Imethylene Blue Ekunyamekeleni Ulusu: Imixube Nobungqina

Imethylene blue inobungqina baselabhoratri obuthembisayo ngokuphathelele ukuguga kolusu, kwaye abavelisi banika ingxelo yovavanyo olwenziwe ebantwini lwezinye iimveliso zokuthambisa ezigqityiweyo. Ezi ziphumo ziphendula imibuzo eyahlukileyo. Akukho nanye eyenza ibhotile yemethylene blue ekrwada ilingane nekhrimu yobuso evavanyiweyo, kwaye akukho nanye engqina ukuba ilunyango lwe-eczema, ipsoriasis, okanye irosacea.

Kulo naliphi na ibango lokunyamekela ulusu, chonga izinto ezintathu: yintoni efakiweyo, ifakwe entwenini, kwaye yintoni etshintshileyo. Uxinaniso kulwelo lokukhulisa iiseli, impendulo yemodeli yolusu, nomntu ochaza ukuba ulusu lwakhe lugudile ngakumbi azizomilinganiselo enokuthatha indawo yomnye.

Oko kwavavanywa sisifundo solusu esisoloko sicatshulwa

Isifundo sikaXiong noogxa bakhe sango-2017 savavanya iifibroblast zomaleko ongaphakathi wolusu lomntu kunye nolusu olwakhiwe ngokutsha. Iifibroblast ziiseli zezicubu ezidibanisayo; ukuzikhulisa kwisitya kususa umqobo wangaphandle ekufuneka ikhrimu yobuso idibane nawo.

Iifibroblast ezikhuliswe elabhoratri zaza zachanabeka kwi-100 nM yemethylene blue kangangeeveki ezine zabonisa utshintsho kwimilinganiselo yoxinzelelo lweoksideshini nokuguga kweeseli. Kulusu olwakhiwe ngokutsha olunobukhulu obupheleleyo, iiveki ezimbini zemethylene blue kulwelo lokukhulisa iiseli zandisa ukufuma nobukhulu bomaleko ongaphakathi wolusu obulinganisiweyo. Kuxinaniso olwavavanywayo, olona lwando lobukhulu lwenzeka kwi-0.5 µM. Oku kukuchanabeka okwenziwa kuvavanyo, asiyomiyalelo yokulungiselela ikhrimu.

Enye inkcukacha ibalulekile kumabango ngecollagen: ababhali banika ingxelo yokwanda kokubonakaliswa kwe-COL2A1 kodwa abazange babone utshintsho kwicollagen yohlobo I. Uvavanyo lwabo olunxulumene namanxeba lwalinganisa ukuvaleka komkrwelo kumaleko omnye weefibroblast. Aluzange luvavanye ukuphiliswa kwamanxeba ebantwini.

Ulusu olwakhiwe ngokutsha lunezicubu ezilungelelaniswe ngakumbi kuneeseli ezizimeleyo. Sekunjalo, alunakungqina ukuba ingakanani imveliso ethile yokuthambisa efikelela kwizicubu eziphilayo zolusu lobuso, ukuba imibimbi iyaphucuka na ngokubonakalayo, okanye indlela ukusetyenziswa ngokuphindaphindiweyo okubachaphazela ngayo abantu abahlukeneyo.

Uthelekiso: umxube nemodeli yophando

Sebenzisa olu thelekiso ukufumana ubungqina obuxhasa ibango elikwileyibhile okanye kumajelo onxibelelwano. Ikholamu esekunene ichonga umlinganiselo ongekhoyo, endaweni yokucinga ukuba lonke uvavanyo luphendula umbuzo ofanayo.

Into okanye ungenelelo	Imodeli nokuchanabeka	Oko ubungqina bunokukuphendula	Oko kusafuna uvavanyo oluthe ngqo
Imethylene blue efakwe kulwelo lwaselabhoratri	Iifibroblast zabantu ezikhuliswe elabhoratri; ukuchanabeka ngokuphindaphindiweyo	Iimpendulo zeeseli phantsi kweemeko ezilawulwayo	Ukudluliselwa ngaphaya komqobo wolusu ongophukanga neziphumo zokuthambisa ezibonakalayo
Imethylene blue kulwelo oluxhasa ulusu olwakhiwe ngokutsha	Umaleko wangaphandle nowangaphakathi wolusu owenziwe ngobunjineli	Iimpendulo zezicubu kuloo modeli	Ukusebenza kwekhrimu egqityiweyo efakwe ebantwini
Ikhrimu okanye iserum yorhwebo egqityiweyo	Uvavanyo ebantwini olujoliswe kuloo mveliso	Ukunyamezeleka neziphumo ezilinganiswe ngokwenene kuloo mxube	Igalelo lemethylene blue xa lithelekiswa nesiseko esiyithwalayo nezinye izithako
Idayi ekrwada enyibilikiswe emanzini yaxutywa kwikhrimu yokufumisa, kumafutha ezilwanyana, okanye kwi-oyile yekhokhonathi	Umxube osandul’ ukutshintshwa	Ukuchongwa kwesithako kukodwa akungqini nasiphi na isiphumo semveliso	Ukufana komxube, ukuzinza, ukulondolozwa, ukudluliselwa, ukunyamezeleka, nenzuzo
Imethylene blue kunye nento ephucula ukungena eluswini okanye isixhobo sokukhanya	Ungenelelo oludityanisiweyo	Kuphela iziphumo ezifunyenwe ngaloo ndibaniselwano ithile	Ukuba esinye isinyibilikisi, isixhobo, ukuchanabeka, okanye imeko yolusu ivelisa isiphumo esifanayo

Uvavanyo ebantwini lukhona, kodwa funda ukuba lulinganise ntoni

Akuchanekanga ukuthi akukho vavanyo lokunyamekela ulusu olwenziwe ebantwini. Isishwankathelo sesifundo se-EyePlus+ sikaBluelene sinika ingxelo yokuba akukho kucaphuka okanye ukudumba kolusu okubangelwa kukwaliwa yinto eludibanayo kwiqela elivavanyiweyo. Elo libango lokunyamezeleka elipapashwe ngumvelisi ngemveliso egqityiweyo enezithako ezininzi. Alithethi ukuba wonke umntu oyisebenzisayo uya kuyinyamezela okanye ukuba imethylene blue iyodwa yanciphisa imibimbi.

Ingxelo ye-Fit+Firm yomvelisi nayo ichaza amanqaku anikwe ngabathathi-nxaxheba ngokuphathelele ukufuma, ukuqina, nokwakheka komphezulu wolusu. Umfanekiso wayo wobukhulu bolusu uchazwa ngokucacileyo njengemodeli yolusu enamacala amathathu, nangona uvela ecaleni kweziphumo zovavanyo lwemveliso ebantwini. Ezi zinto zimbini kufuneka zigcinwe zahlukile xa kutolikwa eli phepha.

Izishwankathelo ezivulelekileyo kuluntu ezihloliweyo azingqini uthelekiso olusebenzisa ulwabiwo olungakhethiyo phakathi kwemixube efana kuzo zonke ezinye izinto, enayo nengenayo imethylene blue, ukuze kuhlolwe ukuphucuka kwemibimbi. Uthelekiso olulawulwayo olunjalo lunganceda ukwahlula igalelo lesithako. Ukwaneliseka kwabathathi-nxaxheba kunokuxhasa ukwamkeleka; imilinganiselo engaxhomekekanga kwizimvo kunye neqela lokuthelekisa elifanelekileyo ziphendula umbuzo owahlukileyo.

Imveliso egqityiweyo ingaphezulu kwedayi yayo

Njengomzekelo ocacileyo, uluhlu lwezithako lweBluelene Night Cream luquka amanzi, i-oyile yesikhwebu serayisi, iglycerin, izithako ezinamafutha, into edibanisa i-oyile namanzi, izilondolozi, nemethylene blue. Umxube wayo opheleleyo yinto efakwa ngumthengi. Imibuzo ebuzwa rhoqo yomvelisi ithi uxinaniso lwemethylene blue luyimfihlelo yorhwebo, ngoko ileyibhile ayinakusetyenziswa ukuphinda kwakhiwe loo mxube.

Isiseko sekhrimu yokufumisa yinkqubo ethwala izithako zayo. Sichaphazela ukusasazeka, ukugcinwa kwamanzi, ukukhutshwa kwesithako, nokudibana nolusu. Ukuba ikhrimu enezithako ezininzi iphucula ukoma kolusu, ukubalela lonke olo tshintsho kwisithako esinye kufuna okungaphezulu kobukho beso sithako kwileyibhile.

Kukwanjalo nangombala wemveliso. Ikhrimu enombala ongacacanga ayibonisi uxinaniso oluchanekileyo lwemethylene blue. Inkangeleko ayinakuthatha indawo yovavanyo loxinaniso, imeko yemichiza, okanye ukuzinza. Isikhokelo sethu sezithako zesisombululo semethylene blue sichaza ukuba kutheni zonke izinto eziqulethwe sisisombululo zibalulekile.

Ngaba imethylene blue iyangena eluswini?

Impendulo ixhomekeke kwinto ethethwa “kukungena”. Into inokungena kumaleko wangaphandle oneeseli ezifileyo, obizwa ngokuba yistratum corneum, ingakhange ifikelele kumaleko ongaphakathi wolusu kuxinaniso olusebenzayo okanye idlulele kwinkqubo yokujikeleza kwegazi.

Kuphononongo lwezinyibilikisi olwenziwa ebantwini olubandakanya amavolontiya alishumi asempilweni, abaphandi baqala ngokufaka iziseko ezahlukeneyo kwiindawo zengalo ephakathi kwengqiniba nesihlahla, baza bafaka imethylene blue. Iisampulu ezithathwe kumphezulu wolusu zabonisa ukuba ezinye izinto ezafakwa kuqala zandisa ukugcinwa kwedayi kwistratum corneum, ngoxa ezinye zakunciphisa. Olu yayiluvavanyo lokudluliselwa kwento eluswini, ingelulo uvavanyo lokuchasana nokuguga. Indlela esetyenzisiweyo ayizange ilinganise ukufunxeka nokungena kwinkqubo yomzimba.

Eso siphumo sikwabonisa ukuba kutheni ukuthi “iyanyibilika kwesi sinyibilikisi” kunganelanga. Ukunyibilika kuchaza indlela into eziphatha ngayo kwisikhongozeli. Ukudluliselwa eluswini kufuna nokukhululwa kwayo kwisiseko esiyithwalayo nokuhamba kwayo kwizicubu. Ukunyibilika ngakumbi akuthethi ngokuzenzekelayo ukudluliselwa okuluncedo ngakumbi, kwaye ukudluliselwa ngakumbi akuthethi ngokuzenzekelayo isiphumo esingcono.

Amafutha ezilwanyana, i-oyile yekhokhonathi, neeserum ezenziwe ekhaya

Amafutha ezilwanyana ne-oyile yekhokhonathi ziziseko ezityebileyo ngamafutha. Ukuxuba nje imethylene blue enyibilikiswe emanzini nakweyiphi kwezi akungqini ukuba kwenziwe umxube we-oyile namanzi ofanayo nozinzileyo. Umxube unokubonakala unombala ofanayo ngokukhawuleza emva kokuzanyiswa, kodwa kusale imibuzo engaphendulwanga ngokwahlukana kwawo xa ugciniwe nangomlinganiselo odluliselwa eluswini xa ufakwa ngexesha ngalinye.

Ukufaka isisombululo kwikhrimu esele ikhona nako kuyawutshintsha umxube ovavanywe ngumvelisi. Isikhokelo se-FDA ngokungcoliseka kweemveliso zokuthambisa sichonga amanzi ongeziweyo, izithako ezingcolisekileyo, ukulondolozwa okungasebenziyo, nendlela abathengi abaziphatha ngayo iimveliso njengemingcipheko efanelekileyo ukuqwalaselwa. Uphando ngemethylene blue lokulwa iintsholongwane aluthathi indawo yovavanyo lokulondolozwa kwekhrimu esengqayini.

Ingxoxo enikiweyo ngeekhrimu ezenziwe ekhaya nezinto eziphucula ukungena eluswini ikhankanya i-DMSO neTranscutol njengezinto ezinokusetyenziswa ukuthwala izithako. Ezi ngcebiso aziniki milinganiselo yokhuseleko lomxube ogqityiweyo okanye yokudluliselwa kwawo eluswini. Into ephucula ukungena eluswini inokutshintsha ukuchanabeka kwezinye izithako kwakunye nesithako esisebenzayo ekujoliswe kuso. Ukuhambelana kwesinyibilikisi nezinto elabhoratri akungqini ukuba iserum enezithako ezininzi ifanele ukusetyenziswa ebusweni.

Kukwakho nombuzo wokwenene wophando ngokuphathelele iindibaniselwano nevithamin C. Isifundo saselabhoratri sango-2021 sanika ingxelo yeziphumo ezidibeneyo ezilungileyo kwiiseli zolusu ezikhuliswe elabhoratri. Asizange siqinisekise imixube ekhethwe nje yevithamin C, imethylene blue, iipeptide, iioyile, nezinyibilikisi. Icandelo ngalinye elongeziweyo lazisa enye into enokutshintsha; impendulo engcono yeeseli ayilovavanyo lokuzinza kwemveliso egqityiweyo. Isishwankathelo sophando ngezikhuseli zelanga sihlola umbuzo owahlukileyo wokukhuselwa kwi-UV.

Ukuguga okuphathelele inkangeleko, izifo zokudumba, nokukhanya

Ukuphucuka kokufuma akulingani nokulawulwa kwe-eczema, ipsoriasis, okanye irosacea. Ezi meko zifuna iziphumo ezijoliswe kweso sifo, ezifana neempawu, ubunzima bomonakalo eluswini, nokuphinda kuvele kwemeko. Uvavanyo lokuguga nezishwankathelo zeemveliso zokuthambisa ezingentla azingqini ukuba ikhrimu yemethylene blue ilunyango olusebenzayo kwezi meko. Ububomvu obungapheliyo, ukuxobuka, okanye ukurhawuzelela kufuneka kuhlolwe ngokwako kunokuba kuthathwe njengokuguga okuphathelele inkangeleko.

Ukukhanya nako kuyalutshintsha ungenelelo. Kuvavanyo lwephotodynamic ngemethylene blue, ukukhanya neoksijini zithatha inxaxheba ekuveliseni amasuntswana emichiza asebenza kakhulu. Le nkqubo yemichiza yahlukile kwisizathu sokuthintela ioksideshini esisetyenziswa ngokuqhelekileyo ukuthengisa iimveliso zokunyamekela ulusu. Akunakucingwa ukuba ukongeza iphaneli yokukhanya okubomvu kumxube wasekhaya kuya kwandisa ngokukhuselekileyo inzuzo yokuthambisa. Isikhokelo sobungqina ngemethylene blue nokukhanya okubomvu siyazahlula ezo meko.

Xa uhlola imveliso, cela isifundo saloo mxube, into ekuthelekiswe nayo, ubude bexesha, nesiphumo esilinganisiweyo. Ezo nkcukacha zinika ulwazi olungakumbi kunombala ozuba, indlela esisebenza ngayo isithako, okanye igama elithi “klinikhi” lilodwa.