Tuhinga
Te puru metilīni me te testosterone: te arotake i ngā kerēme
Kāore anō kia whakaūngia te puru metilīni hei rongoā, hei kaiwhakapiki rānei i te testosterone mō ngā tāne. Kāore ngā rapunga mō tēnei tuhinga i kite i tētahi whakamātautau tangata whai rōpū whakatairite e whakaatu ana ka whakapiki te puru metilīni mā te waha i te testosterone o ngā tāne hauora, ka rongoā rānei i te hapa testosterone. Kei roto i ngā taunakitanga e hāngai ana ngā tauira wharanga kararehe, ngā whakamātautau repe pituitary kiore, tētahi kitenga torotoro mō te prolactin i te tangata, me te whakapā tika i ngā pūtau parāoa tangata ki te puru metilīni i waho i te tinana.
Me aro ki aua rangahau, engari kāore e taea te whakakotahi i ā rātou hua hei kerēme whānui e whakapiki ana te puru metilīni i te testosterone, e whakaheke ana i te estrogen me te prolactin, e whakapai ana hoki i te āhei whakaputa uri. Me whai putanga ine motuhake ia kerēme.
He aha ngā taunakitanga e whakaatu ana kua piki te testosterone?
Mā tētahi rangahau tangata whai hua e tautuhi ngā kaiuru, te hanganga o te rongoā, te ara tuku, te mea whakatairite, te roanga, me te whakamātautau ine taiaki. Me wehe te testosterone katoa i te testosterone herekore, me ine hoki mēnā ka mau tonu tētahi panonitanga. Me arotake motuhake ngā tohumate, te kounga o ngā pūtau parāoa, me ngā pānga kino.
Ehara te rongo kua mataara ake koe i te inenga testosterone. Ehara hoki te pai ake o te neke a ngā pūtau parāoa i te inenga testosterone. Kei ngā raho ngā pūtau Leydig whakaputa testosterone, kei waenganui i ngā ngongo whakaputa parāoa, te wāhi e whanake ai ngā pūtau parāoa. Ka pā ēnei mahi ki a rāua anō, engari kāore tētahi hua mō tētahi e whakaū i tētahi atu. Ka tirohia e te arotake whānui mō ngā painga o te puru metilīni i ngā rangahau tangata ngā kerēme hauora whānui, tae atu ki ngā kerēme e aro ana ki ngā tāne.
Te ripanga taunakitanga mō ngā kerēme testosterone
Ka wehe te ripanga i ngā kitenga rangahau i ngā taunakitanga e hiahiatia ana mō tētahi kerēme ki ngā kaihoko. E whakaahua ana ngā rahinga whakamātautau i ngā rangahau, ehara i te tikanga whakamahi mā te tangata.
| Kerēme, pātai rānei | Taupori me te tauira | Ara tuku me te pānga | Putanga i inea me te kitenga | Ngā mea e tautokona ana e ngā taunakitanga |
|---|---|---|---|---|
| Ka whakapiki i te testosterone i muri i te wharanga raho | 35 kiore Wistar tāne i roto i ngā rōpū e rima, tae atu ki te wharanga nā te cisplatin | He werohanga ki te kōhao peritoneal; he puru metilīni 2, 4 mg/kg rānei mō ngā rā e whitu | I pūrongotia he teitei ake te testosterone i te serum me ngā inenga pūtau parāoa i te maimoatanga puru metilīni i ērā o te cisplatin anake | He tohu pānga whakamarumaru i tētahi tauira wharanga nā te hahau rongoā; kāore he pikinga i whakaaturia i ngā tāne hauora |
| Ka whai painga tonu ngā raho | 30 kiore pakeke i tētahi rangahau werohanga ki tētahi wāhi motuhake | He werohanga ki te kiko raho, ki waenganui rānei i ngā uhi raho; he arotakenga i muri i ngā wiki e rua | Nā te werohanga ki te kiko hōhonu i heke ai te testosterone i te serum me te kukū pūtau parāoa i te epididymis; kāore te rōpū i werohia ki waenganui i ngā uhi i whakaatu i ngā panonitanga hira o aua inenga | He mea nui te wāhi whakapā ā-rohe; kāore e tika te whakapae he pānga taiaki whai painga whānui |
| Ka whakaheke i te prolactin | He kiore tāne i pāngia ki te estradiol benzoate, me ngā rōpū whakatairite | He puru metilīni 0.5% i roto i te kai mō ngā wiki e toru | I whakaiti i te pikinga prolactin toto e pā ana ki te estradiol; kāore te puru metilīni anake i whakaheke i te prolactin toto | He urupare i roto i tētahi pūnaha taiaki i whakarerekētia mā te whakamātautau |
| Ka whakarerekē i te prolactin i te tangata | Tekau tūroro whai mamae io uaua ki te rongoā, e waru tāne, e rua wāhine | He whāngai rongoā ki te ia toto mō te 60 meneti; i whakatairitea te 2 mg/kg ki te 0.02 mg/kg | I heke te tohu prolactin whanaunga i muri i ngā pānga e rua; i pūrongotia he rerekētanga i waenganui i ngā maimoatanga | He kitenga torotoro tohu koiora i ngā tūroro mamae, kāore anō kia whakaūngia hei maimoatanga mō te prolactin teitei |
| Ka whakapai i te āhei whakaputa uri o ngā tāne | He tauira tātea nō ngā tāne hauora 20 | He whakaranu tika ki ngā wairewa waikano pokanga me ngā waimehatanga i waho i te tinana | I heke nui te nekeneke o ngā pūtau parāoa i te wā tonu i muri i te whakapā ki te puru metilīni | He kitenga taiwhanga mō te whakapānga pūtau parāoa, ehara i te whakamātautau āhei whakaputa uri mā te waha, i te inenga testosterone rānei |
| Ka whakaheke i te estrogen, ka whakarerekē rānei i te DHT i ngā tāne | Kāore i kitea i tēnei rapunga he whakamātautau tangata whai rōpū whakatairite mō ngā putanga taiaki | Kāore anō kia whakaūngia tētahi maimoatanga mā te waha mō ēnei putanga | Kāore i kitea he ahunga, he rahinga rānei o te pānga kua whakaūngia ā-haumanu | Me whai taunakitanga motuhake mō te estradiol me te dihydrotestosterone |
| Ka whakapiki i te testosterone mā te aukati whākōkī | He whakamātautau taiwhanga mō ngā tauwhitinga rongoā i roto i ngā mōhiohio whakahau rongoā | He whakapānga i te taiwhanga; i whakamahia te testosterone hei matū tūāpapa mō te CYP3A4/5 | I kitea te aukatinga whākōkī | He whakamātautau pākia matū, ehara i te putanga testosterone ā-haumanu |
Ka tirohia i raro nei ngā rangahau kei muri i ēnei rārangi. Ka whakarōpū te whare pukapuka rangahau puru metilīni i ngā taunakitanga mā te taupori rangahau me te hoahoa whakamātautau.
Ngā mea e whakaaturia ana e te whakamātautau cisplatin
I roto i te rangahau kiore a Gholami Jourabi me ōna hoa, i whakaputaina ā-ipurangi i te 2020, ā, i roto i Andrologia i te 2021, nā te cisplatin i heke ai te testosterone i te serum me ngā inenga pūtau parāoa. I pūrongotia e ngā kaituhi he whakapainga nā te puru metilīni ina whakatairitea ki te rōpū cisplatin, me ngā kitenga tirohanga kiko e hāngai ana ki te iti ake o te tūkino.
Ko te whakatairitenga matua ko tērā ki ngā kararehe i whara i ngā matū. Ehara tētahi uara teitei ake i tērā o tētahi rōpū whakatairite kua whara i te taunakitanga ka whakapiki te maimoatanga i tētahi taumata tīmatanga hauora. I whai rōpū puru-metilīni-anake hoki te rangahau, engari ko te whakatairitenga testosterone i te whakarāpopototanga e hāngai ana ki te cisplatin, kāore ki tētahi pikinga kua whakaaturia ki runga ake i ngā rōpū whakatairite hauora kāore i maimoatia. Kāore tēnei whakamātautau werohanga poto e whakaū i tētahi maimoatanga mā te waha mō ngā tāne, i tētahi ara rānei hei tiaki i te āhei whakaputa uri i te wā e rongoāhia ana te mate pukupuku.
He kitenga rerekē anō i raro i ngā āhuatanga kē. I roto i te whakamātautau werohanga ā-rohe a Mazroa me ōna hoa i te 2016, nā te werohanga puru metilīni ki te kiko raho kiore i puta ai te tūkino whānui ki te hanganga me te testosterone serum iti ake. He whāiti ake te tūkino ā-rohe i puta i te werohanga ki waenganui i ngā uhi raho. Kāore tēnei e matapae i te pānga o te tango mā te waha, engari ka aukati i te kerēme ka tiakina ngā raho i ngā āhuatanga katoa.
He pātai rerekē te prolactin, te estrogen, me te DHT
Ko tētahi kitenga prolactin e whakahuatia nuitia ana i ahu mai i tētahi pūnaha taiaki i āta whakarerekētia. I roto i te whakamātautau a Schreiber me ōna hoa i te 1993, i whiwhi ngā kiore tāne i ngā werohanga estradiol benzoate, i te puru metilīni i te kai, i ēnei mea e rua, i tētahi rānei o ēnei kāore. Nā te whakakotahitanga i whakaiti te pikinga prolactin e rere ana i te toto e pā ana ki te estradiol. Kāore te puru metilīni anake i whakarerekē i te prolactin toto.
He mea nui hoki te rerekētanga i waenganui i te toto me te kiko: kāore te maimoatanga i ārai i te pikinga o te nui o te prolactin i roto i te wāhanga o mua o te repe pituitary. Nō reira, kāore te rangahau e whakaatu i tētahi pēhitanga prolactin māmā, ōrite hoki puta noa i te tinana.
He taunakitanga tangata whāiti kei roto i tētahi rangahau i te 2015 i tohaina matapōkeretia ngā maimoatanga, i huna hoki ngā maimoatanga i ngā kaiuru me ngā kairangahau, ki ngā tūroro mamae io tekau. Ko tōna putanga matua ko te mamae. I ine hoki ngā kairangahau i ngā pūmua i mua, i muri hoki i te whāngai puru metilīni ki te ia toto, me te whakatairite i ngā taumata pānga e rua. I heke te prolactin i muri i ngā mea e rua, ā, he rerekētanga i waenganui i ngā maimoatanga. I homai e te whakamātautau ngā inenga pūmua whanaunga, kāore i homai ngā kukū taiaki ā-haumanu pū. Kāore tēnei kitenga torotoro e whakaū i te whakahekenga prolactin e mau tonu ana, i te maimoatanga mō te prolactin toto nui rawa, i tētahi painga testosterone rānei.
Kāore hoki te whakaiti i tētahi urupare ki te estradiol i tukuna e whakamātau ka whakaheke te puru metilīni i te estrogen e rere ana i te toto, ka aukati rānei i te aromatase i ngā tāne. Ko te DHT, arā, te dihydrotestosterone, he putanga taiaki motuhake anō. Kāore tētahi kitenga testosterone e whakakī i te kore o tētahi hua DHT. Me whai inenga tika ngā kerēme mō tēnā taiaki, mō tēnā taiaki, i raro i ngā āhuatanga whakamahi e marohitia ana.
Ehara ngā taunakitanga pūtau parāoa tangata i te whakamātautau taiaki
I roto i te whakamātautau pūtau parāoa tangata a Sheynkin me ōna hoa i te 1999, i whakaranu ngā kairangahau i ngā wāhanga iti o ngā tauira tātea ki ngā matū e whakamahia ana i ngā pokanga pūnaha whakaputa uri. Nā te puru metilīni i heke kino ai te nekeneke o ngā pūtau parāoa i te wā tonu, tae atu ki ngā waimehatanga i whakamātauria. Kāore te wairewa Ringer whai lactate i pā ki te nekeneke.
He taunakitanga taiwhanga tēnei i ahu mai i te tangata. Kāore ngā kaiuru i tango puru metilīni mā te waha, ā, kāore ngā kairangahau i ine i tō rātou testosterone toto, i ngā hapūtanga, i ngā whānautanga ora rānei. Kāore te kitenga e whakaū i te painga, i te tūraru rānei ki te āhei whakaputa uri o tētahi whakapānga rerekē ka pā ki te tinana whānui. Engari e whakaatu ana he aha e kore ai e tika kia whakapotohia te kōrero “i rangahautia ki ngā pūtau parāoa tangata” hei “ka whakapai i te āhei whakaputa uri o ngā tāne.”
Tērā pea he tino rerekē te tikanga o tētahi whakahuatanga testosterone
E whakaahua ana ngā mōhiohio whakahau rongoā mō ProvayBlue i te aukatinga CYP3A4/5 tērā pea ka hāngai ki te roanga o te wā i te taiwhanga, mā te whakamahi i te testosterone hei matū tūāpapa. I konei, he matū te testosterone e whakamahia ana hei whakamātautau i te mahi a tētahi whākōkī. Kāore tōna whakahuatanga i taua kōwae e whakaū i te whakaputanga taiaki nui ake, i ngā kukū toto teitei ake rānei i ngā tūroro.
Waihoki, kāore tētahi whakamārama mō te pūngao pūtau me ōna tukanga e whakakapi i tētahi whakamātautau taiaki. Me whakaatu tonu ka whakarerekē te whakapānga e marohitia ana i te putanga e hāngai ana i te taupori e whai ana kia whakamahia.
Mēnā ko te testosterone iti te āwangawanga
Ko te mahi e tika ana ko te whakaū mēnā he hapa testosterone, ā, he aha te take. E ai ki ngā tūtohutanga tātaritanga a te Endocrine Society, me whai tohumate e hāngai ana me ngā inenga testosterone iti e mau tonu ana, me te whakamātau anō i te ata i muri i te nohopuku. Mā te arotakenga anō e wehe ngā take raho i ngā take repe pituitary, hypothalamus rānei. Kāore e rawaka tētahi hua kotahi, tētahi panonitanga pūngao rānei.
Kaua te puru metilīni e whakakapi i te maimoatanga taiaki kua whakahautia, i te arotakenga rānei o te prolactin, o te testosterone rānei kei waho i ngā taumata noa. Kāore tōna painga taiaki kāore anō kia mōhiotia e whakakore i ōna tūraru kua whakaūngia: ka whakatūpato ngā mōhiohio whakahau rongoā mō te mate huinga tohumate serotonin ina whakamahia me ngā rongoā e pā ana ki te serotonin, ā, ka rāhuitia te whakamahi ina he hapa G6PD nā te tūraru pakaru pūtau toto whero. Ka whakamārama te aratohu haumaru puru metilīni i aua tūraru me tō rātou horopaki.
Mō ia kerēme testosterone, pātaihia he aha i inea, i roto i a wai, mā tēhea ara tuku, ā, i whakatairitea ki te aha. I tēnei wā, ka ārahi aua pātai ki ngā kitenga whakamātautau, kāore ki tētahi pānga whakapiki testosterone i ngā tāne kua whakaaturia.