasinthira kuyankha kwa selo kuvulala popanda kusonyeza kuti imachotsa chomwe chinayambitsa kuvulalako.
Mwachitsanzo, kafukufuku wa 2009 Striatal neuroprotection with methylene blue unawunika makoswe omwe anapatsidwa poizoni wa mitochondrial rotenone mwachindunji m'dera la ubongo, mwina ndi kapena popanda methylene blue yoperekedwa m'deralo. Ofufuza anayesa kukula kwa chotupa, oxidative metabolism, oxidative stress, ndi khalidwe la kuyenda. Chitetezo chomwe chinanenedwa chinali chokhudza kuvulala kwa minofu mu kuyesa. Rotenone si chitsulo cholemera, ndipo kuyesaku sikunali kafukufuku wa anthu wokhudza kuchotsedwa kwa zitsulo.
Palinso pepala la 1980 lonena za ntchito ya enzyme m'makoswe omwe anali ndi poizoni wa lead. Zolemba zake za PubMed zimatchula mutu wa kuyesako koma sizipereka abstract. Zolemba zokhazo sizingatsimikizire zotsatira za chithandizo, kuchotsedwa kwa chitsulo, kapena malingaliro ogwiritsira ntchito mwa anthu. Mutu wokhala ndi mawu oti “lead poisoning” si umboni wokwanira wa chonena cha detox pa intaneti.
Kusiyanitsa kumeneku kumagwiranso ntchito pa umboni wa anthu wa maubwino a methylene blue. Laibulale ya kafukufuku imakonza maphunziro malinga ndi anthu omwe anayesedwa ndi zotsatira zomwe zinayesedwa.
Njira zazifupi ziwiri zomwe zingasocheretse
Choyamba, kuchiza methemoglobinemia si chelation ya zitsulo. Malangizo operekera PROVAYBLUE kudzera m'mtsempha amafotokoza ntchito ya methylene blue posintha iron ya hemoglobin kuchokera ku ferric kupita ku ferrous state. Iron imasintha oxidation state pamene ikupitiriza kukhala gawo la hemoglobin. Izi sizikusonyeza kuchotsedwa kwa iron kapena zitsulo zina m'thupi.
Chachiwiri, maphunziro a “removal” achilengedwe angasinthe maudindo omwe owerenga amaganiza. Pepala lotchedwa Removal of mercury and methylene blue from aqueous solution limafufuza adsorbent ya graphene-oxide yosinthidwa kuti igwire ntchito inayake. Mercury ndi methylene blue ndi zinthu zomwe zikuchotsedwa m'madzi. Methylene blue si chithandizo chomwe chikuchotsa mercury mwa wodwala.
Ngati mukuganiza kuti munakumana ndi poizoni weniweni
Yambani ndi chinthu chomwe chikukhudzidwa, gwero lake, nthawi, ndi njira yomwe munakumana nacho. Tengani chidebe cha mankhwala, zambiri za kuntchito, kapena lipoti loyenera la labotale kwa dokotala kapena ntchito ya poizoni. Kusankha ndi kutanthauzira kuyezetsa kumadalira chitsulo chomwe chikuganiziridwa ndi mmene munakumana nacho.
Musamwe chelator kuti mupangitse mkodzo kuyesa positive. Malingaliro a American College of Medical Toxicology pa provoked urine testing amafotokoza kuti ma chelator angawonjezere kuchotsedwa kwa zitsulo mwa anthu omwe ali ndi poizoni komanso omwe alibe. Kuyerekezera zotsatira zimenezo ndi malire oyerekezera a mkodzo wosapangitsidwa kungabweretse kuzindikira matenda kolakwika ndi chithandizo chosafunika.
Methylene blue ilinso ndi zotsatira zake zosafunika ndi zoletsa kugwiritsa ntchito, kuphatikizapo kulumikizana kofunika ndi mankhwala ena komanso zoopsa kwa anthu omwe ali ndi G6PD deficiency. Kumva kuti simuli bwino mutamwa si umboni wakuti zitsulo zikuyamba kusunthidwa m'thupi.
Ngati mukuganiza kuti pali poizoni wadzidzidzi, funsani ntchito ya poizoni mwamsanga. Malangizo a Poison Control pa ngozi zadzidzidzi amalangiza kupeza thandizo lachipatala mwamsanga ngati munthu wagwa, ali ndi seizures, akuvutika kupuma, kapena sangathe kudzutsidwa. Ku United States, Poison Control ndi 1-800-222-1222 ndipo nambala ya ngozi ndi 911; m'madera ena, gwiritsani ntchito ntchito zam'deralo. Musachedwetse kuyezetsa kuti muyese njira ya methylene blue detox.