Te puru metilīni mō te MCAS me te kore manawanui ki te hitamīni: ngā mea e whakaaturia ana e ngā taunakitanga

Ehara te puru metilīni i te maimoatanga kua whakamanahia mō te mate whakahohe pūtau mast (MCAS), mō te kore manawanui ki te hitamīni rānei. Kāore ngā tuhinga rangahau i kitea mō tēnei tuhinga i whakarato whakamātautau tūroro whai rōpū whakatairite e whakaatu ana i te painga toitū mō tētahi o ēnei mate. Kei roto i ngā kitenga e wātea ana ko ngā whakamātautau taiwhanga me tētahi pūrongo take e pā ana ki te wā huri noa i te pokanga, ā, he pātai whāiti kē tā ēnei e whakautu ana.

He mea nui tēnei wehewehenga, nā te mea he pānga rerekē ngā mea e kīia ana e “whakaiti ana i te mumura,” “whakapūmau ana i ngā pūtau mast,” me “whakakore ana i te hitamīni.” E kore e taea te whakamahi noa i ngā taunakitanga mō tētahi hei taunakitanga mō ērā atu.

E toru ngā kupu me noho wehe

E pā ana te MCAS ki ngā whakaeke auau puta noa i te tinana e tuku ai ngā pūtau mast i ngā matū takawaenga. Ko te hitamīni tētahi matū takawaenga, engari ka whakaputa hoki ngā pūtau mast i ētahi atu matū tuku tohu. E whakamārama ana te American Academy of Allergy, Asthma & Immunology i te aromatawai MCAS mā te huinga o ngā whakaeke whai āhuatanga motuhake, te pikinga o ngā matū takawaenga e hāngai ana i te wā o ngā tohu ina whakaritea ki te taumata taketake, me te urupare ki te maimoatanga e aro ana ki aua matū takawaenga. Kāore te huinga tohu anake e whakaū i te tātaritanga mate.

Ko te pāwera inamata e takawaengatia ana e te IgE he urupare ārai mate ki tētahi matū whakaoho pāwera motuhake. Mā te here o taua matū ki te IgE kei runga i ngā pūtau mast e whakaoho ai pea te tukunga matū takawaenga. Ka whai wāhi pea ngā pūtau mast ki tēnei ara pāwera e mōhiotia whānuitia ana, engari ehara i te mea he MCAS kāore i te mōhiotia te pūtake tō ia tangata pāwera. Ka kapi hoki i te kupu “pāwera” ētahi atu tukanga i tua atu i tēnei ara inamata.

Ka whakamahia whānuitia te kupu kore manawanui ki te hitamīni mō ngā tauhohenga kino e whakapaetia ana nā te hitamīni i roto i te kai. Ehara tēnei i te mea ōrite ki te pāwera kai, ki te MCAS rānei. E whakaahua ana tētahi aratohu nō 2021 nā ngā rōpū maha mō te hitamīni kua kainga i ngā taunakitanga iti, taupatupatu hoki e hono ana i te horomanga ki ngā tohu ka taea te whakaputa anō, ā, e whakatūpato ana kāore ngā inenga diamine oxidase i te wē toto e taea te whakaū i te tātaritanga mate. He whakamārama e whakaarohia ana mō ngā tohu tā tēnei kupu e tohu ana; kāore te tauhohenga ki te kai anake e whakaū i te ngoikore o te wawahanga hitamīni.

Ngā mea i inea tūturu e ngā whakamātautau pūtau mast

Kāore ngā kitenga whakamātautau tika e tautoko ana i te whakamārama māmā e mea ana ka ārai pono te puru metilīni i te tukunga matū i ngā pūtau mast.

I te rangahau a Kimura me ōna hoa nō 1999 mō te tohanga toto moroiti o te kiore, i mātakitaki ngā kairangahau i ngā pūtau mast i te taha o ngā ia toto whakahoki iti o te kiriwhatu tautoko whēkau, mā te whakamahi karu whakarahi i roto i te kararehe ora. Nā te tuku ā-rohe i te puru metilīni mā te rere wai ki runga i te kiko i te kukū 50 micromolar i whakaoho te tukunga o ngā matū o ngā kōpura pūtau. I nui ake hoki te piri o ngā pūtau toto mā ki te paparanga o roto o te ia toto, ā, i pōturi ake tō rātou takahuri haere. Nā te hoatu ketotifen i mua i aukati te urupare tuku matū i ngā kōpura. He whakaritenga whakamātautau kararehe tēnei e tirotiro ana i te tuku tohu e pā ana ki te nitric oxide, ehara i te maimoatanga ā-waha mō te tangata whai MCAS.

I ine tika tētahi rangahau nō 2001 mō ngā pūtau basophil tangata me ngā pūtau mast o te kiriwhatu o te kiore i te tukunga hitamīni. Kāore te puru metilīni i whakarerekē i te tukunga taketake, i te tukunga i whakaohohia ā-pūnaha ārai mate rānei, i ngā pūtau basophil tangata i raro i ngā āhuatanga i whakamātauria. He pūtau ārai mate whai hononga ngā pūtau basophil, engari ehara i te mea ka taea te whakakapi ki ngā pūtau mast o te kiko.

I kitea e tētahi atu whakamātautau e whakamahi ana i te rārangi pūtau RBL-2H3 o te kiore kāore he pānga o te puru metilīni ki te tukunga hitamīni taketake, ki te tukunga rānei i whakaohohia e te L-arginine. He rerekē ngā tohu huri noa me ngā matū ka pā i roto i te whakamātautau ki tētahi rārangi pūtau, ki ngā pūtau kua wehea, me ngā pūtau mast kei roto i tētahi whakaritenga whakamātautau ia toto moroiti ora. Kāore te kitenga kāore he pānga, te kitenga tuku matū i ngā kōpura rānei, i ēnei tauira e matapae i ia urupare tangata. Ina whakaarohia ngātahitia, ka uaua te whakamana i te kerēme whānui he “kaiwhakapūmau pūtau mast” tēnei.

He tawhiti ake ngā inenga mumura whānui i te pātai haumanu. Kāore te huringa o tētahi cytokine, o tētahi pūmua tuku tohu rānei, e whakaū kua heke te tukunga matū i ngā kōpura pūtau mast, ki te kore taua tukunga i inea. Ahakoa kua whakaaturia te hekenga o te tukunga matū takawaenga, me whai tonu he taunakitanga tūroro hei whakaū kua iti ake ngā whakaeke, kua pai ake rānei te āhei ki ngā mahi o ia rā. E hāngai ana ki konei te wehewehenga i waenga i ngā tohu mumura me ngā putanga hauora.

He pātai kē tā tētahi take hōhipera e whakautu ana

E whakaahua ana te pūrongo take nō 2017 mō te pokanga tango poketoto i te pūkahukahu i tētahi tūroro tērā pea he mate pūtau mast tōna, i pāngia e te ohorere ā-tinana nā te whānuitanga o ngā ia toto i muri i te pokanga. I whiwhi te tūroro i ngā kaitāmi H1 me H2, ngā pūtaiaki, me te puru metilīni, ā, i pai ake ngā āhuatanga rere toto.

He kitenga haumanu tērā, engari ko te putanga ko te whakaoranga o te tohanga toto i tētahi horopaki pokanga matatini. He maha ngā maimoatanga i hoatu, kāore he rōpū whakatairite, ā, kāore i mārama te tātaritanga mate. Kāore e taea e te pūrongo te wehe i te wāhi o te puru metilīni i taua putanga, te whakaatu i whakamutua e ia te tukunga matū takawaenga, te whakaū rānei ka pai ake ngā tauhohenga kai mauroa mā te whakamahi auau. He whāinga maimoatanga rerekē te whakapai ake i ngā pānga o tētahi whakaeke ki te pēhanga toto, me te ārai i taua whakaeke.

Te whakatairite mate me ngā putanga ine

Whakamahia tēnei whakatairite hei tautuhi i ngā mea e tino hiahiatia ana mō tētahi painga e whakaarohia ana. He whakakotahitanga hou ngā whakaritenga taunakitanga kei raro nei o ngā wehewehenga tātaritanga mate me ngā wehewehenga whakamātautau o runga, ehara i te taputapu tātaritanga mate kua whakamanaia.

Ehara te wawahanga hitamīni i te aukatinga MAO

E rua ngā ara pākia matua o te hitamīni e whai wāhi ai te diamine oxidase (DAO) me te histamine N-methyltransferase (HNMT). He whākōkī rerekē ēnei i te monoamine oxidase A (MAO-A). Ka wehe te whakaahua uhi i te tukunga matū takawaenga i ēnei ara wawahanga; ko ōna tapanga whākōkī e tautuhi ana i ngā ara, kaua i ngā hua ka hangaia mai i te hitamīni.

I whakaatu a Ramsay me ōna hoa i te aukatinga o te MAO-A e te puru metilīni, he kitenga e hāngai ana ki te paitini serotonin. Ehara te aukati i te MAO-A i te taunakitanga ka piki te mahi a te DAO, a te HNMT rānei, ā, kāore e whakaatu ana i te tere ake o te whakakorenga hitamīni. Kāore te ōrite o ngā ingoa whākōkī e whakaū i tētahi pānga maimoatanga kotahi.

He wehewehenga rangahau hoki e ngāwari ana te kore kite. I tētahi rangahau whakamātautau DAO nō 2020 e whai wāhi ana ngā tūroro 22 me ngā tāngata whakatairite 22, i whakaputaina te puru metilīni hei hua whai tae o tētahi tauhohenga taiwhanga i whakamahia hei whakatau tata i te mahi whākōkī. Kāore ngā kaiuru i te whiwhi maimoatanga puru metilīni. Nō reira, ahakoa ka kitea ēnei kupu e rua i roto i tētahi tuhinga rangahau, ehara i te mea kua kitea he rangahau maimoatanga.

He aha ngā huringa tohu e kore ai e whakaū i te tukanga

Kei roto i te kōrerorero huinga nāna tēnei pātai i whakaoho ngā pūrongo mō te pai ake o te nakunaku kai me te iti ake o te hiahia ohotata ki te mimi i muri i te whakamahi puru metilīni. E whakaahua ana aua pūrongo i ngā huringa i rongohia. Kāore aua pūrongo e ine i te kukū hitamīni, e whakaū i te MCAS, e whakaatu rānei kua ātete te kiko tōngāmimi ki te hitamīni.

Ka piki, ka heke ngā tohu i te wā e huri ana te kai, te kawheine, te wai o te tinana, ngā rongoā, me ētahi atu mea ka pā ki te tinana. Ka tika pea tētahi kitenga, ahakoa kāore tōna whakamārama e whakaarohia ana i te tika. Me whai aromatawai motuhake hoki te hiahia ohotata ki te mimi: he kitenga rerekē ngā tohu tōngāmimi me te whakapokenga ara mimi kua whakaūngia. Kāore te whakamāmā tohu anake e taea te tautuhi ko te whakapokenga, ko te mahi pūtau mast rānei te pūtake.

He mea whai take tonu te tairongo nui

Ka taea e te puru metilīni tonu te whakaputa tairongo nui. E whakaahua ana ngā mōhiohio whakahau rongoā PROVAYBLUE mō te tuku ā-ia toto i te pāwera tino kino, ā, e rāhui ana i te whakamahi mēnā kua pā kē he tairongo nui taumaha ki tētahi hua o te kāwai puru metilīni. E whakatūpato ana hoki mō te mate serotonin ina whakamahia me ngā rongoā pāhekoheko, ā, e rāhui ana i te whakamahi i te hunga he ngoikoretanga G6PD tō rātou. E whakaū ana tēnei tapanga i ngā mōrearea nui; kāore e ine ana i ia tūraru mō tētahi hua ā-waha kāore anō kia rangahaua.

Kāore ngā taunakitanga e whakamana ana i te whakakapi i ngā rongoā ārai hitamīni kua whakahaua, i ētahi atu tiaki kua whakamanahia rānei, ki te puru metilīni. Ki te uaua te hā, ki te pupuhi te korokoro, ki te hinga rānei te tangata, me rapu āwhina hauora ohotata, kaua e whakamātau ki tētahi waikano. Mō tētahi kōrerorero haumanu kua whakamaheretia, mauria te kerēme tika, te hua, ngā rongoā e whakamahia ana i tēnei wā, me te hītori o ngā tohu, mā te whakamahi i ēnei pātai hei ui mō te puru metilīni. Ko te pātai whai take, he aha te tātaritanga mate me te putanga e whāia ana e te maimoatanga e whakaarohia ana, ā, kei reira rānei he taunakitanga mō taua whakamahinga motuhake.