Inqaku
I-methylene blue ye-ME/CFS: amabango ngamandla neempawu ezilibazisekayo
I-methylene blue ayikaqinisekiswa njengonyango olusebenzayo lwe-ME/CFS. Kukhangelo loncwadi lophando olwenzelwe eli nqaku, akufunyanwanga lingo luneqela lothelekiso kwizigulana olubonisa ukuba iyanciphisa ukungaziva kakuhle emva kokuzibhokoxa (PEM) okanye iphucula ukusebenza kwemihla ngemihla okuzinzileyo kwesi sifo. Iziphumo zaselabhoratri zichaza isizathu sokuba lo mbuzo ube nomdla kubaphandi. Azikawuphenduli kwizigulana.
Owona mahluko uluncedo uphakathi kokuziva unamandla ngakumbi ngoku nokukwazi ukwenza into ngokuphindaphindiweyo ngaphandle kokugula ngakumbi kamva. Ingxelo yokuqala ayinakuqinisekisa eyesibini.
I-ME/CFS ingaphezulu kokudinwa okuzingileyo
I-myalgic encephalomyelitis/isindrom yokudinwa okungapheliyo sisifo esinciphisa amandla okusebenza, esinepateni ethile yeempawu. Imiqathango yoxilongo eshwankathelwe yi-CDC iquka ukuncipha kakhulu kwemisebenzi umntu awayekwazi ukuyenza ngaphambi kokugula, okuhlala ngaphezu kweenyanga ezintandathu, ukudinwa okungakhululeki kakhulu ngokuphumla, i-PEM, nokulala okungahlaziyiyo. Kukwafuneka kubekho ukuphazamiseka kokusebenza kwengqondo okanye ukungakwazi ukunyamezela ukuma okanye ukuhlala nkqo. Ukungakwazi ukunyamezela ukuba nkqo kuthetha ukuba iimpawu ziya zisiba mandundu xa umntu eme okanye ehleli nkqo.
Le miqathango ifuna uvavanyo lukagqirha, oluquka ukuqwalaselwa kwezinye izizathu ezinokuchaza iimpawu. Ukudinwa kuphela akuqinisekisi i-ME/CFS, yaye iziphumo ezivela kubantu abanokudinwa okuqhelekileyo azinakusetyenziswa kuyo nje.
I-PEM kukuba mandundu kwesifo emva komgudu womzimba okanye wengqondo umntu awayekwazi ukuwunyamezela ngaphambili. Njengoko i-CDC icacisa kwisikhokelo sayo sokhathalelo lwezigulana, ukuba mandundu kudla ngokubonakala kwiiyure eziyi-12 ukuya kweziyi-48 kamva yaye kunokuqhubeka iintsuku okanye iiveki. Ngoko ke uvavanyo lwasemva kwemini lunokuphoswa sisiphumo esibalulekileyo somsebenzi waloo ntsasa.
Oko uphando lwe-mitochondria lukwenzayo ngokwenene
I-mitochondria zinceda ukuguqula izondlo zibe ngamandla anokusetyenziswa ziiseli. I-methylene blue inokuthatha inxaxheba kwiinkqubo ze-oxidation-reduction, yamkele ize inike ii-electron. Kwimifuniselo ka-Wen noogxa bakhe yango-2011, yaxhasa enye indlela yokudluliselwa kwee-electron ukusuka kwi-NADH ukuya kwi-cytochrome c phantsi kweemeko zovavanyo. Iiseli zemithambo-luvo ezikhuliswe elabhoratri zabonisa utshintsho ekusebenziseni ioksijini, yaye abaphandi bafunda neemodeli kwiimpuku zokwenzakala okufana ne-Parkinson nokunqongophala kokuhamba kwegazi ebuchotsheni. Le yayiyimifuniselo yaselabhoratri neyezilwanyana, ingengawo amalingo onyango lwe-ME/CFS.
Kukwakho uphando ngemetabolism olujoliswe kwesi sifo. U-Tomas noogxa bakhe bafunda iiseli zokhuselo lomzimba ezisegazini zabantu abane-CFS nezabantu abasempilweni ababesetyenziswa kuthelekiso, bafumana umahluko kwi-oxidative phosphorylation, ingakumbi ekuphefumleni kweeseli kwelona nqanaba liphezulu. Isiphumo esasilinganiswa yayikukuziphatha kweeseli ezithathwe njengeesampulu kuvavanyo lwaselabhoratri. Izigulana azizange zinikwe i-methylene blue, yaye uphando aluzange lulinganise ukuphucuka kwe-PEM emva konyango.
Ezinye iziphumo zenza ingcaciso elula ethi “ukuveliswa kwamandla okuphantsi” ibe nzima ngakumbi. Kuphononongo luka-Fluge noogxa bakhe lwezigulana eziyi-200 nabathathi-nxaxheba abasempilweni abayi-102, iipateni zee-amino acid zacebisa utshintsho kwimetabolism yamandla. Iiseli zezihlunu ezikhuliswe elabhoratri zaza zadityaniswa neserum yezigulana zabonisa ukwanda kokuphefumla kwe-mitochondria kunye nokukhutshwa kwe-lactate ngokugqithisileyo. Iiseli ezahlukeneyo neemeko zovavanyo ezahlukeneyo zinokuvelisa iipateni ezahlukeneyo. Ngoko ke “ukuphefumla okungakumbi kweeseli” akusiso isalathisi sokuchacha esizicacisayo.
Isigqibo esidibanisa ezi zifundo nonyango siquka inyathelo elingekavavanywa: iyeza elitshintsha ukudluliselwa kwee-electron kufuneka likwaphucule inkqubo yesifo echaphazelekayo, kwizicubu ezifanelekileyo, ngaphandle kweengozi eziphelisa inzuzo. Amabango abanzi nge-methylene blue ne-mitochondria afuna kwaloo mahluko phakathi kwendlela esebenza ngayo neziphumo.
Itheyibhile yobungqina neziphumo
| Ubungqina okanye ibango | Oko bunokukuqinisekisa | Oko kusafunekayo kwi-ME/CFS |
|---|---|---|
| I-methylene blue itshintsha ukuphefumla kweeseli zemithambo-luvo | Impembelelo ye-biochemistry kwinkqubo ethile yaselabhoratri | Ubungqina bokuba loo mpembelelo iphucula isigulo kunokutshintsha kuphela isiphumo sovavanyo |
| Iiseli zegazi lezigulana zibonisa umahluko kwiinkqubo zamandla | Unxulumano phakathi kwemeko yesifo nemilinganiselo yeeseli | Uthelekiso lonyango olubonisa inzuzo ebalulekileyo ngokwezonyango |
| Umntu uxela ukuphaphama ngakumbi emva kokuyithatha | Amava akhe ngelo xesha | Uvavanyo lweempawu ezilibazisekayo, iziphumo ezingathandekiyo, nokusebenza kwiintsuku ezilandelelanayo |
| Amanqaku okudinwa ayaphucuka | Utshintsho kumlinganiselo othile weempawu | Ukuba i-PEM, ukulala, ukusebenza kwengqondo, nemisebenzi eyimfuneko yemihla ngemihla nazo ziyaphucuka |
| Izihlandlo zokuba mandundu kakhulu ziyancipha ngoxa imisebenzi incipha kakhulu | Utshintsho olwenzeka kunye nokuncipha kwemisebenzi efuna umgudu | Ukuba ukuphucuka kubangelwa kukulungelelanisa imisebenzi, lunyango, kukuguquguquka kwendalo, okanye zizinto ezininzi |
Ingxoxo ye-Phoenix Rising nge-methylene blue ibonisa imibuzo yezigulana ngamava, ukhuseleko, nomgangatho wemveliso. Iincoko ezinjalo zinokuchonga iinkxalabo ezifanele ukuphandwa. Azinalo uthelekiso olulawulwayo nokulandelelwa okungaguquguqukiyo okufunekayo ukuze kumiselwe ukusebenza konyango.
Vavanya iintsuku ezilandelayo, hayi nje iyure emnandi
Cinga ngomntu oqikelelwayo oziva ecinga ngokucacileyo ngakumbi ngoMvulo aze achithe ixesha elide ephendula imiyalezo neembalelwano. NgoLwesibini ufuna uncedo ekulungiseleleni ukutya; ngoLwesithathu ukukwazi ukugxila kusabi kubi kunesiqhelo. Ukubiza uMvulo ngokuba kukuphucuka ngaphandle kokubhala okwenzeke ngoLwesibini nangoLwesithathu kungalahla ulwazi olubalulekileyo ngokwezonyango. Kwakhona bekuya kuba kukungxama ukuchaza ukuba mandundu njengokubangelwe yinto ethathiweyo okanye ngumsebenzi owongezelelweyo ngaphandle kokuqwalasela lonke ulandelelwano.
Iziphumo eziluncedo ziquka ubuzaza nobude be-PEM, ukukwazi ukuphinda imisebenzi ebalulekileyo emntwini, ixesha lokuchacha, nenkxaso efunekayo. Umntu unokuxabisa ukufunda umyalezo omfutshane okanye ukuzihlamba ngaphandle koncedo ngaphezu kotshintsho kwinani lovavanyo lwaselabhoratri. Ezo zinto ziphambili kuye kufuneka zikhokele nayiphi na ingxoxo yezonyango.
Ekulawuleni imisebenzi, i-NICE icebisa indlela elungiselelwe umntu ngamnye ngaphakathi kwemida yakhe yamandla yangoku yaye ilumkisa ngokuchasene neenkqubo ezisebenzisa ukunyuswa komthambo ngokwamanqanaba amiselweyo. Ukuziva ungcono okwethutyana akusosizathu sokuvavanya umda ngokuzibhokoxa ngakumbi.
Idayari yemisebenzi neempawu ezilibazisekayo
Sebenzisa idayari yombhalo enokuprintwa ukubhala ubomi obuqhelekileyo ukuze uxoxe nogqirha. Sisixhobo sokunceda ukuqwalasela, asiyondlela yokunika amanqaku oxilongo okanye isicwangciso sokulinga i-methylene blue. Bhala kuphela oko unako ukukulawula. Umkhathaleli anganceda, yaye ukushiya ezinye iindawo zingabhalwanga kwamkelekile.
Khetha izalathisi ezimbini okanye ezintathu eziluncedo kuwe, njengokukwazi ukunyamezela ukufunda, ukulungiselela ukutya, okanye uncedo ekuzihlambeni. Chaza okwenzeke ngokwenene endaweni yokwenza umsebenzi ukuze ulinganise amandla akho. Bhala iimfuno zomzimba, zengqondo, zeemvakalelo, zezivamvo, nezokuhlala okanye ukuma nkqo xa kufanelekile. Quka ukuphumla nalo naluphi na utshintsho esele lwenziwe kumayeza okanye kwiinkqubo zemihla ngemihla.
| Ixesha | Umsebenzi neemeko | Iimpawu nokusebenza |
|---|---|---|
| Ngaphambi komsebenzi oqhelekileyo | Umhla/ixesha; umsebenzi wamva nje; ukulala | Iimpawu eziqhelekileyo namhlanje; uncedo esele lufuneka |
| Ngexesha lomsebenzi okanye kungekudala emva kwawo | Okwenzekileyo; ubude bexesha obuqikelelweyo; ukuhlala, ukuma, okanye ukungqengqa | Iimpawu ezivele ngoko nangoko; umsebenzi ogqityiweyo, ofinyeziweyo, okanye oyekiweyo |
| Ngosuku olulandelayo | Iimfuno ezintsha nokuphumla | Iimpawu ezintsha okanye ezimbi ngakumbi; ixesha eziqale ngalo; utshintsho kubuchule bemihla ngemihla |
| Ngosuku lwesibini | Iimfuno ezintsha nokuphumla | Ukuqhubeka kokuba mandundu okanye ukuba mandundu okulibazisekileyo; uncedo olufunekayo |
| Kwiintsuku ezilandelayo xa kufuneka | Inkcazelo emfutshane yeemeko zosuku ngalunye | Ukubuyela kwimeko eqhelekileyo, okanye utshintsho oluqhubekayo |
Yiza nolu landelelwano kwidinga, kuquka neentsuku ezibonakala zingatshintshanga. Buza ukuba ukuphucuka okubonakalayo kwenzeke phantsi kweemfuno ezifanayo, ngoncedo olungakumbi, okanye ngokuphumla okungakumbi kakhulu. Idayari yomntu ngamnye ayinakuqinisekisa unobangela, kodwa inokwenza udliwano olufutshane nogqirha lube nolwazi oluluncedo ngakumbi.
Ukhuseleko luyinxalenye yombuzo wonyango
I-methylene blue inefuthe lomayeza emzimbeni. Ulwazi lwase-U.S. lokumiselwa kwe-PROVAYBLUE efakwa emthanjeni lubhekisa kwi-methemoglobinemia efunyenweyo, hayi kwi-ME/CFS. Lulumkisa ngesindrom ye-serotonin enzulu xa isetyenziswa namayeza achaphazela i-serotonin nee-opioid, yaye luyakwalela ukusetyenziswa kwayo kubantu abanokusilela kwe-G6PD ngenxa yomngcipheko we-anemia ebangelwa kukuqhekeka kweeseli ezibomvu zegazi. Olu lwazi lwechiza elitofwayo aluqinisekisi isicwangciso sokuzinyanga ngechiza elithathwa ngomlomo.
Yiza noluhlu olupheleleyo lwamayeza nezongezo kwisondlo kwingxoxo nogqirha nge-methylene blue. Musa ukuyeka unyango olumiselweyo ukuze uyisebenzise endaweni yalo. Umbuzo ekufuneka usonjululwe ngowokuba ubungqina obujoliswe kwesi sifo buxhasa na inzuzo ebalulekileyo kuwe, kukho nendlela yokuqaphela ukuba mandundu okulibazisekayo neziphumo ezingathandekiyo ezifanelekileyo.