Methylene blue posamalira khungu: kapangidwe ka zinthu ndi umboni wa mayeso pa anthu

Methylene blue ili ndi umboni wolimbikitsa wochokera mu labotale wokhudza kukalamba kwa khungu, ndipo opanga zinthu amanena kuti ayesa zodzoladzola zina zomalizidwa pa anthu. Zotsatirazi zimayankha mafunso osiyanasiyana. Palibe mwa izi chimene chimapangitsa botolo la methylene blue yosapangidwa kukhala kirimu kufanana ndi kirimu ya nkhope yoyesedwa, ndipo palibe chimene chimatsimikizira kuti ndi mankhwala ochizira eczema, psoriasis, kapena rosacea.

Pa zonena zilizonse zokhudza kusamalira khungu, dziwani zinthu zitatu: chimene chinagwiritsidwa ntchito, kumene chinagwiritsidwa ntchito, ndi chimene chinasintha. Kuchuluka kwa chinthu m'madzi omeretsera maselo, mmene khungu lachitsanzo limayankhira, ndi munthu kunena kuti khungu lake lasalala si miyeso imene ingalowe m'malo mwa inzake.

Zimene kafukufuku wa khungu wotchulidwa kawirikawiri anayesa

Kafukufuku wa 2017 wa Xiong ndi anzake anayesa maselo a fibroblast a m'kati mwa khungu la anthu ndi khungu lopangidwa mu labotale. Ma fibroblast ndi maselo a minofu yolumikiza; kuwakulitsa m'mbale ya labotale kumachotsa chotchinga chakunja chimene kirimu ya nkhope iyenera kudutsa.

Ma fibroblast okulitsidwa mu labotale amene anapatsidwa methylene blue ya 100 nM kwa milungu inayi anasonyeza kusintha pa miyeso ya kupanikizika kwa maselo chifukwa cha okosideshoni ndi kukalamba kwa maselo. Pa khungu lopangidwa mu labotale lokhala ndi zigawo zonse, masabata awiri a methylene blue m'madzi omeretsera maselo anawonjezera chinyezi ndi kukhuthala kwa gawo la m'kati mwa khungu komwe kunayesedwa. Pa kuchuluka konse koyesedwa, kuwonjezeka kwakukulu kwambiri kwa kukhuthala kunachitika pa 0.5 µM. Izi ndi njira zoperekera chinthu m'mayeso, osati malangizo opangira kirimu.

Mfundo imodzi ndi yofunika pa zonena za kolajeni: olemba kafukufukuyu ananena kuti kugwira ntchito kwa jini la COL2A1 kunawonjezeka, koma sanaone kusintha kwa kolajeni wa mtundu I. Mayeso awo okhudza mabala anayeza kutsekeka kwa mzere wokwangulidwa pa wosanjikiza umodzi wa ma fibroblast. Sanayese kuchira kwa mabala pa anthu.

Khungu lopangidwa mu labotale limakhala ndi minofu yokonzedwa bwino kuposa maselo olekanitsidwa. Komabe, silingatsimikizire kuchuluka kwa chodzoladzola chinachake komwe kumafika ku maselo amoyo a khungu la nkhope, ngati makwinya amachepa mooneka, kapena mmene kugwiritsa ntchito mobwerezabwereza kumakhudzira anthu osiyanasiyana.

Kuyerekezera: kapangidwe ka zinthu ndi chitsanzo chogwiritsidwa ntchito mu kafukufuku

Gwiritsani ntchito kuyerekezera kumeneku kuti mupeze umboni umene uli kumbuyo kwa zonena pa lebulo kapena pa malo ochezera a pa intaneti. Mzere woimirira wa kumanja kwambiri ukusonyeza muyeso umene ukusowa, m'malo mongoganiza kuti mayeso onse amayankha funso lomwelo.

Mayeso pa anthu alipo, koma werengani chimene anayeza

Sizikanakhala zolondola kunena kuti palibe mayeso a zinthu zosamalira khungu pa anthu. Chidule cha kafukufuku wa EyePlus+ wa Bluelene chimanena kuti m'gulu loyesedwa munalibe kunyerenyeseka kwa khungu kapena kutupa kwa khungu chifukwa cha ziwengo zobwera pokhudza chinthu. Izi ndi zonena zofalitsidwa ndi wopanga zokhudza kulekerera kwa khungu pa chinthu chomalizidwa chokhala ndi zosakaniza zingapo. Sizikutanthauza kuti khungu la aliyense wogwiritsa ntchito lidzachilekerera kapena kuti methylene blue yokha ndiyo inachepetsa makwinya.

Lipoti la Fit+Firm la wopanga limafotokozanso mmene otenga nawo mbali anaweruzira chinyezi, kulimba, ndi mmene khungu limamvekera pokhudza. Chithunzi chake cha kukhuthala kwa khungu chimafotokozedwa momveka bwino kuti ndi chitsanzo cha khungu cha mbali zitatu, ngakhale kuti chikuoneka pafupi ndi zotsatira za mayeso a chinthucho pa anthu. Ziwirizi ziyenera kukhalabe zosiyana potanthauzira tsambalo.

Zidule zopezeka kwa anthu onse zimene zinawunikidwa sizitsimikizira kuti panachitika kuyerekezera kwa magulu opatsidwa mwamwayi zinthu zofanana m'zonse kupatula kukhala ndi methylene blue kapena kusakhala nayo, pofuna kuona kuchepa kwa makwinya. Kuyerekezera koyendetsedwa kotereku kungathandize kusiyanitsa zimene chosakanizachi chimathandizira. Kukhutira kwa otenga nawo mbali kungathandize kusonyeza kuti chinthu chikuvomerezeka kwa ogwiritsa ntchito; miyeso yosadalira maganizo ndi chinthu choyenera choyerekezera zimayankha funso lina.

Chinthu chomalizidwa sichimangokhala utoto wake

Monga chitsanzo chenicheni, mndandanda wa zosakaniza za Bluelene Night Cream uli ndi madzi, mafuta a chinangwa cha mpunga, glycerin, zosakaniza za mafuta, chothandiza kusakaniza madzi ndi mafuta, zoteteza kuti chinthu chisawonongeke, ndi methylene blue. Chinthu chonse chopangidwa ndi zosakaniza zimenezi ndicho kasitomala amapaka. Mafunso ofunsidwa kawirikawiri a wopanga amanena kuti kuchuluka kwa methylene blue yake ndi chinsinsi cha kampani, choncho lebulo silingagwiritsidwe ntchito kuti munthu apangenso chinthu chofananacho.

Chosakaniza chonyamulira m'chonyowetsa khungu ndi njira yake yonyamulira zosakaniza zina. Chimakhudza kufalikira popaka, kusunga madzi, kutulutsa chosakaniza, ndi kukhudzana ndi khungu. Ngati kirimu yokhala ndi zosakaniza zambiri imachepetsa kuuma kwa khungu, kunena kuti kusintha konseko kwachitika chifukwa cha chosakaniza chimodzi kumafuna zambiri kuposa kungopezeka kwa chosakanizacho pa lebulo.

N'chimodzimodzinso ndi mtundu wa chinthu. Kirimu ya mtundu wofewa siimasonyeza kuchuluka kwenikweni kwa methylene blue. Maonekedwe sangalowe m'malo mwa kuyesa kuchuluka, mkhalidwe wa mankhwalawo, kapena kusasinthika kwake. Buku lathu lofotokoza zosakaniza za methylene blue yosungunulidwa limafotokoza chifukwa chake zonse zimene zili m'chinthu chosungunulidwa n'zofunika.

Kodi methylene blue imalowa m'khungu?

Yankho limadalira zimene mawu akuti “kulowa” akutanthauza. Chinthu chingalowe m'wosanjikiza wakunja wa khungu wotchedwa stratum corneum popanda kufika m'gawo la m'kati mwa khungu pa kuchuluka kogwira ntchito kapena kulowa m'magazi oyenda m'thupi.

Mu kafukufuku wa zosungunulira pa anthu khumi athanzi amene anadzipereka, ofufuza anayamba kupaka zosakaniza zonyamulira zosiyanasiyana pa malo a mkono pakati pa chigongono ndi dzanja, kenako anapaka methylene blue. Zitsanzo za minofu yotengedwa pamwamba pa khungu zinasonyeza kuti zina mwa zinthu zimene anapaka poyamba zinawonjezera utoto wotsalira mu stratum corneum, pamene zina zinauchepetsa. Awa anali mayeso a kufikitsa chinthu m'khungu, osati mayeso oletsa kukalamba. Njirayo siinayeze kuyamwidwa kwa chinthucho ndi kufalikira kwake m'thupi.

Zotsatira zimenezo zimasonyezanso chifukwa chake kunena kuti “chimasungunuka m'chosungunulira ichi” sikokwanira. Kusungunuka kumafotokoza mmene chinthu chimakhalira m'chidebe. Kuti chifike m'khungu, chiyeneranso kutuluka m'chosakaniza chochinyamulira ndi kuyenda kudzera muminofu. Kusungunuka kwambiri sikutanthauza kokha kuti chinthu chimafika bwino kumene chingathandize, ndipo kufika kwambiri sikutanthauza kokha kuti zotsatira zake zimakhala zabwino.

Mafuta a nyama, mafuta a kokonati, ndi maseramu opangira kunyumba

Mafuta a nyama ndi mafuta a kokonati ndi zosakaniza zoyambira zokhala ndi mafuta ambiri. Kungosakaniza methylene blue yosungunulidwa m'madzi ndi chilichonse mwa zimenezi sikutsimikizira kuti madzi ndi mafutawo asakanikirana mofanana komanso kuti sadzalekananso. Chosakanizacho chingaoneke cha mtundu wofanana mutangosakaniza, koma mafunso angakhalebe osayankhidwa okhudza kulekana kwake pamene chasungidwa ndi kuchuluka kwa chinthu komwe kumaperekedwa nthawi iliyonse yopaka.

Kuwonjezera chinthu chosungunulidwa mu kirimu yomwe ilipo kumasinthanso kapangidwe kamene wopanga anayesa. Malangizo a FDA okhudza kuipitsidwa kwa zodzoladzola amatchula madzi owonjezedwa, zosakaniza zoipitsidwa, kuteteza chinthu kuti chisawonongeke kosagwira ntchito, ndi mmene ogwiritsa ntchito amachigwirira ngati zinthu zimene zingabweretse chiopsezo. Kafukufuku wa methylene blue wokhudza kulimbana ndi tizilombo sangalowe m'malo mwa kuyesa mmene mtsuko wa kirimu watetezedwera kuti usawonongeke.

Nkhani yoperekedwa yokambirana za makirimu opangira kunyumba ndi zinthu zothandiza kulowa m'khungu imatchula DMSO ndi Transcutol ngati zinthu zimene zinganyamulire zosakaniza. Malingalirowa sapereka miyeso ya chitetezo cha chosakaniza chomalizidwa kapena mmene chimafikira m'khungu. Chothandiza kulowa m'khungu chingasinthe kuchuluka kwa zosakaniza zina zimene zimafika m'khungu, komanso kwa chosakaniza chimene chikufuna kugwira ntchito. Kuti chosungunulira n'chogwirizana ndi chinthu mu labotale sikutsimikizira kuti seramu yokhala ndi zosakaniza zambiri ndi yoyenera kugwiritsidwa ntchito pa nkhope.

Palinso funso lenileni la kafukufuku lokhudza kuphatikiza ndi vitamini C. Kafukufuku wa mu labotale wa 2021 ananena kuti kuphatikizaku kunali ndi zotsatira zabwino pa maselo a khungu okulitsidwa mu labotale. Sanatsimikizire kusakaniza kulikonse kosankhidwa mwachisawawa kwa vitamini C, methylene blue, ma peptide, mafuta, ndi zosungunulira. Chilichonse chowonjezedwa chimabweretsa chinthu china chimene chingasinthe zotsatira; maselo kuyankha bwino si kuyesa kusasinthika kwa chinthu chomalizidwa. Chidule cha kafukufuku wa zoteteza khungu ku dzuwa chimafotokoza funso lapadera la kuteteza ku kuwala kwa UV.

Kukalamba kwa khungu pa nkhani ya zodzoladzola, matenda otupa khungu, ndi kuwala

Kuwonjezeka kwa chinyezi sikufanana ndi kuwongolera eczema, psoriasis, kapena rosacea. Matendawa amafuna zotsatira zoyesedwa zokhudzana ndi matenda enieniwo, monga zizindikiro, kuopsa kwa malo okhudzidwa pakhungu, ndi kubwereranso kwa matendawo. Mayeso a kukalamba ndi zidule za zodzoladzola zomwe zili pamwambazi sizitsimikizira kuti kirimu ya methylene blue ndi mankhwala ogwira ntchito ochizira matendawa. Kufiira kosaleka, kusenda kwa khungu, kapena kuyabwa ziyenera kuunikidwa monga zilili, osati kuchitidwa ngati kukalamba kwa khungu pa nkhani ya zodzoladzola.

Kuwala kumasinthanso njira imene ikugwiritsidwa ntchito. Mu mayeso a methylene blue yogwira ntchito mothandizidwa ndi kuwala, kuwala ndi okosijeni zimathandizira kupanga zinthu za mankhwala zomwe zimachita zinthu ndi zina mosavuta. Njira ya mankhwala imeneyi imasiyana ndi chifukwa cha kuchepetsa okosideshoni chimene chimagwiritsidwa ntchito kawirikawiri potsatsa zinthu zosamalira khungu. Kuwonjezera chipangizo cha kuwala kofiira pa chosakaniza chopangira kunyumba sikuyenera kungoganiziridwa kuti kumawonjezera phindu la zodzoladzola popanda chiopsezo. Buku la umboni wokhudza methylene blue ndi kuwala kofiira limasiyanitsa mikhalidwe imeneyi.

Mukamaunika chinthu, funsani za kafukufuku wa kapangidwe kameneko, chinthu choyerekezera nacho, nthawi yomwe mayesowo anatenga, ndi zotsatira zimene zinayesedwa. Mfundo zimenezi zimapereka chidziwitso chochuluka kuposa mtundu wabuluu, mmene chosakaniza chimagwirira ntchito, kapena mawu akuti “chayesedwa kuchipatala” paokha.