Ubururu bwa Metilene mu Kwita ku Ruhu: Imvange n'Ibimenyetso

Ubururu bwa metilene bufite ibimenyetso bitanga icyizere mu bushakashatsi bwo muri laboratwari ku gusaza k'uruhu, kandi ababukoresha mu gukora ibicuruzwa batangaza ko bagerageje ku bantu bimwe mu bicuruzwa byabo byo kwisiga byarangiye gutunganywa. Ibyavuye muri ubwo bushakashatsi bisubiza ibibazo bitandukanye. Nta na kimwe muri byo gituma icupa ry'ubururu bwa metilene butaratunganywamo igicuruzwa kingana n'amavuta yo mu maso yageragejwe, kandi nta na kimwe cyemeza umuti wa ekizema, psoriyazisi cyangwa rozaseya.

Ku kintu cyose kivugwa ku kwita ku ruhu, banza umenye ibintu bitatu: icyashyizweho, aho cyashyizwe n'icyahindutse. Igipimo cy'ikinyabutabire mu mvange itunga utugirangingo, impinduka mu cyitegererezo cy'uruhu n'umuntu uvuga ko uruhu rwe rwarushijeho koroha si ibipimo bishobora gusimburana.

Icyo ubushakashatsi ku ruhu bukunze kuvugwa bwagerageje

Ubushakashatsi bwa Xiong na bagenzi be bwo mu 2017 bwagerageje utugirangingo twa fibroblaste two mu gice cy'imbere cy'uruhu rw'abantu n'uruhu rwubatswe muri laboratwari. Fibroblaste ni utugirangingo tw'ingirabuzika zihuza; kudukuza mu gakoresho ka laboratwari bikuraho inzitizi yo ku ruhu amavuta yo mu maso aba agomba kubanza gucamo.

Utugirangingo twa fibroblaste twakuze muri laboratwari kandi tukamara ibyumweru bine duhura n'ubururu bwa metilene ku gipimo cya 100 nM twagaragaje impinduka mu bipimo by'iyangirika riterwa na okisidasiyo no gusaza kw'utugirangingo. Mu ruhu rwubatswe muri laboratwari rufite ibice byose by'ububyimba bwarwo, ibyumweru bibiri by'ubururu bwa metilene mu mvange irutunga byongereye ubuhehere bwapimwe n'ububyimba bw'igice cy'imbere cy'uruhu. Mu bipimo byageragejwe, ukwiyongera kw'ububyimba kwakabije kwabonetse kuri 0.5 µM. Ibi ni uburyo bwakoreshejwe mu igerageza, si amabwiriza yo gutegura amavuta.

Hari ikintu kimwe cy'ingenzi ku bivugwa kuri kolajeni: abanditsi batangaje ko imikorere ya COL2A1 yiyongereye, ariko ntibabonye impinduka muri kolajeni yo mu bwoko bwa I. Igerageza ryabo rijyanye n'ibikomere ryapimye uko ahantu hakobowe mu gice kimwe cy'utugirangingo twa fibroblaste hafunze. Ntiryagerageje gukira kw'ibikomere ku bantu.

Uruhu rwubatswe muri laboratwari rufite imitunganyirize y'ingirabuzika iruta iy'utugirangingo twonyine. Ariko na rwo ntirushobora kwemeza ingano y'igicuruzwa runaka cyo kwisiga igera mu ruhu ruzima rwo mu maso, niba iminkanyari igabanuka ku buryo bugaragara, cyangwa uko gukoresha igicuruzwa kenshi bigira ingaruka ku bantu batandukanye.

Igereranya: imvange n'icyitegererezo cy'ubushakashatsi

Koresha iri gereranya kugira ngo umenye ibimenyetso bishyigikira ibiri ku kirango cyangwa ibivugwa ku mbuga nkoranyambaga. Inkingi iri iburyo cyane igaragaza igipimo kibura, aho gufata ko buri gerageza risubiza ikibazo kimwe.

Ikintu cyangwa uburyo bwakoreshejwe	Icyitegererezo n'uko cyahuye n'ikintu cyageragejwe	Icyo ibimenyetso bishobora gusobanura	Ibigikeneye kugeragezwa mu buryo butaziguye
Ubururu bwa metilene bwongewe mu mvange ya laboratwari	Utugirangingo twa fibroblaste tw'abantu twakuze muri laboratwari; guhura na bwo kenshi	Impinduka mu tugirangingo mu bihe bigenzurwa	Kunyura mu nzitizi y'uruhu rutangiritse n'impinduka zigaragara mu isura y'uruhu
Ubururu bwa metilene mu mvange itunga uruhu rwubatswe muri laboratwari	Igice cy'inyuma n'icy'imbere by'uruhu byubatswe muri laboratwari	Impinduka ku rwego rw'ingirabuzika muri icyo cyitegererezo	Uko amavuta yarangiye gutunganywa akora iyo asizwe ku bantu
Amavuta cyangwa serumu byarangiye gutunganywa bigurishwa	Igerageza ku bantu ryihariye kuri icyo gicuruzwa	Uko cyihanganirwa n'ibyapimwe koko kuri iyo mvange	Uruhare rw'ubururu bwa metilene ugereranyije n'imvange ibutwara n'ibindi biyigize
Irangi ritunganijwe mu mazi rivanzwe n'amavuta atanga ubuhehere, ibinure by'inyamaswa cyangwa amavuta ya kokona	Imvange imaze guhindurwa	Kumenya gusa ibiyigize ntibyemeza umusaruro w'igicuruzwa	Kuba imvange imwe hose, kudahinduka, kurindwa kwangirika, kugeza ibiyigize mu ruhu, kwihanganirwa n'inyungu
Ubururu bwa metilene hamwe n'ikintu cyongera kwinjira mu ruhu cyangwa igikoresho gitanga urumuri	Uburyo buhuje ibintu byinshi	Gusa ibyabonetse hakoreshejwe uko guhuza kwihariye	Niba ikindi kinyabutabire gishongesha, igikoresho, uburyo bwo guhura n'uruhu cyangwa imiterere y'uruhu bitanga umusaruro umwe

Igerageza ku bantu rirahari, ariko soma icyo ryapimye

Ntibyaba ari ukuri kuvuga ko nta gerageza ry'ibicuruzwa byo kwita ku ruhu ryakozwe ku bantu. Incamake y'ubushakashatsi bwa EyePlus+ bwa Bluelene ivuga ko mu itsinda ryageragejwe nta kurakara k'uruhu cyangwa kubyimbirwa kw'uruhu guterwa na aleriji yo guhura n'igicuruzwa byabonetse. Icyo ni ikivugwa ku kwihanganirwa kw'igicuruzwa cyarangiye gutunganywa kirimo ibintu byinshi, cyatangajwe n'uwagikoze. Ntibivuga ko buri muntu ugikoresha azacyihanganira cyangwa ko ubururu bwa metilene bwonyine bwagabanyije iminkanyari.

Raporo ya Fit+Firm y'uwakoze igicuruzwa inasobanura uko abitabiriye ubushakashatsi bashyize amanota ku buhehere, gukomera n'imiterere y'uruhu. Ishusho yayo y'ububyimba bw'uruhu isobanurwa mu buryo bweruye ko ari icyitegererezo cy'uruhu gifite ibipimo bitatu, nubwo igaragara iruhande rw'ibyavuye mu igerageza ry'igicuruzwa ku bantu. Ibyo byombi bigomba gukomeza gutandukanywa mu gusobanukirwa urwo rupapuro.

Incamake zashyizwe ahagaragara zasuzumwe ntizigaragaza igereranya ririmo kugabanya abitabiriye ubushakashatsi mu matsinda ku buryo bwa tombola, hagati y'imvange zisa muri byose uretse ko imwe irimo ubururu bwa metilene indi itaburimo, hagamijwe kureba igabanuka ry'iminkanyari. Igereranya rigenzurwa nk'iryo ryafasha gutandukanya uruhare rw'icyo kinyabutabire. Kuba abitabiriye banyuzwe bishobora gushyigikira ko igicuruzwa cyemewe n'abagikoresha; ibipimo bidashingiye ku marangamutima n'itsinda ry'igereranya rikwiye bisubiza ikindi kibazo.

Igicuruzwa cyarangiye gutunganywa kirenze irangi ryacyo

Dufashe urugero rufatika, urutonde rw'ibigize Bluelene Night Cream rurimo amazi, amavuta yo mu gikumbi cy'umuceri, giserini, ibintu by'ibinure, ikintu gifasha amazi n'amavuta kuvangana, ibirinda igicuruzwa kwangirika n'ubururu bwa metilene. Imvange yacyo yose ni yo umukiriya yisiga. Ibibazo bikunze kubazwa by'uwagikoze bivuga ko igipimo cy'ubururu bwa metilene kirimo ari ibanga ry'ikigo, bityo ikirango ntigishobora gukoreshwa mu kongera gukora iyo mvange.

Imvange itwara ibiyigize mu mavuta atanga ubuhehere ni uburyo bwo kubigeza ku ruhu. Igira uruhare mu gusakara kw'amavuta, kugumana amazi, kurekurwa kw'ikinyabutabire no guhura kwacyo n'uruhu. Iyo amavuta arimo ibintu byinshi agabanyije kuma k'uruhu, kuvuga ko impinduka yose yatewe n'ikintu kimwe bisaba ibirenze kuba icyo kintu kiri ku rutonde rw'ibiyagize.

Ni na ko bimeze ku ibara ry'igicuruzwa. Amavuta afite ibara ryoroheje ntahishura igipimo nyacyo cy'ubururu bwa metilene. Uko agaragara ntibishobora gusimbura isesengura ry'igipimo, imiterere y'ikinyabutabire cyangwa ubushobozi bwo kudahinduka. Inyandiko yacu isobanura ibigize umuti w'ubururu bwa metilene ushongejwe isobanura impamvu ibiwugize byose ari ingenzi.

Ese ubururu bwa metilene bwinjira mu ruhu?

Igisubizo giterwa n'icyo “kwinjira” bivuga. Ikintu gishobora kwinjira mu gice cyo hejuru cy'uruhu kigizwe n'utugirangingo twapfuye, cyitwa stratum corneum, kitageze mu gice cy'imbere cy'uruhu ku gipimo gishobora kugira icyo gikora cyangwa ngo cyinjire mu maraso atembera.

Mu bushakashatsi ku binyabutabire bishongesha bwakorewe ku bakorerabushake icumi bafite ubuzima bwiza, abashakashatsi babanje gushyira imvange zitwara ibinyabutabire zitandukanye ku duce tw'uruhu rwo hagati y'inkokora n'ukuboko, hanyuma bashyiraho ubururu bwa metilene. Ingero zafashwe ku buso bw'uruhu zerekanye ko bimwe mu byabanje gushyirwaho byongereye irangi riguma muri stratum corneum, naho ibindi bikarigabanya. Iri ryari igerageza ryo kugeza ikinyabutabire mu ruhu, si igerageza ryo kurwanya gusaza. Uburyo bwakoreshejwe ntibwapimye uko cyinjira mu maraso ngo kigere mu mubiri wose.

Ibyo byabonetse binerekana impamvu kuvuga ngo “kirashonga muri iki kinyabutabire” bidahagije. Ubushobozi bwo gushonga busobanura uko ikintu cyitwara mu gikoresho kirimo. Kugera mu ruhu bisaba kandi kurekurwa kiva mu mvange igitwara no kunyura mu ngirabuzika. Gushonga cyane ntibihita bivuga ko kigera mu ruhu ku buryo bw'ingirakamaro kurushaho, kandi kugera mu ruhu cyane ntibihita bivuga umusaruro mwiza kurushaho.

Ibinure by'inyamaswa, amavuta ya kokona na serumu zikorwa mu rugo

Ibinure by'inyamaswa n'amavuta ya kokona ni ibikoresho fatizo bikungahaye ku binure. Kuvanga gusa ubururu bwa metilene bushongejwe mu mazi muri kimwe muri byo ntibyemeza ko habonetse imvange y'amazi n'amavuta imeze kimwe hose kandi idahinduka. Imvange ishobora kugaragara ifite ibara rimwe hose ikimara kuvangwa, ariko ibibazo byo kumenya niba izatandukana mu gihe ibitswe n'ingano igezwa ku ruhu buri gihe isizwe bigakomeza kubura ibisubizo.

Kongera umuti ushongejwe mu mavuta asanzwe na byo bihindura imvange uwabikoze yagerageje. Amabwiriza ya FDA ku kwandura kw'ibicuruzwa byo kwisiga agaragaza ko amazi yongewemo, ibintu byanduye, uburyo bwo kurinda igicuruzwa kwangirika budakora neza n'uko abakiriya bagifata ari ibyago bireba iki kibazo. Ubushakashatsi ku bushobozi bw'ubururu bwa metilene bwo kurwanya mikorobe ntibusimbura igerageza ry'uburyo bwo kurinda agacupa k'amavuta kwangirika.

Ikiganiro cyatanzwe ku mavuta akorerwa mu rugo n'ibintu byongera kwinjira mu ruhu kivuga DMSO na Transcutol nk'ibishobora gutwara ibinyabutabire. Ibyo bitekerezo ntibitanga ibipimo by'umutekano w'imvange yarangiye cyangwa uko igeza ibiyigize mu ruhu. Ikintu cyongera kwinjira mu ruhu gishobora guhindura ingano y'ibindi biyigize bigera mu ruhu, kimwe n'ikinyabutabire cyari kigamijwe. Kuba ikinyabutabire gishongesha kibasha gukorana n'ibindi muri laboratwari ntibyemeza ko serumu irimo ibintu byinshi ikwiriye gukoreshwa mu maso.

Hari kandi ikibazo nyakuri cy'ubushakashatsi ku kuvanga na vitamine C. Ubushakashatsi bwo muri laboratwari bwo mu 2021 bwatangaje ingaruka nziza zo kubihuza ku tugirangingo tw'uruhu twakuze muri laboratwari. Ntibwemeje imvange uko ari ko kose za vitamine C, ubururu bwa metilene, peptide, amavuta n'ibinyabutabire bishongesha. Buri kintu cyongeweho kizana indi mpinduka igomba gusuzumwa; impinduka nziza kurushaho mu tugirangingo si igerageza ryo kudahinduka kw'igicuruzwa cyarangiye gutunganywa. Incamake y'ubushakashatsi ku birinda izuba isuzuma ikibazo gitandukanye cyo kurinda imirasire ya UV.

Gusaza k'uruhu mu bijyanye n'ubwiza, indwara zitera kubyimbirwa n'urumuri

Kwiyongera k'ubuhehere ntibingana no kugenzura ekizema, psoriyazisi cyangwa rozaseya. Izo ndwara zisaba gupima ibyihariye kuri buri ndwara, nk'ibimenyetso byayo, ubukana bw'ibice by'uruhu byangiritse no kongera kugaruka kwayo. Amagerageza ku gusaza n'incamake ku bicuruzwa byo kwisiga byavuzwe haruguru ntibyemeza ko amavuta arimo ubururu bwa metilene ari umuti ukora neza kuri izo ndwara. Gutukura, kuvuvuka cyangwa kuryaryatwa bikomeza bigomba gusuzumwa nk'ibibazo byihariye, aho gufatwa nk'ugusaza k'uruhu kujyanye n'ubwiza.

Urumuri na rwo ruhindura uburyo bukoreshwa. Mu magerageza akoresha ubururu bwa metilene bukorana n'urumuri, urumuri na ogisijeni bigira uruhare mu kubyara ibinyabutabire bikorana cyane n'ibindi. Iyi mikoranire y'ibinyabutabire itandukanye n'igitekerezo cyo kurwanya okisidasiyo gikunze gukoreshwa mu kwamamaza ibicuruzwa byo kwita ku ruhu. Ntibikwiye gufatwa ko kongeraho igikoresho gitanga urumuri rutukura ku mvange yakorewe mu rugo bizongera inyungu ku isura y'uruhu mu buryo butekanye. Inyandiko isobanura ibimenyetso ku bururu bwa metilene n'urumuri rutukura itandukanya ubwo buryo bukoreshwamo.

Mu gusuzuma igicuruzwa, saba ubushakashatsi bwakozwe kuri iyo mvange, icyo cyagereranyijwe na cyo, igihe bwamaze n'icyapimwe. Ibyo bisobanuro bitanga amakuru arushijeho kuba ingirakamaro kuruta ibara ry'ubururu, uburyo ikinyabutabire gikora cyangwa ijambo “cyageragejwe ku bantu” ryonyine.