Chinyorwa
Kudyidzana kwemethylene blue nemishonga: mishonga yekuora mwoyo, maopioid, uye hurwere hweserotonin yakawandisa
Methylene blue inogona kukonzera kudyidzana kwakakomba nemishonga inokanganisa serotonin. Ruzivo rwekunyorera PROVAYBLUE inopinzwa mutsinga rune yambiro yakaiswa mubhokisi pamusoro pehurwere hweserotonin yakawandisa hunogona kuuraya kana ikashandiswa pamwe nemishonga inoshandura mashandiro eserotonin uye maopioid. Chigadzirwa chinonwiwa hachingoerekani chasununguka panjodzi iyoyo.
Usati wawedzera methylene blue, ita kuti nyanzvi yemishonga kana munhu anonyora mishonga aongorore runyorwa rwose rwemishonga, kusanganisira yaunombotora apo neapo, zvigadzirwa zvechikosoro, zvinowedzera kudya, uye mhando yemethylene blue yauri kuda kushandisa. Usarega mushonga wauri kutotora kuti ugone kuiwedzera. Mubvunzo unobatsira ndewekuti musanganiswa iwoyo chaiwo wakakodzera munhu wacho here, kwete kuti mumwe munhu paindaneti akambouedza here.
Nei dhayi richidyidzana nemishonga yekuora mwoyo
Serotonin ikemikari inotakura mashoko mumuviri. Zvainoita zvinoenderana, pakati pezvimwe zvinhu, nekukurumidza kunoita masero kuitora zvakare nekuiputsa. Mishonga inosarudza kudzivisa kutorwazve kweserotonin, kana kuti SSRIs, inoderedza kutorwazve kwayo. Monoamine oxidase A, yakapfupikiswa kuti MAO-A, ienzyme inobatsira pakuputswa kweserotonin. Kudzivisa maitiro ose ari maviri kunogona kuita kuti kushanda kweserotonin kuwandise.
Muongororo yaRamsay, Dunford, naGillman ya2007 pamusoro pemaenzyme, methylene blue yakadzivisa zvakanyanya MAO-A yemunhu yakanga yacheneswa. Chiyero chekudzivisa chakataurwa chaiva chinenge 27 nanomolar. MAO-B yaida huwandu hwakanyanya kukwirira. Ichi chaiva chiedzo chemurabhoritari, kwete ongororo yekuona mwero unogamuchirika wekunwa kana yekuyera mukana wekuti mishonga idyidzane.
Kudziviswa kwacho kwaigona kudzokera kumashure. Izvozvo zvinotsanangura kudyidzana neenzyme; hazvirevi kuti zvinokuvadza zvinenge zvaitika zvichava zvishoma kana kuti zvakachengeteka kuzvigadzirisa kumba. Zvakawanikwa murabhoritari zvinotsanangura nzira inokonzera zvakataurwa muzviitiko zvevarwere, asi hazvipi muganhu wakachengeteka wemunhu mumwe nomumwe.
Tafura yekudyidzana: boka remishonga, nzira yekuipinza mumuviri, uye humbowo
Tafura iyi inosiyanisa yambiro yakavakirwa pazviitiko zvevarwere, nzira inogona kutsanangura kudyidzana, uye kusakwana kwehumbowo hwakananga. Mienzaniso haibatanidzi mushonga wose uri muboka. Chikamu chenzira yekupinza mumuviri chinoreva methylene blue, kunze kwekunge imwe nzira yataurwa.
| Boka remishonga kana mubvunzo | Humbowo hunoenderana nenzira yekupinza mumuviri | Zvinorehwa nezvakawanikwa |
|---|---|---|
| Mishonga yekuora mwoyo inoshandura mashandiro eserotonin: SSRIs, SNRIs, uye clomipramine | Ruzivo rwemushonga weIV runoyambira kuti isashandiswa pamwe chete. Mishumo yakaburitswa yezviitiko zvevarwere inosanganisira kupinzwa mumuviri kwete nemukanwa; panewo chiitiko chechigadzirwa chemishonga yakasanganiswa chinonwiwa. | Iyi injodzi yakakomba yekudyidzana yakatosimbiswa, kwete mubvunzo wefungidziro chete pamusoro pekukodzera kushandiswa pamwe chete. |
| Mishonga inodzivisa MAO, kusanganisira MAOIs inoshandiswa muhutano hwepfungwa uye linezolid | Ruzivo rwemushonga weIV runodoma mishonga iyi pakati pemisanganiswa inofanira kudziviswa. | Methylene blue inowedzera kudziviswa kweMAO; chinangwa chinowanzoitirwa mushonga hachiratidzi njodzi dzose dzekudyidzana kwawo. |
| Bupropion, kusanganisira Wellbutrin | Ruzivo rwebupropion runotaura zvakananga nezvemethylene blue yeIV uye kukwira kweBP kunogona kukonzerwa nazvo. | Kusava muboka reSSRIs hakuratidzi kuti mishonga inogona kushandiswa pamwe chete zvakachengeteka. |
| Mishonga yeamphetamine inokurudzira kushanda kwemuviri, kusanganisira Adderall XR | Ruzivo rwazvino rweamphetamine runosanganisira methylene blue yeIV pamishonga isingabvumirwi kushandiswa pamwe neMAOIs nekuda kwenjodzi yekukwira kweBP kwakanyanya. | Kukuvadzwa kwemwoyo netsinga kunokosha pamwe nekukuvadzwa kunokonzerwa neserotonin. Mashoko aya pamusoro peIV haasimbisi kuti kunwa mishonga iyi pamwe chete kwakachengeteka. |
| Maopioid, kusanganisira buprenorphine/naloxone kana Suboxone | Ruzivo rweSUBOXONE runodoma methylene blue yeIV pakati pemishonga inoshandura mashandiro eserotonin inodyidzana nayo, uye runotsanangura kukuvadzwa kunokonzerwa nemaopioid kune chekuita neMAOIs. | Mushonga unomutsa zvishoma mareceptor emaopioid uchiri kuda kuongororwa kuti uone kudyidzana kwawo. Yambiro iyi hairevi kuti opioid imwe neimwe ine njodzi yakafanana. |
| Mimwe mishonga inoshandura mashandiro eserotonin, kusanganisira buspirone uye dextromethorphan | Ruzivo rwemethylene blue yeIV runodoma mishonga iyi zvakananga. | Mushonga wekushushikana kana chinhu chiri mumushonga wechikosoro unotengwa pasina kunyorerwa chinogona kukosha sezvinoita mushonga wekuora mwoyo. |
| Gabapentin nemibvunzo ine chekuita nemimwe mishonga inodzivisa pfari | Pane hurukuro yepaindaneti inotsanangura zviratidzo mushure mekushandiswa pamwe chete. Iyi haisi ongororo yakasimbiswa yevarwere pamusoro pekudyidzana kunoenderana nenzira yekupinza mumuviri. | Zvinokuvadza zvakataurwa zvinofanira kuongororwa; hazviratidzi kuti gabapentin ndiyo yakakonzera hurwere hweserotonin yakawandisa. |
| Mishonga inodzivisa PDE5, kusanganisira sildenafil kana Viagra | Zvakawanikwa muzviedzo pamusoro penzira yenitric oxide zvinobatsira kutsanangura mashandiro, asi haisi ongororo yevanhu yekuchengeteka kwekunwa mishonga iyi pamwe chete. | Nzira yemashandiro chete haisimbisi kuchinja kunofungidzirwa kwezvinoitwa nemushonga kana kutaura kuti mishonga inokodzera kushandiswa pamwe chete. |
| Ivermectin nemimwe misanganiswa isina kunyatsodzidzwa | Hapana ongororo yakadzorwa yekudyidzana kwemishonga muvanhu yakawanikwa mumanyuko akatariswa pachinyorwa chino. | Musanganiswa uyu hausati wanyatsotsanangurwa zvakakwana. Kushaya zvakawanikwa pakutsvaga kudyidzana hakusi humbowo hwekuchengeteka. |
Chikamu chekudyidzana chiri muruzivo rwemushonga weIV chinodomawo mirtazapine uye bupropion. Runyorwa runongogumira pamazita anozivikanwa emishonga yekuora mwoyo ruchasiya mimwe mishonga inokosha.
Chii chinochinja kana methylene blue ikamedzwa?
Nzira yekupinza mumuviri inoshandura huwandu hunosvika mumuviri, saka mushumo weIV haugoni kupa fungidziro yenjodzi yakayerwa nenhamba yemvura yemushonga inonwiwa. Kufungidzira kubva kune rimwe divi hakushandewo: kushomeka kwemishumo yekunwa hakusimbisi kuti musanganiswa unonwiwa wakachengeteka.
Mushumo waZuschlag nevamwe wa2018 unotsanangura kufungidzirwa kwehurwere hweserotonin yakawandisa mushure mekunge murwere aitora mishonga yakati wandei inoshandura mashandiro eserotonin atanga kunwa mushonga wekuderedza marwadzo epanzira yeweti waiva nemethylene blue. Ongororo yavo yakaperekedza mushumo uyu yakawana zviitiko 50 zvekare zvaisanganisira methylene blue yaipinzwa mumuviri kwete nemukanwa pamwe nemishonga yekuora mwoyo inoshandura mashandiro eserotonin.
Musiyano iwoyo unobatsira. Chiitiko chekunwa chaisanganisira mushonga une zvinhu zvakati wandei, kwete chiedzo chakadzorwa chemvura ine chinhu chimwe chete inotengeswa kuvatengi. Hachigoni kutiudza kuti bhodhoro rakati rinokonzera kudyidzana kangani. Asi chinopikisa kutaura kuti kumedza methylene blue kunoita kuti kukuvadzwa neserotonin kusakwanisika. Mishumo yezviitiko inoratidza njodzi; pasina nhamba nehunhu hwevanhu vose vakashandisa mushonga, haiyeri kuti zviitiko izvi zvinoitika kakawanda sei.
Wellbutrin, mishonga inokurudzira kushanda kwemuviri, uye Suboxone zvinoda kufungwa nezvazvo zvakasiyana
Wellbutrin ibupropion, kwete SSRI. Ruzivo rwayo rwekunyorera mushonga runoratidza njodzi yekukwira kweBP kana ikashandiswa nemethylene blue yeIV. Saka, kuti “hainyanyi kushanda kuburikidza neserotonin” haisi mhinduro yakakwana kumubvunzo wekushandisa mishonga iyi pamwe chete.
Pamishonga inokurudzira kushanda kwemuviri, ruzivo rweADDERALL XR runosanganisira pachena methylene blue yeIV pamishonga isingabvumirwi kushandiswa pamwe neMAOIs. Kukwira kweBP kwakanyanya injodzi yakasiyana nenzira yemashandiro eserotonin yatsanangurwa pamusoro. Mishonga yakasiyana inokurudzira kushanda kwemuviri ichiri kuda kuongororwa mumwe nomumwe.
Suboxone ine buprenorphine uye naloxone. Tafura yayo yekudyidzana inotsanangura hurwere hweserotonin yakawandisa uye kukuvadzwa kunokonzerwa nemaopioid kune chekuita neMAOIs, kusanganisira kudzikira kwekufema kana koma. Kuva nenaloxone hakusimbisi kuti hapana njodzi yekudyidzana. Vanhu vari kurapwa dambudziko rekushandisa maopioid vanofanira kubatanidza boka ravo revarapi vasati vawedzera methylene blue.
Gabapentin: mushumo wezvinokuvadza hausi kusimbiswa kwechirwere
Mubvunzo paforamu yePhoenix Rising pamusoro pegabapentin nemethylene blue unotsanangura kuvhiringidzika pakuziva pauri kana zviri kuitika uye kunyanyokurudzirwa kwemanzwiro. Munyori akashamisika kana hurwere hweserotonin yakawandisa hwaiva ihwo hwakakonzera izvi. Mubvunzo iwoyo haugoni kupindurwa kubva pane zvakanyorwa: hapana kuongororwa kwakaitwa nachiremba kana tsananguro yakasimbiswa yezviratidzo zvacho.
Gabapentin ine mashandiro akasiyana neSSRI. Ruzivo rwayo runotsanangura kusungirira pachikamu chealpha-2-delta chemigero yecalcium inovhurwa nekuchinja kwemagetsi emasero, ruchibvumawo kuti nzira chaiyo yainoita nayo basa rekurapa haisati yanyatsojeka. Musiyano uyu unodzivisa kuiswa muboka risiri iro; hauratidzi kuti kuwedzera methylene blue hakukuvadzi. Usaedza kurapa kwekukurumidzira kunokurudzirwa paforamu kuti uedze kuona chakakonzera zvakaitika.
Sildenafil uye ivermectin: nzira dzemashandiro hadzisi humbowo hwekukodzera kushandiswa pamwe chete
Sildenafil inotsigira nzira yenitric oxide/cyclic GMP nekudzivisa PDE5. Tsananguro yesainzi yeEMA pamusoro peViagra inotsanangura nzira iyi uye kushandiswa kwemethylene blue muzviedzo. Muzviedzo zvetsinga dzakaparadzaniswa nemuviri uye maenzyme akacheneswa, methylene blue yakavhiringidza kufambiswa kwezviratidzo nenitric oxide, ichikonzera zvakasiyana panzvimbo dzakasiyana dzainoshanda uye pahuwandu hwakasiyana.
Zvakacherechedzwa izvi zvinoita kuti kutaura pamusoro pekuchinja kungangoitika pane zvinoitwa nesildenafil kunzwisisike maererano nekushanda kwemuviri. Hazvisimbisi mhedzisiro inogona kufanotaurwa muvanhu, musanganiswa wakachengeteka, kana nzira yekuenzanisa zvinoitwa nemushonga mumwe nezvemumwe. Mibvunzo yemishonga inodzivisa PDE5 iri muchikamu chemashandiro emishonga pamwoyo netsinga, kwete kungoiswa muboka rimwe chete rehumbowo sekudyidzana neSSRI.
Paivermectin, kushayikwa kweongororo yakadzorwa yekudyidzana muzvinyorwa zvakawanikwa kunosiya mukaha muhumbowo. Zvinyorwa zverabhoritari zvinotaura nezvezvinhu zvose zviri zviviri zvinogona kunge zvichizvienzanisa kana kushandisa chimwe sechiyero chekuenzanisa muchiedzo. Izvozvo haisi ongororo yevanhu vanozvitora pamwe chete. Saizvozvowo, hurukuro dzisina kurongwa pamusoro pezvakaitika kuvanhu hadzipi nhoroondo dzemishonga yavakashandisa kana kuteverwa kwakarongeka kunodiwa kuti musanganiswa unzi wakachengeteka.
Zviratidzo zvinoda kuongororwa nekukurumidza
Kukuvadzwa neserotonin kunogona kusanganisira kubatanidzwa kwekusagadzikana kana kuvhiringidzika, kupisa muviri kana kudikitira zvakanyanya, kurova kwemwoyo nekukurumidza, kudedera, kuomarara kwetsandanyama, uye kugwinha kusingadzoreki. Zviratidzo izvi zviri muyambiro yehurwere hweserotonin yakawandisa iri muruzivo rweamphetamine. Hazvisi runyorwa rwekushandisa kumba kuzvisimbisira chirwere.
Mushure mekushandisa mishonga inofungidzirwa kuti inogona kudyidzana, zviratidzo zvitsva zvinoda mazano ekurapa nekukurumidza. Kuvhiringidzika kwakanyanya, kupisa muviri kwakanyanya, pfari, kudonha, kana kutadza kufema zvinoda rubatsiro rwechimbichimbi ipapo ipapo. Ipa zvakaputirwa chigadzirwa, runyorwa rwemishonga, nzira yayakapinzwa nayo mumuviri, huwandu, uye nguva yayakatorwa; usatore imwe methylene blue paunenge uchitsvaga mazano.
Kana uri kuronga kuti mishonga yako iongororwe, shandisa mibvunzo yekubvunza murapi pamusoro pemethylene blue. Gwaro rakazara rekuchengeteka kwemethylene blue rinotsanangura njodzi dzinopfuura kudyidzana kwemishonga, kusanganisira nyaya yakasiyana yekushomeka kweG6PD uye kuparara kwemasero matsvuku eropa. Kuongorora kwakakwana kunoda zvose runyorwa rwemishonga nenhoroondo yehutano hwemunhu ine chekuita nenyaya iyi.