Chinyorwa
Methylene blue nezvirwere zveitsvo kana chiropa
Chirwere cheitsvo kana chiropa chinoshandura mibvunzo inofanira kupindurwa methylene blue isati yashandiswa. Nyaya huru ndeyekuti muviri unobata sei chinhu ichi, pamwe chete nechikonzero chekurapa. Chinhu chinogona kubatsira padambudziko rakati reutano asi chichida mamwe matanho ekungwarira kana nhengo inobatsira kuchibvisa isingashandi zvakanaka.
Pamethylene blue, humbowo hune chekuita neitsvo nechiropa hahuna kuenzana. Zviyero zvakaitwa muvanhu zvinoratidza kuti huwandu hwemushonga mumuviri nekureba kwenguva yainogara imomo zvinowedzera kana itsvo dzisingashandi zvakanaka. Kusashanda zvakanaka kwechiropa kune yambiro yekunyatsoongorora murwere, asi ruzivo rwemushonga rwakaongororwa pano harupi zviyero zvakafanana zvinoenderana nekuoma kwekusashanda kwechiropa. Hapana pane izvi chinosimbisa kuti methylene blue mushonga wechirwere cheitsvo chisingaperi kana chirwere chechiropa.
Chirwere cheitsvo: kuwedzera kwehuwandu hwemushonga mumuviri nenguva yainogara imomo kwakayerwa
Pharmacokinetics inotsanangura zvinoitika kumushonga kana wapihwa: kupararira kwawo mumuviri, kushandurwa kwawo nemaitiro emakemikari, uye kubviswa kwawo. Huwandu hwemushonga huri mumuviri pamwe nenguva yaunogara imomo ndizvo zvinoumba chinonzi exposure. Vanhu vaviri vanogona kupihwa huwandu hwakafanana asi huwandu hunogara mumiviri yavo nenguva yahunodaro zvosiyana.
Ruzivo rwePROVAYBLUE rwekunyorera mushonga runopa zviyero zvepharmacokinetics zvine chekuita neitsvo mushure mekupihwa mushonga kamwe chete nemutsinga. Huwandu hwemethylene blue mumuviri pamwe nenguva yayakagara imomo mumaawa 96 zvakawedzera ne52%, 116% ne192% pakusashanda zvakanaka kweitsvo kwakapfava, kuri pakati nepakati, uye kwakanyanya, zvichitevedzana. Chiyero chakashandiswa chaiva AUC, nzvimbo iri pasi pemutsetse wegirafu unoratidza huwandu hwemushonga nenguva.
Kuwedzera ne192% kunoreva kuti chiyero ichi chaiva chinenge ka2.92 pane chiyero cheboka rekuenzanisa. Hazvirevi kuti pane mukana we192% wekukuvadzwa kweitsvo. Huwandu hwemushonga mumuviri nenguva yaunogara imomo zvakasiyana nekukuvara: chekutanga chinoyera mushonga; chechipiri chinoyera zvinoitika kumurwere. Kuenzanisa kwepharmacokinetics hakugoni pachako kuratidza muganhu unotangira kukuvadza kwemushonga kumunhu mumwe nemumwe.
Zviyero izvi hazvigoniwo kusimbisa hurongwa hwekushandisa mushonga nemuromo zuva nezuva. Zvinotsanangura muyedzo wakati wekupihwa mushonga nemutsinga, asi kushandisa nemuromo kakawanda kunoshandura nzira, nguva, uye mafambiro ehuwandu hwemushonga mumuviri zviri kuongororwa. Kugovanisa huwandu hwemushonga hunowanikwa paindaneti nereshiyo yechiyero ichi hakushanduri muyedzo iwoyo kuita chirongwa chekurapa chakasimbiswa.
Chirwere chechiropa: danho rekungwarira rine mukaha wakakosha muumboo
Mubvunzo wechiropa haufaniri kupindurwa nekungotora zvikamu muzana zvine chekuita neitsvo. Ruzivo rwechigadzirwa cheProveblue rweEurope runoratidza kushaikwa kwemashoko pamusoro pekuchengeteka uye kushanda kwemushonga kana chiropa chisingashandi zvakanaka. Kushaikwa kwemashoko kunoreva kuti hapana mhinduro yakasimbiswa kuboka revanhu rinotsanangurwa; hakurevi kuti zvakaratidzwa kuti muviri wavo unobata mushonga sezvinowanzoitika.
Ruzivo rwemushonga rweUS runokurudzira kuongorora murwere kwenguva yakareba kuti paonekwe kukuvadza kwemushonga uye kudyidzana kungaitika nemimwe mishonga kana chiropa chisingashandi zvakanaka, nokuti kubviswa kwemushonga mumuviri kunogona kunonoka. Iri idanho rekungwarira pakurapa, kwete kuwedzera kwakayerwa muzvikamu muzana kwechirwere chechiropa chakapfava, chiri pakati nepakati, kana chakanyanya. Haripi huwandu humwe chete hwemaawa ekuwedzera ekuongorora hunoshanda kumunhu wese, kana fomura yekugadzirisa huwandu hwemushonga inosarudzwa nemurwere.
Musiyano uyu wakakosha paunoverenga zano rakadai sekuti “chiropa chinoushandura nemaitiro emakemikari, saka unobatsira chiropa.” Kushandurwa uku kunotsanangura maitiro emakemikari. Hakutsananguri kugadzirisa kukuvara, kuvandudzwa kwekushanda kwechiropa kana kudzorerwa shure kwefibrosis. Mabhenefiti iwayo anoda zvidzidzo zvakagadzirirwa kuyera mhedzisiro iyoyo.
Kuenzanisa matanho ekungwarira pakurapa nemikaha muumboo
Kuenzanisa uku kunobatanidza kunobva mashoko, mamiriro ekurapa, nemubvunzo usati wapindurwa. PROVAYBLUE ndicho chigadzirwa cheUS; Proveblue ndicho chigadzirwa cheEurope. Magwaro ose ari maviri ane chekuita nemishonga inobayiwa yekurapa methemoglobinemia, dambudziko rinokanganisa kugona kweropa kutakura okisijeni. Mirayiridzo yawo haifaniri kubatanidzwa kuita hurongwa hwekushandisa kumba.
| Mubvunzo | Kusashanda zvakanaka kweitsvo | Kusashanda zvakanaka kwechiropa |
|---|---|---|
| Chii chinoyerwa zvakananga? | Ruzivo rwemushonga rweUS, chikamu 12.3: kuwedzera kweAUC mushure mekupihwa mushonga kamwe chete nemutsinga (IV). | Ruzivo rwemushonga rweEurope, chikamu 4.2: kuchengeteka uye kushanda kwemushonga kana chiropa chisingashandi zvakanaka hazvina kusimbiswa; mashoko acho haawanikwi. |
| Nderipi danho rekungwarira pakurapa rakabudiswa? | Ruzivo rwemushonga rweUS, zvikamu 2.2 ne8.6: kupihwa mushonga kamwe chete kana kusashanda zvakanaka kuri pakati nepakati kana kwakanyanya, pachifungwa dzimwe nzira dzekurapa kana mhinduro yemurwere isina kukwana. | Ruzivo rwemushonga rweUS, chikamu 8.7: kuongorora kwenguva yakareba kuti paonekwe kukuvadza kwemushonga uye kudyidzana nemimwe mishonga. |
| Humbowo hunogumira papi? | Ruzivo rwemushonga rweEurope, chikamu 4.2: kuchengeteka uye kushanda kwemushonga hazvina kusimbiswa pachirwere cheitsvo chasvika padanho rekupedzisira, murwere angave achiitwa dialysis kana kuti kwete. | Hapana gwaro rinopa nhamba yekuwanza chiyero chehuwandu hwemushonga mumuviri nenguva yaunogara imomo inoenderana nekuoma kwekusashanda kwechiropa. |
| Chii chingasimbisa kubatsirwa kwenhengo? | Miedzo muvanhu inoyera mhedzisiro inokosha ine chekuita neitsvo muboka revanhu vane chirwere chiri kutarisirwa. | Miedzo muvanhu inoyera mhedzisiro inokosha ine chekuita nechiropa muboka revanhu vane chirwere chiri kutarisirwa. |
Mutsara wekupedzisira unotsanangura humbowo hunodiwa kuti zvinenge zvichinzi zvinobatsira zviongororwe. Hautauri kuti miedzo inodiwa yakatoburitsa mhedzisiro yakanaka.
Zvidzidzo zvemhuka zvinoratidza kudzivirirwa kweitsvo kana chiropa here?
Mimwe miedzo inopa chikonzero chekutsvakurudza. Haipe kurudziro yekurapa munhu ane chirwere chenhengo chisingaperi.
Muchidzidzo chaSarac nevamwe chekumiswa nekudzorerwa kwekuyerera kweropa kuitsvo, makonzo echirume 21 akakamurwa kuita mapoka matatu. Nzira yakashandiswa kukonzera kukuvara yakamisa kuyerera kweropa mutsinga dzinoendesa ropa kuitsvo kweawa imwe, ichiteverwa nemaawa mana ekuyerera kwakadzorerwa. Methylene blue yakabaiwa mukati medumbu kukuvara kusati kwakonzerwa. Zvichienzaniswa neboka rakakuvadzwa risina kurapwa, mhuka dzakarapwa dzaiva nekukuvara kushoma kwenyama uye shanduko muzviyero zvakati zvekukuvadzwa kunokonzerwa neoxidation.
Uhwu humbowo pamusoro pekukuvara kwakakonzerwa nemuyedzo kwenguva pfupi mumakonzo. Hahuratidzi kuti kunwa methylene blue kunovandudza kusefa kweitsvo mumunhu ane chirwere cheitsvo chisingaperi chava nenguva yakareba. Kurapa kukuvara kwemuyedzo kwakarongwa kusati kwaitika kwakasiyanawo nekurapa chirwere chatovapo.
Zvakawanikwa pamusoro pechiropa zvinoratidza kuti sei “chinhu chinodzivisa oxidation” isiri tsananguro yakakwana yekubatsira. Muyedzo wa2018 mumakonzo echirume eWistar 35 wakaongorora kuderedzwa kweropa mune chimwe chikamu chechiropa kwemaminitsi 60 uye kudzorerwa kwekuyerera kweropa kwemaminitsi 15. Vatsvakurudzi vakapa methylene blue nemutsinga kuyerera kweropa kusati kwadzorerwa, ndokuenzanisa zviyero zvenyama neropa mumapoka emuyedzo. Kukuvadzwa kwemafuta neoxidation kwakaderera, asi zviyero zvemitochondria zvakaongororwa hazvina kudzokera pazvaiva. AST yakawedzera mumapoka akanga aderedzerwa ropa, ane kana asina methylene blue.
Mhedzisiro yakanaka ine chekuita nemaitiro emakemikari mumuviri inogona kuvapo pamwe nemhedzisiro isina kushanduka pakushanda kwenhengo. Kungotaura chiyero chakanaka chete kwaizoita kuti muyedzo uyu uite sewapindura mubvunzo wakakura kupfuura wawakanyatsoongorora. Chidzidzo ichi kana muyedzo weitsvo hazvisimbisi kurapwa kwecirrhosis, chirwere chemafuta muchiropa kana chirwere cheitsvo chisingaperi muvanhu.
Zvaunofanira kuuya nazvo pakukurukura nenyanzvi yezveutano
Kana kushandisa kuri kwekusarudza, chirwere cheitsvo kana chiropa chinoda kukurukurwa mushonga usati waiswa mumuviri. Uya nemashoko anoita kuti pfungwa yekuushandisa ikwanise kuongororwa:
- Chirwere chakaonekwa uye zvabuda mubvunzo dzemurabhoritari dzichangobva kuitwa dzine chekuita nacho, kusanganisira nhoroondo ipi zvayo yedialysis.
- Chigadzirwa chaicho, kusimba kwacho, nzira yaunoda kuchishandisa nayo, nechikonzero chekufunga kuchishandisa.
- Mishonga yose nezvinowedzera kudya, pamwe nenguva nehuwandu hwemethylene blue yakatotorwa.
Mashoko pamusoro pemishonga achiri kukosha pamwe chete nekushanda kwenhengo. Ongororo yakazara yekuchengeteka inotsanangura mamiriro asingabvumiri kushandiswa nezvinokuvadza zvinogona kuitika; gwaro rekudyidzana kwemishonga rinotsanangura kuti sei runyorwa rwemishonga rwakakosha. Usarega wega kurapwa kwawakanyorerwa kuti uwane mukana wekushandisa methylene blue.
Mubvunzo unobatsira ndewakananga: humbowo hupi hunotsigira chigadzirwa ichi nenzira iyi pachinangwa ichi, mumunhu ane nhengo isingashandi zvakanaka kusvika padanho iri? Kutaura kwakawanda pamusoro pekushanda kwemitochondria hakugoni kuupindura.