Uribel, Uro-MP, neUrogesic Blue: Kuenzanisa Zviri Mukati

Murwere anotanga kunwa kapusuro kebhuruu nekuda kwekupisa pakuita weti nekuda kuita weti nekukurumidza. Weti inoshanduka kuva yebhuruu. Kana bhodhoro rinotevera richiratidza rimwe zita remhando yemushonga, murwere anobvunza mubvunzo une musoro: dhayi yebhuruu ndiyo yaiita basa here, uye chigadzirwa chipi nechipi chine methylene blue chinoshanda zvakafanana here?

Kunzwisisa kwakadaro hakuna kururama, uye zvakanyorwa pamushonga zvinotsanangura chikonzero. Mushonga weUribel, Uro-MP, neUrogesic Blue mishonga ine zvinhu zvakawanda zvakasanganiswa. Methylene blue chimwe chete chezvinhu zvakawanda zviri mukati, uye inotsanangurwa pamushonga sechinhu chine simba shoma rekudzivirira utachiona, kwete semushonga wacho wose. Kuti uenzanise zvigadzirwa izvi, verenga chinhu chimwe nechimwe nebasa racho rakataurwa pane kungotarisa ruvara.

Zvigadzirwa zvose zvitatu zvinokurukurwa pano zvinowanikwa muDailyMed semishonga isina kubvumidzwa, ine mashoko emushonga anopiwa nemugadziri. Mamiriro iwayo anokosha. Anoreva kuti mashoko emushonga anotsanangura zviri muchigadzirwa chinotengeswa, asi zvigadzirwa zvacho hazvina kuongororwa neFDA nenzira imwe chete inoshandiswa pakubvumidza mushonga mutsva unopiwa nechitupa chachiremba. Tarisa zvakanyorwa pamushonga wawakapiwa, kwete zita reboka remhando dzemushonga, usati wafunga kuti zvakafanana.

Kuenzanisa zviri mukati mechigadzirwa chimwe nechimwe

Tafura inoshandisa mashoko azvino emishonga muUS. Huwandu hwakaratidzwa ndehwekapusuro kamwe chete keUribel neUro-MP, uye hwepiritsi rimwe chete rakaputirwa reUrogesic Blue.

Chinhu chakanyorwa pamushonga nebasa racho	Kapusuro keUribel	Kapusuro keUro-MP	Piritsi rakaputirwa reUrogesic Blue
Methenamine, inorwisa mabhakitiriya muweti kuburikidza neformaldehyde muweti ine asidhi	118 mg	118 mg	81.6 mg
Sodium phosphate monobasic, inochengetedza weti iine asidhi kuti methenamine ishande	40.8 mg	40.8 mg	40.8 mg
Phenyl salicylate, mushonga une simba shoma wekuderedza marwadzo	36 mg	36 mg	Haimo
Methylene blue, chinhu chine simba shoma rekudzivirira utachiona	10 mg	10 mg	10.8 mg
Hyoscyamine sulfate, inodzivisa kushanda kwetsinga dzeparasympathetic uye inoderedza kugwinha kwetsandanyama	0.12 mg	0.12 mg	0.12 mg

Mashoko azvino eUribel anonyora zvinhu zvishanu izvi uye anotsanangura basa rechimwe nechimwe rataurwa pamusoro. Mashoko azvino eUro-MP anoenderana neUribel pachinhu chimwe nechimwe nehuwandu hwakafanana, asi mhando yemunyu wephosphate ndiyo chete inotsanangurwa zvakasiyana. Mashoko azvino eUrogesic Blue anotsanangura piritsi rine zvinhu zvina, rine huwandu hwakasiyana hwemethenamine nemethylene blue, uye risina phenyl salicylate.

Pane chimwe chinhu pakurava mashoko emushonga chinofanira kucherechedzwa. Chikamu cheTsananguro cheUribel chinoti methenamine 118 mg, asi tafura yezviri mukati iri papeji imwe chete yeDailyMed inoratidza 120 mg. Shandisa huwandu hwe118 mg huri muchikamu cheTsananguro nepakeji pakutsanangura zviri mukapusuro kamwe chete, uye tora kusawirirana uku sechikonzero chekusimbisa zviri papakeji yawakapiwa, kwete sehuwandu hweimwe mhando yemushonga.

Basa rechinhu chimwe nechimwe sezvakanyorwa pamushonga

Methenamine ndiyo inoita basa guru rekurwisa mabhakitiriya rinotsanangurwa mumashoko emishonga iyi. Muweti ine asidhi inoshanduka kuva formaldehyde, iyo inotsanangurwa pamushonga seinouraya mabhakitiriya kana kumisa kukura kwawo. Mashandiro iwayo anotsanangura kuti nei chinhu chinoita kuti weti ive neasidhi chichikosha. Sodium phosphate monobasic inobatsira kuchengetedza weti iine asidhi kuitira kuti methenamine iparare sezvinotarisirwa. Saka mishonga inokwidza pH yeweti, kusanganisira mimwe mishonga inoderedza asidhi yemudumbu, thiazides, nemishonga inoita kuti weti ive nealkali, inogona kuderedza kushanda kwemethenamine kunotsanangurwa pamushonga.

Phenyl salicylate ine basa rakatemerwa zvishoma. Mashoko emushonga anoti inoburitsa salicylate, inotsanangurwa sechinhu chine simba shoma rekuderedza marwadzo. Iri muUribel neUro-MP uye haimo muUrogesic Blue yazvino. Murwere anochinja kubva pakapusuro kane zvinhu zvishanu kuenda kupiritsi rine zvinhu zvina, obva aona kuti marwadzo haachaderedzwi zvakanyanya, ane musiyano wakajeka wakanyorwa pamushonga wekukurukura nachiremba akamunyorera mushonga, kwete chinhu chisingatsananguriki.

Methylene blue ine basa rekutsigira mumashoko emishonga iyi. Mashoko emishonga yakaita seUribel neaya eUrogesic Blue ose anoidaidza kuti chinhu chine simba shoma rekudzivirira utachiona. Mashoko iwayo akasarudzwa nemaune. Haatsananguri methylene blue semushonga unoshanda woga pakurapa matambudziko enzira dzeweti, uye hapana pamashoko emishonga iyi mitatu panoti methylene blue yoga inogona kutsiviwa nemusanganiswa wacho. Ruvara rwebhuruu runoratidza kuti irimo. Haruyeri kushanda kwezvimwe zviri mukati.

Hyoscyamine sulfate ndiyo inoderedza kugwinha kwetsandanyama. Mashoko emushonga anoitsanangura sechinhu chinodzivisa kushanda kwetsinga dzeparasympathetic, zvichideredza zviratidzo zvine chekuita nekugwinha kwedundira. Mashandiro mamwe chetewo anotsanangura yambiro dzakanyorwa pamushonga: kuoma muromo, kuona zvisina kujeka, dzungu kana kukotsira, kurova kwemwoyo nekukurumidza, uye kunetseka kuita weti kunogona kusvika pakungoerekana watadza kubudisa weti. Mashoko emishonga anorayira varwere kurega kuishandisa votsvaga rubatsiro rwekurapwa kana mwoyo uchirova nekukurumidza, vaine dzungu, kana vachiona zvisina kujeka, uye anonyanya kuyambira nezveglaucoma, kuvharika kwemudumbu kana mumatumbu, myasthenia gravis, uye kuvharika kwenzira dzeweti.

Nei methylene blue yoga isingatsivi musanganiswa

Bvisa zvinhu zvina muchigadzirwa chine zvinhu zvishanu, uye dhayi yasara haigoni kuchengetedza mabasa emusanganiswa akanyorwa pamushonga. Methenamine inopa basa rekurwisa mabhakitiriya kuburikidza neformaldehyde. Phosphate inochengetedza mamiriro ane asidhi ayo basa racho rinovimba nawo. Hyoscyamine inopa basa rekuderedza kugwinha kwetsandanyama. MuUribel neUro-MP, phenyl salicylate inopa chikamu chekuderedza marwadzo chakanyorwa pamushonga. Mushonga wemvura unotengeswa kuvatengi une chinhu chimwe chete hauna mamwe mabasa iwayo anotsanangurwa pamushonga pahuwandu uhwu, uye hapana mashoko emusanganiswa anotsigira kuchinjana kwakadaro.

Kuongororwa kwekuchengeteka kunochinjawo kana mushonga wose uchitariswa. Mashoko ekunyorera methylene blue inopinzwa mutsinga ane yambiro yakaiswa mubhokisi nezveserotonin syndrome yakakomba uye inogona kuuraya kana ikashandiswa nemishonga ine chekuita neserotonin nemaopioid. Mashoko emishonga mitatu yakasanganiswa yenzira dzeweti haana yambiro iyoyo yakaiswa mubhokisi, uye zvikamu zvawo zvekudyidzana nemimwe mishonga zvinonyanya kutaura nezvekudzivisa kushanda kwemuscarinic receptors, kuchinja pH yeweti, ngozi yekuumbwa kwemakristasi muweti kana sulfonamide ikasangana neformaldehyde, kusashivirira salicylate, nezvimwe zvakabatana nazvo. Kusavapo kweyambiro iyoyo hakurevi kuti musanganiswa une methylene blue wakachengeteka kushandiswa nemishonga yekurapa kuora mwoyo. Sezvo ngozi ine chekuita neserotonin pakushandisa methylene blue isingapinzwi mutsinga uye iri pahuwandu hushoma isati yanyatsonzwisiswa, munhu wese anotora SSRI, SNRI, MAOI, linezolid, dextromethorphan, bupropion, mushonga unokurudzira kushanda kwemuviri, kana opioid anofanira kutanga aita kuti chiremba anonyora mushonga nemufamasisti vaongorore rondedzero yose yemishonga yake. Gwaro redu rekudyidzana kwemethylene blue nemimwe mishonga rinotsanangura zvakadzama kuti nzira yekupinza mushonga mumuviri inokanganisa sei kufunga uku.

Peji rimwe remhando dzakasiyana, kwete zita rimwe rebhodhoro rose

Kutsvaga mishonga isina zita remugadziri inofanana neUribel kunokonzera kuvhiringidzika kwakawanda. Mushonga usina zita remugadziri unonyora zvinhu zvishanu zvakafanana pahuwandu hwe118 mg, 40.8 mg, 36 mg, 10 mg, ne0.12 mg unofanira kuva mumutsara mumwe chete wekuenzanisa neUribel ine zita remugadziri. Zita remugadziri neruvara rwekapusuro hazvitsananguri kuti mushonga chii. Rondedzero yezviri mukati ndiyo inodaro.

Uro-MP iri mumutsara mumwe chete nechikonzero chimwe chete. Mashoko ayo azvino anoenderana nezvinhu zvishanu zviri muUribel pahuwandu hwakafanana, saka kuiisa papeji rimwe chete kunodzivirira kuita sokunge pane musiyano usipo pakati pemisanganiswa miviri inenge yakafanana. Urogesic Blue inofanirawo kuva papeji rimwe chete asi mumutsara wakasiyana, nokuti piritsi razvino rine musanganiswa wakagadziridzwa wezvinhu zvina, une 81.6 mg yemethenamine ne10.8 mg yemethylene blue uye usina phenyl salicylate. Kubata mazita ose matatu sokunge anoreva mushonga mumwe chete kunosiya musiyano iwoyo. Tsvakurudzo yakabatana nezviratidzo zvenzira dzeweti inochengeta kuenzanisa uku kwakanangana nemubvunzo wekurapa, ukuwo nzira yedu yekuverenga mashoko emushonga ichiratidza kuti ungaenzanisa sei bhodhoro ripi neripi rawakapiwa netafura iri pamusoro.

Mabhodhoro ekare anowedzera mumwe mukana wekukanganisa. Misanganiswa yemishonga ine midzi yemazita aya yakachinja nekufamba kwenguva, uye piritsi remakore apfuura ringasaenderana nemashoko emushonga wazvino. Usashandise rondedzero yekare yezviri mukati sokunge ichiri kushanda nhasi. Verenga zviri pabhodhoro raunaro.

Kana zviratidzo zvachinja, tarisa chinhu chakakodzera chiri mumushonga

Kuchinja kunoitika mushure mekutanga kana kuchinjira kune chimwe chezvigadzirwa izvi kunoda kuona kuti chii chakukonzera. Chinhu chimwe nechimwe chine mashandiro anochisiyanisa nezvimwe, uye mashoko emushonga anobatsira kuona kuti mubvunzo unofanira kunangana nechipi.

Kupisa kushoma asi kuramba uchida kuita weti nekukurumidza uye uchirwadziwa nekugwinha kunoratidza musiyano pakati pekuderedza marwadzo nekuderedza kugwinha kwetsandanyama. Phenyl salicylate inobata marwadzo mashoma, ukuwo hyoscyamine ichibata kugwinha kwetsandanyama. Kana kuchinjira kuUrogesic Blue kuchibvisa phenyl salicylate, kupisa kunoramba kuripo kunoda kukurukurwa zvakananga pamusoro pechikamu chekuderedza marwadzo chisisipo, pane kuwedzera huwandu hwepiritsi idzva.

Kuoma muromo kutsva, kuona zvinhu zviri pedyo zvisina kujeka, kutadza kuita tsvina zvakanaka, kurova kwemwoyo nekukurumidza, kana kunetseka kutanga kubudisa weti zvinonongedzera kuhyoscyamine. Aya mashandiro ekudzivisa muscarinic receptors akanyorwa pamushonga, uye kutadza kubudisa weti kungada kurapwa nekukasika. Usaedza kuzvirwisa nemumwe mushonga unozorodza dundira usina kubvunza chiremba anonyora mushonga, nokuti mimwe mishonga inodzivisa muscarinic receptors inogona kuwedzera mashandiro aya.

Mapundu paganda, kurira munzeve, kana kusashivirira mushonga kumunhu asingashiviriri aspirin zvinonongedzera kuchikamu chesalicylate chiri muUribel neUro-MP. Mashoko emishonga anotaura kuti varwere vasingashiviriri salicylates vanogonawo kusashivirira zvigadzirwa izvi. Kusarudza mushonga usina salicylate kunoitwa nachiremba anonyora mushonga, kwete kuzvichinjira wega, nokuti mushonga unotsiva uyu uchiri nemethenamine, methylene blue, nehyoscyamine, izvo zvinewo zvazvinorambidza.

Mibvunzo pamusoro pemakemikari anokonzera weti ine makore inofanira kunangana nemethenamine nephosphate pamwe chete. Weti ine alkali inokanganisa mashandiro emethenamine akanyorwa pamushonga, uye mashoko emishonga anoyambira kuti mishonga yesulfonamide inogona kuumba zvimedu zvakasimba painosangana neformaldehyde muweti, zvichiwedzera ngozi yekuumbwa kwemakristasi muweti. Yambiro iyoyo inotsanangura kudyidzana nemumwe mushonga wesulfonamide. Haitauri kuti zvigadzirwa izvi zvenzira dzeweti zvine mushonga unorwisa mabhakitiriya wesulfa. Uya nerondedzero yose yemishonga yako pakuongororwa, kusanganisira mishonga inoderedza asidhi yemudumbu nemathiazide. Mibvunzo pamusoro pemafambiro ehutachiona nenguva yekurapwazve iri munzira yedu yekuchengeta munhu ane hutachiona hwenzira dzeweti.

Usafunga kuti chigadzirwa chekunze chine zita rakafanana chakangofanana

Misanganiswa yemishonga inodzivirira utachiona uye inoderedza marwadzo enzira dzeweti inosiyana nenyika. Chigadzirwa chinotengeswa kunze kwenyika chine zita rakafanana rinotaura nezvebhuruu kana methenamine chinogona kuva nezvinhu zvakasiyana, mhando dzakasiyana dzemunyu, kana huwandu hwakasiyana nezviri pamashoko emishonga yeUS yaenzaniswa pano. Kuenzanisa kunovimbika chete kunoshandisa gwaro riri mupakeji kana pfupiso yezvimiro zvechigadzirwa zvenyika yacho, zvepakeji chaiyo yawakapiwa. Enzanisa nzvimbo dzose shanu mutafura: methenamine, mhando yephosphate, kuvapo kana kusavapo kwephenyl salicylate, huwandu hwemethylene blue, nehuwandu hwehyoscyamine. Kuenzanisa kusina zvose izvi kunongoratidza kufanana kweboka remishonga, kwete kufanana kwezviri mukati. Maitiro emazita anoyambuka miganhu yenyika anokurukurwa mukuenzanisa kwedu zvigadzirwa zvenzira dzeweti zvepasi rose.

Uya nezvinhu zvitatu pakaunda yepamishonga: bhodhoro remushonga wawakapiwa, rondedzero yose yemishonga nezvinowedzera kudya kusanganisira zvinhu zvine chekuita neserotonin nemishonga inoderedza asidhi yemudumbu, uye chiratidzo chachinja. Zvinhu zvitatu izvi zvinobatsira mufamasisti kubatanidza dambudziko nechinhu chiri mumushonga chakonzera dambudziko racho, pane kuramba muchikakavadzana pamusoro pezita remhando yemushonga.