Isihloko
I-methylene blue ekunakekeleni isikhumba: ukwakheka kwemikhiqizo nobufakazi obuvela kubantu
I-methylene blue inobufakazi baselabhorethri obuthembisayo ngokuphathelene nokuguga kwesikhumba, futhi abakhiqizi babika ukuhlolwa kubantu kweminye imikhiqizo yezimonyo esiqediwe. Le miphumela iphendula imibuzo ehlukene. Akukho kulokhu okwenza ibhodlela le-methylene blue engakalungiswa libe ngokulingana nokhilimu wobuso ohloliwe, futhi akukho okusungula indlela yokwelapha i-eczema, i-psoriasis, noma i-rosacea.
Kunoma yisiphi isimangalo sokunakekelwa kwesikhumba, thola izinto ezintathu: ukuthi yini esetshenzisiwe, isetshenziswe kuphi, nokuthi yini eshintshile. Izinga lokugxila kokuthile oketshezini lokukhulisa amaseli, ukusabela kwemodeli yesikhumba, nomuntu obika ukuthi isikhumba sakhe sibushelelezi ngokwengeziwe akuzona izilinganiso ezingashintshaniswa.
Lokho okwahlolwa ucwaningo lwesikhumba oluvame ukucashunwa
Ucwaningo luka-Xiong nozakwabo lwango-2017 lwahlola ama-fibroblast e-dermis yomuntu kanye nesikhumba esakhiwe kabusha. Ama-fibroblast angamaseli ezicubu ezixhumanisayo; ukuwakhulisa esitsheni kususa umgoqo ongaphandle ukhilimu wobuso okufanele uhlangane nawo.
Ama-fibroblast akhuliswa elabhorethri achayeka ku-100 nM we-methylene blue amasonto amane abonisa izinguquko ezilinganisweni zokucindezeleka okubangelwa yi-oxidation nezokuguga kwamaseli. Esikhumbeni esakhiwe kabusha esinazo zonke izingqimba, amasonto amabili e-methylene blue oketshezini lokukhulisa amaseli andisa amazinga amanzi esikhumbeni nokujiya kwe-dermis okwakulinganisiwe. Phakathi kwamazinga okugxila ahloliwe, ukusabela okukhulu kakhulu kokujiya kwenzeka ku-0.5 µM. Lokhu ukuchayeka kokuhlola, hhayi imiyalelo yokulungisa ukhilimu.
Kunomniningwane owodwa obalulekile ezimangalweni nge-collagen: ababhali babika ukwanda kokubonakaliswa kwe-COL2A1 kodwa abazange babone ushintsho ku-collagen yohlobo I. Ukuhlola kwabo okuphathelene namanxeba kwalinganisa ukuvaleka kokuklwebheka ongqimbeni olulodwa lwama-fibroblast. Akuzange kuhlolwe ukuphola kwamanxeba kubantu.
Isikhumba esakhiwe kabusha sinezicubu ezihleleke kangcono kunamaseli ahlukanisiwe. Noma kunjalo, asikwazi ukusungula ukuthi ungakanani umkhiqizo othile wezimonyo ofinyelela esikhumbeni sobuso esiphilayo, ukuthi imibimbi iyathuthuka yini ngokubonakalayo, noma ukuthi ukusetshenziswa okuphindaphindiwe kubathinta kanjani abantu abahlukahlukene.
Ukuqhathanisa: ukwakheka komkhiqizo nemodeli yocwaningo
Sebenzisa lokhu kuqhathanisa ukuze uthole ubufakazi obusekela ilebula noma isimangalo ezinkundleni zokuxhumana. Ikholomu engakwesokudla kakhulu ikhomba isilinganiso esingekho, kunokuba kucatshangwe ukuthi konke ukuhlola kuphendula umbuzo ofanayo.
| Into noma isinyathelo esihlolwayo | Imodeli nokuchayeka | Lokho ubufakazi obungakuphendula | Lokho okusadinga ukuhlolwa ngokuqondile |
|---|---|---|---|
| I-methylene blue efakwe oketshezini lwaselabhorethri | Ama-fibroblast abantu akhuliswa elabhorethri; ukuchayeka okuphindaphindiwe | Ukusabela kwamaseli ngaphansi kwezimo ezilawulwayo | Ukudluliselwa ngomgoqo wesikhumba ongaphazamisekile nemiphumela yezimonyo ebonakalayo |
| I-methylene blue oketshezini olusekela isikhumba esakhiwe kabusha | I-epidermis ne-dermis okwakhiwe ngobuchwepheshe | Ukusabela kwezicubu kuleyo modeli | Ukusebenza kokhilimu osuqediwe ogcotshwa kubantu |
| Ukhilimu noma i-serum yokuhweba esiqediwe | Ukuhlolwa kubantu okuqondene nalowo mkhiqizo | Ukubekezeleleka nemiphumela elinganiselwe ngempela yaleyo ngxube | Igalelo le-methylene blue uma liqhathaniswa nesisekelo sayo nezinye izithako |
| Udayi ongakalungiswa oncibilikiswe emanzini waxutshwa nokuthambisa isikhumba, amafutha ezilwane, noma amafutha kakhukhunathi | Ingxube esanda kuguqulwa | Ukwazi isithako kuphela akusunguli miphumela yomkhiqizo | Ukufana kwengxube, ukuzinza, ukuvikelwa ekonakaleni, ukudluliselwa esikhumbeni, ukubekezeleleka, nenzuzo |
| I-methylene blue kanye nesithuthukisi sokungena noma idivayisi yokukhanya | Isinyathelo esihlanganisiwe | Imiphumela etholwe kuphela ngaleyo nhlanganisela ethile | Ukuthi esinye isincibilikisi, idivayisi, ukuchayeka, noma isimo sesikhumba siveza umphumela ofanayo yini |
Ukuhlolwa kubantu kukhona, kodwa funda lokho okwakulinganiswa
Bekungeke kunembile ukusho ukuthi akukho ukuhlolwa kokunakekelwa kwesikhumba kubantu. Isifinyezo socwaningo lwe-EyePlus+ se-Bluelene sibika ukuthi eqenjini elihloliwe kwakungekho ukucasuka noma ukuvuvukala kwesikhumba okubangelwa ukusabela kokungezwani ngemva kokuthintana nomkhiqizo. Leso isimangalo sokubekezeleleka esishicilelwe umkhiqizi mayelana nomkhiqizo osuqediwe onezithako eziningana. Akusho ukuthi wonke umsebenzisi uzowubekezelela noma ukuthi i-methylene blue iyodwa yehlisa imibimbi.
Umbiko we-Fit+Firm womkhiqizi nawo uchaza izilinganiso zabahlanganyeli ngokuphathelene nokuba namanzi kwesikhumba, ukuqina kwaso, nokuthungwa kwaso. Umfanekiso wokujiya kwesikhumba uchazwa ngokusobala njengemodeli yesikhumba enobukhulu obuthathu, nakuba uvela eceleni kwemiphumela yokuhlolwa komkhiqizo kubantu. Lokhu kokubili kufanele kugcinwe kuhlukene lapho kuchazwa ikhasi.
Izifinyezo ezitholakala emphakathini ezibuyekeziwe azisunguli ukuqhathanisa okusebenzisa ukwabiwa okungahleliwe kwezingxube ezifanayo kukho konke okunye, ezine-methylene blue nezingenayo, ukuze kubonakale ukuthuthuka kwemibimbi. Ukuqhathanisa okulawulwayo kwalolo hlobo kungasiza ukuhlukanisa igalelo lalesi sithako. Ukwaneliseka kwabahlanganyeli kungasekela ukwamukeleka komkhiqizo; izilinganiso ezingancikile emibonweni kanye nento efanele yokuqhathanisa kuphendula umbuzo ohlukile.
Umkhiqizo osuqediwe ungaphezu kukadayi wawo
Njengesibonelo esiqondile, uhlu lwezithako lwe-Bluelene Night Cream luhlanganisa amanzi, amafutha ezinhlamvu zangaphandle zelayisi, i-glycerin, izithako ezinamafutha, isihlanganisi samafutha namanzi, izivimbeli zokonakala, kanye ne-methylene blue. Ingxube yayo ephelele iyona into ikhasimende eliyigcobayo. Imibuzo evame ukubuzwa yomkhiqizi ithi izinga lokugxila kwe-methylene blue liyimfihlo yomkhiqizi, ngakho ilebula ayinakusetshenziswa ukuze kwakhiwe kabusha le ngxube.
Isisekelo somkhiqizo wokuthambisa isikhumba siyisistimu ethwala izithako zawo. Sithinta ukusabalala, ukugcinwa kwamanzi, ukukhululwa kwesithako, nokuthintana nesikhumba. Uma ukhilimu onezithako eziningi uthuthukisa ukoma kwesikhumba, ukunikeza isithako esisodwa udumo lwalo lonke ushintsho kudinga okungaphezu kokuba khona kwaso kulebula.
Okufanayo kuyasebenza nasembaleni womkhiqizo. Ukhilimu onombala okhanyayo awuvezi izinga eliqondile lokugxila kwe-methylene blue. Ukubukeka akukwazi ukuthatha indawo yokuhlolwa kwezinga lokugxila, isimo samakhemikhali, noma ukuzinza. Umhlahlandlela wethu wezithako zesisombululo se-methylene blue uchaza ukuthi kungani konke okuqukethwe yisisombululo kubalulekile.
Ingabe i-methylene blue iyangena esikhumbeni?
Impendulo incike ekutheni “ukungena” kusho ukuthini. Into ingangena ongqimbeni lwangaphandle oluthiwa i-stratum corneum ngaphandle kokufinyelela ku-dermis ngezinga lokugxila elisebenzayo noma ukudlulela ekujikelezeni kwegazi.
Ocwaningweni lwezincibilikisi kubantu olwahlanganisa amavolontiya ayishumi aphilile, abacwaningi baqala ngokugcoba izindawo ezingalweni ezingaphansi ngesisekelo esihlukahlukene base begcoba i-methylene blue. Ukuhlolwa kwamasampula athathwe ebusweni besikhumba kwabonisa ukuthi ezinye zalezi zinyathelo zangaphambi kokugcoba zandisa ukugcinwa kukadayi ku-stratum corneum, kuyilapho ezinye zikwehlisa. Lokhu kwakuwukuhlola ukudluliselwa esikhumbeni, hhayi isivivinyo sokumelana nokuguga. Indlela esetshenzisiwe ayizange ilinganise ukumuncwa okusabalalela emzimbeni.
Lokho okutholakele kubonisa nokuthi kungani ukuthi “iyancibilika kulesi sincibilikisi” kunganele. Ukuncibilika kuchaza ukuziphatha kwento esitsheni. Ukudluliselwa esikhumbeni kudinga futhi ukukhululwa esisekelweni nokuhamba phakathi kwezicubu. Ukuncibilika okwengeziwe akusho ngokuzenzakalela ukudluliselwa okuwusizo okwengeziwe, futhi ukudluliselwa okwengeziwe akusho ngokuzenzakalela umphumela ongcono.
Amafutha ezilwane, amafutha kakhukhunathi, nama-serum enziwe ekhaya
Amafutha ezilwane namafutha kakhukhunathi kuyizisekelo ezicebile ngama-lipid. Ukumane uxove i-methylene blue encibilikiswe emanzini kunoma yikuphi kwalokhu akusunguli ingxube yamafutha namanzi efanayo futhi ezinzile. Ingxube ingabonakala inombala ofanayo ngokushesha ngemva kokuxovwa, kodwa ishiye imibuzo engaphenduliwe ngokuhlukana kwayo lapho igcinwa nangenani elidluliselwa esikhumbeni ekugcotshweni ngakunye.
Ukufaka isisombululo kukhilimu osuvele ukhona nakho kuguqula ingxube umkhiqizi ayihlolile. Isiqondiso se-FDA ngokungcoliswa kwezimonyo sikhomba amanzi afakiwe, izithako ezingcolile, ukuvikelwa ekonakaleni okungasebenzi, nokuphathwa ngumthengi njengezingozi ezifanele ukucatshangelwa. Ucwaningo lwe-methylene blue lokulwa namagciwane aluthathi indawo yokuhlolwa kokuvikelwa ekonakaleni kwesitsha sikakhilimu.
Ingxoxo enikeziwe ngokhilimu abenziwe ekhaya nezithuthukisi zokungena esikhumbeni iphakamisa i-DMSO ne-Transcutol njengabathwali abangase basetshenziswe. Lezi ziphakamiso azinikezi izilinganiso zokuphepha noma zokudluliselwa esikhumbeni kwengxube esiqediwe. Isithuthukisi singashintsha ukuchayeka kwezinye izithako kanye nesithako esisebenzayo esihlosiwe. Ukuhambisana kwesincibilikisi nezinto zaselabhorethri akusunguli ukuthi i-serum enezithako eziningi ifanele ukusetshenziswa ebusweni.
Kukhona nombuzo wangempela wocwaningo mayelana nezinhlanganisela zikavithamini C. Ucwaningo lwaselabhorethri lwango-2021 lwabika imiphumela emihle yenhlanganisela kumaseli esikhumba akhuliswa elabhorethri. Aluzange luqinisekise izingxube ezenziwe ngokuthanda zikavithamini C, i-methylene blue, ama-peptide, amafutha, nezincibilikisi. Yonke into efakwayo yethula enye into engaguquka; ukusabela okungcono kwamaseli akukhona ukuhlolwa kokuzinza komkhiqizo osuqediwe. Ukubuka konke kocwaningo ngezivikeli zelanga kuhlola umbuzo ohlukile wokuvikelwa emisebeni ye-UV.
Ukuguga okuqondene nezimonyo, izifo zokuvuvukala, nokukhanya
Ukwanda kwamanzi esikhumbeni akulingani nokulawulwa kwe-eczema, i-psoriasis, noma i-rosacea. Lezi zimo zidinga imiphumela eqondene nesifo, njengezimpawu, ubunzima bezindawo ezilimele esikhumbeni, nokubuya kwazo. Ukuhlola ukuguga nezifinyezo zezimonyo ezingenhla akusunguli ukhilimu we-methylene blue njengendlela ephumelelayo yokwelapha lezi zimo. Ububomvu, ukuxebuka, noma ukuluma okuqhubekayo kufanele kuhlolwe njengakho ngokwako kunokuba kuthathwe njengokuguga okuqondene nezimonyo.
Ukukhanya nakho kuguqula isinyathelo esisetshenziswayo. Ekuhloleni kwe-photodynamic nge-methylene blue, ukukhanya nomoya-mpilo kubamba iqhaza ekwakheni izinhlobo zamakhemikhali ezisabela kalula. Le nqubo yamakhemikhali yehlukile emcabangweni wokulwa ne-oxidation ovame ukusetshenziswa ekukhangiseni imikhiqizo yokunakekela isikhumba. Akunakucatshangwa ukuthi ukufaka iphaneli yokukhanya okubomvu engxubeni eyenziwe ekhaya kungandisa ngokuphepha inzuzo yezimonyo. Umhlahlandlela wobufakazi nge-methylene blue nokukhanya okubomvu uhlukanisa lezo zimo.
Lapho uhlola umkhiqizo, cela ucwaningo lwaleyo ngxube, into eyayiqhathaniswa nayo, isikhathi sokuhlola, nomphumela owalinganiswa. Leyo mininingwane inikeza ulwazi oluthe xaxa kunombala oluhlaza okwesibhakabhaka, indlela isithako esisebenza ngayo, noma igama elithi “okwasemtholampilo” lilodwa.