Tuhinga
Te puru metilīni me te nohopuku: he aha tā ngā rangahau kai-whaiaro ā-pūtau e whakaatu ana
Kua rangahautia te puru metilīni i roto i ngā pūtau kua pāngia e te ahotea e hāngai ana ki ngā matūkai. Kāore tēnā e whakaū ana ka pai ake te hauora mā te tango i taua matū i te wā o te nohopuku ā-wā. I roto i ngā pūtake i tirohia mō tēnei tuhinga, kāore mātou i kite i tētahi whakamātautau whai-rōpū-whakataurite ki te tangata e whakaatu ana i tētahi painga mō te kai-whaiaro ā-pūtau, i tētahi painga haumanu rānei, nā te whakakotahi i te puru metilīni me te nohopuku.
E toru ngā pātai motuhake: he aha tā tētahi whakamātautau taiwhanga i ine ai, e hāngai ana rānei tētahi whakaritenga ki tētahi whakamāramatanga motuhake o te nohopuku, ā, ka rerekē rānei tōna ngongotanga, te āhei rānei o te tinana ki te aro atu ki taua whakaritenga, ina tangohia me te kore kai. E kore te whakautu pai ki tētahi pātai e whakautu i ērā atu.
Te tikanga o te tango i te wē toto i te whakamātautau kua whakahuatia
I roto i te rangahau pūtau io a Xie mā i te tau 2013, i whakamahia e ngā kairangahau ngā pūtau HT22, he rārangi pūtau nō te hippocampus o te kiore. I whakakapia te ranunga whakatipu pūtau kua tāpirihia he wē toto (serum) ki te DMEM kore wē toto. I noho tonu ngā pūtau ki roto i te ranunga taiwhanga; kāore i whakawhitia ki te wai noa.
I whakaiti te puru metilīni i te apoptosis, arā, he momo mate pūtau kua whakaritea, e pā ana ki te tangohanga o te wē toto. I ine hoki ngā kairangahau i te whakapoke LC3B me ngā taumata pūmua, i tirotiro i te pūmua p62 e hāngai ana ki te kai-whaiaro ā-pūtau, ā, i whakamahi i ngā matū aukati hei whakamātau i te tikanga mahi i whakaarotia. I tohu ā rātou hua ki te whai wāhi o te tuku tohu AMPK, me te kore aukatinga mTOR e whakapaetia ana i ētahi kōrero tuihono. I tirohia te kiko roro i muri i te hoatutanga o te puru metilīni i ētahi whakamātautau motuhake ki te kiore.
Ka whakarerekē te tangohanga o te wē toto i te ranunga e tautoko ana i ngā pūtau whakatipu, tae atu ki ngā wāhanga e tautoko ana i te tipu. Kāore tēnei e tārua i ngā urupare ngātahi o ngā taiaki, te nakunaku, me ngā kiko o te tangata e mahue ana i a ia ētahi kai. Waihoki, kāore te pai ake o te oranga o tēnei rārangi pūtau e whakaū ana i tētahi pānga e hiahiatia ana mō ia momo pūtau, mō ia mate rānei.
He mahere whakataurite i ngā kerēme me ngā rangahau
Ka wehe tēnei mahere i te mahi wawaotanga mai i te putanga i inea. He iti ake te whaihua o te ingoa rangahau i te mōhio ki te mea i whakarerekētia me te mea i tatauria.
| Te kerēme e aromātaihia ana | Te tauira tūturu, te whakatauritenga rānei e hiahiatia ana | Te putanga i inea | He aha ka taea e ngā taunakitanga te tautoko |
|---|---|---|---|
| “Ka āwhina te puru metilīni i ngā pūtau e nohopuku ana.” | Xie 2013: ngā pūtau HT22 o te kiore i tangohia ai te wē toto, me te puru metilīni, me te kore hoki | Te apoptosis, te āhei ki te ora, me ngā inenga e hāngai ana ki te kai-whaiaro ā-pūtau | Te whakamarumaru i raro i taua āhuatanga whakatipu; kāore he putanga mō te nohopuku a te tangata |
| “Ka whakahohe i tētahi ara pūngao, nō reira ka tāwhai i te nohopuku.” | Atamna 2015: ngā pūtau fibroblast IMR90 tangata kua whakatipuhia, i hoatu ai te puru metilīni | Te ōwehenga NAD/NADH, te tāpiritanga rōpū phosphate ki te AMPK, te mahi whākōkī mitokōria, me ngā putanga e hāngai ana ki te kaumātuatanga pūtau | He urupare pūtau ki te matū; kāore he wawaotanga ā-kai |
| “Ka whakaū ngā rangahau nohopuku i te whaihua o te whakakotahitanga.” | Te whakamātautau DIRECT: ngā tūroro mate pukupuku ū kua kōwhiria, e whiwhi ana i te haumanu matū, me te whakataurite i tētahi tikanga kai e tāwhai ana i te nohopuku ki te kai o ia rā | Ngā pānga paitini o te maimoatanga me ngā inenga o te urupare puku | He taunakitanga mō tētahi tikanga kai hei tautoko i te haumanu matū; ehara te puru metilīni i te mea tautoko i whakamātauria |
| “Ka whakakaha tahi ngā wawaotanga e rua.” | He whakatauritenga kei roto ko te kore o ngā wawaotanga e rua, ko ia wawaotanga takitahi, me ngā mea e rua ngātahi | Te putanga kotahi kua tautuhia i mua mō ngā rōpū katoa, me tētahi tātaritanga pāhekoheko | He whakamātautau mēnā ka nui ake tō rāua pānga ngātahi i ngā pānga motuhake e tūmanakohia ana; kāore i whakaūngia e ngā rangahau o runga |
| “E kore tēnei e whati i taku nohopuku.” | Te whakaritenga pū, ngā kai whakauru me ngā ture nohopuku e hāngai ana | Ngā rahinga kai whakauru, te ū rānei ki aua ture | He whakautu mō te hanganga, mō te whakamāramatanga rānei; kāore he inenga o te kai-whaiaro ā-pūtau |
He whakahiatotanga taketake tēnei mahere o ngā rangahau kua kōrerohia i konei. Ko ōna rārangi whakamutunga e rua e whakaahua ana i ngā taunakitanga ka hiahiatia mō tētahi kerēme, ehara i te pūrongo mō ngā whakamātautau kua oti.
Ehara te whakahohe AMPK i te putanga nohopuku
Ko tērā atu tuhinga e whakahuatia nuitia ana, arā, te rangahau a Atamna mā i te tau 2015 mō ngā ara pūngao me ngā ara whakamarumaru pūtau, i whakamahi i ngā pūtau fibroblast tangata i whakatipuhia ki waho i te tinana. I pūrongotia he panonitanga rangitahi o te tāpiritanga rōpū phosphate ki te AMPK, he panonitanga o te mahi a te matatini-IV mitokōria, me te hekenga o te mimiti o ngā telomere i ngā pūtau whakatipu i hoatu ai te matū. He inenga ā-pūtau ēnei. Ko te kupu “tangata” e whakaahua ana i te takenga o ngā pūtau, ehara i te hunga i whakaurua ki tētahi whakamātautau nohopuku.
Ka taea e tētahi ara tairongo pūngao te urupare ki ngā whakaongaonga maha. Kāore te kitenga o taua urupare e mea ana ka taea te whakawhiti i tētahi whakaongaonga mō tētahi atu. Ko ngā taunakitanga ka whakarerekē te puru metilīni i te AMPK, me ngā taunakitanga ka pā te whakawhāiti kai ki te pākia, kāore e whakaatu ana he whai painga, he pānga tāpiri, he pānga whakakaha tahi rānei tō te whakakotahitanga. Me whai putanga motuhake anō ngā kerēme mō te roa o te oranga, e whakamāramatia ana i ngā taunakitanga mō te puru metilīni me te roa o te oranga.
Ko te kai-whaiaro ā-pūtau tonu he tukanga ka tukuna ai ngā matū pūtau ki ngā lysosome kia wāwāhia, kia hangaruatia. Kāore e taea te whakatau i tōna mahi mā te tapanga pūngoi o tētahi tāpiringa anake. Ka wehe ngā aratohu whakamātautau kai-whaiaro ā-pūtau i te maha o ngā hanganga kai-whaiaro ā-pūtau mai i te rere o te kai-whaiaro ā-pūtau, arā, te haere o ngā matū mā te tukanga katoa. Ka tohu pea te nui ake o ngā hanganga i te nui ake o te hanganga hou, i te tōmuri rānei o te whakawātea. Kāore e taea e tētahi tohu kotahi te whakatau i taua rerekētanga.
Ka tirotiro hōhonu ake tā mātou whakamārama mō ngā whakamātautau puru metilīni, AMPK me te kai-whaiaro ā-pūtau i aua inenga.
Ka whati rānei te nohopuku i te puru metilīni?
Kāore he whakautu āe, kāo rānei, e tū motuhake ana i te whakaritenga. Ko te “puru metilīni” te ingoa o tētahi matū hohe, ehara i te rārangi kai whakauru katoa, i te tātaritanga matūkai rānei.
- Mō tētahi whakamāramatanga e whakaae pū ana ki te wai anake, he mea tāpiri ki te wai te whakaritenga puru metilīni. Ahakoa kīia he kore pūngoi, ehara tonu i te wai noa.
- Mō tētahi ture e hāngai ana ki ngā pūngoi, tirohia te hanganga pū o te whakaritenga. Me whakaaro ki ngā rahinga tūturu o te huka, te tirikara, te hinu, me ētahi atu matū kawe whai pūngao. Kaua e whakatau i tētahi uara pūngoi i runga anake i te tae, te ōrau kukū, te ingoa rānei o te matū hohe.
- Mō tētahi “nohopuku kai-whaiaro ā-pūtau,” kāore te korenga o te huka tāpiri, te iti rānei o te rahinga pūngoi kua tuhia, e whakaū ana i te āhua o te rere kai-whaiaro ā-pūtau i roto i ngā kiko o te tangata.
- Mō tētahi whakamātautau hauora, whāia ngā tohutohu a te ratonga whakamātautau. Ka wehe mārama ngā tohutohu a MedlinePlus mō te nohopuku i mua i ngā whakamātautau toto i te inu wai noa mai i ngā whakatau mō te rongoā, ā, ka tohutohu kia kaua e whakamutu i ngā rongoā me te kore tohutohu a te kaiwhakarato hauora.
Me whai whakamātautau rerekē tētahi kerēme mō te ngongotanga: me whakataurite te whakaritenga kotahi i raro i ngā āhuatanga kai me ngā āhuatanga nohopuku kua tautuhia, me te ine i ngā kukūtanga i roto i te toto i roto i te wā. Kāore te rongo wawe ake i tētahi pānga e whakaū ana i te nui ake o te ngongotanga. Tirohia te ngongotanga me te tohanga o te puru metilīni mō ngā taunakitanga e hāngai ana ki ia ara tuku. Kāore ngā rangahau pūtau o runga e whakaū ana i tētahi ture mō te tango me te kai.
Kāore e taea e te nohopuku me te puru metilīni te whakakapi i te maimoatanga mate pukupuku
Kāore ngā pūrongo mō te iti ake o te mamae i te wā nohopuku e whakaū ana kua mimiti tētahi puku, kua roa ake rānei te oranga. Ina panoni ngātahi ngā matū maha, ngā tikanga kai, me ngā rongoā mamae, kāore e taea e tētahi kōrero whaiaro te tautuhi ko tēhea wawaotanga i hua ai te pai ake.
He rangahau tūturu mō ngā wawaotanga ā-kai i te wā tiaki mate pukupuku. I rangahau te whakamātautau DIRECT matapōkere o te wāhanga 2 i tētahi tikanga kai e tāwhai ana i te nohopuku i te taha o te haumanu matū i mua i te maimoatanga matua, mō ngā tūroro mate pukupuku ū HER2-tōraro o te wāhanga II/III. Kāore i kitea he rerekētanga o ngā pānga paitini i waenga i ngā rōpū, ā, i pūrongotia ētahi tātaritanga urupare pai. I hāngai ēnei kitenga ki tētahi taupori tūroro kua kōwhiria me tētahi tikanga kai tautoko. Kāore i whakamātau i te puru metilīni, i whakaatu i te whaihua o te nohopuku wai-anake, i whakaū rānei i tētahi whakakapi mō te haumanu matū.
Kaua e whakaroa, e whakakapi rānei i te maimoatanga mate pukupuku kua tohua ki tēnei whakakotahitanga. Mō te tangata e heke ana tōna taumaha, e uaua ana rānei te kai, ka taupatupatu pea te whakawhāiti anō i te kai ki ngā hiahia maimoatanga. Ka whakamārama ngā tohutohu matūkai a te National Cancer Institute he aha i nui ai te rawaka o ngā pūngoi me te pūmua, te aromatawai matūkai, me te tautoko kua whakaritea mō te tangata takitahi i te wā maimoatanga mate pukupuku.
He mōrea rongoā anō tō te puru metilīni, ahakoa te nohopuku. Ka whakatūpato ngā mōhiohio tuku rongoā mō PROVAYBLUE mō te mate huinga tohu serotonin ina whakamahia me ngā rongoā e pā ana ki te serotonin me ngā opioid, ā, e aukati ana i tōna whakamahinga ina he ngoikoretanga G6PD tō te tangata. Kāore taua tapanga hua werohanga e whakamana ana i tētahi whakaritenga ā-waha mā te kaihoko, i tētahi hōtaka nohopuku rānei. Kawea te hua pū me te rārangi rongoā ki te tīma maimoatanga i mua i te whakaaro ki te whakamahi.
Ina aromātai koe i tētahi kerēme hou, tautuhia te tauira, te wawaotanga, te mea whakataurite, me te putanga mā te whakamahi i te aratohu pānui rangahau puru metilīni. Me whai taunakitanga nō te hunga nohopuku tētahi kerēme mō te hunga nohopuku, ā, me whai taunakitanga e tino whakamātau ana i te whakakotahitanga tētahi kerēme mō taua whakakotahitanga.