Methylene blue pa ME/CFS: umboni ndi PEM

Sizinatsimikizidwe kuti methylene blue ndi mankhwala othandiza pa ME/CFS. Pofufuza zolemba za nkhaniyi, sipanapezeke mayesero a odwala okhala ndi gulu loyerekezera osonyeza kuti imachepetsa kusamva bwino pambuyo pochita zinthu (PEM) kapena imathandiza odwala matendawa kuchita zinthu za tsiku ndi tsiku mosalekeza. Zotsatira za mu labotale zimafotokoza chifukwa chake funsoli limakopa ofufuza. Koma sizinaliyankhebe kwa odwala.

Kusiyanitsa kothandiza kwambiri ndi pakati pa kumva kuti muli ndi mphamvu zambiri panopa ndi kuthekera kochita chinthu mobwerezabwereza popanda kudwala kwambiri pambuyo pake. Kufotokoza koyamba sikungatsimikizire kwachiwiri.

ME/CFS si kutopa kosalekeza kokha

Myalgic encephalomyelitis/chronic fatigue syndrome ndi matenda olepheretsa munthu kuchita zinthu, omwe ali ndi zizindikiro zapadera. Zofunikira pozindikira matendawa zomwe CDC yafotokoza mwachidule zikuphatikiza kuchepa kwakukulu kwa zochita zomwe munthu ankatha kuchita asanadwale, komwe kumatenga miyezi yoposa isanu ndi umodzi, kutopa kosachepetsedwa kwambiri ndi kupuma, PEM, ndi kugona kosabwezeretsa mphamvu. Pakufunikanso kuchepa kwa luso loganiza kapena kusamva bwino munthu akakhala woimirira. Kusamva bwino munthu akakhala woimirira kumatanthauza kuti zizindikiro zimakulirakulira thupi likakhala loimirira.

Zofunikira zimenezi zimafuna kuunikidwa ndi katswiri wa zaumoyo, kuphatikizapo kuganizira zifukwa zina zomwe zingafotokoze zizindikirozo. Kutopa kokha sikutsimikizira ME/CFS, ndipo zotsatira za anthu omwe ali ndi kutopa wamba sizingogwiritsidwa ntchito pa matendawa.

PEM ndi kukulirakulira kwa matenda pambuyo pa ntchito ya thupi kapena ya maganizo yomwe munthuyo ankatha kuipirira kale. Monga CDC ikufotokozera m'malangizo ake osamalira odwala, kukulirakuliraku nthawi zambiri kumaonekera patatha maola 12 mpaka 48 ndipo kungapitirire kwa masiku kapena milungu. Choncho kuunika munthu masana kungaphonye zotsatira zofunika za zomwe anachita m'mawa wa tsikulo.

Zomwe kafukufuku wa mitochondria amathandiza kumvetsa

Mitochondria zimathandiza kusintha zakudya kukhala mphamvu zomwe maselo angagwiritse ntchito. Methylene blue imatha kutenga nawo mbali m'zochitika za oxidation-reduction, polandira ndi kupereka ma electron. Mu mayesero a Wen ndi anzake a 2011, inathandiza njira ina yosamutsira ma electron kuchokera ku NADH kupita ku cytochrome c m'mikhalidwe ya mayesero. Maselo a mitsempha okulitsidwa mu labotale anasonyeza kusintha kwa kagwiritsidwe ntchito ka oxygen, ndipo ofufuzawo anaphunziranso makoswe okhala ndi kuvulala kofanana ndi kwa Parkinson ndi kuchepa kwa magazi opita ku ubongo. Awa anali mayesero a mu labotale ndi a nyama, osati mayesero a chithandizo cha ME/CFS.

Palinso kafukufuku wa kagwiritsidwe ntchito ka zakudya ndi mphamvu m'thupi wokhudza matendawa mwachindunji. Tomas ndi anzake anaphunzira maselo a chitetezo cha m'thupi a m'magazi a anthu omwe ali ndi CFS ndi a anthu athanzi oyerekezera nawo, ndipo anapeza kusiyana pa oxidative phosphorylation, makamaka pa kupuma kwa maselo kwakukulu kwambiri. Chomwe anayeza chinali mmene maselo otengedwa kwa anthuwo ankachitira pa mayesero a mu labotale. Odwala sanapatsidwe methylene blue, ndipo kafukufukuyu sanayeze kuchepa kwa PEM pambuyo pa chithandizo.

Zotsatira zina zimapangitsa kuti kufotokoza matendawa ngati “kupanga mphamvu zochepa” kokha kukhale kovuta. Mu kafukufuku wa Fluge ndi anzake wa odwala 200 ndi anthu athanzi 102, mmene ma amino acid analili kunasonyeza kuti kagwiritsidwe ntchito ka mphamvu m'thupi kanasinthika. Maselo a minofu okulitsidwa mu labotale omwe anaikidwa m'madzi a m'magazi a odwala anasonyeza kuwonjezeka kwa kupuma kwa mitochondria limodzi ndi kutulutsa lactate yochuluka kwambiri. Maselo osiyanasiyana ndi mikhalidwe yosiyanasiyana ya mayesero zingapereke zotsatira zosiyana. Choncho “kupuma kwa maselo kochuluka” si chizindikiro cha kuchira chomwe chimadzifotokoza chokha.

Kugwirizanitsa maphunzirowa ndi chithandizo kumadalira mfundo yomwe sinayesedwe: mankhwala omwe amasintha kusamutsidwa kwa ma electron ayeneranso kuthandiza pa njira ya matenda yomwe ikukhudzidwa, m'minofu yomwe ikukhudzidwa, popanda kuvulaza m'njira yomwe imachotsa phindu lake. Zonena zambiri za methylene blue zokhudza mitochondria zimafunikanso kusiyanitsa kumeneku pakati pa mmene imagwirira ntchito ndi zotsatira zake.

Tebulo loyerekezera umboni ndi zotsatira

Umboni kapena zonena	Zomwe ungatsimikizire	Zomwe zikufunikabe pa ME/CFS
Methylene blue imasintha kupuma kwa maselo a mitsempha	Kusintha kwa zochitika za mankhwala a m'selo mu dongosolo lodziwika la mu labotale	Umboni wakuti kusinthako kumathandiza pa matenda osati kungosintha zotsatira za mayeso
Maselo a m'magazi a odwala amasonyeza kusiyana pa kagwiritsidwe ntchito ka mphamvu	Kugwirizana pakati pa kukhala ndi matenda ndi miyezo ya maselo	Kuyerekezera chithandizo kosonyeza phindu lofunika pa thanzi la wodwala
Munthu akunena kuti anakhala watcheru kwambiri ataitenga	Zomwe anakumana nazo panthawiyo	Kuunika zizindikiro zochedwa, zotsatira zovulaza, ndi kuthekera kochita zinthu kwa masiku otsatizana
Mulingo woyezera kutopa ukusonyeza kusintha kwabwino	Kusintha pa muyezo wa chizindikiro china chodziwika	Kaya PEM, kugona, kuganiza, ndi zochita zofunika za tsiku ndi tsiku nazonso zikusintha bwino
Nthawi za kukulirakulira kwa zizindikiro zikuchepa pamene zochita zachepa kwambiri	Kusintha komwe kukuchitika limodzi ndi kuchepa kwa zochita	Kaya kusintha kwabwinoko kukuchokera ku kusintha zochita, chithandizo, kusinthasintha kwachibadwa, kapena zinthu zingapo

Zokambirana za Phoenix Rising zokhudza methylene blue zimasonyeza mafunso a odwala okhudza zomwe amakumana nazo, chitetezo, ndi ubwino wa zinthu zogulitsidwa. Zokambirana zoterezi zingapeze nkhani zofunika kufufuza. Zimasowa kuyerekezera kolamulidwa ndi kutsatira odwala mosasinthasintha zomwe zikufunika kuti mudziwe ngati chithandizo chikugwira ntchito.

Unikani masiku otsatira, osati ola labwino lokha

Ganizirani za munthu wongoyerekeza yemwe amamva kuti akuganiza bwino Lolemba ndipo amathera nthawi yaitali kusamalira makalata ndi mauthenga. Lachiwiri amafunikira thandizo pokonza chakudya; Lachitatu luso lake lokhazikika pa chinthu limakhalabe loipa kuposa masiku onse. Kunena kuti Lolemba anasintha bwino popanda kulemba zomwe zinachitika Lachiwiri ndi Lachitatu kungasiye mfundo zofunika pa chisamaliro cha wodwala. Kungakhalenso kufulumira kunena kuti kukulirakulira kwa matendawo kunachitika chifukwa cha chinthu chomwe watenga kapena chifukwa cha kuwonjezera zochita popanda kuganizira zochitika zonse motsatizana.

Zotsatira zothandiza kuunika zikuphatikiza kuopsa ndi kutalika kwa PEM, kuthekera kobwereza zochita zomwe zili zofunika kwa munthuyo, nthawi yobwerera pa mmene amakhalira nthawi zonse, ndi thandizo lomwe amafunikira. Munthu angaone kuti kuwerenga uthenga waufupi kapena kudzisamba popanda thandizo n'kofunika kwambiri kuposa kusintha kwa nambala ya mayeso a mu labotale. Zinthu zofunika zimenezo ziyenera kutsogolera zokambirana zilizonse ndi katswiri wa zaumoyo.

Posamalira zochita, NICE imalimbikitsa njira yogwirizana ndi munthu payekha, yosapitirira mphamvu zomwe ali nazo panopa ndipo imalangiza kuti pasagwiritsidwe ntchito mapulogalamu owonjezera masewera olimbitsa thupi ndi milingo yokhazikitsidwa pasadakhale. Kumva bwino kwakanthawi sikupereka chifukwa choyesera malire anu mwa kudzikakamiza kwambiri.

Buku lolembera zochita ndi zizindikiro zochedwa

Gwiritsani ntchito buku lolembera lolembedwa ngati mawu lomwe mungasindikize polemba moyo wa tsiku ndi tsiku kuti mukambirane ndi katswiri wa zaumoyo. Ndi chothandizira kuona zomwe zikuchitika, osati muyezo wozindikira matenda kapena ndondomeko yoyesera methylene blue. Lembani zokhazo zomwe mungakwanitse. Wokusamalirani angathandize, ndipo n'zovomerezeka ngati pali zina zomwe simunalembe.

Sankhani zizindikiro ziwiri kapena zitatu zothandiza kwa inu, monga kuthekera kopirira kuwerenga, kukonza chakudya, kapena thandizo posamba. Fotokozani zomwe zinachitikadi m'malo mochita ntchito kuti muyeze kuthekera kwanu. Lembani zochita zofuna mphamvu za thupi, kuganiza, kuthana ndi malingaliro, kupirira zomwe ziwalo zomva zimalandira, ndi kukhala woimirira pamene zili zoyenera. Phatikizani kupuma ndi kusintha kulikonse komwe kwachitika kale pa mankhwala kapena zochita za nthawi zonse.

Nthawi	Zochita ndi mmene zinthu zinalili	Zizindikiro ndi kuthekera kochita zinthu
Musanayambe chochita cha nthawi zonse	Tsiku/nthawi; zochita zaposachedwa; kugona	Zizindikiro za nthawi zonse lero; thandizo lomwe likufunika kale
Pamene mukuchita kapena posakhalitsa pambuyo pake	Zomwe zinachitika; nthawi yomwe zinatenga pafupifupi; kukhala pansi, kuimirira, kapena kutsamira	Zizindikiro zanthawi yomweyo; ntchito yomalizidwa, yofupikitsidwa, kapena yosiyidwa
Tsiku lotsatira	Zochita zatsopano ndi kupuma	Zizindikiro zatsopano kapena zowonjezereka; nthawi yoyambira; kusintha kwa kuthekera kochita zinthu za tsiku ndi tsiku
Tsiku lachiwiri	Zochita zatsopano ndi kupuma	Kukulirakulira kopitirirabe kapena kochedwa; thandizo lofunika
Masiku ena otsatira ngati pakufunika	Kufotokoza mwachidule mmene tsiku lililonse linalili	Kubwerera pa mmene mumakhalira nthawi zonse, kapena kusintha kopitirirabe

Bweretsani zolemba za zochitikazi motsatizana, kuphatikizapo masiku omwe akuoneka kuti palibe chomwe chinasintha, ku nthawi yokumana ndi katswiri. Funsani ngati kusintha kooneka kukhala kwabwino kunachitika pamene zochita zinali zofanana, thandizo linawonjezeka, kapena kupuma kunawonjezeka kwambiri. Buku la munthu payekha silingatsimikizire chimene chinayambitsa kusintha, koma lingathandize kuti kukambirana kwachidule kupereke mfundo zambiri.

Chitetezo ndi mbali ya funso lokhudza chithandizo

Methylene blue imagwira ntchito m'thupi monga mankhwala. Malangizo a ku U.S. operekera PROVAYBLUE yolowetsedwa mumtsempha amakhudza methemoglobinemia yomwe si yobadwa nayo, osati ME/CFS. Amachenjeza za vuto lalikulu la serotonin syndrome ikagwiritsidwa ntchito limodzi ndi mankhwala okhudza serotonin ndi opioids, ndipo amaletsa kuigwiritsa ntchito ngati munthu ali ndi kusowa kwa G6PD chifukwa cha chiopsezo cha kuchepa kwa magazi chifukwa cha kuwonongeka kwa maselo ofiira a m'magazi. Malangizo a mankhwala obayawa satsimikizira kuti ndondomeko yodzipangira chithandizo chomwa ndi yovomerezeka.

Bweretsani mndandanda wonse wa mankhwala ndi zowonjezera zakudya ku zokambirana ndi katswiri wa zaumoyo zokhudza methylene blue. Musasiye chithandizo chimene mwapatsidwa kuti muyambe kuigwiritsa ntchito. Funso loti liyankhidwe ndi lakuti kodi umboni wokhudza matendawa mwachindunji ukuthandizira phindu lofunika kwa inu, limodzi ndi njira yodziwira kukulirakulira kochedwa kwa zizindikiro ndi zotsatira zovulaza zomwe zikukhudzana nayo.