Chinyorwa
Methylene blue yeME/CFS: zvinotaurwa pamusoro pesimba nezviratidzo zvinononoka
Methylene blue haisati yaratidzwa kuva mushonga unoshanda pakurapa ME/CFS. Mukutsvaga zvinyorwa zvesainzi zvechinyorwa chino, hapana muyedzo wevarwere une boka rekuenzanisa wakawanikwa uchiratidza kuti inoderedza kusanzwa zvakanaka mushure mekushandisa simba (PEM) kana kuvandudza kugona kuita mabasa ezuva nezuva kwenguva yakareba muchirwere ichi. Zvakawanikwa murabhoritari zvinotsanangura kuti nei mubvunzo uyu uchifadza vaongorori. Hazvisati zvaupa mhinduro kuvarwere.
Musiyano unonyanya kubatsira uri pakati pekunzwa une simba rakawanda iye zvino nekugona kuita chinhu uchichidzokorora usingazonyanyi kurwara gare gare. Kuzivisa chekutanga hakugoni kuratidza chechipiri.
ME/CFS inopfuura kungoramba wakaneta
Myalgic encephalomyelitis/chronic fatigue syndrome chirwere chinokanganisa zvikuru kugona kuita mabasa, chine maitiro ezviratidzo anochisiyanisa. Zvinodiwa pakusimbisa chirwere zvakapfupikiswa neCDC zvinosanganisira kuderera kukuru kwemabasa aiitwa munhu asati arwara kunotora mwedzi inopfuura mitanhatu, kuneta kusingadereri zvakanyanya nekuzorora, PEM, uye kurara kusingazorodze. Kukanganisika kwekufunga kana kusakwanisa kushivirira kumira kana kugara wakatwasuka kunodiwawo. Kusakwanisa kushivirira kumira kana kugara wakatwasuka kunoreva kuti zviratidzo zvinowedzera paunenge wakatwasuka.
Izvi zvinodiwa zvinoda kuongororwa nenyanzvi yezveutano, kusanganisira kufunga nezvezvimwe zvingatsanangura zviratidzo. Kuneta kwega hakusimbisi ME/CFS, uye zvakawanikwa muvanhu vane kuneta kwakajairika hazvigoni kungoshandiswa kuchirwere ichi.
PEM kuwedzera kwehurwere mushure mekushandisa simba remuviri kana repfungwa izvo munhu aimbozvigona. Sezvo CDC inotsanangura mugwaro rayo rekuchengetwa kwevarwere, kuwedzera kwehurwere kunowanzotanga kuoneka pashure pemaawa 12 kusvika ku48 uye kunogona kuramba kuripo kwemazuva kana mavhiki. Nokudaro, kuongororwa masikati kungapotsa chinhu chakakosha chinokonzerwa nezvakaitwa mangwanani iwayo.
Zvinonyatsobatsira kubva muongororo yemitochondria
Mitochondria inobatsira kushandura zvinovaka muviri kuita simba rinogona kushandiswa nemasero. Methylene blue inogona kutora chikamu mumaitiro eoxidation-reduction, ichigamuchira nekupa maerekitironi. Muongororo dzaWen nevamwe dza2011, yakabatsira imwe nzira yekutamisa maerekitironi kubva kuNADH kuenda kucytochrome c pasi pemamiriro emuyedzo. Masero etsinga akakuriswa murabhoritari akaratidza shanduko mukushandiswa kweokisijeni, uye vaongorori vakaongororawo makonzo aiva nekukuvara kwakafanana nekweParkinson uye kushomeka kweropa rinosvika muuropi. Iyi yaiva ongororo yemurabhoritari neyemhuka, kwete miedzo yekurapa ME/CFS.
Kunewo ongororo yemashandurirwo ezvinhu mumuviri yakanangana nechirwere ichi. Tomas nevamwe vakaongorora masero ekudzivirira zvirwere ari muropa revanhu vane CFS pamwe neevanhu vane utano vekuenzanisa, vachiona misiyano muoxidative phosphorylation, kunyanya pakufema kwemasero kwakanyanya kwavanogona kuita. Chaipimwa kwaiva maitiro emasero akatorwa paaiedzwa murabhoritari. Varwere havana kupiwa methylene blue, uye ongororo yacho haina kuyera kuvandudzika kwePEM mushure mekurapwa.
Zvimwe zvakawanikwa zvinoita kuti tsananguro iri nyore yekuti “kugadzirwa kwesimba kwakaderera” isakwana. Muongororo yaFluge nevamwe yevarwere 200 nevanhu vane utano 102, maitiro emaamino acid airatidza kuti mashandurirwo esimba mumuviri akanga achinja. Masero etsandanyama akakuriswa uye akaiswa museramu yeropa revarwere akaratidza kuwedzera kwekufema kwemitochondria pamwe nekubudiswa kwelactate yakawandisa. Masero akasiyana nemamiriro akasiyana emiedzo anogona kubudisa maitiro akasiyana. Nokudaro, “kufema kwakawanda” hakusi chiratidzo chokupora chine zvachinoreva zviri pachena pachacho.
Kubatanidza ongororo idzi nekurapa kunosanganisira danho risati raedzwa: mushonga unoshandura kutamiswa kwemaerekitironi unofanirawo kuvandudza maitiro echirwere akakodzera, mumatishu akakodzera, pasina kukuvadza kunobvisa zvinobatsira zvacho. Zvinotaurwa zvakakura pamusoro pemethylene blue nemitochondria zvinodawo kusiyaniswa kumwe chete pakati pemashandiro acho nemugumisiro.
Tafura yehumbowo nemigumisiro
| Humbowo kana zvinotaurwa | Zvazvinogona kuratidza | Zvichiri kudiwa paME/CFS |
|---|---|---|
| Methylene blue inoshandura kufema kwemasero etsinga | Shanduko yemakemikari mumasero mumamiriro erabhoritari akatsanangurwa | Humbowo hwokuti shanduko yacho inovandudza hurwere pane kungoshandura zvinobuda pamuyedzo |
| Masero eropa revarwere anoratidza misiyano mukugadzirwa nekushandiswa kwesimba | Kubatana pakati pekuva nechirwere nezviyero zvemasero | Kuenzaniswa kwekurapa kunoratidza kubatsira kunokosha pautano hwemurwere |
| Mumwe munhu anoti anonzwa akasvinura zvikuru mushure mekuishandisa | Zvaakasangana nazvo panguva iyoyo | Kuongororwa kwezviratidzo zvinononoka, zvinokuvadza, uye kugona kuita mabasa kwemazuva akatevedzana |
| Chiyero chekuneta chinovandudzika | Shanduko pachiyero chechiratidzo chakatsanangurwa | Kana PEM, kurara, kufunga, uye mabasa anodiwa ezuva nezuva zvichivandudzikawo |
| Nguva dzekuwedzera kukuru kwehurwere dzinoderera uku mabasa achiderera zvakanyanya | Shanduko inoitika pamwe nekuderedzwa kwezvinoda simba | Kana kuvandudzika kuchikonzerwa nekugadzirisa mabasa, kurapa, shanduko dzinongoitika, kana zvinhu zvakawanda |
Hurukuro yePhoenix Rising pamusoro pemethylene blue inoratidza mibvunzo yevarwere pamusoro pezvavanosangana nazvo, kuchengeteka, uye kunaka kwechigadzirwa. Hurukuro dzakadaro dzinogona kuratidza zvinonetsa zvakakodzera kuongororwa. Hadzina kuenzanisa kwakarongeka nekutevera varwere nguva dzose zvinodiwa kuti zvionekwe kana kurapa kuchishanda.
Ongorora mazuva anotevera, kwete awa yakanaka chete
Fungidzira munhu anonzwa pfungwa dzake dzakajeka paMuvhuro uye anopedza nguva yakareba achibata tsamba nemameseji. PaChipiri anoda kubatsirwa kugadzira chikafu; paChitatu kugona kuisa pfungwa pachinhu kuchiri kwakaipa kupfuura nguva dzose. Kuti paMuvhuro pane kuvandudzika usinganyori zvakaitika paChipiri neChitatu kunenge kuri kurasa mashoko akakosha pakurapa. Zvingavawo kukurumidza kuti kuwedzera kwehurwere kwakakonzerwa nechinhu chaakashandisa kana nemabasa akawedzera usina kufunga nezvekutevedzana kwose kwezvakaitika.
Migumisiro inobatsira inosanganisira kukura uye kureba kwePEM, kugona kudzokorora mabasa anokosha kumunhu, nguva yekudzokera pamamiriro ake enguva dzose, uye rubatsiro runodiwa. Munhu angakoshesa kuverenga meseji pfupi kana kugeza asingabatsirwi kupfuura shanduko yenhamba yemurabhoritari. Zvinhu izvozvo zvaanokoshesa zvinofanira kutungamirira hurukuro ipi neipi nenyanzvi yezveutano.
Pakuronga mabasa, NICE inokurudzira nzira inoenderana nemunhu mumiganhu yesimba raainaro panguva iyoyo uye inopa zano rokuti pasashandiswa zvirongwa zvinowedzera kurovedza muviri nematanho akatarwa. Kunzwa zviri nani kwechinguvana hakuiti kuti zvive zvakakodzera kuedza muganhu wako nekuzvimanikidza zvakanyanya.
Bhuku rekunyora mabasa nezviratidzo zvinononoka
Shandisa bhuku rekunyora remavara rinogona kudhindwa kunyora zvinoitika muupenyu hwemazuva ose kuitira hurukuro nenyanzvi yezveutano. Ichi chinobatsira kucherechedza, hachisi chiyero chekusimbisa chirwere kana chirongwa chekuyedza methylene blue. Nyora chete zvaunokwanisa. Anochengeta murwere anogona kubatsira, uye hazvina kuipa kana zvimwe zvisina kunyorwa.
Sarudza zviratidzo zviviri kana zvitatu zvinokubatsira iwe pachako, zvakadai sekugona kuverenga, kugadzira chikafu, kana rubatsiro pakugeza. Tsanangura zvakaitika chaizvo pane kuita basa kuti uyere zvaunokwanisa. Nyora zvinoda simba remuviri, kufunga, manzwiro, kushandiswa kwenjere dzokunzwa, uye kugara kana kumira wakatwasuka pazvinenge zvakakodzera. Sanganisira kuzorora neshanduko dzipi nedzipi dzakatoitwa kumishonga kana maitiro ezuva nezuva.
| Nguva | Basa nemamiriro acho | Zviratidzo nekugona kuita mabasa |
|---|---|---|
| Usati waita basa rakajairika | Zuva/nguva; mabasa achangobva kuitwa; kurara | Zviratidzo zvenguva dzose nhasi; rubatsiro rwanga rwatodiwa |
| Panguva yacho kana nguva pfupi mushure mayo | Zvakaitika; nguva yazvakatora inofungidzirwa; kugara, kumira, kana kutsenhama | Zviratidzo zvinobva zvaitika; basa rapedzwa, rapfupikiswa, kana rasiyiwa |
| Zuva rinotevera | Zvinhu zvitsva zvinoda simba nekuzorora | Zviratidzo zvitsva kana zvawedzera; nguva yazvatanga; shanduko mukugona kuita mabasa ezuva nezuva |
| Zuva rechipiri | Zvinhu zvitsva zvinoda simba nekuzorora | Kuwedzera kwehurwere kuri kuramba kuripo kana kwanonoka kutanga; rubatsiro runodiwa |
| Mazuva anotevera kana zvichidiwa | Tsananguro pfupi yemamiriro ezuva | Kudzokera pamamiriro ako enguva dzose, kana shanduko iri kuramba iripo |
Enda nezvakanyorwa zvichitevedzana, kusanganisira mazuva anoita seasina kuchinja, paunosangana nenyanzvi yezveutano. Bvunza kana kuvandudzika kunooneka kwakaitika pachidiwa simba rakafanana, paine rubatsiro rwakawanda, kana pakuzorora zvakanyanya kupfuura kare. Bhuku remunhu mumwe chete harigoni kuratidza chinokonzera shanduko, asi rinogona kuita kuti hurukuro pfupi inyatsobatsira.
Kuchengeteka kunofanirawo kuva mumubvunzo wekurapa
Methylene blue ine mashandiro emushonga mumuviri. Mashoko ekuU.S. ekurayira PROVAYBLUE inopiwa mutsinga ane chekuita nemethemoglobinemia inowanikwa, kwete ME/CFS. Anoyambira nezveserotonin syndrome yakakomba kana ichishandiswa nemishonga inoshanda paserotonin uye nemaopioid, uye anorambidza kushandiswa kana paine kushomeka kweG6PD nokuda kwenjodzi yehemolytic anemia. Mashoko aya emushonga unobaiwa haasimbisi kuti chirongwa chekuzvirapa nemushonga unonwiwa chakakodzera.
Uya nerondedzero yakazara yemishonga nezvinowedzera kudya pahurukuro nenyanzvi yezveutano pamusoro pemethylene blue. Usarega kurapa kwawakanyorerwa kuti utange kuishandisa. Mubvunzo unofanira kupindurwa ndewekuti humbowo hwakanangana nechirwere hunotsigira kubatsira kwakakosha kwauri here, paine nzira yekuziva kuwedzera kwehurwere kunononoka uye zvinokuvadza zvakakodzera kutariswa.