Chinyorwa
Methylene blue nekuderedza uremu: zvinonyatsoongororwa nezvidzidzo
Hazvisati zvasimbiswa kuti methylene blue mushonga unoshanda pakuderedza uremu muvanhu kana ichitorwa nemuromo. Zvidzidzo zvakawanikwa nokuda kwechinyorwa chino hazvina muyedzo wevanhu une boka rekuenzanisa unoratidza kuti kuitora kunokonzera kuderera kwemafuta emuviri kunoramba kuripo. Zvinosanganisira miedzo yemetabolism, zviyero zveuremu hwemhuka, uye zvidzidzo zvevanhu vane kufutisa umo dhayi iyi yaiva nerimwe basa.
Misiyano iyoyo inoshandura mhinduro. Sero rechiropa rinoshandisa okisijeni yakawanda chinhu chinoonekwa pamashandiro aro. Nguruve inowedzera uremu zvishoma mushure menzira yekuedza inoitwa mudumbu mhedzisiro yekurapa mhuka. Munhu anorasikirwa nemafuta mushure mekurapwa nebharuni remudumbu anoratidza mhedzisiro muvanhu, asi izvi hazvitsaure zvinenge zvaitwa nedhayi iri mukati mebharuni.
Chii chinganzi humbowo hwekuderedza uremu?
Uremu hwemuviri hunosanganisira mafuta, matishu asiri mafuta, mapfupa, mvura, uye zviri mudumbu nemuura. Nhamba yakaderera pachikero haitauri kuti ndechipi chezvinhu izvi chachinja. Zviyero zvezvinoumba muviri, zvakadai sedual-energy X-ray absorptiometry (DXA), zvinobatsira kupatsanura huwandu hwemafuta kubva kumatishu akapfava asiri mafuta nemaminerari emapfupa. Kunyange zvakadaro, matishu asiri mafuta haangorevi tsandanyama dzakabatana nemapfupa chete.
Chidzidzo chinogutsa pamusoro pekudzora uremu chinofanira kuenzanisa nzira dzekurapa dzakatsanangurwa zvakajeka muvanhu vanofananidzika, kuyera shanduko kwenguva yakakodzera, kufunga nezvekudya nedzimwe nzira dzinoshandiswa, uye kushuma zvinokuvadza nevakabuda muchidzidzo. Chinofanira kusiyanisa kuderedza uremu hwagara huripo nekudzivirira kuwedzera kweuremu, uye kuderera kwekutanga nekuchengetedza uremu hwadzikira.
Zviratidzo zvemetabolism zvinopindura mibvunzo yakamanikana. Mafuta ari muchiropa anotsanangura kuungana kwemafuta munhengo iyoyo. Kunzwisisa insulin kunotsanangura kuti muviri unopindura sei kuinsulin. Kushandiswa kweokisijeni nemasero kunotsanangura chikamu chemetabolism yesimba mumamiriro emuyedzo. Hapana chimwe chezvizvi chinotsiva kuderera kwemafuta emuviri muvanhu kwakayerwa uye kunoramba kuripo.
Kuenzanisa zvinonzi zvinoitika nezvidzidzo
Kuenzanisa uku kunopatsanura mhedzisiro yakayerwa nezvingafungidzirwa nemuverengi kuti zvakaratidzwa. Malinki ezvidzidzo anoenda kumishumo yepakutanga kana marekodhi ayo ePubMed.
| Zviri kuongororwa zvinonzi zvinoitika | Chidzidzo nenzira yakashandiswa | Zvakayerwa kana kushumwa | Zvinotsigirwa nemhedzisiro |
|---|---|---|---|
| “Inomutsa metabolism, saka inopisa mafuta emuviri.” | Shin nevamwe, 2014: miedzo yemasero echiropa uye muenzaniso wembeva dzaipiwa kudya kune mafuta akawanda; kushandiswa kwemethylene blue kwaisanganisira kuitora nemuromo. | Kufambiswa kwezviratidzo kune chekuita neSIRT1/AMPK, zviyero zvemitochondria, uye kuderera kwekuungana kwemafuta muchiropa nesteatohepatitis mumuenzaniso wemhuka. | Fungidziro pamusoro pemetabolism yechiropa. Hazvisimbisi kuderera kweuremu muvanhu kunoramba kuripo. |
| “Chidzidzo chekufutisa chakaratidza kuti methylene blue inoderedza uremu.” | Lee nevamwe, 2022: mudziyo wemudumbu wakaputirwa nemethylene blue pamwe nekurapa kwephotodynamic kunomutswa nelaser munguruve. | Pavhiki imwe, kuwedzera kweuremu hwemuviri kwakashumwa kwaiva 12% nekurapa kwephotodynamic zvichienzaniswa ne24% muboka rekuenzanisa; mazinga eghrelin aivawo akaderera. | Kuwedzera kweuremu kushoma mushure menzira yemhuka yakabatanidza zvinhu zvakawanda. Shanduko dzose dziri mbiri dzakashumwa dzaiva kuwedzera kweuremu. |
| “Methylene blue yakaderedza uremu hwemuviri isina kuderedza kudya.” | Yang nevamwe, 2023: methylene blue yakaiswa zvakananga muduodenum pamwe nekurapa kwephotodynamic; pfupiso inoti makonzo aipiwa kudya kune mafuta akawanda ndiwo akashandiswa kuyedza kushanda kwenzira iyi. | Uremu hwemuviri hwakaderera pane hweboka raiitwa nzira inotevedzera kurapwa asi isiri kurapa chaiko pamazuva 30, kuvandudzika kwezviyero zvine chekuita neglucose, uye pasina musiyano wakakosha pakuwanda kwekudya. | Mhedzisiro yenzira inoitwa muura isati yaedzwa muvanhu, kwete humbowo hwekumedza methylene blue sechinowedzerwa pakudya. |
| “Zvidzidzo zvevanhu zvakayera kuderera kwemafuta zvichishandisa methylene blue.” | Boka rakateverwa kwemwedzi mitanhatu richishandisa bharuni remudumbu: bharuni raiva nemvura ine munyu nemethylene blue; 39 pavatori vechikamu 50 vakapedza nguva yekuteverwa. | DXA yakaratidza kuderera kwehuwandu hwemafuta nehuwandu hwematishu asiri mafuta mushure mekurapwa nebharuni. | Shanduko yezvinoumba muviri wevanhu mushure mekushandiswa kwemudziyo. Kushanda kwedhayi pachayo hakuna kuedzwa. |
| “Muyedzo wekuderedza uremu waigovera vanhu mumapoka zvisina kurerekera waisanganisira dhayi iyi.” | Muyedzo webharuni waiva neboka raiitwa nzira inotevedzera kurapwa uye vanhu vachichinjana nzira dzacho: nguva dzekurapwa nebharuni nenguva dzenzira inotevedzera kurapwa asi isiri kurapa chaiko, pamwe nekurapwa kuburikidza nekudya. | Kuderera kweBMI nechikamu muzana cheuremu hwakawandisa hwakarasika. | Humbowo pamusoro penzira yekurapwa nebharuni yose. Kugovera vanhu mumapoka zvisina kurerekera hakushanduri chinhu chose chinoshandiswa pakurapa kuti chive icho chinokonzera mhedzisiro yacho. |
Nei mashandiro emetabolism asingapedzi mubvunzo uyu
Chidzidzo chechiropa cha2014 inzvimbo yakakodzera yekutangira pafungidziro yemashandiro mumuviri. Mumasero echiropa, methylene blue yakashandura reshiyo yeNAD+/NADH nemaitiro ane chekuita nekushanda kwemitochondria nekugadziriswa kwemafuta. Muyedzo wembeva waisanganisira mavhiki masere ekudya kune mafuta akawanda uye wakawana kuungana kwemafuta akawandisa muchiropa kwakaderera.
Uhwu humbowo hunobatsira hunobva mumuyedzo pamusoro petishu chaiyo nemuenzaniso wechirwere. Kuti zvifungidzirwe kuti izvi zvinoreva kuderera kwemafuta mumuviri wose, panodiwa mamwe matanho: shanduko yacho inofanira kuitika pahuwandu hunogona kutsungirirwa nevanhu, kuramba iripo pakudya nekuita mabasa zvakajairika, kushandura simba rose rinosara richichengetwa mumuviri, uye kuburitsa mhedzisiro yakakosha pakurapa. Kuyera danho rekutanga hakugoni kusimbisa anozotevera.
“ATP yakawanda” haisiwo tsananguro yakakwana yekuderedza uremu. ATP imorekuru inoshandiswa nemasero kufambisa simba. Kugadzirwa kwayo, chinopa simba chinodiwa kuigadzira, uye simba rose rinoshandiswa pazuva zvinhu zvine hukama asi zvakasiyana. Zvinonzi zvinoitika pamusoro pekushanda zvakanaka kwemitochondria zvinoda zviyero zvakananga zvisati zvanzi zvinoreva macalorie anoshandiswa kana mafuta anorasika.
Ongororo yedu yezvakanakira methylene blue mukutsvakurudza kwevanhu inoshandisa musiyano mumwe chete uyu pakati pemashandiro anofungidzirwa kuti anogoneka nerubatsiro rwakaonekwa pamurwere.
Nzira dzinomutswa nechiedza ibazi rakasiyana rekutsvakurudza
Kurapa kwephotodynamic kunobatanidza chinhu chinopindura kuchiedza nechiedza chinoiswa pachiri kuti pave neshanduko mumuviri panzvimbo iyoyo. Muchidzidzo chenguruve cha2022, methylene blue yakaiswa mumudziyo wemudumbu ikamutswa nechiedza chelaser. Nzira yacho yaisanganisira mudziyo, kubata kwawo matishu, dhayi, uye kuvhenekerwa. Kubvisa zvinhu izvozvo kunoshandura kurapa kuri kutaurwa nezvako.
Mushumo weduodenum wa2023 wakaongorora kurapwa kweimwe nzvimbo muura uye wakashuma shanduko dzenguva pfupi mumavilli eduodenum. Musoro wawo unoti “muenzaniso wembeva,” asi pfupiso yawo inotsanangura makonzo aipiwa kudya kune mafuta akawanda pakuyedza kushanda kwenzira iyi pametabolism. Musiyano iwoyo mumushumo ndechimwe chikonzero chekuverenga nzira dzakashandiswa pane kufungidzira muyedzo kubva pamusoro wechinyorwa. Zvakawanikwa izvi hazvipembedzi kubatanidza kumedza dhayi nekushandisa panera yechiedza chitsvuku kumba.
Zviyero zvekuderera kwemafuta muvanhu zvinoda kutsanangurwa nechikonzero chaicho
Boka rebharuni rakateverwa kwemwedzi mitanhatu rinoratidza matambudziko maviri akasiyana pakududzira. Pavatori vechikamu vakapedza nguva yekuteverwa, uremu hweavhareji hwakaderera ne11.7 kg. DXA yakanyora kuderera kweavhareji kwe7.53 kg muhuwandu hwemafuta uye 3.70 kg muhuwandu hwematishu asiri mafuta. Saka shanduko yechikero yakanga isiri mafuta chete.
Dambudziko rechipiri nderekuti chii chakakonzera shanduko. Vanhu ava vakaisirwa bharuni remudumbu raiva nemvura ine munyu nedhayi. Havana kugoverwa zvisina kurerekera kuti vamwe vatore methylene blue nemuromo vamwe vachitora placebo. Zviyero zvezvinoumba muviri idata chairo revanhu, asi kuti shanduko idzodzo dzakakonzerwa nemethylene blue kungave kupindura mubvunzo usina kuedzwa nechidzidzo. Raibhurari yekutsvakurudza inoronga zvidzidzo maererano nenzira yakashandiswa nemhedzisiro kuitira kuti misiyano iyi irambe ichioneka.
Humbowo hunopembedza kuitora kuti uremu huderedzwe here?
Humbowo hwaongororwa pano hahusimbisi rubatsiro pakuderedza uremu runogona kuenzaniswa nenjodzi dzekuramba uchiitora nemuromo. Chiratidzo chemetabolism mumhuka hachigoni kupa huwandu hunoshanda muvanhu kana nguva yekuishandisa, uye nzira inoshandisa mudziyo haigoni kupa chirongwa chekuitora nemuromo.
Ruzivo rweUS rwekupa Provayblue inopinzwa mutsinga runotsanangura methemoglobinemia inowanikwa mushure mekuzvarwa sechikonzero chekuishandisa. Runoyambira nezveserotonin syndrome yakakomba kana ichishandiswa nemishonga inobata serotonin nemaopioid, uye runorambidza kushandiswa kune vane kushomeka kweG6PD nokuda kwenjodzi yehemolytic anemia. Yambiro idzodzo dzekurapa hadzisi mvumo yekuti zvigadzirwa zvinotorwa nemuromo nevatengi zvakachengeteka. Dzinoratidza kuti kunyange chinangwa chisina kusimbiswa chekuderedza uremu chinoda kutariswa kwemashandiro emishonga mumuviri.
Kumunhu ari kufunga kushandisa methylene blue nokuti uremu hwakachinja mushure mekutanga mumwe mushonga, kuongorora mishonga kunobatsira kupfuura kuwedzera chinhu chichiri kuyedzwa. Ongorora humbowo hwemigumisiro isingadiwi, mamiriro anorambidza kushandiswa, nekudyidzana kwemishonga nachiremba kana nyanzvi yemishonga. Zvinonzi zvinoitika zvinokodzera kutorwa sedanho zvinoda nzira yakatsanangurwa yekushandisa muvanhu, zviyero zvemafuta kana uremu, uye kuteverwa kunoratidza kana rubatsiro rwacho ruchiramba ruripo.