Methylene blue ọ na-ewepụ ọla arọ? Ihe akaebe banyere detox

Methylene blue abụghị ọgwụgwọ e guzobere maka iwepụ ọla arọ n'ahụ. Isi mmalite ụlọ ọgwụ na nyocha e nyochara maka edemede a achọpụtaghị ihe akaebe sitere n'aka mmadụ na-egosi na ọ na-abawanye nke ukwuu iwepụ lead, mercury, cadmium, ma ọ bụ arsenic ma na-eme ka nsonaazụ nsị ka mma. Nke a bụ oke nke ihe akaebe a chọtara, ọ bụghị ihe akaebe na ewepụla ohere nke mmekọrịta kemịkal niile nwere ike ịdị.

A na-ejikọtakarị nkwupụta atọ dị iche iche n'otu okwu “detox”: ngwaahịa nwere obere mmetọ, ihe na-agbanwe nzaghachi sel nye nrụgide, na ọgwụgwọ na-ewepụ ihe na-egbu egbu n'ahụ mmadụ. Ihe akaebe maka otu n'ime ha anaghị egosi na ndị ọzọ bụ eziokwu.

Ngwaahịa dị ọcha bụ nsonaazụ gbasara ịdị mma

Panel ọla arọ na-enyocha sample ngwaahịa e nyefere. Ọ nwere ike ịkọ ọnụọgụ lead, mercury, cadmium, na arsenic, tinyere units, methods, na reporting limits. Arsenic bụ metalloid, ọ bụ ezie na a na-etinyekarị ya na panels a na-akọwa dịka ule ọla arọ.

Usoro FDA maka elemental analysis na-egosi ọrụ nyocha ahụ: tụọ elements akọwapụtara n'ime ihe a kọwara nke ọma site n'iji usoro ndị a kwadoro. Nsonaazụ dị n'okpuru reporting limit pụtara na ụlọ nyocha enweghị ike ịkọ ọnụọgụ karịrị oke ahụ n'okpuru ọnọdụ ndị ahụ. Ọ pụtaghị na element ahụ adịghị ma ọlị n'ụzọ mgbakọ na mwepụ.

Maka methylene blue, nke a na-aza ma sample a nwalere ọ na-ebute contaminant a tụrụ. Ọ naghị ekwu ihe ọ bụla gbasara iwepụ mmetọ dịlarị n'ahụ. Certificate na-egosi lead dị ala enweghị ike igosi ọrụ chelation nke lead, dịka ule mmiri enweghị ike igosi otú ọgwụ si arụ ọrụ.

Nduzi anyị banyere ọla arọ, Azure B, na impurities ndị ọzọ dị na methylene blue na-akọwa ihe mere elemental panel ji hapụkwa ajụjụ ndị ọzọ gbasara ịdị mma na-enweghị azịza. Njirimara ngwaahịa, impurities metụtara dye, na elemental contaminants chọrọ ụdị ihe akaebe nyocha dị iche iche.

Gịnị ka iwepụ ọla ga-achọ n'ezie?

Chelation gụnyere kemịkal ijikọ metal ion. N'ịgwọ ọrịa, ajụjụ bara uru bụ ma mmekọrịta ahụ ọ na-enyere ahụ aka iwepụ ọla ahụ dị mkpa n'ihe ize ndụ a na-anabata. Njikọ n'ime test tube naanị enweghị ike igosi na ihe ahụ rutere tissue kwesịrị ekwesị, jidere ọla ahụ n'oge njem, ma ọ bụ mepụta uru ụlọ ọgwụ.

Nkọwa FDA banyere medical chelation na-ekewa ọgwụgwọ prescription a na-elekọta anya na ngwaahịa ndị a na-akwadoghị nke a na-ere maka detox n'ụlọ. Ọ na-ekwu na FDA akwadoghị ngwaahịa chelation ọ bụla maka ojiji over-the-counter.

Nkwupụta a pụrụ ịtụkwasị obi na methylene blue na-ewepụ ọla ga-achọ aha ọla akọwapụtara, exposure achọpụtara, formulation na route akọwapụtara, comparison groups kwesịrị ekwesị, na measurements n'ime oge. Ndị nyocha ga-achọ ịmata ọdịiche dị n'etiti mmụba n'iwepụ ihe na redistribution n'etiti ọbara na tissues ma ọ bụ mbelata exposure na-aga n'ihu. Health outcomes na adverse effects dị mkpa n'akụkụ laboratory values.

“Na-akwado detox pathways” anaghị enye measurements ndị ahụ na-efu. Otu aka ahụ, mechanism a tụrụ aro nke metụtara njikọ sulfur, nke e chepụtara site na structure nke molecule, anaghị enye ha.

Tebụl nkwupụta na ihe akaebe

Jiri tebụl a mata ihe report na-atụ n'ezie tupu ịnakwere nkwupụta so ya.

Nkwupụta ma ọ bụ ihe a hụrụ	Ihe akaebe na-aza ya	Ihe ọ na-enweghị ike igosi naanị ya
“Batch a nwere obere mmetọ ọla arọ”	Elemental results jikọtara na batch, units, reporting limits, njirimara sample, na method kwesịrị ekwesị a kwadoro	Iwepụ ọla n'ahụ mmadụ; enweghị impurity ọ bụla ọzọ
“Methylene blue na-ebelata oxidative stress”	Controlled cellular ma ọ bụ animal measurements nke redox endpoints akọwapụtara, tinyere assay controls kwesịrị ekwesị	Njikọ ọla, mmụba metal excretion, ma ọ bụ ịdị irè ọgwụgwọ n'ime mmadụ
“Ọla na-ejikọta n'ime nnwale ụlọ nyocha”	Direct binding measurements n'okpuru ọnọdụ kemịkal akọwapụtara	Njikọ kwụsiri ike n'ahụ, njem dị nchebe, ma ọ bụ elimination
“Ahụ na-ewepụkwu ọla”	Metal-specific measurements a kwadoro, nwere collection timing, comparators, na interpretation kwesịrị ekwesị	Na poisoning dị, na total harmful tissue burden belatara, ma ọ bụ na ahụike ka mma
“Methylene blue na-eme detox nke ọla arọ”	Ihe akaebe ọgwụgwọ mmadụ na-ejikọta exposure, intervention, metal disposition, meaningful outcomes, na harms	Ihe akaebe a chọtara maka edemede a eguzobeghị nkwupụta sara mbara a
“Mmamịrị ghọrọ anụnụ anụnụ ma ọ bụ akwụkwọ ndụ akwụkwọ ndụ”	Ihe akaebe nke coloration metụtara dye	Measurement nke iwepụ lead, mercury, arsenic, ma ọ bụ cadmium

Tebụl a bụ enyemaka maka ịgụ ihe akaebe, ọ bụghị protocol maka ule ma ọ bụ ọgwụgwọ.

Mmetụta antioxidant anaghị atụ iwepụ ọla

Methylene blue na-ekere òkè na kemistri oxidation-reduction. Ya mere, nnwale nwere ike nyochaa otú ọ si agbanwe nzaghachi sel nye mmerụ ahụ na-enweghị igosi na ọ na-ewepụ ihe kpatara mmerụ ahụ.

Dịka ọmụmaatụ, ọmụmụ 2009 Striatal neuroprotection with methylene blue nyochara oke e nyere mitochondrial toxin rotenone ozugbo n'otu mpaghara ụbụrụ, ma ọ bụ na methylene blue e nyere n'otu mpaghara ahụ ma ọ bụ na-enweghị ya. Ndị nyocha tụlere lesion size, oxidative metabolism, oxidative stress, na motor behavior. Nchedo a kọrọ metụtara experimental tissue injury. Rotenone abụghị ọla arọ, nke a abụghịkwa human metal-excretion trial.

E nwekwara akwụkwọ 1980 banyere enzyme activity n'ime oke nwere lead poisoning. PubMed record ya na-egosi isiokwu nnwale ahụ mana ọ naghị enye abstract. Record ahụ naanị enweghị ike igosi treatment effect, iwepụ ọla, ma ọ bụ recommendation maka mmadụ. Title nwere okwu “lead poisoning” ezughị dịka ihe akaebe maka nkwupụta detox n'ịntanetị.

Ọdịiche ndị a na-emetụta ihe akaebe sitere n'aka mmadụ banyere uru methylene blue. Research library na-ahazi ọmụmụ dabere na populations na endpoints ha n'ezie.

Ụzọ mkpirisi abụọ na-eduhie eduhie

Nke mbụ, ịgwọ methemoglobinemia abụghị metal chelation. Prescribing information maka intravenous PROVAYBLUE na-akọwa ọrụ methylene blue n'ịgbanwe hemoglobin iron site na ferric state gaa na ferrous state. Iron na-agbanwe oxidation state ka ọ ka bụ akụkụ nke hemoglobin. Nke a anaghị egosi iwepụ iron ma ọ bụ ọla ndị ọzọ n'ahụ.

Nke abụọ, ọmụmụ environmental “removal” nwere ike ịtụgharị ọrụ ndị na-agụ akwụkwọ chere na ihe ndị ahụ nwere. Akwụkwọ aha ya bụ Removal of mercury and methylene blue from aqueous solution na-enyocha functionalized graphene-oxide adsorbent. Mercury na methylene blue bụ ihe ndị a na-ewepụ n'ime mmiri. Methylene blue abụghị ọgwụgwọ na-ewepụ mercury n'ahụ onye ọrịa.

Ọ bụrụ na ị na-enyo exposure n'ezie

Malite na substance, source, timing, na route nke exposure. Were container ngwaahịa, ozi ebe ọrụ, ma ọ bụ laboratory report dị mkpa gakwuru clinician ma ọ bụ poison service. Nhọrọ na interpretation nke testing dabere na metal a na-enyo na ọnọdụ exposure.

Aṅụla chelator iji mepụta positive urine test. Ọnọdụ American College of Medical Toxicology banyere provoked urine testing na-akọwa na chelators nwere ike ịbawanye metal excretion n'ime ndị nwere poisoning na ndị na-enweghị ya. Iji tụnyere nsonaazụ ndị ahụ na ordinary unprovoked reference ranges nwere ike ibute diagnoses na-eduhie eduhie na ọgwụgwọ na-adịghị mkpa.

Methylene blue nwekwara side effects na contraindications nke ya, gụnyere drug interactions dị mkpa na risks n'ime G6PD deficiency. Inwe mmetụta na-adịghị mma mgbe i were ya abụghị ihe akaebe na a na-eme ka ọla na-agagharị n'ahụ.

Maka suspected acute poisoning, kpọtụrụ poison service ozugbo. Nduzi mberede Poison Control na-atụ aro enyemaka mberede ozugbo maka collapse, seizures, trouble breathing, ma ọ bụ inability to awaken. Na United States, Poison Control bụ 1-800-222-1222 na emergency number bụ 911; n'ebe ndị ọzọ, jiri local services. Egbula oge assessment iji nwalee methylene blue detox regimen.