I-methylene blue ku-ME/CFS: ubufakazi ne-PEM

Akukafakazelwa ukuthi i-methylene blue iyindlela ephumelelayo yokwelapha i-ME/CFS. Ekuseshweni kwemibhalo yocwaningo okwenziwe kulesi sihloko, alutholakalanga ucwaningo lokwelashwa kweziguli oluneqembu lokuqhathanisa olubonisa ukuthi inciphisa ukwanda kokugula ngemva kokuzikhandla (PEM) noma ithuthukisa ukukwazi ukwenza imisebenzi yansuku zonke ngokungaguquguquki kubantu abanalesi sifo. Okutholwe elabhorethri kuchaza ukuthi kungani lo mbuzo uthakazelisa abacwaningi. Kodwa akukawuphenduli ezigulini.

Umehluko obaluleke kakhulu uphakathi kokuzizwa unamandla engeziwe manje nokukwazi ukwenza okuthile ngokuphindaphindiwe ngaphandle kokuba ugule kakhulu kamuva. Umbiko wokokuqala awukwazi ukufakazela okwesibili.

I-ME/CFS ingaphezu kokukhathala okuqhubekayo

I-myalgic encephalomyelitis/isifo sokukhathala okungapheli yisifo esikhinyabeza ikhono lokwenza imisebenzi, esinephethini yezimpawu ezisihlukanisayo. Izindlela zokuxilonga ezifingqwe yi-CDC zihlanganisa ukuncipha okukhulu kwemisebenzi umuntu ayekwazi ukuyenza ngaphambi kokugula okuqhubeka isikhathi esingaphezu kwezinyanga eziyisithupha, ukukhathala okungadambi kakhulu ngokuphumula, i-PEM, nokulala okungamshiyi umuntu ezizwa ephumule. Kudingeka futhi ukuphazamiseka kwamakhono okucabanga noma ukungakwazi ukubekezelela ukuba sesimweni esiqondile. Ukungakwazi ukubekezelela ukuba sesimweni esiqondile kusho ukuthi izimpawu ziba zimbi kakhulu lapho umuntu emi noma ehlezi eqondile.

Lezi zindlela zidinga ukuhlolwa ngochwepheshe wezempilo, okuhlanganisa ukucabangela ezinye izincazelo zezimpawu. Ukukhathala kukodwa akufakazeli ukuthi umuntu une-ME/CFS, futhi imiphumela evela kubantu abanokukhathala okuvamile ayikwazi ukumane isetshenziswe kulesi sifo.

I-PEM iwukuba kubi kakhulu kokugula ngemva kokuzikhandla ngokomzimba noma ngokwengqondo umuntu ayekwazi ukukubekezelela ngaphambili. Njengoba i-CDC ichaza eziqondisweni zayo zokunakekelwa kweziguli, lokhu kuba kubi ngokuvamile kubonakala emahoreni angu-12 kuya kwangu-48 kamuva futhi kungaqhubeka izinsuku noma amasonto. Ngakho ukuhlolwa ntambama kungase kungawuboni umphumela obalulekile womsebenzi owenziwe ekuseni ngalolo suku.

Lokho ucwaningo lwama-mitochondria olukunikelayo ngempela

Ama-mitochondria asiza ukuguqula izakhi zokudla zibe amandla asetshenziswa amaseli. I-methylene blue ingabamba iqhaza ekusabeleni kwe-oxidation nokwe-reduction, yamukele futhi inikele ngama-electron. Ezivivinyweni zika-Wen nozakwabo zango-2011, yasekela enye indlela yokudlulisa ama-electron esuka ku-NADH iya ku-cytochrome c ngaphansi kwezimo zokuhlola. Amaseli ezinzwa akhuliswe elabhorethri abonisa ushintsho ekusetshenzisweni kwe-oxygen, futhi abacwaningi baphinde bahlola amagundane anezimo zokulimala okufana nesifo sika-Parkinson nokuntuleka kwegazi ebuchosheni. Lezi kwakuyizivivinyo zaselabhorethri nasezilwaneni, hhayi izivivinyo zokwelapha i-ME/CFS.

Kukhona futhi ucwaningo lokugaywa kwezinto emzimbeni oluqondene nalesi sifo. U-Tomas nozakwabo bahlola amaseli amasosha omzimba asegazini labantu abane-CFS nabantu abaphilile ababeqhathaniswa nabo, bathola umehluko ku-oxidative phosphorylation, ikakhulukazi ezingeni eliphezulu kakhulu lokuphefumula kwamaseli. Umphumela owalinganiswa wawuwukuthi amaseli athathwe njengamasampula aziphatha kanjani ekuhlolweni kwaselabhorethri. Iziguli azinikwanga i-methylene blue, futhi ucwaningo aluzange lulinganise ukuthuthuka kwe-PEM ngemva kokwelashwa.

Okunye okutholakele kwenza incazelo elula yokuthi “ukukhiqizwa kwamandla kuphansi” ibe yinkimbinkimbi. Ocwaningweni luka-Fluge nozakwabo olwaluneziguli ezingu-200 nabahlanganyeli abaphilile abangu-102, amaphethini ama-amino acid asikisela ushintsho ekugayweni kwezinto ukuze kukhiqizwe amandla. Amaseli emisipha akhuliswe elabhorethri achayeka ku-serum yeziguli abonisa ukwanda kokuphefumula kwama-mitochondria kanye nokukhishwa kwe-lactate ngokweqile. Amaseli ahlukene nezimo zokuhlola ezihlukene kungaveza amaphethini ahlukene. Ngakho “ukuphefumula okwengeziwe” akulona uphawu lokululama oluzichaza ngokwalo.

Isiphetho esixhumanisa lolu cwaningo nokwelashwa sinesinyathelo esingakahlolwa: umuthi oshintsha ukudluliswa kwama-electron kufanele uphinde uthuthukise inqubo yesifo efanele, ezicutshini ezifanele, ngaphandle kwemiphumela eyingozi esusa inzuzo. Izimangalo ezibanzi nge-methylene blue nama-mitochondria nazo zidinga ukuthi indlela yokusebenza ihlukaniswe nomphumela.

Ithebula elixhumanisa ubufakazi nemiphumela

Ubufakazi noma isimangalo	Lokho okungakufakazela	Lokho okusadingeka ku-ME/CFS
I-methylene blue ishintsha ukuphefumula kumaseli ezinzwa	Umphumela wamakhemikhali ezinto eziphilayo ohlelweni lwaselabhorethri oluchaziwe	Ubufakazi bokuthi umphumela uthuthukisa ukugula kunokuba ushintshe nje ukuhlolwa
Amaseli egazi eziguli abonisa umehluko ezinqubweni zamandla	Ukuhlobana phakathi kokuba nesifo nezilinganiso zamaseli	Ukuqhathaniswa kokwelashwa okubonisa inzuzo ebalulekile empilweni yesiguli
Umuntu ubika ukuphaphama okwengeziwe ngemva kokuyithatha	Lokho akuzwile ngaleso sikhathi	Ukuhlolwa kwezimpawu ezibambezelekile, imiphumela engemihle, nokukwazi ukwenza imisebenzi ezinsukwini ezilandelanayo
Amaphuzu esilinganiso sokukhathala ayathuthuka	Ushintsho esilinganisweni sophawu esithile	Ukuthi i-PEM, ukulala, amakhono okucabanga nemisebenzi yansuku zonke edingekayo nakho kuyathuthuka yini
Iziwombe zokuba kubi kakhulu ziyehla kuyilapho imisebenzi incipha kakhulu	Ushintsho olwenzeka kanye nokuncipha kwemisebenzi edinga amandla	Ukuthi ukuthuthuka kubangelwa ukulungiswa kwemisebenzi, ukwelashwa, ukuguquguquka kwemvelo, noma izici eziningana

Ingxoxo ye-Phoenix Rising nge-methylene blue ibonisa imibuzo yeziguli ngalokho ezikuzwayo, ukuphepha, nekhwalithi yomkhiqizo. Izingxoxo ezinjalo zingaveza ukukhathazeka okufanele kucwaningwe. Azinakho ukuqhathanisa okulawulwayo nokulandelela okungaguquguquki okudingekayo ukuze kunqunywe ukuphumelela kokwelashwa.

Hlola izinsuku ezilandelayo, hhayi ihora elihle kuphela

Cabanga ngomuntu oyisibonelo ozizwa ecabanga ngokucace kakhudlwana ngoMsombuluko bese echitha isikhathi eside ephendula izincwadi nemiyalezo. NgoLwesibili udinga usizo lokulungisa ukudla; ngoLwesithathu ikhono lokugxila lisalokhu libi kunokujwayelekile. Ukubiza uMsombuluko ngokuthi ukuthuthuka ngaphandle kokubhala okwenzeke ngoLwesibili nangoLwesithathu kungalahla ulwazi olubalulekile kwezokwelapha. Kungaba futhi ngaphambi kwesikhathi ukusola into ayithathile noma umsebenzi owengeziwe ngokuba kubi ngaphandle kokucabangela lonke ukulandelana kwezehlakalo.

Imiphumela ewusizo ihlanganisa ubunzima nobude be-PEM, ukukwazi ukuphinda imisebenzi ebalulekile kumuntu, isikhathi sokululama, nosizo oludingekayo. Umuntu angase akwazise ukukwazi ukufunda umyalezo omfushane noma ukugeza ngaphandle kosizo ngaphezu koshintsho enanini elilinganiswa elabhorethri. Lezo zinto ezibalulekile kuye kufanele ziqondise noma iyiphi ingxoxo nochwepheshe wezempilo.

Ekuphatheni imisebenzi, i-NICE incoma indlela ehambisana nomuntu ngamunye ngaphakathi kwemikhawulo yakhe yamanje yamandla futhi yeluleka ngokugwema izinhlelo ezisebenzisa ukwandiswa kokuzivocavoca ngezinyathelo ezimisiwe. Ukuzizwa ungcono okwesikhashana akusona isizathu sokuhlola umkhawulo ngokuzikhandla kakhulu.

Idayari yemisebenzi nezimpawu ezibambezelekile

Sebenzisa idayari yombhalo ephrintekayo ukubhala okwenzeka empilweni evamile ukuze uxoxe nochwepheshe wezempilo. Iyithuluzi lokusiza ukuqaphela, hhayi isilinganiso sokuxilonga noma uhlelo lokuhlola i-methylene blue. Bhala kuphela lokho okwaziyo ukukwenza. Umnakekeli angasiza, futhi kuyamukeleka ukungabhali ezinye izikhathi.

Khetha izinkomba ezimbili noma ezintathu eziwusizo kuwe, njengokuthi ungakwazi ukufunda isikhathi esingakanani, ukulungisa ukudla, noma usizo oludingayo lapho ugeza. Chaza okwenzeke ngempela esikhundleni sokwenza umsebenzi ngenhloso yokulinganisa ikhono lakho. Bhala imisebenzi edinga amandla omzimba, ukucabanga, imizwa, izinzwa, noma ukuba sesimweni esiqondile lapho kufanele khona. Faka ukuphumula nanoma yiziphi izinguquko esezenziwe emithini noma ezinqubweni zansuku zonke.

Isikhathi	Umsebenzi nezimo zawo	Izimpawu nokukwazi ukwenza imisebenzi
Ngaphambi komsebenzi ovamile	Usuku/isikhathi; imisebenzi yakamuva; ukulala	Izimpawu ezijwayelekile namuhla; usizo oseluvele ludingeka
Ngesikhathi somsebenzi noma ngokushesha ngemva kwawo	Okwenzekile; isikhathi esilinganiselwayo; ukuhlala, ukuma, noma ukuncika uhleli	Izimpawu ezivele ngokushesha; umsebenzi uqediwe, ufinyeziwe, noma uyekiwe
Ngosuku olulandelayo	Imisebenzi emisha edinga amandla nokuphumula	Izimpawu ezintsha noma ezimbi kakhulu; isikhathi eziqale ngaso; ushintsho emakhonweni ansuku zonke
Ngosuku lwesibili	Imisebenzi emisha edinga amandla nokuphumula	Ukuba kubi okuqhubekayo noma okubambezelekile; usizo oludingekayo
Ngezinsuku zakamuva uma kudingeka	Incazelo emfushane yezimo zosuku	Ukubuyela esimweni esijwayelekile, noma ushintsho oluqhubekayo

Yiza nalokhu kulandelana kwezehlakalo ngesikhathi sokubonana nochwepheshe, kuhlanganise nezinsuku ezibonakala zingashintshile. Buza ukuthi ukuthuthuka okubonakalayo kwenzeke yini lapho imisebenzi edinga amandla ifana, kukhona usizo olwengeziwe, noma ukuphumula kwandiswe kakhulu. Idayari yomuntu ayikwazi ukufakazela imbangela, kodwa ingenza ukubonana okufushane kube nolwazi olwengeziwe.

Ukuphepha kuyingxenye yombuzo wokwelashwa

I-methylene blue inomsebenzi wemithi emzimbeni. Ulwazi lwase-U.S. lokunikeza i-PROVAYBLUE efakwa emthanjeni luphathelene ne-methemoglobinemia etholakala kamuva, hhayi i-ME/CFS. Luxwayisa ngesifo esiyingozi sokwanda kwe-serotonin lapho isetshenziswa nemithi ethinta i-serotonin nama-opioid, futhi luthi akufanele isetshenziswe lapho kukhona ukushoda kwe-G6PD ngenxa yengozi yokuntuleka kwegazi okubangelwa ukubhujiswa kwamangqamuzana abomvu egazi. Lolu lwazi lomuthi womjovo aluqinisekisi uhlelo lokuzelapha ngokuwuphuza.

Yiza nohlu oluphelele lwemithi nezithasiselo engxoxweni nochwepheshe wezempilo nge-methylene blue. Ungayeki ukwelashwa okunikezwe udokotela ukuze uyisebenzise. Umbuzo okufanele uxazululwe ukuthi ubufakazi obuqondene nalesi sifo buyayisekela yini inzuzo ebalulekile kuwe, kube nendlela yokubona ukuba kubi okubambezelekile nemiphumela engemihle efanele ukunakwa.