Chinyorwa
Methylene blue pamwe nedoro, caffeine, nezvokuwedzera pakudya
Methylene blue haigoni kunzi yakachengeteka kushandiswa pamwe nedoro, kofi, kana musanganiswa wezvokuwedzera pakudya nekuda kwemashoko okuti “hapana kudyidzana kunozivikanwa.” Mashoko iwayo angareva kuti hapana akaongorora musanganiswa wacho zvakakwana. Angavanzawo chimwe chinobatsira kuziva: ongororo yakayera mugumisiro mumwe chete ikasaona shanduko, asi mimwe migumisiro yakasara isina kuongororwa.
Doro necaffeine zvine humwe uchapupu hunobva zvakananga muongororo dzevanhu. Kana iri creatine, shilajit, N-acetylcysteine (NAC), necoenzyme Q10 (CoQ10), zvinyorwa zvakawanikwa zvechinyorwa chino hazviratidzi kuchengeteka kana kubatsira kwekugara zvichishandiswa nemuromo pamwe nemethylene blue. Aya mapoka euchapupu akasiyana, uye tafura iri pasi inoachengeta akaparadzana.
Tafura yeuchapupu hwekudyidzana
“Kushaikwa kweuchapupu kubva kuongororo dzevanhu” kunoreva kuti uchapupu hwakakodzera hwekuongorora musanganiswa muvanhu hahuna kuwanikwa pachinyorwa chino. Hazvirevi kuti kudyidzana kunokuvadza kwakaratidzwa, kana kuti hapana ongororo inogona kunge iripo. Tafura iyi inotaura nezvemisanganiswa ine chekuita nemararamiro; kudyidzana nemishonga inonyorwa nachiremba uye serotonin syndrome zvinoda ongororo yakasiyana yemishonga.
| Musanganiswa | Uchapupu huripo | Zvinotsigirwa neuchapupu | Zvisati zvajeka |
|---|---|---|---|
| Doro | Ongororo yemafambiro uye kubviswa kweethanol mumuviri wemakonzo nevanhu vane utano vakazvipira yaisanganisira zviyero zvakatorwa muvanhu. | Methylene blue haina kushandura mafambiro uye kubviswa kweethanol mumuviri wevanhu vakazvipira. | Izvi hazviratidzi kuti kunwa doro kwakachengeteka, hazvidzivisi kudhakwa, uye hazvitsigiri nzira yokurapa kusanzwa zvakanaka kunotevera kunwa doro. |
| Kofi kana caffeine | Mashoko ekunyora PROVAYBLUE semushonga anotaura nezveongororo yekudyidzana yakaitwa muvanhu. | Huwandu hwecaffeine hwaiwanikwa mumuviri hahuna kuchinja payakapiwa pamwe nemethylene blue yakapinzwa mutsinga pasi pemamiriro akaongororwa. | Mugumisiro uyu haupedzi mibvunzo yekushandisa kakawanda nemuromo, zvigadzirwa zvakasiyana, zvinokanganisa kurara, uye kusiyana kwemaitiro anoita miviri yevanhu. |
| Creatine | Uchapupu kubva kuongororo dzevanhu hwemusanganiswa uyu hahuna kuwanikwa. | Hapana mashoko anotsigirwa neuchapupu okuti kusanganisa izvi zviviri kunowedzera kubatsira pakufunga kana pakurovedza muviri. | Kuti muviri unoshivirira sei musanganiswa uyu, migumisiro yawo nekufamba kwenguva, uye kudyidzana kwawo mukati memusanganiswa mukuru hazvisati zvajeka. |
| Shilajit | Uchapupu kubva kuongororo dzevanhu hwemusanganiswa uyu hahuna kuwanikwa. | Kuitsanangura sechinhu chine maminerari kana “chinotsigira mitochondria” hakuratidzi kuti inokodzera kushandiswa pamwe nemethylene blue. | Zvinhu chaizvo zviri muchigadzirwa uye kuchengeteka kwekuchishandisa pamwe nemethylene blue zvinoda kuongororwa zvakasiyana. |
| NAC | Ongororo dzisati dzaitwa muvanhu dzinosanganisira ongororo yemusanganiswa mumakati ane chepfu yeacetaminophen. | Musanganiswa uyu wakaongororwa mune imwe nyaya chaiyo yekuiswa muchetura kwemhuka. | Uhwu hahusi uchapupu hwekushandisa musanganiswa wezvokuwedzera pakudya zuva nezuva muvanhu kana hwenzira yokudzima kushanda kwemethylene blue. |
| CoQ10 | Uchapupu kubva kuongororo dzevanhu hwemusanganiswa uyu hahuna kuwanikwa. | Kutaurwa kwazvo zviri zviviri munyaya dzesimba remasero hakuratidzi kuti kushanda pamwe kunounza rubatsiro. | Kuchengeteka kwemusanganiswa nerubatsiro rwakawedzerwa hazvisati zvaratidzwa; CoQ10 inewo kudyidzana kwayo nemishonga. |
Mufananidzo webutiro imepu yepfungwa yemapoka aya euchapupu. Mifananidzo yezvinhu zvinoumba misanganiswa inoratidza mibvunzo, kwete magadzirirwo akaongororwa kana misanganiswa inokurudzirwa.
Doro: mugumisiro wakaonekwa mumhuka hauna kuonekwa muvanhu
Vatsvakurudzi vakaongorora kana methylene blue ichichinja mashandisirwo uye kubviswa kweethanol mumuviri, pane kungovimba nechikonzero chinobva pamashandiro emakemikari omumuviri.
Muongororo ya2000 yakaitwa naVonlanthen, Beer, naLauterburg, methylene blue yakawedzera kuputswa kweethanol mumasero echiropa akaparadzaniswa uye mumakonzo mapenyu. Asi muvanhu vane utano vakazvipira, haina kushandura mafambiro uye kubviswa kweethanol mumuviri kana kugadzirisa kukwira kwereshiyo yelactate nepyruvate kwaibatanidzwa neethanol, chiratidzo cheshanduko yeredox yakanga ichiongororwa.
Izvi zvinoratidza pachena kuti rubatsiro rwaifungidzirwa haruna kuonekwa pasi pemamiriro eongororo yevanhu. Hazvipi chikonzero chokushandisa methylene blue kuti kudhakwa kupere nokukurumidza. Zvinoratidzawo kuti kuyera mashandisirwo emakemikari mumuviri nekuongorora kuchengeteka zvinhu zvakasiyana: kusachinja kwekubviswa kweethanol hakukuudzi kuti kugona kutonga zvinhu, kudzora mafambiro omuviri, kana zviratidzo hazvizokanganiswi.
Usashandisa methylene blue sechikonzero chokunwa doro kana senzira yokugadzirisa zvinokonzerwa nekunwa. Kana methylene blue iri chikamu chokurapwa, bvunza boka riri kukurapa nezvedoro mumamiriro ekurapwa ikoko. Mibvunzo pamusoro petyramine nezvokudya zvakaviriswa ine chokuita nekudziviswa kwekushanda kwemonoamine oxidase, asi haina kufanana nekuyera kubviswa kweethanol mumuviri.
Kofi: kusachinja kwehuwandu hunowanikwa mumuviri mugumisiro une muganhu
Ongororo yecaffeine inotaurwa pamashoko emushonga yakashandisa chipimo che2 mg/kg chemethylene blue chakapinzwa mutsinga. Caffeine yakashandiswa kuongorora CYP1A2, enzyme inobatanidzwa mukuputswa kwayo mumuviri. Kusachinja kwehuwandu hunowanikwa mumuviri kwakataurwa kunopindura mubvunzo wokuti methylene blue yakachinja here huwandu hwecaffeine hwaitenderera mumuviri pasi pemamiriro iwayo. Uku kutsanangurwa kweongororo, kwete kurudziro yechipimo chokushandisa nemuromo.
Munhu anonwa kofi anowanzoda mhinduro yakakura kupfuura iyoyo: musanganiswa uyu uchaita kuti ndizvidye mwoyo, nditadze kurara, kana kuti uchakanganisa kumhanya kwekurova kwemwoyo wangu here? Mugumisiro wemafambiro emushonga mumuviri haugoni kupindura mibvunzo yose iyi. FDA inotsanangura kutadza kurara, kunzwa mwoyo uchirova zvakasimba kana zvisina kujairika, kuzvidya mwoyo, uye kusvotwa pakati pemigumisiro yakaipa yecaffeine pachayo. Kuonekwa kwezviratidzo izvi mushure mekushandisa musanganiswa hakuratidzi, pachako, kudyidzana kutsva kwemakemikari kana kuratidza shanduko muuwandu hwemakemikari anotakura mashoko pakati pemasero etsinga.
Sanganisira kwese kunobva caffeine pakutsanangura zvakapinda mumuviri: kofi, tii, zvinwiwa zvinowedzera simba, zvigadzirwa zvinoshandiswa usati warovedza muviri, uye mapiritsi. Muganhu wakajairika wecaffeine kuvanhu vakuru vane utano hausi muganhu wekuchengeteka wakaongororwa pamisanganiswa ine methylene blue. Uye mugumisiro wecaffeine haupedzi mibvunzo pamusoro pezvimwe zvinhu zvose zviri mumusanganiswa unowedzera simba.
Zvokuwedzera pakudya: mashandiro anofungidzirwa haasi musanganiswa wakaongororwa
Creatine, NAC, neCoQ10 zvinowanzotaurwa pamwe chete pakukurukura kugadzirwa nekushandiswa kwesimba mumuviri kana kushushikana kwemasero kunokonzerwa neoxidation. Mapoka akakura iwayo haafanotauri mugumisiro uchazoonekwa muvanhu pakuwedzera methylene blue. Ongororo yemusanganiswa inobatsira ingaenzanisa musanganiswa nezvinhu zvinouumba zvichishandiswa chimwe nechimwe choga, yoongorora zvose rubatsiro nekukuvadza. Ongororo dzakasiyana dzechinhu chimwe nechimwe hadzigoni kupa kuenzanisa ikoko.
NAC muenzaniso unonyanya kubatsira. Kuenzanisa kwakaitwa murabhoritari kwaisanganisira methemoglobinemia yakakonzerwa nenitric oxide kwakaongorora methylene blue, riboflavin, neNAC kunze kwemuviri. Kuwana mazita azvo pamwe chete muchinyorwa cheongororo hakuratidzi kuti vanhu vanofanira kuzvimedza pamwe chete. Kuenzanisa kwemurabhoritari kana ongororo yemakati akaiswa muchetura hazviratidzi kuti NAC inodzivirira huturu hwemethylene blue.
Kuziva kuti chigadzirwa chacho chii chaizvo kunowedzera mumwe mubvunzo panyaya yeshilajit nemisanganiswa ine zvinhu zvakawanda. NCCIH inotsanangura zvinonetsa pamusoro pesimbi dzine chepfu mune zvimwe zvigadzirwa zveAyurveda. Izvi hazviratidzi kuti chigadzirwa chose cheshilajit chine tsvina inokuvadza. Zvinoreva kuti zvinhu zviri muchigadzirwa nekunaka kwacho inyaya dzakasiyana nekudyidzana kwemishonga; kupasa bvunzo yezvinosvibisa hakuratidzi kuchengeteka kwemusanganiswa.
Kudyidzana kunogonawo kusanganisira chinhu chechitatu. NCCIH inotaura nezvekudyidzana kunogona kuitika pakati peCoQ10 newarfarin kana insulin. Izvi hazvisi uchapupu hwekudyidzana nemethylene blue. Zvinoratidza kuti kuongorora zvinhu zviviri chete zvataurwa pakutsvaga kunogona kupotsa musanganiswa une kukosha pakurapwa.
Zvaunofanira kuuya nazvo pakuongororwa kwekudyidzana
Kudziviswa kwekushanda kwemonoamine oxidase A yemunhu yakacheneswa nemethylene blue kwakaratidzwa muongororo dzemashandiro emishonga. Huturu hweserotonin hwakakomba hunoitika pamwe nemishonga inokanganisa serotonin hunozivikanwawo mumashoko ayo emushonga. Kuti chigadzirwa chinonzi chokuwedzera pakudya hakubvisi kudiwa kwekuongorora zvinhu zvacho zvinoshanda maererano nenjodzi idzodzo.
Huya nemavara chaiwo ezvigadzirwa, kuwanda kwemethylene blue mumusanganiswa uye nzira yayakashandiswa nayo, huwandu hwakatorwa, nguva yazvakapinda mumuviri, mimwe mishonga, uye chero zviratidzo zvitsva kumufamasi kana nyanzvi yezvekurapa. Kuziva nguva kunobatsira kutsanangura zvakapinda mumuviri nezvakaitika; hakupi nguva yokupatsanura kushandiswa yakasimbiswa yechikwata chezvinhu chisina kuongororwa. Usarega kurapwa kwakanyorwa nachiremba kuti uwane mukana wokushandisa methylene blue.
Kuvhiringidzika kutsva kana kusagadzikana pamwe nefivha, kudikitira zvakanyanya, kudedera, kana kuomarara kwetsandanyama mushure mekushandisa musanganiswa zvinoda kuongororwa nachiremba nokukurumidza. Mamwe mamiriro anoita kuti isafanira kushandiswa uye mashoko anodiwa pakuongorora kuita kwemuviri kusina kunaka anotsanangurwa muzvinokonzerwa nemethylene blue uye kuchengeteka kwayo.