Te kahurangi metilīni mō te COVID-19 me te COVID roa: ngā taunakitanga

I tīmata te aro ki te kahurangi metilīni mō te COVID i tētahi pātai whaitake. He iti te utu o te pūhui, kua roa e whakamahia ana i te ao rongoā, ā, i kitea i ngā mahi taiwhanga he pānga ki te SARS-CoV-2. Engari kāore i roa ka wehe taua pātai kotahi hei pātai rerekē e toru, ā, ka hē te pānui a te hunga e whakahanumi ana i aua pātai i ngā taunakitanga.

Ko ēnei ngā pātai e toru: ka rongoā rānei i te pokenga whakapeka i ngā tūroro, ka whakakore rānei i te kaha o te huaketo i waho i te tinana, ā, ka āwhina rānei i ngā tohumate whai muri i te wā whakapeka e kīia nei ko te COVID roa. He rerekē te hoahoa rangahau, te putanga hei ine, me te whakautu mō ia pātai. Ka wehewehea ēnei i tēnei tuhinga, ā, ka mutu ki tētahi rēhita hei tirotiro māu i mua i te whakatau tahi me tētahi mātanga haumanu.

Te pokenga whakapeka: he tohu hāora e kitea tonutia ana, engari kāore he taunakitanga mō te whakaora

I whakatakotoria ngā take tuatahi mō te whakamahi anō i tēnei rongoā ki tētahi mahi hou i tētahi arotake ā-kōrero i te 2021. I tirohia te mātai rongoā o te kahurangi metilīni, ā, i whakarārangitia ngā whakamātautau rēhita e rima mō te kahurangi metilīni i te whakahaere i te COVID-19. He whaihua taua arotake hei mahere tīmatanga, ehara i te taunakitanga whakaū. I whakaarohia ētahi tukanga pērā i te huringa hāoratanga–whakaitinga me te whakaiti i te wharanga nā te hāoratanga, ā, i whakarārangitia ngā whakamātautau kāore anō te nuinga kia oti i taua wā. Kua rerekē te tūnga o ngā whakamātautau mai i taua wā, nō reira me tirotiro anō ia tāurunga, kaua e whakawhirinaki noa ki te rārangi o te 2021.

He ōrite rawa te ia o ngā kitenga puta noa i ngā whakaputanga o muri mai kia taea ai te whakaahua. I whakamātau ētahi rangahau hōhipera i Īrāna i te kahurangi metilīni hei wāhanga o tētahi huinga i tāpirihia ki te tiaki paerewa. I pūrongotia e rātou te pai ake o te whakahāoratanga i te wā poto, me te poto ake o te noho ki te hōhipera. I tētahi pūrongo wāhanga 2 mō ngā tūroro 80, tata ki te 7 rā te roa o te noho mō te huinga, ki te whakataurite ki te tata ki te 12 rā mō te tiaki paerewa anake. I tohu tētahi pūrongo nui ake, he rite ki te wāhanga 3, mō ngā tūroro 223, ki taua ahunga anō, engari kāore te rerekētanga o te mate i eke ki te taumata hira ā-tatauranga. He rangahau ēnei kāore i huna te momo maimoatanga, ā, he huinga maimoatanga maha ngā wāhanga. He mea nui tēnei mō ngā take ka hoki atu tātou ki raro nei.

Ka mārama ake te āhua i tētahi rangahau tohatoha matapōkere hou ake. I roto i ngā tūroro COVID-19 ARDS 122 e noho ana ki te hōhipera, he nui ake te pikinga o te kukūtanga hāora o te toto i te rōpū i whiwhi kahurangi metilīni mā te waha me te maimoatanga paerewa, i tō te rōpū maimoatanga paerewa anake. He pāhekoheko hira ā-tatauranga i waenga i te rōpū me te wā. Heoi, kāore i tino rerekē ā-tatauranga te roa o te noho hōhipera, te mate rānei i te kotahi me te toru marama, i taua whakamātautau ARDS tohatoha matapōkere. I tētahi rangahau iti o ngā maimoatanga whakaora ohotata, kāore he rōpū whakataurite, i hoatu te kahurangi metilīni mā te ia toto ki ngā tūroro tino māuiui 50. I pūrongotia he ōwehenga hāora teitei ake i muri i te maimoatanga. Engari, nā te matenga o te 20 me te kore rōpū whakataurite, kāore taua raupapa take maimoatanga whakaora ohotata e āhei ki te whakaatu nā te rongoā te panonitanga.

Ko te whakamātautau tino pakari, he rōpū rongoā horihori tōna, mō te pānga ārai huaketo, e tohu ana ki te ahunga kē. I tohatoha matapōkeretia e te whakamātautau NCT04635605 ngā tūroro waho kia whiwhi i tētahi horopeta kotahi o te kahurangi metilīni mā te waha, i te rongoā horihori rānei, ā, i inea te nui o te huaketo me tōna whakakorenga. Kāore i kitea he whai huatanga ki te huaketo, e whakarāpopototia ana i te pūrongo whakamātautau kua whakaputaina. Kāore hoki i heke te urunga ki te hōhipera i tētahi whakamātautau whai pānga, engari motuhake, i whakamātau i te wē toto o te hunga kua ora, kua tukatukahia ki te kahurangi metilīni i mua i te tuku toto. I taua rangahau tūroro waho 376, i kitea he tata ōrite ngā auau urunga ki te hōhipera me ngā panonitanga o te nui o te huaketo i ngā rōpū wē toto me te rongoā horihori, i te whakamātautau wē toto COnV-ert. He tukanga hua toto te tukatuka wē toto ki te kahurangi metilīni, ehara i te maimoatanga kahurangi metilīni puta noa i te tinana. Nō reira, kaua e kiia he whakamātautau i te tango i te rongoā.

Kia mārama te kōrero: mō te COVID, ka kitea tonutia he tohu i ngā inenga whakahāoratanga mō te kahurangi metilīni, engari kāore he whakaaturanga tūturu mō te tere ake o te whakakore huaketo, te iti ake o ngā urunga hōhipera, te iti ake rānei o te mate. He mea whaihua te aroturuki i te kukūtanga hāora, engari ehara i te mea kotahi ki te whakaora i te pokenga.

I ētahi wā ka whakaaro te hunga kātahi anō ka ako me pēhea te kahurangi metilīni e mahi ai hei matū hāoratanga–whakaitinga, ko te pai ake o te hāora he tohu mō te patu huaketo. Kāore. E whakaata ana te whakahāoratanga i te wharanga pūkahukahu, te mahi a te pūtoto, me te rere toto. E whakaata ana te nui o te huaketo i tōna whakareatanga. Ka pā tētahi rongoā ki tētahi, me te kore e pā ki tērā atu.

Te whakakore i te kaha o te huaketo i te taiwhanga: he hua pakari, he whāiti te tikanga

I te taiwhanga, he tino pakari ake te āhua o ngā hua, ā, nā taua rerekētanga ka rangirua te maha o ngā whakarāpopototanga. I ngā mahi whakatipu pūtau tuatahi, i pūrongotia ngā kukūtanga iti i te awhe micromolar i puta ai te haurua o te pānga mōrahi ki te SARS-CoV-2 i ngā pūtau Vero E6. Koia te pūtake mō ngā whakamātautau tangata i kōrerotia i ngā rangahau whakatipu pūtau tuatahi. Kātahi ka whakaatu ngā whakamātautau whakapā tika i te whakakino a te kahurangi metilīni i te RNA huaketo i muri i ngā hāora whakapā, ahakoa kāore i whakahohehia ki te rama, pērā i ngā mahi a Cagno me ōna hoa rangahau.

Mā te rama ka tino nui ake te pānga. Nā te whakakotahi i te kahurangi metilīni me te rama taiaho whero i tino whakakorehia te kaha o ngā whakatārewatanga huaketo kukū nui, ā, i tiakina ngā paparanga pūtau kotahi i te rangahau whakakorenga mā te pānga o te rama. He ōrite te kōrero i ngā mahi hua toto: nā te kahurangi metilīni tata ki te 0.8 micromolar me te rama kitea i heke ai te kaha whakapoke o te SARS-CoV-2 i te wē toto mā te tata ki ngā taumata whakatekau e rima. He tino iti ake te pānga o te kahurangi metilīni kāore he rama, e ai ki ngā whakamātautau whakaiti tukumate i te wē toto. I pūrongotia he whakakorenga tukumate ōrite i ngā tauira haumanu mā te whakamārama poto i tētahi rangahau whakakorenga tukumate i ngā tauira o muri mai.

Ko te aronga tika, he matū patu huaketo i waho i ngā pūtau, ehara i te matū ārai huaketo i roto i ngā pūtau. I whakamārama tētahi rangahau tukanga i te 2024 i taua rerekētanga: i whakakore tūturu te kahurangi metilīni i te kaha o ngā matūriki coronavirus i waho i ngā pūtau i te pōuri, engari tata ki te kore tōna pānga ina kua pangia kē ngā pūtau. Kāore hoki te tuku horopeta mā te waha i tiaki i ngā kiore whakaraerae i te pokenga whakamate i taua whakataurite i waho me roto i ngā pūtau.

E whakamārama ana taua rerekētanga i te ia o ngā kitenga haumanu. Ka tino pai pea tētahi pūhui hei matū whakakore tukumate mō ngā mata, ngā tauira, te wē toto rānei, ina koa me te rama, engari ka kore tonu e whai hua hei matū ārai huaketo puta noa i te tinana. Ko te take, he rerekē te kiko arahau kua pangia i tētahi ngongo whakamātautau. E tautoko ana te whakakorenga i te taiwhanga i ngā whakamahinga mō te haumaru o ngā taputapu me te toto. Kāore e whakaū ana i te kahurangi metilīni mō te COVID hei maimoatanga tūroro kua whakamanatia e ngā taunakitanga.

Te COVID roa: he whakapae anake, kāore he whakamātautau tohatoha matapōkere kua oti

He taumata raro ake ngā taunakitanga mō te kahurangi metilīni mō te COVID roa. Ko te pepa o te 2021 e whai ana i te kupu "te pōuritanga whai muri i te COVID" i tōna taitara, e whakahuatia nuitia ana, he reta whakapae, ehara i te whakamātautau. E whakatakoto ana i ngā ara o te mitokōria me te mumura io e puta ai pea he painga, engari kāore e pūrongo ana i ngā putanga whai muri i te wā whakapeka i whakatauritea ki tētahi rōpū whakahaere, i taua reta whakapae mō ngā tohumate whai muri i te COVID. He whakaaro tīmatanga tērā, ehara i te hua.

Tae noa ki te mutunga o te 2026, kāore mātou i kitea he whakamātautau tohatoha matapōkere kua rēhitatia, kua oti hoki, e whakamātau motuhake ana i te kahurangi metilīni mō ngā pānga toenga kua mau i muri i te wā whakapeka. Kāore ngā pūrongo iti i whai i ngā tūroro whakapeka i muri i te maimoatanga kahurangi metilīni, i te maimoatanga mā te pānga o te rama rānei, me te ui mō ngā tohumate e mau tonu ana, e āhei ki te whakakī i taua āputa. He iti, kāore he rōpū whakataurite, ā, he maha ka whakakotahi i te kahurangi metilīni me te maimoatanga rama, me ētahi atu rongoā rānei. Nō reira, kāore e taea te whakaatu i te ārai, i te maimoatanga rānei, o te COVID roa.

Me pātai te tangata e arotake ana i tētahi kerēme i konei i ngā pātai e toru. I tautuhia rānei te taupori hei hunga whai muri i te wā whakapeka, kaua hei hunga whakapeka. He rōpū whakataurite rānei. I inea rānei te ngenge, te kore āhei ki te whakapau kaha, te uaua o te whakaaro, tētahi atu tohumate i tautuhia i mua rānei, mā tētahi tauine kua whakamana. Ki te kāo te whakautu ki tētahi o ēnei, he pārongo horopaki te pūrongo, ehara i te taunakitanga whai huatanga.

He kōrero mō ngā huinga maimoatanga me te naltrexone horopeta iti

Ka whakahoahoa ētahi kawa tuihono i te kahurangi metilīni me te naltrexone horopeta iti mō te ngenge whai muri i te pokenga huaketo. Ka puta he raruraru mō te tautuhi i te pūtake o te pānga. Ina tīmata tahi ngā maimoatanga e rua, ā, ka panoni ngā tohumate, kāore taua panonitanga e tohu ko tēhea maimoatanga i whai wāhi, mēnā rānei i whai wāhi tētahi, mēnā rānei he haumaru te huinga. Ka whakamārama hoki pea te whakaora māori, te whakatā, te urupare ki te rongoā horihori, me te tiaki i taua wā anō, i te pai ake o te āhua.

E pā ana hoki taua arorau ki ngā whakamātautau huinga mō te COVID whakapeka i runga ake nei. I aua whakamātautau, i hoatu te kahurangi metilīni me te huaora C, te N-acetylcysteine, ētahi atu matū rānei, i te taha o te tiaki paerewa. Kāore te poto ake o te noho i te rōpū huinga e wehe i te pānga o te kahurangi metilīni. Ko te hunga e tango ana i te kahurangi metilīni me ētahi atu tāpiringa, rongoā rānei, me arotake tahi me tētahi mātanga haumanu i ngā pārongo pāhekoheko me ngā āhuatanga e kore ai e tika te whakamahi. Kaua e whakapae e hāngai ana ki a rātou tētahi kōrero wheako mō tētahi huinga. He tino hāngai ngā āhuatanga haumaru o te kahurangi metilīni, nā te mea ka tino rerekē te aromatawai mōrea i ngā rongoā e pā ana ki te serotonin, te hapa G6PD, te ngoikore o ngā tākihi, me te hapūtanga.

He rēhita whakamātautau me ngā rangahau, me ngā putanga hei ine mō ia āhuatanga

Whakamahia tēnei ripanga hei tohutoro taketake mō tēnei tuhinga. Mā te āhuatanga e tautuhi ko tēhea putanga hei ine e whai tikanga ana. E whakaata ana ngā tāurunga rēhita i te tūnga i pūrongotia tae noa ki te mutunga o te 2026; tirohia te tūnga o nāianei i mua i te whakahua hei tohutoro, nā te mea ka tōmuri ngā tuhinga rēhita i ngā whakaputanga.

Me pēhea te whakamahi i ēnei taunakitanga

Me wehe tonu ngā horopaki e toru. Mō te pokenga whakapeka, ko te whakarāpopototanga pono, ka pai ake pea te whakahāoratanga, engari kāore anō kia whakaūngia he pānga ki te whakakorenga huaketo, te urunga hōhipera, te ora tonu rānei. Mō te whakahaere i te taiwhanga, he tikanga whakakorenga kua whakaūngia te kahurangi metilīni me te rama i ngā horopaki i whakamātauria ai. Mō te COVID roa, kāore he tūāpapa whakamātautau mō te maimoatanga i tēnei wā.

Ko te tangata e whakaaro ana ki te whakamahi, me kōrero ki tētahi mātanga haumanu mō te horopeta, te wā tuku, ngā rongoā pāhekoheko, me tōna āheinga ki te whiwhi maimoatanga. Me tirotiro hoki mēnā ka panoni te whakataurite o ngā painga me ngā mōrea i ngā hua o tētahi whakamātautau o muri mai. Ka whakahoungia ngā tuhinga whakamātautau i muri i te tukunga o ngā arotake ki te whakaputa, ā, kua neke kē tēnei kaupapa mai i ngā marohitanga ki ngā hua wāhanga. He mea nui ake taua tikanga tirotiro anō i te rēhita i tētahi rangahau kotahi.