Chinyorwa
Methylene blue netestosterone: kuongorora zvinotaurwa
Methylene blue haisati yasimbiswa semushonga kana sechinowedzera testosterone muvarume. Kutsvaga kwakaitwa kugadzirira chinyorwa ichi hakuna kuwana muyedzo wevanhu une boka rekuenzanisa unoratidza kuti methylene blue inotorwa nemuromo inowedzera testosterone muvarume vane utano kana kuti inorapa kushomeka kwetestosterone. Humbowo hunoenderana nenyaya iyi hunosanganisira zviedzo zvekukuvara mumhuka, zviedzo zvepituitary yemakonzo, zvakawanikwa zvekutanga pamusoro peprolactin muvanhu, uye kuisa methylene blue zvakananga pamasero embeu yevanhu ari kunze kwemuviri.
Zvidzidzo izvozvo zvinofanirwa kutariswa, asi migumisiro yazvo haigoni kubatanidzwa kuita chirevo chakafara chekuti methylene blue inowedzera testosterone, inoderedza estrogen neprolactin, uye inovandudza kugona kubereka. Chirevo chimwe nechimwe chinoda mugumisiro wacho wakayerwa.
Chii chinonzi humbowo hwekuwedzera kwetestosterone?
Chidzidzo chinobatsira chakaitwa muvanhu chaizotsanangura vatori vechikamu, magadzirirwo echinhu chakaedzwa, nzira yekuchipa, chaienzaniswa nacho, nguva yechidzidzo, uye nzira yekuyera mahormone. Chaizosiyanisa testosterone yose netestosterone yakasununguka, choyera kana shanduko ipi neipi yakaramba iripo. Zviratidzo, kunaka kwemasero embeu, nemigumisiro yakaipa zvaizoda kuongororwa zvakasiyana.
Kunzwa wakasvinura zvakanyanya hakuyeri testosterone. Kufamba kuri nani kwemasero embeu hakuyerawo testosterone. Machende ane masero eLeydig anogadzira testosterone ari pakati pemachubhu umo masero embeu anokura. Mabasa aya anodyidzana, asi mugumisiro weimwe haupi humbowo hweimwe. Ongororo yakafara yezvakanakira methylene blue mutsvakurudzo yevanhu inotaura nezvezvirevo zveutano zvakajairika, kusanganisira zvinonangana nevarume.
Tafura yehumbowo hwezvinotaurwa pamusoro petestosterone
Tafura iyi inosiyanisa zvakawanikwa nezvingadiwa kuti chirevo chinoitirwa vatengi chisimbiswe. Huwandu hwakashandiswa muzviedzo hunotsanangura zvidzidzo, kwete nzira yekushandisa chinhu ichi muvanhu.
| Chirevo kana mubvunzo | Boka rakaongororwa nemhando yemuyedzo | Nzira yekupihwa uye huwandu nenguva | Mugumisiro wakayerwa nezvakawanikwa | Zvinotsigirwa nehumbowo |
|---|---|---|---|---|
| Inowedzera testosterone mushure mekukuvara kwemachende | Makonzo echirume eWistar 35 ari mumapoka mashanu, kusanganisira kukuvara kwakakonzerwa necisplatin | Majekiseni mukati memhango yedumbu; methylene blue 2 kana 4 mg/kg kwemazuva manomwe | Testosterone muserum reropa nezviyero zvemasero embeu zvakanzi zvakakwirira pakupihwa methylene blue kupfuura pakupihwa cisplatin chete | Chiratidzo chemugumisiro wekudzivirira kukuvara mumuyedzo wekukuvara kunokonzerwa nemishonga yekurapa gomarara; hapana kuwedzera kwakaratidzwa muvarume vane utano |
| Inogara ichibatsira machende | Makonzo akura 30 muchidzidzo chekubaya jekiseni panzvimbo chaiyo | Jekiseni munyama yechende kana pakati pezvikamu zvinofukidza chende; kuongororwa mushure memavhiki maviri | Jekiseni rakabayiwa mukati menyama rakaderedza testosterone muserum reropa nehuwandu hwemasero embeu muepididymis; boka rakabayiwa pakati pezvikamu zvinofukidza chende harina kuratidza shanduko dzinokosha pazviyero izvozvo | Nzvimbo yakaiswa chinhu chacho ine basa; hazvigoni kungofungidzirwa kuti chine mugumisiro wakanaka pamahormone nguva dzose |
| Inoderedza prolactin | Makonzo echirume akapihwa estradiol benzoate, aine mapoka ekuenzanisa | Methylene blue pa0.5% muchikafu kwemavhiki matatu | Yakaderedza kukwira kweprolactin muropa kwakabatana neestradiol; methylene blue yoga haina kuderedza prolactin muropa | Mhinduro yakaitika muhurongwa hwemahormone hwakanga hwachinjwa nemuyedzo |
| Inochinja prolactin muvanhu | Varwere gumi vane marwadzo anobva mukukuvadzwa kwetsinga asingapinduri pakurapwa, varume vasere nevakadzi vaviri | Kupihwa mutsinga zvishoma nezvishoma kwemaminitsi 60; 2 mg/kg ichienzaniswa ne0.02 mg/kg | Chiyero cheprolactin chakaenzaniswa chakaderera mushure mekupihwa huwandu hwose huri huviri; musiyano pakati penzira mbiri dzekupihwa wakataurwa | Zvakawanikwa zvekutanga pamusoro pechiratidzo chemumuviri muvarwere vane marwadzo, kwete kurapwa kwakasimbiswa kweprolactin yakakwirira |
| Inovandudza kugona kubereka kwevarume | Mienzaniso yemvura yembeu kubva kuvarume vane utano 20 | Kusanganiswa zvakananga nemishonga yedhayi inoshandiswa pakuvhiya pamwe nezvakaderedzwa kusimba, kunze kwemuviri | Kufamba kwemasero embeu kwakaderera zvikuru pakarepo mushure mekusangana nemethylene blue | Zvakawanikwa murabhoritari pakusangana kwemasero embeu nechinhu ichi, kwete muyedzo wekugona kubereka pakutorwa nemuromo kana kuyerwa kwetestosterone |
| Inoderedza estrogen kana kuchinja DHT muvarume | Hapana muyedzo wevanhu une boka rekuenzanisa wakayera migumisiro yemahormone wakawanikwa mukutsvaga uku | Hapana nzira yekupihwa nemuromo yakasimbiswa pamigumisiro iyi | Hapana kuzivikanwa kwakasimbiswa pakurapa kwekuti mugumisiro unowedzera kana kuderedza, kana kuti wakakura zvakadini | Humbowo hwakasiyana hunodiwa paestradiol nedihydrotestosterone |
| Inowedzera testosterone kuburikidza nekudzivisa kushanda kweenzyme | Zviedzo zvekurabhoritari zvekudyidzana kwemishonga zviri muruzivo rwekunyora mushonga | Kuiswa muchidzidzo kunze kwemuviri; testosterone yakashandiswa sechinhu chinoshandurwa neCYP3A4/5 | Kudziviswa kwekushanda kweenzyme kwakaonekwa | Muyedzo wekushandurwa kwezvinhu mumuviri, kwete mugumisiro wetestosterone wakayerwa pakurapa vanhu |
Zvidzidzo zviri shure kwemitsara iyi zvinoongororwa pazasi. Muunganidzwa wetsvakurudzo yemethylene blue unoronga humbowo zvichienderana neboka rakaongororwa nemagadzirirwo emuyedzo.
Zvinonyatsoratidzwa nemuyedzo wecisplatin
Muchidzidzo chemakonzo chaGholami Jourabi nevamwe, chakabudiswa paindaneti muna 2020 uye muAndrologia muna 2021, cisplatin yakaderedza testosterone muserum reropa nezviyero zvemasero embeu. Vanyori vakataura kuvandudzika pakupihwa methylene blue vachienzanisa neboka recisplatin, pamwe nezvakawanikwa pakuongorora nyama pasi pemaikorosikopu zvaienderana nekuderera kwekukuvara.
Kuenzanisa kwakakosha ndekwekuenzanisa nemhuka dzakakuvadzwa nekemikari. Chiyero chakakwirira kupfuura cheboka rakakuvadzwa rekuenzanisa hachisi humbowo hwekuti kurapwa kunokwidza chiyero chepakutanga chemhuka ine utano. Chidzidzo ichi chaivawo neboka rakapihwa methylene blue chete, asi kuenzanisa testosterone muchidimbu chechidzidzo kuri kuenzanisa necisplatin, kwete kuratidza kuwedzera kupfuura zviyero zvemhuka dzine utano dzisina kupihwa mushonga. Muyedzo uyu mupfupi wemajekiseni hausimbisi nzira yekupihwa nemuromo kuvarume kana nzira yekuchengetedza kugona kubereka panguva yekurapwa kwegomarara.
Humbowo hunoratidzawo mugumisiro wakasiyana kana mamiriro akasiyana. Mumuyedzo waMazroa nevamwe wa2016 wekubaya jekiseni panzvimbo chaiyo, kubaya methylene blue munyama yechende rekonzo kwakakonzera kukuvara kwakapararira kwechimiro chenyama uye kuderera kwetestosterone muserum reropa. Kubaya pakati pezvikamu zvinofukidza chende kwakakonzera kukuvara kwenzvimbo diki. Izvi hazvifanotaura mugumisiro wekutorwa nemuromo, asi zvinodzivisa chirevo chekuti inodzivirira machende mumamiriro ose.
Prolactin, estrogen, neDHT inyaya dzakasiyana
Zvakawanikwa pamusoro peprolactin zvinowanzotaurwa zvakabva muhurongwa hwemahormone hwakachinjwa nemaune. Mumuyedzo waSchreiber nevamwe wa1993, makonzo echirume akapihwa majekiseni eestradiol benzoate, methylene blue muchikafu, zvose zviri zviviri, kana kusapihwa chimwe chazvo. Kubatanidzwa kwezviviri izvi kwakaderedza kukwira kweprolactin inotenderera muropa kwakabatana neestradiol. Methylene blue yoga haina kuchinja prolactin muropa.
Musiyano pakati peropa nenyama unokoshawo: kupihwa kwezvinhu izvi hakuna kudzivisa kuwedzera kweprolactin mukati mechikamu chepamberi chepituitary. Saka chidzidzo ichi hachiratidzi kudzvinyirirwa kweprolactin kuri nyore uye kwakafanana mumuviri wose.
Chidzidzo cha2015 muvarwere gumi vane marwadzo anobva mukukuvadzwa kwetsinga, vakaiswa mumapoka nemukana uye vatori vechikamu nevaongorori vasingazivi kuti munhu apiwa chii chinopa chiratidzo chine miganhu muvanhu. Mugumisiro mukuru wayo wakayerwa waiva marwadzo. Vatsvakurudzi vakayerawo mapuroteni pamberi nepashure pekupihwa methylene blue mutsinga, vachienzanisa huwandu huviri hwekupihwa. Prolactin yakaderera mushure mezvose zviri zviviri, paine musiyano pakati penzira mbiri dzekupihwa. Muyedzo wekuyera wakapa zviyero zvemapuroteni zvinoenzaniswa, kwete huwandu chaihwo hwemahormone hunoshandiswa pakurapa. Zvakawanikwa izvi zvekutanga hazvisimbisi kuderera kweprolactin kunoramba kuripo, kurapwa kweprolactin yakawandisa, kana kubatsira testosterone.
Kuderedza mhinduro kune estradiol yakapihwa hakuratidziwo kuti methylene blue inoderedza estrogen inotenderera muropa kana kudzivisa kushanda kwearomatase muvarume. DHT, kana kuti dihydrotestosterone, mumwe mugumisiro wehomoni wakasiyana. Zvakawanikwa pamusoro petestosterone hazvigoni kutsiva mugumisiro weDHT usipo. Zvinotaurwa pamusoro peimwe neimwe yehomoni idzi zvinoda zviyero zvakananga mumamiriro ekushandiswa ari kukurudzirwa.
Humbowo hwemasero embeu yevanhu hausi muyedzo wemahormone
Mumuyedzo waSheynkin nevamwe wa1999 wemasero embeu yevanhu, vatsvakurudzi vakasanganisa zvikamu zvemienzaniso yemvura yembeu nezvinhu zvinoshandiswa pakuvhiya nhengo dzekubereka. Methylene blue yakakonzera kuderera kukuru, kwepakarepo kwekufamba kwemasero embeu, kusanganisira payakanga yaderedzwa kusimba sezvakaedzwa. Mushonga wemvura waRinger une lactate hauna kuchinja kufamba kwacho.
Uhwu humbowo hwekurabhoritari hunobva pazvinhu zvakatorwa muvanhu. Vatori vechikamu havana kutora methylene blue nemuromo, uye vaongorori havana kuyera testosterone yavo muropa, kubata pamuviri, kana kuzvarwa kwevana vari vapenyu. Zvakawanikwa izvi hazvigoni kusimbisa kubatsira kana njodzi pakugona kubereka kana methylene blue ikapihwa neimwe nzira inosvika mumuviri wose. Zvinoratidza kuti nei mashoko ekuti “yakaongororwa mumasero embeu yevanhu” asingambofaniri kupfupikiswa achinzi “inovandudza kugona kubereka kwevarume.”
Kutaurwa kwetestosterone kunogona kureva chimwe chinhu chakasiyana zvachose
Ruzivo rwekunyora mushonga weProvayBlue runotsanangura mukana wekudziviswa kwekushanda kweCYP3A4/5 kunoenderana nenguva muzviedzo zvekunze kwemuviri, pachishandiswa testosterone sechinhu chinoshandurwa neenzyme. Pano, testosterone chinhu chinoshandiswa kuyedza kushanda kweenzyme. Kuonekwa kwayo mundima iyoyo hakusimbisi kuwedzera kwekugadzirwa kwehomoni kana kuwanda kwayo muropa revarwere.
Saizvozvowo, tsananguro yemashandiro esimba remasero haigoni kutsiva muyedzo wemahormone. Inofanira kuramba ichiratidza kuti nzira neuwandu hwekupihwa zviri kukurudzirwa zvinochinja mugumisiro wakakodzera muboka revanhu rinotarisirwa.
Kana chiri kunetsa chiri testosterone yakaderera
Basa rinofanira kuitwa nderekusimbisa kana kushomeka kwetestosterone kuripo uye kuti nei kuripo. Zvinokurudzirwa neEndocrine Society pakuongorora zvinoda zviratidzo zvinoenderana nekushomeka uku pamwe netestosterone inoramba ichiyerwa iri yakaderera, pachidzokororwa kuyerwa mangwanani munhu asati adya. Kumwe kuongorora kunosiyanisa zvikonzero zvinobva mumachende nezvinobva mupituitary kana muhypothalamus. Mugumisiro mumwe chete kana shanduko yekunzwa une simba hazvina kukwana.
Methylene blue haifaniri kutsiva kurapwa kwemahormone kwakanyorwa nachiremba kana kuongororwa kweprolactin kana testosterone isiri pamwero wakajairika. Kusava nechokwadi kwekubatsira kwayo mahormone hakubvisi njodzi dzayo dzakasimbiswa: ruzivo rwekunyora mushonga runoyambira nezveserotonin syndrome kana ichishandiswa nemishonga inokanganisa serotonin uye runorambidza kushandiswa kana paine kushomeka kweG6PD nekuda kwenjodzi yekuparara kwemasero matsvuku eropa. Gwaro rekuchengeteka kwemethylene blue rinotsanangura njodzi idzi mumamiriro adzo.
Pachirevo chipi nechipi pamusoro petestosterone, bvunza kuti chii chakayerwa, muna ani, nenzira ipi yekupihwa, uye chichienzaniswa nei. Parizvino, mibvunzo iyoyo inotungamirira kune zvakawanikwa muzviedzo, kwete kumugumisiro wakaratidzwa wekuwedzera testosterone muvarume.