Inqaku
Iblue yemethylene nesifo sezintso okanye sesibindi
Isifo sezintso okanye sesibindi sitshintsha imibuzo ekufuneka iphendulwe ngaphambi kokusetyenziswa kweblue yemethylene. Umba ophambili yindlela umzimba oyiphatha ngayo le khompawundi, kunye nesizathu sonyango. Into inokunceda kwingxaki ethile yezonyango kodwa ifune amanyathelo ongezelelweyo okulumkela xa ilungu elibandakanyekayo ekuyisuseni lingasebenzi kakuhle.
Kwiblue yemethylene, ubungqina obuphathelele izintso nesibindi abulingani. Imilinganiselo eyenziwe ebantwini ibonisa ukwanda kokuchanabeka xa izintso zingasebenzi kakuhle. Xa isibindi singasebenzi kakuhle, kukho isilumkiso sokubeka isigulane esweni kunyango, kodwa iinkcukacha zechiza ezihlolwe apha aziboneleli ngemilinganiselo yokuchanabeka efanayo ngokwenqanaba lobunzima bale meko. Akukho nanye kwezi ziphumo emisela iblue yemethylene njengonyango lwesifo sezintso esingapheliyo okanye lwesifo sesibindi.
Isifo sezintso: ukwanda kokuchanabeka sisiphumo esilinganisiweyo
Ipharmacokinetics ichaza okwenzeka kwichiza emva kokuba linikezelwe: ukusasazeka kwalo, ukuguqulwa kwalo ngokwemichiza nokukhutshwa kwalo emzimbeni. Ukuchanabeka kudibanisa ubungakanani bechiza obukhoyo kunye nexesha elihlala likhona. Abantu ababini banokunikwa ubungakanani obufanayo kodwa babe nokuchanabeka okwahlukileyo.
Iinkcukacha zokumisela iPROVAYBLUE zixela imilinganiselo yepharmacokinetics enxulumene nezintso emva kokunikezelwa kube kanye ngomthambo. Ukuchanabeka kwiblue yemethylene kwiiyure eziyi-96 kwanda nge-52%, 116% ne-192% xa ukungasebenzi kakuhle kwezintso kwakungephi, kuphakathi okanye kunzima, ngokulandelelana. Umlinganiselo wawuyi-AUC, indawo ephantsi kwegophe elibonisa uxinaniso ngokuhamba kwexesha.
Ukwanda nge-192% kuthetha ukuchanabeka okumalunga nokuphindwe ka-2.92 kunoko kuthelekiswa nako. Akuthethi ukuba kukho amathuba ayi-192% okonakala kwezintso. Ukuchanabeka nokwenzakala ziziphumo ezahlukeneyo: eyokuqala ilinganisa ichiza; eyesibini ilinganisa isiphumo kwisigulane. Uthelekiso lwepharmacokinetics alunakuthi ngokwalo luchaze umda wobutyhefu kumntu othile.
Le milinganiselo ayinako nokumisela isicwangciso sokuthatha ichiza ngomlomo yonke imihla. Ichaza uvavanyo oluthile lokunikezelwa ngomthambo, kanti ukusetyenziswa ngokuphindaphindiweyo ngomlomo kutshintsha indlela yokunikezelwa, amaxesha kunye nendlela yokuchanabeka evavanywayo. Ukwahlula idosi efunyenwe kwi-intanethi ngomlinganiselo wokuchanabeka akunakuluguqula olo vavanyo lube sisicwangciso sonyango esiqinisekisiweyo.
Isifo sesibindi: isilumkiso esihamba nokunqongophala kwedatha ebalulekileyo
Umbuzo ophathelele isibindi awufanele uphendulwe ngokukopa iipesenti zezintso. Iinkcukacha zemveliso yeProveblue yaseYurophu zichaza ukunqongophala kwedatha yokhuseleko nokusebenza xa isibindi singasebenzi kakuhle. Ukunqongophala kwedatha kuthetha ukuba akukho mpendulo imiselweyo kwiqela labantu elichaziweyo; akuthethi ukuba kubonisiwe ukuba umzimba uliphatha ngendlela eqhelekileyo ichiza.
Iinkcukacha zechiza zase-US zicebisa ukubekwa esweni ixesha elide ukujonga ubuthi kunye nokusebenzisana okunokwenzeka namanye amachiza xa isibindi singasebenzi kakuhle, kuba ukukhutshwa kwechiza emzimbeni kunokulibaziseka. Elo linyathelo lokulumkela kunyango, kungekhona ipesenti elinganisiweyo yokwanda xa isifo sesibindi singekho nzima, siphakathi okanye sinzima. Azichazi inani elinye leeyure ezongezelelweyo zokubekwa esweni elisebenza kumntu wonke, okanye indlela yokubala uhlengahlengiso olunokukhethwa sisigulane.
Lo mahluko ubalulekile xa kufundwa icebiso elithi “isibindi siyayiguqula ngokwemetabolism, ngoko ixhasa isibindi.” Imetabolism ichaza ukulungiswa ngokwemichiza. Ayichazi ukulungiswa komonakalo, ukuphuculwa kokusebenza kwesibindi okanye ukubuyiselwa umva kwefibrosis. Ezo nzuzo zifuna izifundo ezilungiselelwe ukulinganisa ezo ziphumo.
Uthelekiso lwamanyathelo okulumkela kunyango nezikhewu kubungqina
Olu thelekiso ludibanisa umthombo, imeko yonyango nombuzo ongaphendulwanga. IPROVAYBLUE yimveliso yase-US; iProveblue yimveliso yaseYurophu. Omabini amaxwebhu aphathelele amayeza atofwayo e-methemoglobinemia, imeko echaphazela amandla egazi okuthwala ioksijini. Imiyalelo yawo ayifanele idityaniswe ibe yinkqubo yokusetyenziswa ekhaya.
| Umbuzo | Ukungasebenzi kakuhle kwezintso | Ukungasebenzi kakuhle kwesibindi |
|---|---|---|
| Yintoni elinganiswa ngokuthe ngqo? | Iinkcukacha zechiza zase-US, icandelo 12.3: ukwanda kwe-AUC emva kokunikezelwa kube kanye nge-IV. | Iinkcukacha zechiza zaseYurophu, icandelo 4.2: ukhuseleko nokusebenza xa isibindi singasebenzi kakuhle akukamiselwa; idatha ayifumaneki. |
| Leliphi inyathelo lokulumkela kunyango elipapashiweyo? | Iinkcukacha zechiza zase-US, amacandelo 2.2 no-8.6: ukunikezelwa kube kanye xa ukungasebenzi kakuhle kuphakathi okanye kunzima, kuqwalaselwe ezinye iindlela zongenelelo ukuba impendulo ayanelanga. | Iinkcukacha zechiza zase-US, icandelo 8.7: ukubekwa esweni ixesha elide ukujonga ubuthi nokusebenzisana namanye amachiza. |
| Uphelela phi umda wobungqina? | Iinkcukacha zechiza zaseYurophu, icandelo 4.2: ukhuseleko nokusebenza akukamiselwa kwisifo sezintso esikwinqanaba lokugqibela, nokuba umntu wenziwa idialysis okanye akayenziwa. | Akukho nanye kwezi nkcukacha zechiza enika isiphindaphindi sokuchanabeka ngokwenqanaba lobunzima bemeko. |
| Yintoni enokumisela inzuzo kwilungu lomzimba? | Ulingo ebantwini olulinganisa iziphumo ezibalulekileyo kwizintso kwiqela labantu abanesifo ekujoliswe kuso. | Ulingo ebantwini olulinganisa iziphumo ezibalulekileyo kwisibindi kwiqela labantu abanesifo ekujoliswe kuso. |
Umqolo wokugqibela uchaza ubungqina obufunekayo ukuze kuvavanywe ibango. Awulilo ibango lokuba ulingo olufunekayo luvelise iziphumo ezihle.
Ngaba izifundo zezilwanyana zibonisa ukukhuselwa kwezintso okanye kwesibindi?
Ezinye iimvavanyo zinika isizathu sokuphanda. Aziniki ngcebiso yonyango kumntu onesifo esingapheliyo selungu lomzimba.
Kuphononongo lukaSarac noogxa bakhe lokunqongophala nokubuyiselwa kwegazi kwizintso, iimpuku ezingamaduna eziyi-21 zahlulwa zaba ngamaqela amathathu. Indlela yokudala ukwenzakala yaphazamisa ukuhamba kwegazi kwimithambo yezintso kangangeyure enye, kwalandela iiyure ezine zokuhamba kwegazi okubuyiselweyo. Iblue yemethylene yatofwa kumngxuma wesisu ngaphambi kokwenzakala. Xa zithelekiswa neqela elonzakeleyo elinganyangwanga, izilwanyana ezanyangwayo zazinomonakalo wezicubu ongaphantsi kunye notshintsho kwimilinganiselo eliqela yoxinzelelo lweoksideshini.
Obo bubungqina bokwenzakala okwexesha elifutshane okubangelwe luvavanyo kwiimpuku. Abubonisi ukuba ukusela iblue yemethylene kuphucula ukuhluzwa kumntu onesifo sezintso esingapheliyo ekudala sinaye. Unyango olunikezelwa ngaphambi kokwenzakala okucwangcisiweyo kuvavanyo nalo lwahlukile ekunyangeni isifo esele sikhona.
Iziphumo zesibindi zibonisa ukuba kutheni igama elithi “antioxidant” liyinkcazelo engaphelelanga yenzuzo. Uvavanyo luka-2018 kwiimpuku ezingamaduna zeWistar eziyi-35 luhlolisise ukunqongophala kwegazi kwinxalenye yesibindi kangangemizuzu eyi-60 nokubuyiselwa kwegazi kangangemizuzu eyi-15. Abaphandi banikezela iblue yemethylene ngomthambo ngaphambi kokubuyiselwa kwegazi baza bathelekisa imilinganiselo yezicubu neyegazi phakathi kwamaqela ovavanyo. Iperoksideshini yeelipid yehla, kodwa imilinganiselo yemitochondria ayizange ibuyele kwimeko yayo yangaphambili. I-AST yanda kumaqela anokunqongophala kwegazi, nokuba ayefumene iblue yemethylene okanye engayifumananga.
Isiphumo esihle sebhayokhemistri nesiphumo sokusebenza esingaguqukanga zinokubakho ngaxeshanye. Ukuxela kuphela umlinganiselo omhle kungenza olu vavanyo lubonakale ngathi luphendula umbuzo obanzi kunalowo lwawumvavanya ngokwenene. Akukho nanye phakathi kwesi sifundo novavanyo lwezintso emisela unyango lwecirrhosis, isifo sesibindi esinamafutha okanye isifo sezintso esingapheliyo ebantwini.
Into omawuyizise kwingxoxo yezonyango
Xa ukusetyenziswa kukuzikhethela, isifo sezintso okanye sesibindi sifuna kuxoxwe ngaso ngaphambi kokuchanabeka. Yiza neenkcukacha ezenza ukuba oko kucetywayo kube nokuvavanywa:
- Uxilongo kunye neziphumo zamva nje ezifanelekileyo zelebhu, kuquka nayiphi na imbali yedialysis.
- Imveliso echanekileyo, uxinaniso, indlela ecetywayo yokunikezelwa kunye nesizathu sokuyiqwalasela.
- Onke amayeza nezongezelelo, kunye nexesha nobungakanani bayo nayiphi na iblue yemethylene esele ithathiwe.
Iinkcukacha zamayeza zihlala zibalulekile kunye nokusebenza kwamalungu omzimba. Isishwankathelo esibanzi sokhuseleko sichaza iimeko apho ichiza lingafanele lisetyenziswe khona kunye neziphumo ezingathandekiyo; isalathiso sokusebenzisana kwamachiza sichaza ukuba kutheni uluhlu lwamayeza lubalulekile. Musa ukuyeka unyango olumiselweyo ngokwakho ukuze kuvuleke indawo yeblue yemethylene.
Umbuzo oluncedo ucacile: bubuphi ubungqina obuxhasa le mveliso nale ndlela yokunikezelwa kule njongo, kumntu oneli nqanaba lokungasebenzi kakuhle kwelungu lomzimba? Ibango elibanzi ngomsebenzi wemitochondria alinako ukuwuphendula.