Kuvulazidwa ndi methylene blue ngati poizoni ndi kugwiritsa ntchito mopitirira muyeso: zizindikiro zochenjeza

Mukakayikira kuti munthu wakhudzidwa kwambiri ndi methylene blue, funani kuunikidwa ndi akatswiri nthawi yomweyo. Musadikire zizindikiro kapena kuwerengera mlingo wopitirira muyeso womwe mukuganiza kuti ndi wotetezeka. Ngati munthuyo wakomoka, akugwidwa ndi khunyu, akuvutika kupuma, kapena sakudzuka mukamuyesa kudzutsa, imbani nambala ya zadzidzidzi ya kwanuko. Ku United States, imbani 911 pa zochitika zadzidzidzi zimenezi; pa zochitika zina, funsani Poison Control pa 1-800-222-1222 mwamsanga kuti mulandire malangizo okhudza kukhudzidwa ndi mankhwalawo. Zizindikiro zimenezi zofuna thandizo lachangu zikutsatira malangizo a National Capital Poison Center a chithandizo choyamba.

Mawu akuti “kuvulazidwa ndi methylene blue ngati poizoni” angatanthauze zochitika ziwiri zosiyana: kuvulazidwa ndi poizoni kumene dokotala amagwiritsa ntchito methylene blue pochiza, komanso kuvulazidwa ndi methylene blue yokha. Kusokoneza zinthu ziwirizi kungapangitse munthu kumwa kapena kugwiritsa ntchito zambiri za chinthu chomwecho chimene chikufunika kuunikidwa.

Mankhwala othana ndi poizoni pa vuto linalake la magazi

Hemoglobin yomwe ili m'maselo ofiira a magazi imatengera mpweya wa oxygen ku minofu ya thupi. Pa methemoglobinemia, gawo lalikulu mosayenera limakhala ngati methemoglobin, zomwe zimalepheretsa kutumiza oxygen bwino. Kufotokozera kwa MedlinePlus za methemoglobinemia kumasiyanitsa mitundu yotengera kwa makolo ndi matenda obwera chifukwa chokhudzidwa ndi zinthu monga mankhwala kapena makemikolo ena. Zizindikiro zingaphatikizepo khungu labuluu, kupuma movutikira, ndi kusintha kwa kuzindikira zomwe zikuchitika.

Methylene blue yoperekedwa kudzera mumtsempha ndi mankhwala ochizira methemoglobinemia yobwera chifukwa chokhudzidwa ndi zinthu zina. Cholinga chake ndi kuthandiza kubwezeretsa hemoglobin yogwira ntchito bwino. Imeneyi ndi ntchito yake pa vuto linalake lachipatala, osati mankhwala a poizoni aliyense kapena a khungu lililonse looneka labuluu. Buku lofotokoza methylene blue pa methemoglobinemia limafotokoza mmene mankhwalawa amagwiritsidwira ntchito pa vutoli.

Funso	Kugwiritsa ntchito ngati mankhwala othana ndi poizoni	Kukayikira kukhudzidwa nayo komwe kungavulaze
Kodi vuto loyambirira ndi liti?	Methemoglobinemia yobwera chifukwa chokhudzidwa ndi zinthu zina, yomwe madokotala azindikira ndi kuunika	Kukhudzidwa ndi methylene blue komwe kungavulaze
Kodi methylene blue ili ndi ntchito yanji?	Mankhwala osankhidwa kuti athandize pa vuto linalake	Chinthu chimene madokotala ayenera kuchiganizira ngati chingakhale choyambitsa matenda
Kodi mfundo zofunika ndi ziti?	Matenda omwe azindikiridwa, zinthu zokhudza wodwalayo, mmene thupi likuyankhira ku chithandizo	Chinthu chomwe chagwiritsidwa ntchito, njira yomwe chalowera m'thupi, kuchuluka kwake, nthawi, zizindikiro, ndi mankhwala ena
Kodi wowerenga ayenera kuchita chiyani?	Kutsatira malangizo a gulu lomwe likupereka chithandizo	Kulankhula mwamsanga ndi malo othandiza pa nkhani za poizoni kapena ntchito ya zadzidzidzi

Kusiyana kumeneku kumakhalabe kofunika ngakhale kugwiritsa ntchito koyambirira kunali mwadala ndipo kunafotokozedwa ngati chowonjezera cha zakudya kapena chithandizo cha umoyo wabwino. Chifukwa chogwiritsira ntchito chinthu sichitsimikizira kuti kukhudzidwa nacho ndi kotetezeka.

Mmene kuvulazidwa ndi mankhwalawa kungaonekere

Malangizo a National Capital Poison Center okhudza methylene blue amafotokoza nseru, mutu, chizungulire, ndi kusintha kwa mtundu kukhala buluu, komanso mfundo yodabwitsa yakuti milingo ikuluikulu ingayambitse methemoglobinemia. Mkodzo wabuluu wokha susonyeza kukula kwa ngozi yobwera chifukwa cha kukhudzidwa ndi mankhwalawo. Momwemonso, milomo yomwe yayamba kukhala yabuluu pamodzi ndi kupuma movutikira siyenera kunyalanyazidwa poganiza kuti yangodetsedwa ndi utoto.

Kuvulazidwa chifukwa cha serotonin ndi vuto linanso lofunika kuganizira, makamaka pakakhala mankhwala omwe amasokonezana ndi methylene blue. Kutentha thupi, kusakhazikika kapena kusokonezeka maganizo, kutuluka thukuta, kugunda mofulumira kwa mtima, ndi kuuma kwa minofu zingachitike pamodzi. Zizindikiro zatsopano pambuyo pokhudzidwa ndi mankhwalawo zimafunika kuunikidwa mwamsanga; wowerenga sayenera kuyesa kuzindikira matenda pogwiritsa ntchito mndandanda wa zizindikiro.

Zambiri za kupereka mankhwala a PROVAYBLUE zimafotokozanso hemolysis, kutanthauza kuwonongeka kwa maselo ofiira a magazi, komanso kusamvana kwakukulu kwa thupi ndi mankhwalawo. Kusowa kwa G6PD ndi chifukwa choletsa kugwiritsa ntchito mankhwalawa chifukwa cha chiopsezo cha kuchepa kwa magazi chifukwa cha kuwonongeka kwa maselo ofiira. Kuchepa kwa magazi kungayambe kuonekera patatha tsiku limodzi kapena kuposerapo pambuyo pa chithandizo. Kupweteka pachifuwa, kupuma kwa mluzu, kapena kuchepa kwa oxygen m'thupi ndi zina mwa zotsatira zomwe zanenedwa za kugwiritsa ntchito mopitirira muyeso. Choncho, kumva kuti muli bwino nthawi yomweyo pambuyo pokhudzidwa ndi mankhwalawo sikungatsimikizire kuti mavuto sadzachitika pambuyo pake.

Zolemba za mankhwalawa zimachenjeza za mankhwala omwe amakhudza serotonin ndi ma opioid, kuphatikizapo chiopsezo chokhudzana ndi dextromethorphan. Perekani kwa akatswiri mndandanda wonse wa mankhwala omwe mukugwiritsa ntchito. Kufotokozera kwa kusowa kwa G6PD ndi methylene blue kumasonyeza chifukwa china chimene zinthu zokhudza munthu aliyense payekha zilili zofunika.

Chifukwa chimene njira yolowera m'thupi imasinthira zimene ziyenera kuunikidwa

Kumeza madzi osungunuliramo mankhwala, kulandira jekeseni, kuwazidwa m'diso, ndi kupuma ufa ndi njira zosiyana zokhudzidwa ndi mankhwalawo. Nenani njira yeniyeni yomwe yachitika, ngakhale itasiyana ndi njira yomwe chinthucho chinapangidwira kuti chigwiritsidwe ntchito. Kunena kuti “madontho awiri” sikokwanira popanda kudziwa botolo lomwe lagwiritsidwa ntchito; kunena kuti “sirinji imodzi” sikokwanira popanda kudziwa kuchuluka kwa mankhwala m'madziwo ndi kuchuluka kwa madziwo. Buku la kutanthauzira mayunitsi a mlingo wa methylene blue limafotokoza kusiyana kwa miyeso imeneyi.

Kufotokozera kwa Poison Control za mawu okhudza kukhudzidwa ndi zinthu ndi kugwiritsa ntchito mopitirira muyeso kumasiyanitsa zinthu m'njira yothandiza: kukhudzidwa kumatanthauza kukumana ndi chinthu chomwe chingavulaze, pamene kuvulazidwa ndi poizoni kumatanthauza zotsatira zowononga. Kuyimba foni chifukwa cha kukhudzidwa ndi chinthu sikufuna kuti mutsimikizire kaye kuti kuvulazidwa ndi poizoni kwachitika. Njira yomwe chinthucho chalowera m'thupi, kuchuluka kwake, nthawi, ndi zizindikiro zimathandiza akatswiri kusankha kuunika komwe kukufunika.

Ngati chinthucho chawazidwa m'diso, yambani kutsuka nthawi yomweyo ndi madzi a kutentha kofanana ndi kwa m'chipinda kwa mphindi 15–20 ndipo chotsani magalasi oikidwa m'diso. Ngati chafika pakhungu, vulani zovala zomwe zakhudzidwa ndipo tsukani ndi madzi oyenda kwa mphindi zosachepera 15. Ngati mwachipuma, pitani pamalo a mpweya wabwino popanda kulowa pamalo osatetezeka. Funani malangizo a malo othandiza pa nkhani za poizoni pamene mukuchita chithandizo choyambachi kapena mukamaliza. Musapangitse munthu kusanza atameza chinthucho. Chithandizo choyamba sichiyenera kuchedwetsa thandizo la zadzidzidzi ngati pali zizindikiro zazikulu.

Mndandanda wa mfundo zokhudza kukhudzidwa ndi mankhwalawo

Gwiritsani ntchito mfundo izi pokambirana pa foni. Musachedwetse kuyimba foni kuti muyambe mwadzaza tebulo. Werengani zolemba za pa chinthucho monga zilili; lembani mfundo yosatsimikizika kuti siyikudziwika m'malo mongopeka. Chithunzi chingasunge zolemba za pa chinthucho popanda kuthira kemikoloyo m'chidebe china.

Mfundo zoti munene	Zambiri zoti mulembe kapena muwerenge mokweza
Munthuyo ndi mmene alili panopa	Zaka; kulemera koyerekeza ngati kukudziwika; ngati ali maso ndipo akuyankha kapena ayi; ngati akupuma bwinobwino kapena ayi; malo omwe ali panopa
Chinthu chenicheni chomwe chagwiritsidwa ntchito	Dzina ndi wopanga; kuchuluka kwa mankhwala osungunukamo ndi mayunitsi monga zalembedwera; zinthu zomwe chili nazo; kukula kwa botolo; ntchito yomwe chinapangidwira; chithunzi cha zolemba zake kapena chidebe choyambirira
Zimene zinachitika pokhudzidwa nacho	Chinamezedwa, chinaperekedwa kudzera mu jekeseni, chinafika m'diso, pakhungu, kapena chinapumidwa; nthawi yeniyeni kapena yoyerekeza bwino kwambiri; chinachitika kamodzi kapena mobwerezabwereza; kuchuluka koyerekeza ndi mmene kunayesedwera
Zizindikiro ndi kusintha	Zomwe zinachitika poyamba; nthawi yomwe zizindikiro zinayamba; ngati zikuipiraipira; kusanza, kusintha kwa kupuma, kusokonezeka maganizo, kutentha thupi, kapena zizindikiro za minofu
Mbiri ya zachipatala ndi zomwe zachitidwa	Mankhwala, zowonjezera za zakudya, ndi zinthu zina zomwe zagwiritsidwa ntchito; kusowa kwa G6PD komwe kukudziwika; mimba; matenda a impso kapena chiwindi; kutsuka kapena zinthu zina zomwe zachitika kale

Ngati kuchuluka kwake sikukutsimikizika, fotokozani zomwe zikudziwika: mwachitsanzo, “Botolo linali lotseguka ndipo madzi ena akusowa; palibe amene anaona akumezedwa.” Zimenezi ndi zothandiza kwambiri kuposa kusintha kusatsimikizikako kukhala mlingo wooneka ngati wolondola. Sungani chidebecho kuti gulu la akatswiri lizitha kuchiona ngati kuchita zimenezo kuli kotetezeka.

Palibe ndondomeko yogwiritsira ntchito mankhwala othana ndi poizoni kunyumba

Musagwiritse ntchito methylene blue yowonjezera, makala okonzedwa kuti azimanga poizoni, kapena chinthu china pofuna “kuthetsa” zomwe zakukhudzani popanda malangizo a akatswiri. Malangizo a NHS okhudza kuvulazidwa ndi poizoni amalangiza kupeza thandizo lachipatala nthawi yomweyo ngati mukukayikira kuvulazidwa ndi poizoni, amachenjeza kuti zizindikiro zingachedwe kuonekera, ndipo amalangiza kuti musapangitse munthu kusanza kapena kumupatsa chakudya kapena chakumwa pamene mukudikira thandizo. Chithandizo ndi kuyang'aniridwa zimadalira chinthucho ndi zomwe zapezeka pa kuunika kwachipatala.

Zolemba za methylene blue zimafuna kuyang'anira kuvulazidwa kwa mtima ndi mapapo, magazi, ndi dongosolo la mitsempha ya ubongo pambuyo pa kugwiritsa ntchito mopitirira muyeso, ndi kupereka chithandizo chothandizira thupi ngati chikufunika. Zimanenanso kuti methylene blue ingasokoneze zomwe chipangizo choyezera oxygen m'magazi chimasonyeza. Muyezo wa oxygen wotengedwa kunyumba sungalowe m'malo mwa kuunikidwa.

Pali chifukwa chokhudzana ndi mmene mankhwalawa amagwirira ntchito chimene chimapangitsa kuwerengera madontho kukhala kosakwanira pozindikira chiopsezo cha kusokonezana ndi mankhwala ena. Mu kafukufuku wa ma enzyme wa Ramsay ndi anzake wa 2007, methylene blue inalepheretsa kugwira ntchito kwa monoamine oxidase A ya munthu yomwe inapatulidwa ndi kuyeretsedwa, enzyme yomwe imathandiza pakusintha kwa serotonin m'thupi. Awa anali mayeso a mu labotale, osati mayeso ofotokoza kuchuluka kotetezeka kumeza kapena malire a kugwiritsa ntchito mopitirira muyeso. Malangizo achipatala okhudza kukhudzidwa ndi mankhwalawa ayenera kuganizira chinthu chenicheni chomwe chagwiritsidwa ntchito, njira yomwe chalowera m'thupi, wodwalayo, ndi zinthu zina zomwe zakhudzidwa.